PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications

(2019) Pramod Darvin et al.   Journal of Oncology

The role of IL-1B in breast cancer bone metastasis

(2018) Claudia Tulotta et al.   ENDOCRINE-RELATED CANCER

Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells

(2018) Varun Sasidharan Nair et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Safety and efficacy of anti-PD-1 therapy for metastatic melanoma and non-small-cell lung cancer in patients with viral hepatitis

(2018) Anita Kothapalli et al.   MELANOMA RESEARCH

Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma

(2018) Aung Kyi Thar Min et al.   Cancer Medicine

PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer

(2018) Magalie Dosset et al.   OncoImmunology

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

(2018) Judith A. Seidel et al.   Frontiers in Oncology

Role of mTOR Signaling in Tumor Microenvironment: An Overview

(2018) Fabiana Conciatori et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Programmed Cell Death Protein-1 Predicts the Recurrence of Breast Cancer in Patients Subjected to Radiotherapy After Breast-Preserving Surgery

(2018) Ruyi Huang et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

(2018) Junpei Suzuki et al.   Nature Communications

Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity

(2018) Stéphane Terry et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Akt pathway in oncology therapy and beyond (Review)

(2018) George Nitulescu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The clinical promise of immunotherapy in triple-negative breast cancer

(2018) Praveen Vikas et al.   Cancer Management and Research

Immune checkpoint inhibitors in cancer therapy: a focus on T-regulatory cells

(2017) Varun Sasidharan Nair et al.   IMMUNOLOGY AND CELL BIOLOGY

DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

(2017) Hiro Sato et al.   Nature Communications

The efficacy and safety of anti-PD-1/PD-L1 antibody therapy versus docetaxel for pretreated advanced NSCLC: a meta-analysis

(2017) Guanghong Huang et al.   Oncotarget

Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab

(2017) Hyun Tae Lee et al.   Scientific Reports

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

(2016) Curtis A. Clark et al.   CANCER RESEARCH

Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma

(2016) Toni K. Choueiri et al.   CLINICAL CANCER RESEARCH

Concurrent PI3K and NF-κB activation drives B-cell lymphomagenesis

(2016) H Y Jin et al.   LEUKEMIA

PD-L1 expression in human cancers and its association with clinical outcomes

(2016) Jinming Yu et al.   OncoTargets and Therapy

Interleukin-1β activates focal adhesion kinase and Src to induce matrix metalloproteinase-9 production and invasion of MCF-7 breast cancer cells

(2016) Naing Naing Mon et al.   Oncology Letters

Key roles of necroptotic factors in promoting tumor growth

(2016) Xinjian Liu et al.   Oncotarget

Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis

(2016) Madison Black et al.   Oncotarget

FOXO factors and breast cancer: outfoxing endocrine resistance

(2015) M Bullock   ENDOCRINE-RELATED CANCER

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct Interaction of CD40 on Tumor Cells with CD40L on T Cells Increases the Proliferation of Tumor Cells by Enhancing TGF-β Production and Th17 Differentiation

(2015) Hyemin Kim et al.   PLoS One

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer

(2014) S. Muenst et al.   BREAST CANCER RESEARCH AND TREATMENT

PD-L1 Expression Is Increased in a Subset of Basal Type Breast Cancer Cells

(2014) Hatem Soliman et al.   PLoS One

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

PD-L1 Expression in Triple-Negative Breast Cancer

(2014) E. A. Mittendorf et al.   Cancer Immunology Research

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Cross-Talk between NFkB and the PI3-Kinase/AKT Pathway Can Be Targeted in Primary Effusion Lymphoma (PEL) Cell Lines for Efficient Apoptosis

(2012) Azhar R. Hussain et al.   PLoS One

Epidermal Growth Factor Receptor-mediated Tissue Transglutaminase Overexpression Couples Acquired Tumor Necrosis Factor-related Apoptosis-inducing Ligand Resistance and Migration through c-FLIP and MMP-9 Proteins in Lung Cancer Cells

(2011) Zi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

The Menin Tumor Suppressor Protein Is Phosphorylated in Response to DNA Damage

(2011) Joshua Francis et al.   PLoS One

Claudin-7 Is Frequently Overexpressed in Ovarian Cancer and Promotes Invasion

(2011) Neetu Dahiya et al.   PLoS One

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells

(2009) Wenshi Wang et al.   INTERNATIONAL IMMUNOLOGY

A Network Model of a Cooperative Genetic Landscape in Brain Tumors

(2009) Markus Bredel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

(2008) T. Azuma et al.   BLOOD