TUFT1 Promotes Triple Negative Breast Cancer Metastasis, Stemness, and Chemoresistance by Up-Regulating the Rac1/β-Catenin Pathway

TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling

(2018) Natsumi Kawasaki et al.   Cell Discovery

FSTL1 enhances chemoresistance and maintains stemness in breast cancer cells via integrin β3/Wnt signaling under miR-137 regulation

(2018) Shaoqiang Cheng et al.   CANCER BIOLOGY & THERAPY

OCT4, SOX2, and NAN OG positive expression correlates with poor differentiation, advanced disease stages, and worse overall survival in HER2+ breast cancer patients

(2018) Fan Yang et al.   OncoTargets and Therapy

Breast cancer

(2017) Nadia Harbeck et al.   LANCET

Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma

(2017) Changhwan Yoon et al.   MOLECULAR CANCER RESEARCH

Cadmium stimulates metastasis-associated phenotype in triple-negative breast cancer cells through integrin and β-catenin signaling

(2017) Zhengxi Wei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dickkopf-related protein 2 induces G0/G1 arrest and apoptosis through suppressing Wnt/β-catenin signaling and is frequently methylated in breast cancer

(2017) Junhao Mu et al.   Oncotarget

TUFT1 is expressed in breast cancer and involved in cancer cell proliferation and survival

(2017) Weiguang Liu et al.   Oncotarget

Co-targeting of Tiam1/Rac1 and Notch ameliorates chemoresistance against doxorubicin in a biomimetic 3D lymphoma model

(2017) Muhammad Ikram et al.   Oncotarget

Prognostic Value of E-Cadherin and β-Catenin in Triple-Negative Breast Cancer

(2016) Tiansheng Shen et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

TUFT1 regulates metastasis of pancreatic cancer through HIF1-Snail pathway induced epithelial–mesenchymal transition

(2016) Bin Zhou et al.   CANCER LETTERS

c-Jun N-Terminal Kinase Inactivation by Mitogen-Activated Protein Kinase Phosphatase 1 Determines Resistance to Taxanes and Anthracyclines in Breast Cancer

(2016) R. Rincon et al.   MOLECULAR CANCER THERAPEUTICS

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers

(2016) De Pradip et al.   Oncotarget

Erratum: Corrigendum: PAK1 confers chemoresistance and poor outcome in non-small cell lung cancer via β-catenin-mediated stemness

(2016) Ming-Jenn Chen et al.   Scientific Reports

The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance

(2016) Bridget Kreger et al.   Cancers

An overview of triple-negative breast cancer

(2015) Pankaj Kumar et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Clinical implications of the intrinsic molecular subtypes of breast cancer

(2015) Aleix Prat et al.   BREAST

Impact of breast cancer subtypes and patterns of metastasis on outcome

(2015) Karin Kast et al.   BREAST CANCER RESEARCH AND TREATMENT

Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1

(2015) Jun Rao et al.   CANCER LETTERS

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation

(2015) S. Ka lin et al.   JOURNAL OF CELL SCIENCE

MACC1 promotes carcinogenesis of colorectal cancer via β-catenin signaling pathway

(2015) Tiantian Zhen et al.   Oncotarget

Epigenetics of cancer stem cells: Pathways and therapeutics

(2014) Samriddhi Shukla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells

(2014) S. W. Hofbauer et al.   BLOOD

Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathway

(2014) H Ghebeh et al.   BRITISH JOURNAL OF CANCER

Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC)

(2014) S Skvortsov et al.   BRITISH JOURNAL OF CANCER

Significant association of combination of OCT4, NANOG, and SOX2 gene polymorphisms in susceptibility and response to treatment in North Indian breast cancer patients

(2014) Sonam Tulsyan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasis

(2014) Brock Humphries et al.   CARCINOGENESIS

Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion

(2014) J. Diaz et al.   JOURNAL OF CELL SCIENCE

Molecularly targeted therapies for metastatic triple-negative breast cancer

(2013) Soley Bayraktar et al.   BREAST CANCER RESEARCH AND TREATMENT

Oct-4 is required for an antiapoptotic behavior of chemoresistant colorectal cancer cells enriched for cancer stem cells: Effects associated with STAT3/Survivin

(2013) Kunming Wen et al.   CANCER LETTERS

Rac1 GTPase, a multifunctional player in the regulation of genotoxic stress response

(2013) Gerhard Fritz et al.   CELL CYCLE

E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells

(2013) Lorena Lobos-González et al.   Pigment Cell & Melanoma Research

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

NANOG modulates stemness in human colorectal cancer

(2012) J Zhang et al.   ONCOGENE

Decreased Total MKP-1 Protein Levels Predict Poor Prognosis in Breast Cancer

(2012) Ming-Feng Hou et al.   WORLD JOURNAL OF SURGERY

The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity

(2011) R. Velaithan et al.   BLOOD

A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer

(2010) Roberta Pang et al.   Cell Stem Cell

Metastatic Behavior of Breast Cancer Subtypes

(2010) Hagen Kennecke et al.   JOURNAL OF CLINICAL ONCOLOGY

The cytoskeleton and cancer

(2009) Alan Hall   CANCER AND METASTASIS REVIEWS

Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer

(2009) Aye Aye Thike et al.   MODERN PATHOLOGY

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

Endocytic Trafficking of Rac Is Required for the Spatial Restriction of Signaling in Cell Migration

(2008) Andrea Palamidessi et al.   CELL

Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells

(2008) Pinella Buongiorno et al.   Molecular Cancer

SOX2Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

(2008) Rosaria Maria Rita Gangemi et al.   STEM CELLS