Review
Cell Biology
Stephen W. D'Souza, Jocelyn D. Glazier
Summary: Homocysteine is a metabolite that plays a vital role in embryonic growth and development. Dysregulated activities of the methionine and folate cycles, caused by maternal suboptimal intake of nutrients or gene polymorphisms, can lead to inefficient homocysteine metabolism and elevated concentrations, which negatively impact embryonic development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Emilia Mroz, Daria Murawska, Jakub Naczmanski, Malgorzata Konstantynowicz
Summary: The aim of this study was to determine the effects of hen's age and egg storage duration on selected growth parameters of turkey embryos. The results showed that both hen's age and egg storage duration significantly influenced the relative body weight and relative weight of unused albumen. Eggs laid by younger hens exhibited faster rate of albumen utilization under short-term storage.
Article
Public, Environmental & Occupational Health
Xingdi Yang, Jianjuan Zeng, Yiping Gu, Yiming Fang, Caiyun Wei, Shengkui Tan, Xiaoying Zhang
Summary: This hospital-based study in Guilin, China, aimed to determine the prevalence of birth defects in the region and classify them based on clinical presentation and causation. Of the 147,817 births recorded, 2,003 infants were diagnosed with BDs, with a total prevalence rate of 13.55 per 1,000 births. The study found that congenital heart defects, polydactyly, syndactyly, malformations of the external ear, and talipes equinovarus were the most common BD types.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Cell Biology
Wen Hao Neo, Michael Lie-A-Ling, Muhammad Zaki Hidayatullah Fadlullah, Georges Lacaud
Summary: During ontogeny, the establishment of the hematopoietic system occurs in different phases, from the yolk sac to the main arteries of the embryo. It has been discovered that yolk sac cells, initially thought to only bridge the gap to hematopoietic stem cells (HSCs), also play a role in embryonic organogenesis. Some of these cells persist into adulthood as distinct hematopoietic populations, opening up a new area of research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Mehran Amini, Elham Zadeh-Hashem, Manoochehr Allymehr
Summary: This study investigated the effects of formic acid on hatchability rate and the potential ameliorative role of kinetin on biochemical parameters in hatched broilers. The results showed that injection of formic acid significantly increased mortality, while concurrent administration of kinetin improved hatchability rate. The group receiving formic acid injection exhibited higher oxidative stress levels, which were reduced by kinetin administration.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Biology
Songying Cao, Yanqing Wu, E. Albert Reece, Cheng Xu, Wei-Bin Shen, Sunjay Kaushal, Peixin Yang
Summary: Different types of progenitors are important for organ formation, and their communication is altered in diabetic pregnancy. Exosomal communication plays a vital role in neuroepithelium development, and diabetes disrupts this communication.
COMMUNICATIONS BIOLOGY
(2022)
Review
Cell Biology
Andrew J. Copp, Maryam Clark, Nicholas D. E. Greene
Summary: This article describes the morphological phenotyping of mouse embryos during neurulation stages, focusing on evaluating the outcome of whole embryo cultures between embryonic days 8.5 and 9.5. Phenotyping methods that can be performed using a stereomicroscope at the bench are discussed, including assessment of embryonic health, developmental stage, and growth. Neural tube closure assessment and interpretation of defects are also explained. This detailed embryonic phenotyping, combined with whole embryo culture, provides a basis for various experimental studies in early mouse neural development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Plant Sciences
Hosakatte Niranjana Murthy, Kadanthottu Sebastian Joseph, Kee Yoeup Paek, So Young Park
Summary: Plant micropropagation has been widely used in agriculture, horticulture, forestry, and related fields for large-scale production of high-quality plants. The use of liquid media and bioreactors has increased the yield of healthy plants. This article discusses the design, principle, operational mode, advantages, and disadvantages of various bioreactors used for plant propagation, as well as the parameters that affect plant regeneration with suitable examples.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Cell Biology
Claudia Kappen, Claudia Kruger, Sydney Jones, J. Michael Salbaum
Summary: Maternal diabetes in early pregnancy increases the risk of birth defects in offspring. Changes in the expression of nutrient transporters may contribute to the increased incidence of birth defects. The findings highlight the importance of nutrient transporters in the intrauterine environment and have implications for strategies to reduce birth defects through nutrient supplementation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pathology
Domenico Ribatti, Vincenzo Benagiano
Summary: This review article discusses the potential use of the chick embryo area vasculosa as an in vivo assay for studying both angiogenesis and anti-angiogenesis. It suggests that this alternative method can be more useful than the chorioallantoic membrane in studying tumor growth, angiogenesis, and metastasis, as well as the angiogenic activity of acellular scaffolds and organoids.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Mozhgan Sharokhyan Rezaee, Dieter Liebhart, Claudia Hess, Michael Hess, Surya Paudel
Summary: The study showed that bacterial infections in chicken eggs can lead to embryo mortality, with the lesions in the yolk sac being a major indicator of mortality. Healthy yolk sacs were found to be crucial for the survival of embryos, highlighting the importance of proper yolk sac development.
VETERINARY PATHOLOGY
(2021)
Review
Veterinary Sciences
J. F. Gille, O. J. Ginther
Summary: This article describes the morphology of equine embryos with an emphasis on specific days after ovulation. It includes detailed descriptions and labeled colored photographs of the embryo proper and embryonic vesicle at different stages of development. It also discusses the major morphological changes in the embryo proper and the embryonic vesicle, as well as the growth regression lines and mean days of these morphological events.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Daichi Susaki, Rie Izumi, Takao Oi, Hidenori Takeuchi, Ji Min Shin, Naoya Sugi, Tetsu Kinoshita, Tetsuya Higashiyama, Tomokazu Kawashima, Daisuke Maruyama
Summary: In the synergid cells, F-actin controls secretion of pollen tube attractants toward the outside of the ovule, and its temporal destruction may terminate further attractant supply after fertilization.
Article
Multidisciplinary Sciences
Aynalem Gashaw, Sisay Shine, Osman Yimer, Melat Wodaje
Summary: A hospital-based case-control study in North Shoa Zone Hospitals identified factors such as family annual income less than 24,000ETB, history of still birth, history of abortion, preconception tea use, and pesticides/chemical exposure to be positively associated with neural tube defects. Conversely, preconception care and taking iron/folic acid/multivitamin during pregnancy showed a protective effect against neural tube defects.
Article
Ecology
David Nusbaumer, Laura Garaud, Laurie Ancay, Claus Wedekind
Summary: This study found that sex differences may already exist in the embryos and larvae of lake char, with differences in life history and susceptibilities to environmental stress. Parental effects significantly influenced offspring growth and mortality, but sex differences in embryo performance were not family-specific.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Developmental Biology
Valentina Massa, Laura Avagliano, Paolo Grazioli, Sandra C. P. De Castro, Chiara Parodi, Dawn Savery, Patrizia Vergani, Serena Cuttin, Patrizia Doi, Gaetano Bulfamante, Andrew J. Copp, Nicholas D. E. Greene
BIRTH DEFECTS RESEARCH
(2020)
Article
Cell Biology
Matteo A. Mole, Gabriel L. Galea, Ana Rolo, Antonia Weberling, Oleksandr Nychyk, Sandra C. De Castro, Dawn Savery, Reinhard Faessler, Patricia Ybot-Gonzalez, Nicholas D. E. Greene, Andrew J. Copp
DEVELOPMENTAL CELL
(2020)
Article
Medicine, Research & Experimental
Chloe Santos, Yun Jin Pai, M. Raasib Mahmood, Kit-Yi Leung, Dawn Savery, Simon N. Waddington, Andrew J. Copp, Nicholas D. E. Greene
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Developmental Biology
Dawn Savery, Eirini Maniou, Lucy H. Culshaw, Nicholas D. E. Greene, Andrew J. Copp, Gabriel L. Galea
BIRTH DEFECTS RESEARCH
(2020)
Review
Nutrition & Dietetics
Stephen W. D'Souza, Andrew J. Copp, Nicholas D. E. Greene, Jocelyn D. Glazier
Summary: Supplementation with myo-inositol may reduce the risk of neural tube defects, especially for NTDs unresponsive to folic acid. Maternal myo-inositol intake plays a crucial role in embryonic development, establishing active cellular uptake mechanisms and effectively lowering NTD risk in human pregnancy. The generation of materno-fetal inositol concentration gradients and a transport pathway for myo-inositol delivery contribute to inositol's ability to confer embryonic developmental benefit.
ADVANCES IN NUTRITION
(2021)
Article
Genetics & Heredity
Kit-Yi Leung, Sandra C. P. De Castro, Gabriel L. Galea, Andrew J. Copp, Nicholas D. E. Greene
Summary: The loss of GCSH gene leads to embryonic death in mice prior to mid-gestation, in contrast to the compatibility of GLDC or AMT loss with embryonic survival. This suggests that GCSH may have additional roles beyond the glycine cleavage system.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Gabriel L. Galea, Eirini Maniou, Timothy J. Edwards, Abigail R. Marshall, Ioakeim Ampartzidis, Nicholas D. E. Greene, Andrew J. Copp
Summary: The mosaic deletion of Vangl2 in the murine neuroepithelium causes spina bifida by preventing apical constriction via reduced myosin II and tubulin organization. This non-autonomous effect explains how post-zygotic mutations affecting a minority of cells can lead to catastrophic failure of morphogenesis.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Eirini Maniou, Michael F. Staddon, Abigail R. Marshall, Nicholas D. E. Greene, Andrew J. Copp, Shiladitya Banerjee, Gabriel L. Galea
Summary: Gap closure in mammalian embryos during embryonic hindbrain neuropore (HNP) closure follows specific mechanisms;
Asymmetric closure mechanisms involving pursestring contraction and directional cell motion accelerate the closure process;
Coordination of cellular and tissue-level mechanics is crucial for mammalian embryos to achieve this critical gap closure event.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Letter
Medicine, General & Internal
H. Mohan, M. Guzman Lenis, E. Y. Laurette, O. Tejada, T. Sanghvi, K. -Y. Leung, L. S. Cahill, J. G. Sled, P. Delgado-Olguin, N. D. E. Greene, A. J. Copp, L. Serghides
Article
Developmental Biology
Jordana N. Peake, Rachel L. Knowles, Jill Shawe, Judith Rankin, Andrew J. Copp
Summary: This study found variations in NTD prevalence among different ethnic communities in the UK, with Indian and Bangladeshi mothers being more likely to have NTD-affected pregnancies compared to White mothers. The excess prevalence in Indian mothers was specifically for anencephaly, while in Bangladeshi mothers the trend was for increased spina bifida.
BIRTH DEFECTS RESEARCH
(2021)
Article
Developmental Biology
Alexandra J. Palmer, Dawn Savery, Valentina Massa, Andrew J. Copp, Nicholas D. E. Greene
Summary: Mouse models are utilized to study genetic interactions leading to neural tube defects. This study investigated the potential interactions between Pax3 mutation and canonical Wnt signaling using conditional genetic models. The findings suggest that β-catenin function modulates the frequency of PAX3-related NTDs in mice, affecting both cranial and spinal neural tube closure differently.
Article
Multidisciplinary Sciences
Muzlifah Haniffa, Deanne Taylor, Sten Linnarsson, Bruce J. Aronow, Gary D. Bader, Roger A. Barker, Pablo G. Camara, J. Gray Camp, Alain Chedotal, Andrew Copp, Heather C. Etchevers, Paolo Giacobini, Berthold Gottgens, Guoji Guo, Ania Hupalowska, Kylie R. James, Emily Kirby, Arnold Kriegstein, Joakim Lundeberg, John C. Marioni, Kerstin B. Meyer, Kathy K. Niakan, Mats Nilsson, Bayanne Olabi, Dana Pe'er, Aviv Regev, Jennifer Rood, Orit Rozenblatt-Rosen, Rahul Satija, Sarah A. Teichmann, Barbara Treutlein, Roser Vento-Tormo, Simone Webb
Summary: The Human Developmental Cell Atlas initiative aims to create a comprehensive reference map of cells during development to understand the basis of human development, congenital and childhood disorders, as well as aging, cancer, and regenerative medicine. The initiative integrates scientists’ data on human development and uses state-of-the-art technologies to create a reference atlas across gestation.
Correction
Multidisciplinary Sciences
Gabriel L. Galea, Eirini Maniou, Timothy J. Edwards, Abigail R. Marshall, Ioakeim Ampartzidis, Nicholas D. E. Greene, Andrew J. Copp
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Oleksandr Nychyk, Gabriel L. Galea, Matteo Mole, Dawn Savery, Nicholas D. E. Greene, Philip Stanier, Andrew J. Copp
Summary: The study suggests that reduced sulfation of glycosaminoglycans interacting with heterozygosity for the Vangl2 gene may lead to craniorachischisis in mouse embryos, rather than defective neuroepithelial cell movements. Exogenous sulphate can rescue this defect.
DISEASE MODELS & MECHANISMS
(2022)
Letter
Developmental Biology
Andrew J. Copp, Nicholas D. E. Greene, Jennifer Jao, Rebecca Zash, Haneesha Mohan, Valeriya Dontsova, Lena Serghides
BIRTH DEFECTS RESEARCH
(2022)
