Article
Orthopedics
Manon Pigeolet, Saiful Imam, Gheorghe Cristian Ninulescu, Shafiul Kabir, Pierre R. Smeesters, Hasib Mahmud
Summary: Idiopathic clubfoot affects about 1/1000 alive-born infants, with the majority in low- or middle-income countries. This study in rural Bangladesh evaluated outcomes in patients with neglected clubfoot after surgical treatment, showing good functional outcomes with a posteromedial release regardless of age. Further research is needed to explore the role of triple arthrodesis.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Orthopedics
Ibrahim Karaman, Ramazan Ilter Ozturk, Yigit Umur Cirdi, Mithat Oner
Summary: The study found that dual arthrodesis plus a hexapod spider frame is a valuable option for patients with recurrent or neglected pes equinovarus. This approach can be offered safely to prevent secondary recurrences and complications in cases of rigid feet and challenging cases resistant to soft tissue manipulation.
INDIAN JOURNAL OF ORTHOPAEDICS
(2021)
Review
Oncology
Karim Masrouha, Alice Chu, Wallace Lehman
Summary: The management of idiopathic clubfoot has shifted towards the Ponseti method over surgical release. Relapse of the deformity remains a major issue with no consensus on how to define and manage it. Future efforts should focus on standardizing the definition of relapse with objective criteria for management.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Orthopedics
Pabitra Kumar Sahoo, Mamata Manjari Sahu
Summary: There is no dedicated national program for clubfoot management in India, leading to a high burden of disability from untreated or partly treated clubfoot. This study suggests that neglected clubfoot can be addressed through corrective rehabilitation surgery camps using a community approach.
INDIAN JOURNAL OF ORTHOPAEDICS
(2023)
Article
Orthopedics
Melissa Bent, Maia Hauschild, Susan A. Rethlefsen, Tishya A. L. Wren, Adriana Liang, Rachel Y. Goldstein, Robert M. Kay
Summary: This study compared the gait characteristics of children with late clubfoot relapse following treatment with Ponseti method only, intra-articular surgery, and extra-articular surgery. The results showed that the intra-articular surgery group had significantly greater passive dorsiflexion, inversion weakness, dorsiflexion during the stance phase of gait, and lower maximum power production at push-off compared to the other groups. Conclusion: Late relapse can occur after all types of clubfoot correction, and patients who have undergone posteromedial release surgery show poorer plantarflexor moment and power production during gait.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2023)
Review
Oncology
Cristina Alves, Anna Ey Batlle, Marta Vinyals Rodriguez
Summary: The Ponseti Method is effective in treating neglected clubfoot, with satisfactory outcomes in children who did not receive treatment. However, neglected clubfoot is more challenging to treat compared to newborn clubfoot.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Orthopedics
Mohamed Fadel, Mohamed Fawzy Kandil
Summary: The study evaluated the outcomes of IEF and MIS in correcting NCF, and concluded that the combination of IEF and MIS is an efficient and successful treatment for severe idiopathic NCF in children.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Medicine, General & Internal
Enrico Tiacci, Luca De Carolis, Edoardo Simonetti, Monia Capponi, Achille Ambrosetti, Eugenio Lucia, Agostino Antolino, Alessandro Pulsoni, Samantha Ferrari, Pier L. Zinzani, Stefano Ascani, Vincenzo M. Perriello, Luigi Rigacci, Gianluca Gaidano, Roberta Della Seta, Natalia Frattarelli, Paolo Falcucci, Robin Foa, Giuseppe Visani, Francesco Zaja, Brunangelo Falini
Summary: The combination of BRAF inhibition with rituximab showed promising results in treating refractory or relapsed hairy-cell leukemia, with a durable complete response observed in most patients and minimal toxic effects.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Materials Science, Multidisciplinary
David Vondrasek, Daniel Hadraba, Jan Pribyl, Adam Eckhardt, Martin Ostadal, Frantisek Lopot, Karel Jelen, Martina Doubkova, Jarmila Knitlova, Tomas Novotny, Jiri Janacek
Summary: This study aims to quantify and compare the morphological and mechanical properties of the medial and lateral side tissue from relapsed clubfoot after surgery. Using methods such as optical and atomic force microscopy, the study revealed that the medial side has a higher Young's modulus, more collagen, and less adipose tissue, and that the collagen fibers exhibit a higher frequency of the crimp pattern after surgical dissection. This study offers a comprehensive approach to thoroughly investigate relapsed clubfoot tissue.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Orthopedics
Virginie Nguyen-Khac, Asuka Desroches, Julia Bouchaib, Jean-Paul Padovani, Philippe Wicart
Summary: The aim of this study was to define indications for talectomy in congenital paralytic, dystrophic or idiopathic, inveterate or recurrent, clubfoot. The results showed that talectomy is a valid treatment option for paralytic or dystrophic inveterate or recurrent clubfoot.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2023)
Article
Medicine, General & Internal
Andrew M. Brunner, Richard A. Newcomb, Yi-Bin Chen, Andrew M. Crabbe
Summary: The text discusses the evaluation of a 49-year-old man with relapsed acute myeloid leukemia, identifying a new FLT3-ITD mutation through molecular genetic profiling. Management decisions were made based on a bone marrow biopsy.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Orthopedics
Oliver Loose, Francisco Fernandez Fernandez, Micha Langendoerfer, Thomas Wirth, Oliver Eberhardt
Summary: This paper reports on the treatment of complex atypical clubfoot using the modified Ponseti method, and the midterm outcomes. The results show that all atypical complex clubfeet could be corrected using the modified Ponseti method. However, a high relapse rate was observed in the medium term, though good functional results were achieved with relapse treatment.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Review
Orthopedics
Karim Gaber, Basit Mir, Mohammed Shehab, Waleed Kishta
Summary: This article reviews the advances in surgical management for clubfoot deformity and discusses the long-term outcomes of each approach. The study finds that soft tissue releases and tibialis anterior transfer show good long-term results in young patients. Tibialis anterior transfer also improves correction in surgical relapses. Bony osteotomies and hexapod external fixation may be considered for older patients with rigid clubfoot deformities. Anterior distal tibial epiphysiodesis improves ankle dorsiflexion in recurrent equinus deformity.
CURRENT REVIEWS IN MUSCULOSKELETAL MEDICINE
(2022)
Article
Medicine, General & Internal
Akhil Agnihotri, Suresh Chand, Anil Mehtani, Alok Sud, Siddhartha Sinha, Arvind Kumar
Summary: The study retrospectively analyzed the clinical records of 25 patients with 38 neglected clubfeet treated with a modified Ponseti technique, showing satisfactory long-term deformity correction outcomes with minor losses in correction noticed after two years of treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Editorial Material
Pharmacology & Pharmacy
Ethel D. Weld, Catriona Waitt, Karen Barnes, Facundo Garcia Bournissen
Summary: Clinicians lack evidence for proper medication usage in neglected populations suffering from neglected tropical diseases, highlighting the need for new medicines. Developing and ensuring affordability and accessibility of novel therapies is critical in addressing this issue.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Emergency Medicine
Pavel Kotlarsky, Itai Shavit, Imad Kassis, Mark Eidelman
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2016)
Article
Ophthalmology
Pavel Kotlarsky, Arkady Bolotin, Karina Dorfman, Boris Knyazer, Tova Lifshitz, Jaime Levy
INTERNATIONAL OPHTHALMOLOGY
(2015)
Article
Genetics & Heredity
Reggie C. Hamdy, Harold van Bosse, Haluk Altiok, Khaled Abu-Dalu, Pavel Kotlarsky, Alicja Fafara, Mark Eidelman
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
(2019)
Article
Orthopedics
Daniel Freedman, Pavel Kotlarsky, Mark Eidelman
Summary: Forefoot adduction deformity is the most common congenital foot deformity in newborns. Early diagnosis and treatment are crucial for better outcomes. This study compared the effectiveness of UNFO shoes and standard serial casting in the treatment of RFAD, and found that UNFO shoes are equally effective and more convenient.
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2022)
Article
Orthopedics
Pavel Kotlarsky, Oren Feldman, Itai Shavit, Mark Eidelman
Summary: This study aimed to investigate the use of real-time ultrasound-guided reduction in pediatric forearm and wrist fractures. The results showed that using ultrasound guidance during reduction can decrease the number of reduction attempts and reduce the need for surgery in these fractures.
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2022)
Article
Orthopedics
Michael Zaidman, Pavel Kotlarsky, Mark Eidelman
Summary: This study aimed to analyze the incidence and predictors of recurrence in patients with varus-valgus deformities around the knee treated with temporary hemiepiphysiodesis. The results showed that 10% of patients experienced rebound of the deformity. Risk factors for recurrence included younger age, deformity of the proximal tibia, proximal tibial medial growth plate beaking, and comorbidities.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Article
Surgery
Michael Zaidman, Mark Eidelman, Khaled Abu-Dalu, Pavel Kotlarsky
Summary: This study reviewed clinical records and radiographs of patients with supracondylar humeral fractures and identified a new subtype. By modifying the operative technique, the desired fracture alignment and fixation can be achieved.
SURGICAL TECHNIQUES DEVELOPMENT
(2023)
Article
Orthopedics
Mark Eidelman, Pavel Kotlarsky
Summary: This case report discusses the ankle-sparing reconstruction with serial tibial- and fibular-lengthening procedures for a patient with tibial hemimelia Jones Type 4, which appears to be an effective treatment option. It is noted as the first report of ankle-sparing reconstruction followed until maturity in these patients.
JOURNAL OF LIMB LENGTHENING & RECONSTRUCTION
(2021)
Article
Orthopedics
Pavel Kotlarsky, Gil Gannot, Alexander Katsman, Mark Eidelman
Summary: The study retrospectively reviewed adolescent patients who underwent percutaneous distal metatarsal osteotomy for hallux valgus correction between 2008 and 2015. The results showed significant improvement in symptomatic hallux valgus, with the procedure being safe and effective in treating the condition.
FOOT & ANKLE SPECIALIST
(2021)
Article
Medicine, General & Internal
Shahar Grunner, Pavel Kotlarsky, Yaron Berkovich, Adi Givon, Yaniv Keren
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2016)
Review
Orthopedics
Pavel Kotlarsky, Reuben Haber, Victor Bialik, Mark Eidelman
WORLD JOURNAL OF ORTHOPEDICS
(2015)