Journal
ENGINEERING
Volume 5, Issue 4, Pages 777-794Publisher
ELSEVIER
DOI: 10.1016/j.eng.2019.03.009
Keywords
Three-dimensional bioprinting; Solid tissues; Hollow tissues; Organs-on-chips; Tissue engineering; Drug screening
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Funding
- National Natural Science Foundation of China [51875518, 51475419, 81501607]
- Natural Science Foundation of Zhejiang Province of China [LY15H160019]
- Key Research and Development Projects of Zhejiang Province [2017C01054]
- BBSRC [BB/H008608/1] Funding Source: UKRI
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Three-dimensional (3D) bioprinting is a rapidly growing technology that has been widely used in tissue engineering, disease studies, and drug screening. It provides the unprecedented capacity of depositing various types of biomaterials, cells, and biomolecules in a layer-by-layer fashion, with precisely controlled spatial distribution. This technology is expected to address the organ-shortage issue in the future. In this review, we first introduce three categories of 3D bioprinting strategies: inkjet-based printing (IBP), extrusion-based printing (EBP), and light-based printing (LBP). Biomaterials and cells, which are normally referred to as bioinks, are then discussed. We also systematically describe the recent advancements of 3D bioprinting in fabricating cell-laden artificial tissues and organs with solid or hollow structures, including cartilage, bone, skin, muscle, vascular network, and so on. The development of organs-onchips utilizing 3D bioprinting technology for drug discovery and toxicity testing is reviewed as well. Finally, the main challenges in current studies and an outlook of the future research of 3D bioprinting are discussed. (C) 2019 THE AUTHORS. Published by Elsevier LTD on behalf of Chinese Academy of Engineering and Higher Education Press Limited Company.
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