Review
Pharmacology & Pharmacy
Zahra Tayarani-Najaran, Nilufar Tayarani-Najaran, Samira Eghbali
Summary: Auraptene, a bioactive compound derived from Citrus species, exhibits modulatory effects on cellular signaling pathways and anti-cancer activity. It inhibits cancer cell proliferation and tumor growth through various mechanisms, demonstrating potential anti-cancer effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Vasyl Chumachenko, Pavlo Virych, Guochao Nie, Petro Virych, Oleg Yeshchenko, Pavlo Khort, Anton Tkachenko, Volodymyr Prokopiuk, Nataliia Lukianova, Taras Zadvornyi, Michel Rawiso, Liyao Ding, Nataliya Kutsevol
Summary: Cancer chemotherapy is challenged by high toxicity and drug resistance. Using low toxic nanocarriers in combination with anticancer agents can enhance therapy effectiveness. Modern advances in nanotechnology facilitate the creation of materials with desired properties.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Moupiya Ghosh, Samir Mandal, Anindita Roy, Priyajit Mondal, Subhra Kanti Mukhopadhyay, Subhendu Chakrabarty, Gopal Chakrabarti, S. K. Pradhan
Summary: This study introduces a new strategy to enhance the activity of an antibacterial drug by conjugating it with a Cu-Ag-based nanocarrier. The research shows that the 10% amoxicillin conjugated nanocomposite exhibits the same antibacterial effect as the pure drug, with a more significant interaction with the cell wall and membrane of bacteria.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Physical
Veselina Adimcilar, Mustafa Cesme, Pelin Senel, Ibrahim Danis, Durisehvar Unal, Aysegul Golcu
Summary: The study aimed to prepare a copper complex of Epirubicin and found that the novel copper complex prepared under strongly alkaline conditions exhibited significant anticancer activity and binding affinity to DNA.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Inorganic & Nuclear
Saawan Kumar, Mie Riisom, Stephen M. F. Jamieson, Iman Kavianinia, Paul W. R. Harris, Nils Metzler-Nolte, Margaret A. Brimble, Christian G. Hartinger
Summary: Researchers conjugated a derivative of plecstatin-1 with peptides to enhance their targeting ability towards cancer cells. Metal-peptide conjugates were successfully synthesized and tested for their anticancer activity. Although the activity was relatively low, this study provides a potential strategy to design other metal complexes utilizing the targeting properties of peptides.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Andres Alguacil, Franco Scalambra, Pablo Lorenzo-Luis, Adrian Puerta, Aday Gonzalez-Bakker, Zenaida Mendoza, Jose M. Padron, Antonio Romerosa
Summary: Compounds 1 and 2 were synthesized and characterized. They exhibited nanomolar GI(50) values against six human solid tumors. Further investigation revealed their effects on colony formation in SW1573 cells, the action mechanism in HeLa cells, and their interaction with the pBR322 DNA plasmid.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Medicinal
Salah S. Massoud, Febee R. Louka, Nahed M. H. Salem, Roland C. Fischer, Ana Torvisco, Franz A. Mautner, Jan Vanco, Jan Belza, Zdenek Dvorak, Zdenek Travnicek
Summary: In this study, six copper complexes were synthesized and characterized. The complexes exhibited significant antiproliferative activity against human cancer cells, with the sixth complex showing the highest cytotoxicity compared to the reference drug cisplatin. Complex seven was able to induce apoptosis in A2780 cells, while complexes four and six showed considerable induction of autophagy and a potential cuproptosis effect.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Monika Matiyani, Anita Rana, Neha Karki, Kamal Garwal, Mintu Pal, Nanda Gopal Sahoo
Summary: Cancer is a serious global threat to human health caused by uncontrolled proliferation of malignant cells. Traditional cancer treatments have adverse side effects and high mortality rates, so novel drug delivery systems are urgently needed.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yating Chen, Zhilin Ke, Lingyu Yuan, Meixiang Liang, Shuhua Zhang
Summary: We synthesized and analyzed nine unique copper(II) hydrazylpyridine salicylaldehyde and 1,10-phenanthroline complexes. It was found that these complexes exhibited higher anticancer activity and lower cytotoxicity towards normal cells compared to other substances. Specifically, Cugdupt1 and Cugdupt8 induced cell death through ATP depletion and activation of mitophagy pathways.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Medicinal
Riccardo Carloni, Natalia Sanz del Olmo, Barbara Canonico, Mariele Montanari, Caterina Ciacci, Gianluca Ambrosi, F. Javier de la Mata, Maria Francesca Ottaviani, Sandra Garcia-Gallego
Summary: The study revealed the significant impact of meta-position iminopyridine substituents on the antitumor activity of carbosilane metallodendrimers. New Cu(II) carbosilane metallodendrimers with methyl or methoxy substituents demonstrated low micromolar IC50 values in tumor cell lines, and in vitro assays indicated improved cytotoxicity and selectivity. The most promising candidates exhibited a substantial increase in antitumor activity in U937 tumor cells, possibly through different ROS-production pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Stephen de Doncker, Eva Fischer-Fodor, Catalin Ioan Vlad, Patriciu Achimas-Cadariu, Gregory S. Smith, Siyabonga Ngubane
Summary: Two diphenyl formamidine ligands, four dirhodium(II,II) complexes, and three axially modified low-valent dirhodium(II,II) metallodendrimers were synthesized and evaluated for their anticancer activity against ovarian cancer cell lines. The dirhodium(II,II) complexes exhibited moderate cytotoxicity, with acetate and methyl-substituted formamidinate compounds showing increased cytotoxicity compared to cisplatin in the cisplatin resistant cell line. Methyl- and fluoro-substituted formamidinate complexes also demonstrated comparable or increased cytotoxic activity in another cell line. The low-valent metallodendrimers exhibited some activity, but generally showed decreased cytotoxicity compared to the precursor complexes, except for one case where an acetate-derived metallodendrimer showed higher cytotoxicity than dirhodium(II,II) tetraacetate.
Review
Medicine, Research & Experimental
Sameen Zafar, Muhammad Armaghan, Khushbukhat Khan, Nazia Hassan, Javad Sharifi-Rad, Solomon Habtemariam, Marek Kieliszek, Monica Butnariu, Iulia-Cristina Bagiu, Radu Vasile Bagiu, William C. Cho
Summary: Maytansine is an active drug derived from medicinal plants and microorganisms. Its pharmacological activities primarily include anticancer and antibacterial effects. The anticancer mechanism of maytansine is achieved through interaction with tubulin, inhibiting microtubule assembly and leading to cell cycle arrest and apoptosis. However, its non-selective cytotoxicity limits its clinical applications. Researchers have developed derivatives of maytansine with improved pharmacological activities. This review provides valuable insights into maytansine and its synthetic derivatives as anticancer agents.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Cheng Wang, Shu Dai, Xingtao Zhao, Yafang Zhang, Lihong Gong, Ke Fu, Cheng Ma, Cheng Peng, Yunxia Li
Summary: This review comprehensively summarizes the molecular mechanisms of the anticancer effects of celastrol, a pentacyclic triterpenoid extracted from Tripterygium wilfordii Hook F. It has been found to exhibit significant broad-spectrum anticancer activities by inhibiting tumor cell proliferation, migration and invasion, inducing cell apoptosis, suppressing autophagy, hindering angiogenesis, and inhibiting tumor metastasis. Various signaling pathways have been identified as important molecular targets for its anticancer effects. However, celastrol also has adverse effects, low oral bioavailability, and a narrow therapeutic window, which present challenges for its development as an anticancer drug.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Jovana Rajkovic, Radmila Novakovic, Jelica Grujic-Milanovic, Alibek Ydyrys, Nurzhanat Ablaikhanova, Daniela Calina, Javad Sharifi-Rad, Basem Al-Omari
Summary: This comprehensive review analyzes and discusses the specific mechanisms and molecular targets of calotropin in cancer treatment, providing new perspectives for adjuvant therapy in different types of cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Janos P. Meszaros, Hilda Kovacs, Gabriella Spengler, Ferenc Kovacs, Eva Frank, Eva A. Enyedy
Summary: A salicylhydroxamic acid-estradiol hybrid molecule (E2HA) was synthesized, which forms high-stability complexes with essential metal ions (iron, copper) and exhibits moderate anticancer activity in human cancer cell lines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Marcin Holota, Sylwia Michlewska, Sandra Garcia-Gallego, Natalia Sanz del Olmo, Paula Ortega, Maria Bryszewska, Francisco Javier de la Mata, Maksim Ionov
Summary: Copper carbosilane metallodendrimers were conjugated with conventional anticancer drugs and showed enhanced effectiveness against cancer cells. The combination therapy significantly decreased cancer cell viability and induced apoptosis and necrosis. The presence of copper ions in the dendrimer structures enhanced the anticancer properties of the whole nanosystem.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elzbieta Okla, Piotr Bialecki, Marta Kedzierska, Elzbieta Pedziwiatr-Werbicka, Katarzyna Milowska, Samuel Takvor, Rafael Gomez, Francisco Javier de la Mata, Maria Bryszewska, Maksim Ionov
Summary: Drug delivery systems such as dendrimers, liposomes, polymers or gold/silver nanoparticles could advance modern medicine by overcoming biological barriers. This study evaluated the biophysical properties and biological safety of pegylated gold nanoparticles complexed with therapeutic siRNA against APOE4. The results showed that the complexes were stable and non-toxic to healthy cells, suggesting their potential use in delivering nucleic acids and treating neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sylwia Michlewska, Marek Maly, Dagmara Wojkowska, Kamil Karolczak, Elzbieta Skiba, Marcin Holota, Malgorzata Kubczak, Paula Ortega, Cezary Watala, F. Javier de la Mata, Maria Bryszewska, Maksim Ionov
Summary: In this study, a carbosilane metallodendrimer containing a ruthenium complex was conjugated with anti-cancer drugs, and it was found that the ruthenium enhanced the effectiveness of the drugs. The results showed that stable nanocomplexes were formed between the dendrimer and the drugs, improving their efficacy against cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biophysics
Malgorzata Kubczak, Marika Grodzicka, Sylwia Michlewska, Michael Karimov, Alexander Ewe, Achim Aigner, Maria Bryszewska, Maksim Ionov
Summary: This paper investigates the interaction between tyrosine-modified PEIs and human serum albumin. The study demonstrates that tyrosine-modified PEIs can bind to human serum albumin, and identifies the main molecular forces involved in complex formation. The research also reveals that the polymers can alter the secondary structure of human serum albumin.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biophysics
Sylwia Michlewska, Zuzana Garaiova, Veronika Subjakova, Marcin Holota, Ma lgorzata Kubczak, Marika Grodzicka, Elzbieta Okla, Nikolaos Naziris, Lucja Balcerzak, Paula Ortega, Francisco Javier de la Mata, Tibor Hianik, Iveta Waczulikova, Maria Bryszewska, Maksim Ionov
Summary: In this study, we combined dendritic and liposomal carriers and analyzed the biochemical and biophysical properties of these formulations. Lipid-coated dendritic carriers showed significantly improved transfection profiles and lower toxicity to erythrocyte membranes compared to noncomplexed components. The nanometric size, low polydispersity index, and reduced positive zeta potential of these complexes make them attractive for future drug delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Sylwia Michlewska, Dagmara Wojkowska, Cezary Watala, Elzbieta Skiba, Paula Ortega, Francisco Javier de la Mata, Maria Bryszewska, Maksim Ionov
Summary: Carbosilane metallodendrimers based on the arene Ru(II) complex (CRD13) and integrated with imino-pyridine surface groups have been investigated as an anticancer agent in a mouse model of triple-negative breast cancer. The dendrimer efficiently enters cells and exhibits selective toxicity for 4T1 cells. In vivo investigations have shown that local injection of CRD13 reduces tumor mass without causing toxicity. ICP analyses have indicated that Ru(II) accumulates in all tested tissues, with a higher content detected in the tumor.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Materials Science, Biomaterials
Nikolaos Naziris, Szymon Sekowski, Ewa Olchowik-Grabarek, Adam Buczkowski, Lucja Balcerzak, Varvara Chrysostomou, Stergios Pispas, Magdalena Malecka, Maria Bryszewska, Maksim Ionov
Summary: Lipid nanoparticles have a long history in drug delivery and have been extensively studied, with applications including COVID-19 vaccines. However, there are still many biophysical aspects that need further investigation. The combination of lipid nanoparticles with other biomaterials shows promising potential for more advanced drug delivery platforms.
BIOMATERIALS ADVANCES
(2023)
Article
Medicine, Research & Experimental
Magdalena Strachowska, Karolina Gronkowska, Maciej Sobczak, Marika Grodzicka, Sylwia Michlewska, Kinga Kolacz, Tuhin Sarkar, Joanna Korszun, Maksim Ionov, Agnieszka Robaszkiewicz
Summary: This study tested the efficacy of I-CBP112, a CBP/EP300 bromodomain inhibitor, in overcoming drug resistance in breast cancer and lung cancer models. It was found that I-CBP112 significantly reduced the overexpression of ATP-binding cassette transporters, thereby increasing intracellular drug accumulation and cytotoxicity. The study also demonstrated that I-CBP112 polarized human macrophages into proinflammatory phenotypes. Importantly, I-CBP112 did not show toxicity to primary cell lines or enhance drug toxicity to blood-immune cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
