Journal
BIOMOLECULES
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/biom9040158
Keywords
PI3K; PI 3-kinase; PIK3CA; mouse model; knock-in; transgenic; cancer; overgrowth; PROS
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Funding
- National Health and Medical Research Council (NHMRC) of Australia
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The phosphatidylinositol 3-kinase (PI3K) pathway is involved in a myriad of cellular signalling pathways that regulate cell growth, metabolism, proliferation and survival. As a result, alterations in the PI3K pathway are frequently associated with human cancers. Indeed, PIK3CAthe gene encoding the p110 catalytic subunit of PI3Kis one of the most commonly mutated human oncogenes. PIK3CA mutations have also been implicated in non-malignant conditions including congenital overgrowth syndromes and vascular malformations. In order to study the role of PIK3CA mutations in driving tumorigenesis and tissue overgrowth and to test potential therapeutic interventions for these conditions, model systems are essential. In this review we discuss the various mouse models currently available for preclinical studies into the biological consequences and clinical significance of PIK3CA mutations.
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