Article
Clinical Neurology
H. Halilibrahimoglu, K. Polat, S. Keskin, O. Genc, O. Aslan, E. Ozturk-Isik, C. Yakicier, A. E. Danyeli, M. N. Pamir, K. Ozduman, A. Dincer, A. Ozcan
Summary: This study aimed to investigate the statistical association between IDH and TERT mutations and microstructural changes in normal-appearing white matter using DTI. The results showed that there were significant differences in white matter microstructure between IDH and TERT mutations, indicating the potential for classification.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
H. Halilibrahimoglu, K. Polat, S. Keskin, O. Genc, O. Aslan, E. Ozturk-Isik, C. Yakicier, A. E. Danyeli, M. N. Pamir, K. Ozduman, A. Dincer, A. Ozcan
Summary: IDH and TERT mutations in glioma have distinct microstructural changes in normal-appearing white matter, as revealed by DTI variables. The study found that IDH-only patients had higher FA and RA values and lower Delta FA and Delta RA values compared to TERT-only patients, while double-positive patients had intermediate values. Other microstructural differences were also observed between different mutation statuses.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Neurosciences
Jianfeng Bao, Hui Tu, Yijia Li, Jubao Sun, Zhigang Hu, Fengshou Zhang, Jinghua Li
Summary: Our study revealed widespread microstructure changes in normal-appearing white matter (NAWM) in relapsing-remitting multiple sclerosis (RRMS) patients through a ready-made white matter atlas and probabilistic lesion map. These findings support the hypothesis of demyelination, accumulation of inflammatory cells, and axonal injury in NAWM for RRMS. The DTI-based metrics could be considered as potential non-invasive biomarkers of disease severity.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Jing Jing, Yijun Zhou, Yuesong Pan, Xueli Cai, Wanlin Zhu, Zhe Zhang, Zixiao Li, Chang Liu, Xia Meng, Jian Cheng, Yilong Wang, Hao Li, Zhenzhou Wu, Suying Wang, Haijun Niu, Wei Wen, Tao Liu, Tiemin Wei, Yongjun Wang, Perminder S. Sachdev
Summary: This study investigated the white matter integrity in prediabetes and diabetes and found that microstructural abnormalities in white matter are already present in the prediabetes stage with impaired fasting glucose/ impaired glucose tolerance and are associated with higher glucose measures.
Article
Neurosciences
Maria Salsone, Maria Eugenia Caligiuri, Vincenza Castronovo, Nicola Canessa, Sara Marelli, Andrea Quattrone, Aldo Quattrone, Luigi Ferini-Strambi
Summary: This study investigated the microstructural integrity of normal-appearing white matter (NAWM) in male OSA patients before and after CPAP treatment. The results showed that FA and AD of NAWM in major tracts such as the corpus callosum and internal capsule significantly increased after CPAP treatment, potentially leading to improvement in neurocognitive profile.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Clinical Neurology
Mark R. Etherton, Ona Wu, Anne-Katrin Giese, Natalia S. Rost
Summary: In this study of 319 patients with acute ischemic stroke, it was found that normal-appearing white matter axial diffusivity increases with age and independently predicts white matter hyperintensity volume. Increasing age and admission diastolic blood pressure were also identified as independent predictors of normal-appearing white matter axial diffusivity.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Neurosciences
Wasim Khan, Mohamed Salah Khlif, Remika Mito, Thijs Dhollander, Amy Brodtmann
Summary: Advanced diffusion MRI was used to assess microstructural properties of normal-appearing white matter (NAWM) before it converted to white matter hyperintensities (WMHs) in ischemic stroke. The study found that NAWM converting to WMHs already exhibited changes in tissue compositions, with lower white matter-like and increased fluid-like and gray matter-like properties compared to persistent NAWM. Furthermore, the microstructural compositions were related to overall WMH burden, indicating greater fluid-like properties in NAWM vulnerable to WMH development.
Article
Clinical Neurology
Sharmila Sagnier, Gwenaelle Catheline, Bixente Dilharreguy, Pierre-Antoine Linck, Pierrick Coupe, Fanny Munsch, Antoine Bigourdan, Mathilde Poli, Sabrina Debruxelles, Pauline Renou, Stephane Olindo, Francois Rouanet, Vincent Dousset, Thomas Tourdias, Igor Sibon
Summary: This study aimed to evaluate the relationship between normal-appearing white matter (NAWM) integrity and cognitive outcome after ischemic stroke (IS). The results showed that NAWM integrity deteriorates over the year after an IS and is associated with a slowdown in cognitive recovery.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Clinical Neurology
Yannick Braun, Katharina Filipski, Simon Bernatz, Peter Baumgarten, Bastian Roller, Jenny Zinke, Pia S. Zeiner, Elena Ilina, Christian Senft, Michael W. Ronellenfitsch, Karl H. Plate, Oliver Baehr, Elke Hattingen, Joachim P. Steinbach, Michel Mittelbronn, Patrick N. Harter
Summary: This study aims to characterize metabolic features in different molecular subgroups of gliomas, focusing on the impact of metabolic alterations on patient outcomes. Results showed that DNA methylation patterns of metabolic genes can distinguish between IDHmut and IDHwt gliomas, and mitochondrial DNA copy number and immune cell content analysis can predict patient survival under anti-angiogenic therapy. Genomic signatures related to metabolism could indicate specific tumor subgroups with metabolic vulnerabilities.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Zhaodi Huang, Xiaona Xia, Shuai Guan, Gaolang Gong, Yishan Luo, Lin Shi, Juntao Zhang, Xiangshui Meng
Summary: This study investigated the differences in brain structural and functional profiles between patients with asymptomatic middle cerebral artery (MCA) steno-occlusive disease and normal controls. The results showed that even in the absence of symptoms and white matter abnormalities, patients with MCA steno-occlusive disease exhibited changes in cognitive function and structural and functional profiles, especially in functional connectivity (FC). These alterations in FC may be important mechanisms underlying the neurodegenerative process and could be used as a biomarker for disease progression and therapeutic efficacy evaluation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Yan Fu, Yan Sun, Zhi-Bo Wang, Dan-Dan Zhang, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study used the American Heart Association's Life's Simple 7 (LS7) metric to define cardiovascular and brain health and found that ideal LS7 cardiovascular health factors are associated with both macrostructural and microstructural markers of brain health. The results suggest that better LS7 profiles are linked to better brain health.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Oncology
Mia Andreoli, Melissa-Ann Mackie, David Aaby, Matthew C. Tate
Summary: This study investigates the relationship between white matter tract disruption and cognitive deficits in glioma patients using diffusion tensor imaging (DTI). The findings suggest that WM tract disruption predicts cognitive dysfunction in glioma patients, emphasizing the importance of understanding WM tract organization for surgical resection and functional preservation in these patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Spectroscopy
Zhiyan Sun, Xianhao Wu, Rui Tao, Tianyao Zhang, Xing Liu, Jiangfei Wang, Haibin Wan, Shaowen Zheng, Xiaoyan Zhao, Zhaohui Zhang, Pei Yang
Summary: This study established a predictive model for IDH mutation status in gliomas based on terahertz spectroscopy data. The results showed that gliomas with different IDH mutation status have distinct terahertz spectral features, indicating the potential of terahertz spectroscopy as a new approach for predicting IDH mutation status in gliomas.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Psychiatry
Megan Mio, Kody G. Kennedy, Anahit Grigorian, Yi Zou, Mikaela K. Dimick, Beth Selkirk, Peter J. Kertes, Walter Swardfager, Margaret K. Hahn, Sandra E. Black, Bradley J. MacIntosh, Benjamin I. Goldstein
Summary: Retinal microvascular measures are associated with white matter integrity in patients with BD, particularly in the corpus callosum.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Cell Biology
Mengli Zhang, Huaichao Zhang, Minjie Fu, Jingwen Zhang, Cheng Zhang, Yingying Lv, Fengfeng Fan, Jinsen Zhang, Hao Xu, Dan Ye, Hui Yang, Wei Hua, Ying Mao
Summary: B7H3 expression is significantly decreased in IDH-mutated gliomas, possibly due to the accumulation of 2-HG and enhanced activity of the IDH1-R132H mutant. Inhibition of autophagy can block the degradation of B7H3 in glioma cells, while IDH1-R132H glioma cells exhibit a more active autophagy flux.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Audiology & Speech-Language Pathology
Lena Spitzer, Ferdinand Binkofski, Klaus Willmes, Stefanie Bruehl
Summary: This study indicates that aphasia therapy including cognitive flexibility (CFAT) leads to more improvement in language skills, communicative ability, and verbal cognitive flexibility for patients with aphasia. CFAT is more effective than conventional therapy in improving verbal cognitive flexibility.
INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2021)
Article
Psychiatry
Ravichandran Rajkumar, Claudia Regio Brambilla, Tanja Veselinovic, Joshua Bierbrier, Christine Wyss, Shukti Ramkiran, Linda Orth, Markus Lang, Elena Rota Kops, Joerg Mauler, Juergen Scheins, Bernd Neumaier, Johannes Ermert, Hans Herzog, Karl-Josef Langen, Ferdinand Christoph Binkofski, Christoph Lerche, N. Jon Shah, Irene Neuner
Summary: The study examines the association between neuronal excitation and inhibition balance and neuroreceptor binding availability using PET/MR/EEG data, finding that changes in neuroreceptors may render resting-state networks susceptible to psychiatric conditions. The paradigm employed in this research may help uncover the precise neurobiological mechanisms behind alterations in functional connectivity and EEG oscillations, potentially benefiting individualized healthcare treatment measures.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Neurosciences
Chang-Hoon Choi, Elene Iordanishvili, N. Jon Shah, Ferdinand Binkofski
Summary: A large body of evidence has linked synaptic plasticity to specific functions and energy metabolism in the brain, with altered plasticity and energy regulation associated with neuropsychiatric disorders. Studies using tDCS in humans have shown potential for precise modulation of brain energy and excitability, with MRS allowing for the observation of neurometabolites. The systematic review discussed in this paper highlights the effectiveness of tDCS and MRS in examining neurometabolites in the human brain in vivo.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Giorgio Papitto, Luisa Lugli, Anna M. Borghi, Antonello Pellicano, Ferdinand Binkofski
Summary: The study found that negation acts as a block on motor representations independently of the position of negative particles and the semantic features of the sentence.
Article
Behavioral Sciences
Sarah Willms, Miriam Abel, Avi Karni, Carmit Gal, Julien Doyon, Bradley R. King, Joseph Classen, Jost-Julian Rumpf, Giovanni Buccino, Antonello Pellicano, Juliane Klann, Ferdinand Binkofski
Summary: Recent studies have shown that limb apraxia is a common higher motor impairment following stroke, with a tendency to be underestimated and impacting daily life and personal independence. This pilot study investigates explicit motor learning in apractic stroke patients, focusing on their ability to learn and retain new explicit sequential finger movements over 10 training sessions. Findings suggest that stroke patients with ideomotor apraxia can acquire and maintain a novel sequence of movements, with training potentially improving symptoms of apraxia.
Article
Multidisciplinary Sciences
Kerstin Juetten, Leon Weninger, Verena Mainz, Siegfried Gauggel, Ferdinand Binkofski, Martin Wiesmann, Dorit Merhof, Hans Clusmann, Chuh-Hyoun Na
Summary: The study showed a relative dissociation of structural and functional connectomic coherence in glioma patients at the time of diagnosis, with more structural connectomic aberrations being encountered in IDHwt glioma patients. Healthy controls exhibited strong intramodal connectivity within both the structural and functional connectome.
SCIENTIFIC REPORTS
(2021)
Article
Audiology & Speech-Language Pathology
Stefanie Bruehl, Klaus Willmes, Ferdinand Binkofski
Summary: This study investigates the importance of executive functions in aphasia patients' language performance. The novel treatment approach of interfered-naming shows significant improvement in pure naming and generalization to untrained items. The results suggest that semantic and executive processing are the core sources of improvements.
Article
Clinical Neurology
Nikolina Brcina, Christian Hohenfeld, Anna Heidbreder, Shahram Mirzazade, Janna Krahe, Jennifer Wojtala, Ferdinand Binkofski, Joerg B. Schulz, Johannes Schiefer, Kathrin Reetz, Imis Dogan
Summary: The study found stronger activation and connectivity changes during hand movement tasks in RBD patients, which may reflect early compensatory and reorganization patterns to preserve motor functioning. These findings contribute to a better understanding and prognosis of prodromal stages of alpha-synucleinopathies.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Multidisciplinary Sciences
Antonello Pellicano, Gianluca Mingoia, Christoph Ritter, Giovanni Buccino, Ferdinand Binkofski
Summary: The Mirror Neurons System (MNS) plays a crucial role in understanding the action goals of others, particularly during walking. Bilateral SMA is considered responsible for the core MNS effect for walking, while bilateral parietal opercula modulate respiratory function during walking execution-observation-imagination.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Julia Bungenberg, Karen Humkamp, Christian Hohenfeld, Marcus Immanuel Rust, Ummehan Ermis, Michael Dreher, Niels-Ulrik Korbinian Hartmann, Gernot Marx, Ferdinand Binkofski, Carsten Finke, Joerg B. Schulz, Ana Sofia Costa, Kathrin Reetz
Summary: This study aimed to compare persisting self-reported symptoms in initially hospitalized and non-hospitalized patients after SARS-CoV-2 infection. The results showed that patients in both groups may experience mild deficits in cognitive and memory functions, and fatigue severity was associated with reduced performance in attention and quality of life, as well as more persisting symptoms. MRI examination revealed microbleeds exclusively in hospitalized patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Elisabeth Rounis, Ferdinand Binkofski
Summary: Stroke is a major cause of disability worldwide, and limb apraxia is a group of motor disorders associated with greater disability and dependence after stroke. In this review, a hierarchical organization of limb apraxia is proposed, distinguishing several visuomotor pathways that lead to purposeful actions. Further studies are needed to stratify patients using modern neurophysiology and neuroimaging techniques to provide targeted and personalized therapies for these disorders in the future.
Article
Oncology
Anke Meyer-Baese, Kerstin Juetten, Uwe Meyer-Baese, Ali Moradi Amani, Hagen Malberg, Andreas Stadlbauer, Thomas Kinfe, Chuh-Hyoun Na
Summary: This study investigates the impact of gliomas on the controllability and robustness of neural networks. The findings suggest that glioma patients exhibit changes in network controllability and robustness, which are associated with tumor type and prognosis. This novel approach provides insights into disease evolution and potential treatment targets in brain cancer.
Article
Neurosciences
Lukas Lorentz, Andre Schueppen, Boris Suchan, Ferdinand Binkofski
Summary: This study aims to examine the effects of stereoscopic vs. monoscopic presentation on neural processing during a visual attention task. The results showed that stereoscopic presentation led to increased activation in the V3A area and elevated activation in the dorsal attention network. Additionally, stereoscopic presentation reduced attentional engagement costs.
Article
Psychology, Experimental
Antonello Pellicano, Ferdinand Binkofski
Summary: Responses to object stimuli are influenced by whether protruding handles are aligned with responding hands or not. When salience depends on non-graspable parts, a correspondence effect is produced, but disappears when salience is removed from graspable parts.
PSYCHOLOGICAL RESEARCH-PSYCHOLOGISCHE FORSCHUNG
(2021)