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Biology
Robert J. Huebner, Abdul Naseer Malmi-Kakkada, Shinuo Weng, D. Thirumalai, John B. Wallingford
Summary: Morphogenesis is regulated by the interaction of molecular signals and mechanical forces, with key factors being the local mechanical heterogeneity of cell-cell junctions. The patterning of cadherins and local mechanics along cell-cell junctions is controlled by Planar Cell Polarity signaling, a crucial genetic module for convergent extension.
Article
Multidisciplinary Sciences
Sayantanee Biswas, Michelle R. Emond, Kurtis P. Chenoweth, James D. Jontes
Summary: The study found that lesions in delta-protocadherins increase cell divisions of neural progenitors in the hindbrain due to mis-regulation of the Wnt/beta-catenin signaling pathway. Additionally, delta-protocadherins can form a complex with the Wnt receptor Ryk, which is required for the increased proliferation in protocadherin mutants. This suggests that delta-protocadherins are novel regulators of Wnt/beta-catenin signaling in the development of neural circuits.
Article
Biology
Alessandra Gentile, Anabela Y. R. Bensimon-Brito, Rashmi Priya, Hans-Martin Maischein, Janett Piesker, Stefan Guenther, Felix Gunawan, Didier Y. R. Stainier
Summary: The transcription factor Snai1b is crucial for maintaining myocardial wall integrity in cardiomyocytes by repressing desmin b expression. Loss of Snai1b leads to increased extrusion of cardiomyocytes and enhanced actomyosin contractility. These findings underscore the importance of Snai1 in regulating cardiac morphogenesis beyond its known roles in epithelial-to-mesenchymal transition and cardiac valve formation.
Article
Multidisciplinary Sciences
Tom Brandstaetter, David B. Brueckner, Yu Long Han, Ricard Alert, Ming Guo, Chase P. Broedersz
Summary: Cell migration in rotating spherical tissues exhibits a collective mode with a single-wavelength velocity wave, which is accompanied by a supracellular flow pattern featuring topological defects. This collective migration mode arises from the effect of curvature on the active flocking behavior of cells on a spherical surface.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Emily Burghardt, Jessica Rakijas, Antariksh Tyagi, Pralay Majumder, Bradley J. S. C. Olson, Jocelyn A. McDonald
Summary: The study identified 1,729 genes that are temporally and differentially expressed during border cell migration, forming nine co-expression gene clusters. These genes are involved in regulating cytoskeleton, adhesion, and tissue morphogenesis, as well as immune signaling, ribosome biogenesis, and stress responses. The findings provide new insights into the molecular mechanisms underlying dynamic collective cell migrations in developing tissues.
Article
Biotechnology & Applied Microbiology
Shuntaro Yamada, Mohammed A. Yassin, Francesco Torelli, Jan Hansmann, Jeremy B. A. Green, Thomas Schwarz, Kamal Mustafa
Summary: The fate determination of bone marrow mesenchymal stem/stromal cells (BMSC) is regulated by mechanical cues, such as fluid shear stress. In this study, the researchers analyzed the cytoskeletal modulation and osteogenic profiles of BMSC in a 3D culture condition with fluid stimuli. The results showed that fluid shear stress increased actomyosin contractility and promoted osteogenic gene expression and markers, even without chemical supplementation. The study highlights the importance of cytoskeletal response and unique osteogenic profile in mechanically stimulated BMSC for bone regeneration.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Chen Qu, Wen Yang, Yating Kan, Hui Zuo, Mengqi Wu, Qing Zhang, Heng Wang, Dou Wang, Jiong Chen
Summary: Proper regulation of mitochondrial dynamics is critical for collective migration of Drosophila border cells during oogenesis. Misregulation of mitochondrial fission or fusion results in reduced ATP levels. RhoA/ROCK signaling may couple actomyosin dynamics with mitochondrial dynamics to achieve optimal actomyosin function during cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Robert J. Huebner, Shinuo Weng, Chanjae Lee, Sena Sarikaya, Ophelia Papoulas, Rachael M. Cox, Edward M. Marcotte, John B. Wallingford
Summary: This article investigates the role of the Arvcf protein in controlling head-to-tail axis extension in Xenopus. It is found that Arvcf is necessary for axis extension in the intact organism, but not in isolated tissues. The study also reveals that the force defect is a result of the dampening of pulsatile recruitment of cell adhesion and cytoskeletal proteins.
DEVELOPMENTAL CELL
(2022)
Review
Cell Biology
Zofia Ostrowska-Podhorodecka, Isabel Ding, Masoud Norouzi, Christopher A. McCulloch
Summary: Vimentin plays a role in regulating cell attachment to the ECM and modulating collagen deposition and ECM structure, thus impacting cell migration and ECM remodeling. It interacts with cell adhesion proteins to regulate integrin-dependent adhesions and cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Giorgia Chinigo, Guillaume P. Grolez, Madelaine Audero, Alexandre Bokhobza, Michela Bernardini, Julien Cicero, Robert-Alain Toillon, Quentin Bailleul, Luca Visentin, Federico Alessandro Ruffinatti, Guillaume Brysbaert, Marc F. Lensink, Jerome De Ruyck, Anna Rita Cantelmo, Alessandra Fiorio Pla, Dimitra Gkika
Summary: This study reveals that the TRPM8 channel inhibits cell migration and adhesion in prostate cancer by interacting with the small GTPase Rap1A. The interaction between TRPM8 and Rap1A is critical for the motility control of cancer cells and could potentially be targeted for therapy in various types of tumors.
Article
Biology
Diana Khoromskaia, Guillaume Salbreux, Michael M. Kozlov
Summary: This study investigates the shape transformations of epithelial tissues in three dimensions and identifies the active forces generated by the cytoskeleton as crucial. The interplay between local differential tensions, tissue geometry, and external forces is explored, revealing the mechanical equilibrium shapes and dynamic deformations of epithelial sheets.
Review
Cell Biology
Weili Xu, Tessa Bergsbaken, Karen L. Edelblum
Summary: Intestinal tissue-resident lymphocytes play a critical role in maintaining the mucosal barrier and preventing enteric infections. CD103, an integrin expressed on these lymphocytes, is involved in their activation and function, but the molecular signals it triggers are still not well understood. Research in this field can provide insights into the functional contribution of CD103 and its potential as a therapeutic target for tissue-resident lymphocyte-related diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Cell Biology
Alessandra Bonfanti, Julia Duque, Alexandre Kabla, Guillaume Charras
Summary: In this review, the experimental characterization and theoretical approaches for understanding tissue fracture at the tissue, cellular, and molecular scales are detailed.
TRENDS IN CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Alexandros Glentis, Carles Blanch-Mercader, Lakshmi Balasubramaniam, Thuan Beng Saw, Joseph d'Alessandro, Sebastien Janel, Audrey Douanier, Benedicte Delaval, Frank Lafont, Chwee Teck Lim, Delphine Delacour, Jacques Prost, Wang Xi, Benoit Ladoux
Summary: Researchers have found that epithelial layers in cylindrical tissues with different curvatures exhibit large-scale, persistent, and circumferential rotation. This rotational movement is similar within a common curvature window, even in tissues with inverted curvature. Stable cell-cell adhesion and Rac-1-dependent cell polarity are necessary for this persisting rotation.
Article
Neurosciences
Yuichi Sekine, Ramakrishnan Kannan, Xingxing Wang, Stephen M. Strittmatter
Summary: Neural repair after traumatic spinal cord injury relies on axonal sprouting and regeneration. Rab GTPases were found to inhibit successful sprouting and regeneration. This study identified Rabphilin3A as an effector within regenerating axons, and its loss enhanced axon extension by increasing integrin action in the growth cone.
EXPERIMENTAL NEUROLOGY
(2022)
Editorial Material
Cell Biology
Rashmi Priya, Alpha S. Yap
DEVELOPMENTAL CELL
(2015)
Article
Cell Biology
Guillermo A. Gomez, Robert W. McLachlan, Selwin K. Wu, Benjamin J. Caldwell, Elliott Moussa, Suzie Verma, Michele Bastiani, Rashmi Priya, Robert G. Parton, Katharina Gaus, Jan Sap, Alpha S. Yap
MOLECULAR BIOLOGY OF THE CELL
(2015)
Article
Cell Biology
Rashmi Priya, Kenneth Wee, Srikanth Budnar, Guillermo A. Gomez, Alpha S. Yap, Magdalene Michael
Article
Cell Biology
Luke Coburn, Hender Lopez, Benjamin J. Caldwell, Elliott Moussa, Chloe Yap, Rashmi Priya, Adrian Noppe, Anthony P. Roberts, Vladimir Lobaskin, Alpha S. Yap, Zoltan Neufeld, Guillermo A. Gomez
MOLECULAR BIOLOGY OF THE CELL
(2016)
Article
Cell Biology
Rashmi Priya, Xuan Liang, Jessica L. Teo, Kinga Duszyc, Alpha S. Yap, Guillermo A. Gomez
MOLECULAR BIOLOGY OF THE CELL
(2017)
Article
Cell Biology
Bipul R. Acharya, Selwin K. Wu, Zi Zhao Lieu, Robert G. Parton, Stephan W. Grill, Alexander D. Bershadsky, Guillermo A. Gomez, Alpha S. Yap
Article
Biochemical Research Methods
Rashmi Priya, Guillermo A. Gomez, Srikanth Budnar, Bipul R. Acharya, Andras Czirok, Alpha S. Yap, Zoltan Neufeld
PLOS COMPUTATIONAL BIOLOGY
(2017)
Editorial Material
Cell Biology
Selwin K. Wu, Guillermo A. Gomez, Samantha J. Stehbens, Michael Smutny
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Rashmi Priya, Srinivas Allanki, Alessandra Gentile, Shivani Mansingh, Veronica Uribe, Hans-Martin Maischein, Didier Y. R. Stainier
Article
Biology
Alessandra Gentile, Anabela Y. R. Bensimon-Brito, Rashmi Priya, Hans-Martin Maischein, Janett Piesker, Stefan Guenther, Felix Gunawan, Didier Y. R. Stainier
Summary: The transcription factor Snai1b is crucial for maintaining myocardial wall integrity in cardiomyocytes by repressing desmin b expression. Loss of Snai1b leads to increased extrusion of cardiomyocytes and enhanced actomyosin contractility. These findings underscore the importance of Snai1 in regulating cardiac morphogenesis beyond its known roles in epithelial-to-mesenchymal transition and cardiac valve formation.
Review
Developmental Biology
Mary C. Mullins, Joaquin Navajas Acedo, Rashmi Priya, Lilianna Solnica-Krezel, Stephen W. Wilson
Summary: In the 1990s, labs in Germany and the US conducted the largest genetic mutagenesis screen using zebrafish; the 25th anniversary of the zebrafish issue prompted five researchers to reflect on its significance and impact.
Article
Cell Biology
Selwin K. Wu, Juliana Ariffin, Shu Chian Tay, Remigio Picone
Summary: Centrosome amplification induces a non-canonical senescence-associated secretory phenotype (SASP) that activates paracrine invasion pathway. This SASP lacks DNA damage and NF-kappa B activation, but involves Rac activation and production of reactive oxygen species. It induces the expression of hypoxia-inducible factor 1 alpha and associated genes, including pro-migratory factors such as ANGPTL4. Therefore, the centrosome amplification-induced SASP may explain why extra centrosomes promote malignancy in some experimental models but are neutral in others.
Editorial Material
Cell Biology
Selwin K. Wu, Guillermo A. Gomez, Samantha Stehbens, Bipul R. Acharya, Aparna Ratheesh, Rashmi Priya, Anne Lagendijk, Alexander Bershadsky
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
