Article
Multidisciplinary Sciences
Jeong Ho Song, Ho-Jung Shin, Sang-Yong Son, Hoon Hur, Sang-Uk Han
Summary: This study evaluated the effects of participating in prospective surgical trials on surgical outcomes after radical gastrectomy for gastric cancer, and found that participation in the trials was not associated with surgical outcomes.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Wungki Park, Akhil Chawla, Eileen M. O'Reilly
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer with increasing incidence each year, resulting in a high percentage of patients being diagnosed with advanced disease. Current cytotoxic therapies for PDAC are moderately effective, emphasizing the importance of multidisciplinary management, comprehensive germline testing, and integrated supportive care for all patients.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Valerie Jooste, Leila Bengrine-Lefevre, Sylvain Manfredi, Valerie Quipourt, Pascale Grosclaude, Olivier Facy, Come Lepage, Francois Ghiringhelli, Anne-Marie Bouvier
Summary: Real-world data on the management and outcomes of pancreatic cancer showed that only half of elderly patients aged 75-84 with a surgically resectable tumor actually underwent resection, and a significant percentage of patients aged >= 85 refused chemotherapy, highlighting the need for expanded geriatric assessments.
Article
Oncology
In-Ho Kim, Moon Hyung Choi, In Seok Lee, Tae Ho Hong, Myung Ah. Lee
Summary: This study investigated the clinical impact of sarcopenia and skeletal muscle density (SMD) in patients with metastatic pancreatic adenocarcinoma who underwent palliative first line gemcitabine-based chemotherapy. The results showed that low SMD and low SMI were associated with poor overall survival, and the co-presence of low SMI and low SMD had more powerful prognostic implication for overall survival. Severe chemotherapy toxicity was observed more frequently in patients with sarcopenia and low SMD, suggesting that assessing skeletal muscle parameters comprehensively may be more useful as prognostic factors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvana Parisi, Gianluca Ferini, Alberto Cacciola, Sara Lillo, Consuelo Tamburella, Anna Santacaterina, Antonio Bottari, Anna Brogna, Giacomo Ferrantelli, Antonio Pontoriero, Fabio Minutoli, Stefano Pergolizzi
Summary: This study presents a non-surgical combo-therapy for locally advanced, unresectable pancreatic cancer, which includes induction chemotherapy, concomitant chemoradiotherapy, and stereotactic body radiotherapy boost. The therapy showed feasibility and good tolerance, achieving favorable local control and survival outcomes.
Article
Gastroenterology & Hepatology
Casper W. F. van Eijck, Dana A. M. Mustafa, Disha Vadgama, Noel F. C. C. de Miranda, Bas Groot Koerkamp, Geertjan van Tienhoven, Sjoerd H. van der Burg, Nuria Malats, Casper H. J. van Eijck, Dutch Pancreatic Canc Grp DPCG
Summary: This study investigates the impact of sex disparities on clinical outcomes and tumor immune profiles in patients with pancreatic ductal adenocarcinoma (PDAC). The study found that women who underwent resection preceded by neoadjuvant chemoradiotherapy had a higher overall survival rate compared to men, possibly due to their heightened sensitivity to gemcitabine-based treatment and lower levels of protumoral M2 macrophages in the tumor microenvironment.
Review
Oncology
Pengcheng Zuo, Tian Li, Tao Sun, Wenhao Wu, Yujin Wang, Mingxin Zhang, Zhen Wu, Junting Zhang, Liwei Zhang
Summary: This study retrospectively analyzed the clinical data of 26 patients with high grade pleomorphic xanthoastrocytomas (HGPXAs) who underwent surgical treatment. The results showed that complete surgical excision plus radiotherapy and chemotherapy is recommended as a treatment protocol. Further studies are needed to verify these findings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Maurizio Muscaritoli, Jann Arends, Patrick Bachmann, Vickie Baracos, Nicole Barthelemy, Hartmut Bertz, Federico Bozzetti, Elisabeth Hutterer, Elizabeth Isenring, Stein Kaasa, Zeljko Krznaric, Barry Laird, Maria Larsson, Alessandro Laviano, Stefan Muhlebach, Line Oldervoll, Paula Ravasco, Tora S. Solheim, Florian Strasser, Marian de van der Schueren, Jean-Charles Preiser, Stephan C. Bischoff
Summary: This practical guideline is based on the current scientific ESPEN guidelines on nutrition in cancer patients, providing 43 recommendations for the nutritional and metabolic management of patients with neoplastic diseases. It offers guidance to health care providers involved in the management of cancer patients to offer optimal nutritional care.
CLINICAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Sen Yu, Chunyu Zhang, Ke-Ping Xie
Summary: Pancreatic cancer is difficult to cure due to late diagnosis and early metastasis, and resistance to therapy is a major challenge in treating this disease. Research on therapeutic options and reversal of resistance is crucial for improving outcomes for patients with pancreatic cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Oncology
Stefania Rizzo, Isabel Scala, Angela Rodriguez Robayo, Marco Cefali, Sara De Dosso, Stefano Cappio, Genti Xhepa, Filippo Del Grande
Summary: This systematic review examines the association between body composition and chemotherapy-related toxicity in pancreatic cancer patients, and evaluates the different definitions of sarcopenia. The results show a wide variability in the association between body composition and chemotherapy-related toxicity in PC patients, and there is no uniform definition for sarcopenia.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Duorui Nie, Qingxia Lan, Bin Shi, Fei Xu
Summary: This study investigated different treatment strategies for elderly patients with stage I pancreatic cancer. The results showed that surgical resection and post-operative chemotherapy are recommended for patients who can tolerate treatment, but post-operative chemoradiotherapy does not provide survival benefits compared to post-operative chemotherapy. For untreated patients, radiotherapy, chemotherapy, or the combination of radiotherapy and chemotherapy are significantly related to prognosis, with chemoradiotherapy having the most obvious benefit.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Susie Youn, Angela Chen, Vincent Ha, Carole Chambers, Dean T. Eurich, Michael McCall, Michael B. Sawyer
Summary: The study found that adjusting nab-paclitaxel doses based on muscle mass can predict the risk of chemotherapy toxicity. Factors like BMI, body surface area, and initial drug doses did not significantly impact toxicity occurrence.
CLINICAL NUTRITION
(2021)
Article
Oncology
Wonchul Lee, Jesang Yu, Jae-Lyun Lee, Young Seok Kim, Bumsik Hong
Summary: This study investigated the clinical features and treatment outcomes of primary female urethral cancer (FUC) in 32 patients. The study found some poor prognostic factors and the treatment outcomes varied by pathological type. Multimodal treatment is necessary for female urethral cancer.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Pengcheng Zuo, Yujin Wang, Yiying Mai, Bochao Zhang, Zhen Wu, Junting Zhang, Wanjing Zou, Liwei Zhang
Summary: This study describes the clinical characteristics and surgical prognosis of PIAs, finding that this disease has a higher incidence in males and most cases show evidence of old hemorrhage on preoperative MRI. Through statistical analysis, complete resection surgery plays a crucial role in treating this rare disease.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Pengcheng Zuo, Yujin Wang, Yiying Mai, Bochao Zhang, Zhen Wu, Junting Zhang, Wanjing Zou, Liwei Zhang
Summary: This study retrospectively analyzed 28 cases of primary intracranial angiosarcomas (PIAs) and found a higher incidence in male patients than in female patients. Most cases showed evidence of old hemorrhage on preoperative MRI. Statistical analysis revealed that total resection plays a crucial role in treating this rare disease.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Surgery
Albert Chan, Wei Yi Zhang, Kenneth Chok, Jeff Dai, Ren Ji, Crystal Kwan, Nancy Man, Ronnie Poon, Chung Mau Lo
Summary: The study aimed to evaluate the short- and long-term outcomes of ALPPS for hepatitis-related HCC and found that ALPPS had a higher resection rate with comparable oncological outcomes to PVE in these patients.
Review
Gastroenterology & Hepatology
Kevin Ka-Wan Chu, Kelly Hiu-Ching Wong, Kenneth Siu-Ho Chok
Summary: Liver transplant has evolved from a procedure with high mortality to a routine procedure with good survival outcomes, especially with the development of living donor liver transplant. The scope of indications for liver transplant has expanded to include various types of liver cancers and even multiple organ failure, with increasing use in elderly patients. Further development of noninvasive predictors is needed to improve patient management and outcomes.
Article
Surgery
Tiffany Cho-Lam Wong, James Y. Y. Fung, Tracy Y. S. Cui, S. L. Sin, K. W. Ma, Brian W. H. She, Albert C. Y. Chan, Kenneth S. H. Chok, Jeff W. C. Dai, Tan-To Cheung, Chung-Mau Lo
Summary: The study found that the graft-to-recipient weight ratio can be lowered to 0.6% in LDLT after careful recipient selection, resulting in good outcomes, reduced incidence of small-for-size syndrome, and excellent survival rates.
Article
Gastroenterology & Hepatology
Karen Man-Fong Sze, Daniel Wai-Hung Ho, Yung-Tuen Chiu, Yu-Man Tsui, Lo-Kong Chan, Joyce Man-Fong Lee, Kenneth Siu-Ho Chok, Albert Chi-Yan Chan, Chung-Ngai Tang, Victor Wai-Lun Tang, Irene Lai-Oi Lo, Derek Tsz-Wai Yau, Tan-To Cheung, Irene Oi-Lin Ng
Summary: The study found that HBV integrations are frequent in HCC tumors and are associated with increased TERT mRNA expression and more aggressive tumor behavior. Specifically, integration at the TERT promoter by HBV enhancer I (EnhI) led to TERT activation. Additionally, the E74 like ETS transcription factor 4 (ELF4) was identified as a key factor in driving telomerase activation in HCC cells through interaction with HBV.
Article
Surgery
Albert C. Y. Chan, Kenneth S. H. Chok, Jeff Dai, Simon H. Y. Tsang, Tan To Cheung, Ronnie Poon, S. T. Fan, C. M. Lo
Summary: The study examines the impact of LT experience on the outcome of CLR for hepatobiliary malignancy. The findings show that LT experience improves postoperative outcomes for CLR, especially for locally advanced hepatobiliary malignancies.
Article
Gastroenterology & Hepatology
Kin Pan Au, James Yan Yue Fung, Wing Chiu Dai, Albert Chi Yan Chan, Chung Mau Lo, Kenneth Siu Ho Chok
Summary: This study showed that radical treatment for hepatocellular carcinoma (HCC) oligo-recurrence after liver transplantation can lead to improved survival outcomes. Patients receiving palliative treatment had earlier recurrences and more extensive disease compared to those who received radical treatment.
LIVER TRANSPLANTATION
(2022)
Article
Surgery
Wong Hoi She, Miu Yee Chan, Ka Wing Ma, Simon H. Y. Tsang, Wing Chiu Dai, Albert C. Y. Chan, Chung Mau Lo, Tan To Cheung
Summary: This study identified an AFP level of 256 ng/ml as a predictor of adverse survival outcomes for patients with ruptured hepatocellular carcinoma after resection. Patients with AFP levels equal to or greater than 256 ng/ml had poorer overall and disease-free survival, as well as increased complications and adverse pathological features compared to those with lower AFP levels.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Surgery
Wong Hoi She, Tan To Cheung, Miu Yee Chan, Ka Wan Chu, Ka Wing Ma, Simon H. Y. Tsang, Wing Chiu Dai, Albert C. Y. Chan, Chung Mau Lo
Summary: This study conducted a clinical trial on the use of ICG-FC in LC and showed that ICG-FC did not reduce the conversion rate or complication rate. Further research is needed to determine the routine use of ICG-FC in LC.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Kin Pan Au, Miu Yee Chan, Ka Wan Chu, Crystal Lok Yan Kwan, Ka Wing Ma, Wong Hoi She, Simon Hing Yin Tsang, Wing Chiu Dai, Tan To Cheung, Albert Chi Yan Chan
Summary: The impact of three-dimensional (3D) visualization on laparoscopic hepatectomy for hepatocellular carcinoma was investigated in this retrospective study. The results showed that the availability of 3D laparoscopy has led to a significant increase in the proportion of laparoscopic major hepatectomies and difficult resections. After propensity score matching, patients who underwent 3D laparoscopic hepatectomy had comparable operative time and blood loss with those who underwent 2D laparoscopic hepatectomy, but had lower overall complications. Furthermore, patients who underwent 3D laparoscopic major hepatectomy had a shorter hospital stay compared to those who underwent open surgery.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Surgery
Madhukar S. Patel, Hiroto Egawa, Yong Kyong Kwon, Kenneth Siu Ho Chok, Michael Spiro, Dimitri Aristotle Raptis, Vivek Vij, Abhideep Chaudhary, Yuri Genyk, Claus Niemann, Joerg-Matthias Pollok, Marina Berenguer, Pascale Tinguely, Carlo Frola, Jonathan Potts, Mohammad Alradhawi, Hiu Tat Kwok
Summary: This study aims to identify the lower limit of GRWR compatible with enhanced recovery after living donor liver transplant and provide recommendations from an international expert panel. The results suggest that GRWR of >= .8% is often compatible with enhanced recovery, but grafts < .8% can be used in selected LDLT recipients with optimal donor-recipient selection, surgical technique, and perioperative management.
CLINICAL TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Kin-Pan Au, James Yan-Yue Fung, Wing-Chiu Dai, Albert Chi-Yan Chan, Chung-Mau Lo, Kenneth Siu-Ho Chok
Summary: The impact of tumor biology on radical treatment for oligo-recurrence of post-transplant hepatocellular carcinoma (HCC) remains uncertain. This retrospective study found that early recurrence, liver recurrence, and high levels of AFP upon recurrence were predictors of mortality. Radical treatment was associated with improved post-recurrence survival in patients with early and liver recurrence, but not in patients with high AFP levels. The survival benefits of radical therapy were reduced in early recurrence and high AFP, but remained similar among patients with and without liver recurrence. The presence of multiple biological risk factors diminished the survival benefit of radical therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Tan-To Cheung, Yuk Tong Lee, Raymond Shing-Yan Tang, Wong Hoi She, Kai Chi Cheng, Chin Cheung Cheung, Keith Wan Hang Chiu, Kenneth Siu Ho Chok, Wing Sun Chow, Tak Wing Lai, Wai-Kay Seto, Thomas Yau
Summary: This publication summarizes recommendations for the diagnosis and management of pancreatic cystic lesions, including risk assessment, surgical excision, and post-operative treatment.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Joerg M. Pollok, Pascale Tinguely, Marina Berenguer, Claus U. Niemann, Dimitri A. Raptis, Michael Spiro
Summary: There is significant controversy surrounding enhanced recovery for liver-transplant recipients, and this review aimed to summarize current knowledge, identify key components, and create internationally accepted guidelines. A collaborative effort by the ERAS4OLT.org partnership and specialists from around the world resulted in 80 final recommendations covering various aspects of enhanced recovery for liver transplantation. These guidelines provide a comprehensive overview and can guide the development of enhanced recovery programs globally.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Oncology
Janice Hoi Man Mok, Ka Wing Ma, Kenneth Siu Ho Chok
Summary: This study describes the current practice of living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC) in Queen Mary Hospital, Hong Kong. They carefully select patients using the UCSF criteria and use extended right lobe graft and hepatic venoplasty technique to improve transplantation outcomes. The results show positive outcomes in Hong Kong's organ shortage and high demand for transplantation.
Correction
Oncology
Phoenix Wai Yan Wong, Ka Wing Ma, Tan To Cheung, Wong Hoi She, Wing Chiu Dai, Albert Chi Yan Chan, Kenneth Siu Ho Chok, Chung Mau Lo
