The Anticancer Agent Elesclomol Has Direct Effects on Mitochondrial Bioenergetic Function in Isolated Mammalian Mitochondria

The evaluation of the anti-cancer drug elesclomol that forms a redox-active copper chelate as a potential anti-tubercular drug

(2019) Andile H. Ngwane et al.   IUBMB LIFE

Mitochondrial metabolism promotes adaptation to proteotoxic stress

(2019) Peter Tsvetkov et al.   Nature Chemical Biology

Elesclomol restores mitochondrial function in genetic models of copper deficiency

(2018) Shivatheja Soma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Complex(I)ty of Cancer

(2017) Félix A. Urra et al.   Frontiers in Oncology

A phase I study of elesclomol sodium in patients with acute myeloid leukemia

(2016) David Hedley et al.   LEUKEMIA & LYMPHOMA

Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents

(2015) Josephine Modica-Napolitano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Syntheses and antitumor activities of N′1,N′3-dialkyl-N′1,N′3-di-(alkylcarbonothioyl) malonohydrazide: The discovery of elesclomol

(2013) Shoujun Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Final Results of Phase III SYMMETRY Study: Randomized, Double-Blind Trial of Elesclomol Plus Paclitaxel Versus Paclitaxel Alone As Treatment for Chemotherapy-Naive Patients With Advanced Melanoma

(2013) Steven J. O'Day et al.   JOURNAL OF CLINICAL ONCOLOGY

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

(2012) Masazumi Nagai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

(2012) Marco Spinazzi et al.   Nature Protocols

Mitochondrial Electron Transport Is the Cellular Target of the Oncology Drug Elesclomol

(2012) Ronald K. Blackman et al.   PLoS One

In Vitro Effect of Copper Chloride Exposure on Reactive Oxygen Species Generation and Respiratory Chain Complex Activities of Mitochondria Isolated from Broiler Liver

(2011) Rongsheng Su et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

(2010) Anatoly A. Starkov   Annals of the New York Academy of Sciences

Reactive oxygen species-dependent signaling regulates cancer

(2009) Frank Weinberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

N′1,N′3-Dimethyl-N′1,N′3-bis(phenylcarbonothioyl) Propanedihydrazide (Elesclomol) Selectively Kills Cisplatin Resistant Lung Cancer Cells through Reactive Oxygen Species (ROS)

(2009) Medhi Wangpaichitr et al.   Cancers

Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species

(2008) Romana Fato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Meta-Analysis of Phase II Cooperative Group Trials in Metastatic Stage IV Melanoma to Determine Progression-Free and Overall Survival Benchmarks for Future Phase II Trials

(2008) Edward L. Korn et al.   JOURNAL OF CLINICAL ONCOLOGY

Elesclomol induces cancer cell apoptosis through oxidative stress

(2008) J. R. Kirshner et al.   MOLECULAR CANCER THERAPEUTICS