Article
Immunology
Mei-Ling Dong, Xu Wen, Xin He, Ji-Hua Ren, Hai-Bo Yu, Yi-Ping Qin, Zhen Yang, Min-Li Yang, Chong-Yang Zhou, Hui Zhang, Sheng-Tao Cheng, Juan Chen
Summary: The study found that DDX17 plays an important role in the replication of HBV and the metastasis of HBV-related HCC. By promoting HBV replication and transcription as well as HBx-mediated HCC metastasis, DDX17 has a promotive effect on the development of HBV and HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Guangyuan Song, Xingxin Zhu, Zefeng Xuan, Long Zhao, Haijiang Dong, Jian Chen, Zequn Li, Wenfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Shusen Zheng, Penghong Song
Summary: In this study, we identified that GNA14 is downregulated in HCC and negatively correlated with HBV infection, vascular invasion, and prognosis. HBx regulates GNA14 through DNA methylation, affecting the Notch1 and JMJD6 pathways to inhibit tumor proliferation and metastasis. GNA14 shows potential as a biomarker and therapeutic target in HCC.
Article
Oncology
Cuifang Zhang, Ying Xie, Ruixue Lai, Jianhua Wu, Zhanjun Guo
Summary: Functional analysis reveals that the mutation in the hepatitis B virus X (HBx) gene is associated with hepatocellular carcinoma (HCC) malignancy. The mutation enhances HCC cell proliferation, invasion, and migration, while inhibiting apoptosis. It also promotes tumor growth and alters fibrosis, intracellular reactive oxygen species (ROS), and cytokine levels. The C1653T mutation may serve as a potential biomarker for screening HCC patients and determining the efficacy of apatinib treatment.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Virology
Yongdong Niu, Liming Chen, Manpeng Wu, Weiyi Huang, Xuejun Wu, Danmei Huang, Yangmin Xie, Ganggang Shi
Summary: The study found that both full-length HBx and HBx C-terminal truncation coexist in HCC, and both can activate FXR signaling. Additionally, HBx-C30 has a weaker coactivating effect on FXR-KNG1 signaling compared to full-length HBx.
Article
Oncology
Chunyan Zhang, Huan Yang, Liwei Pan, Guangfu Zhao, Ruofei Zhang, Tianci Zhang, Zhixiong Xiao, Ying Tong, Yi Zhang, Richard Hu, Stephen J. Pandol, Yuan-Ping Han
Summary: This study highlights the potential mechanism of HBV-mediated malignancy through the downregulation of TFEB by HBx, leading to the accumulation of ITGB1 in HCC cells and promoting cell migration.
Article
Biochemistry & Molecular Biology
Hiroaki Kanzaki, Tetsuhiro Chiba, Tatsuya Kaneko, Junjie Ao, Motoyasu Kan, Ryosuke Muroyama, Shingo Nakamoto, Tatsuo Kanda, Hitoshi Maruyama, Jun Kato, Yoh Zen, Ai Kotani, Kazuma Sekiba, Motoyuki Otsuka, Masayuki Ohtsuka, Naoya Kato
Summary: ELAVL1 protein is not only involved in the replication of hepatitis B virus, but also has an impact on the cell growth of hepatocellular carcinoma, making it a potential therapeutic target for HBV-related HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xiao-Wei Dang, Qi Pan, Zhen-Hai Lin, Hao-Hao Wang, Lu-Hao Li, Lin Li, Dong-Qi Shen, Pei-Ju Wang
Summary: This study confirmed that DEPDC1B knockdown restricts tumor growth in vitro and in vivo, and it interacts with CDK1, being a potential therapeutic target involved in HCC growth and progression. The results suggest that DEPDC1B plays a key role in HCC and may be a promising target for therapeutic interventions.
Article
Biotechnology & Applied Microbiology
Xiaoyue Ren, Alex Li, Edward Ying, Jhin Fang, Mingzhu Li, Jiao Yu
Summary: This study revealed that high expression of UBE2T is closely associated with poor prognosis in hepatocellular carcinoma (HCC), as it enhances HCC cell proliferation and migration. Additionally, UBE2T was identified as a downstream target of miR-212-5p.
Article
Oncology
Chun-Ming Li, Jie Zhang, Wu Wu, Zhu Zhu, Feng Li, Di Wu, Xiao-Jun Wang, Chuan-Ming Xie, Jian-Ping Gong
Summary: This study investigated the biological function and potential mechanism of FBXO43 in hepatocellular carcinoma (HCC). The results showed that FBXO43 was upregulated in HCC patient tissues and correlated with poor clinicopathological features. Knockdown of FBXO43 inhibited HCC cell proliferation, migration, and epithelial-mesenchymal transition (EMT), which was mediated by its interaction with cyclin D1 (CCND1) and promotion of CCND1 stability. Targeting the FBXO43-CCND1 axis may provide a new potential strategy for HCC treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Siming Qu, Li Jin, Hanfei Huang, Jie Lin, Weiwu Gao, Zhong Zeng
Summary: ALKBH5 is overexpressed in HBV-related HCC tissues and predicts poor prognosis. The increased ALKBH5 expression is induced by HBx-mediated H3K4me3 modification in a WDR5-dependent manner after HBV infection, leading to m(6)A demethylation of HBx mRNA and stabilization of HBx expression. Positive correlations between HBx and ALKBH5 were observed in HBV-HCC tissues, and targeting ALKBH5 may provide a potential way for HBV-HCC treatment.
Article
Biochemistry & Molecular Biology
Hailong Wang, Jiayu Luo, Xuesi Tian, Linlin Xu, Zhenyu Zhai, Minzhang Cheng, Limin Chen, Shiwen Luo
Summary: DNAJC5 is highly expressed in HCC tissues, promoting cell proliferation and altering the cell cycle. It interacts with SKP2 to enhance p27 degradation and formation of the SKP2-p27 complex. Silencing DNAJC5 rescues the decrease in p27 protein levels mediated by SKP2.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Cell Biology
Yang Ji, Shikun Yang, Xueqi Yan, Li Zhu, Wenjie Yang, Xinchen Yang, Fei Yu, Longqing Shi, Xi Zhu, Yunjie Lu, Chuanyong Zhang, Hao Lu, Feng Zhang
Summary: CircCRIM1 is upregulated in hepatocellular carcinoma (HCC) and is associated with poor prognosis, enhancing cell proliferation and angiogenesis. It promotes HCC progression via the miR-378a-3p/SKP2 axis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jun-Jie Hu, Cui Zhou, Xin Luo, Sheng-Zheng Luo, Zheng-Hong Li, Zi-Xin Xu, Ming-Yi Xu
Summary: LincSCRG1 acts as a competing endogenous RNA (ceRNA) to regulate miR26a and SKP2 expression in hepatocellular carcinoma cells, promoting proliferation and migration both in vitro and in vivo. Targeting lincSCRG1 could be a potential therapeutic strategy for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Fei Cao, Anguo Luo, Chaowen Yang
Summary: Ferroptosis is a significant form of cell death in cancer research, with G6PD and POR being associated with both HCC progression and prognosis. G6PD promotes HCC development by inhibiting ferroptosis, while downregulation of POR is correlated with better prognosis in HCC.
CELLULAR SIGNALLING
(2021)
Article
Multidisciplinary Sciences
Zhengzhong Ni, Jun Lu, Weiyi Huang, Hanif Khan, Xuejun Wu, Danmei Huang, Ganggang Shi, Yongdong Niu, Haihua Huang
Summary: This study identified 12 key genes associated with HBx through RNA sequencing analysis of HepG2 cells overexpressing HBx, and validated their expression in HCC transcription profiles. Among these genes, the expression of ARG1 and TAT was correlated with a good prognosis in HCC patients.