Article
Biochemistry & Molecular Biology
Laszlo Szereday, David U. Nagy, Beata Csiszar, Dora Kevey, Timoteus Feik, Matyas Meggyes
Summary: This study found decreased CD226 expression and increased CD112 and CD155 expression in almost all T cell, NK cell, and monocyte subpopulations in women with early-onset preeclampsia. Additionally, reduced TIGIT and granzyme B expression were observed in preeclamptic CD8+ T cells. These results suggest that inhibitory signals via the TIGIT/CD112 and/or TIGIT/CD155 pathways may contribute to immune response inhibition in early-onset preeclampsia.
Article
Biochemistry & Molecular Biology
Matyas Meggyes, David U. Nagy, Timoteus Feik, Akos Boros, Beata Polgar, Laszlo Szereday
Summary: The study highlights the significance of immune checkpoint molecules in immune regulation during pregnancy. CD226 appears to be a crucial regulator, particularly in CD4(+) T and NKT cells, contributing to maternal immune tolerance in the late phase of pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Motoko Yasutomi, Allison F. Christiaansen, Naoko Imai, Natalia Martin-Orozco, Christian V. Forst, Gang Chen, Hideki Ueno
Summary: Research has shown that CD226 plays an important role in the early differentiation of human Tfh cells, while CD155 promotes the proliferation of naive CD4(+) T cells and Tfh precursors and regulates the expression of multiple Tfh molecules. Blocking CD226 inhibits the proliferation and expression of Tfh markers. However, attenuating CD226 signals increases the expression of certain molecules in CD155-stimulated GC-Tfh cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Annerose E. Ziegler, Pia Fittje, Luisa M. Mueller, Annika E. Ahrenstorf, Kerri Hagemann, Sven H. Hagen, Leonard U. Hess, Annika Niehrs, Tobias Poch, Gevitha Ravichandran, Sebastian M. Loebl, Benedetta Padoan, Sebastien Brias, Jana Hennesen, Myrtille Richard, Laura Richert, Sven Peine, Karl J. Oldhafer, Lutz Fischer, Christoph Schramm, Gloria Martrus, Madeleine J. Bunders, Marcus Altfeld, Sebastian Lunemann
Summary: The interaction between NK cells and their surrounding environment is regulated by activating and inhibitory receptors. The inhibitory receptor TIGIT reduces NK cell cytotoxicity and is involved in NK cell exhaustion, but it is also associated with liver regeneration. The role of human intrahepatic CD56(bright) NK cells in tissue homeostasis regulation is not fully understood.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Loredana Cifaldi, Ombretta Melaiu, Roberto Giovannoni, Monica Benvenuto, Chiara Focaccetti, Daniela Nardozi, Giovanni Barillari, Roberto Bei
Summary: DNAM-1 is a crucial NK cell activating receptor that contributes significantly to the killing of tumor or virus-infected cells by binding to specific ligands, alongside NKG2D and NCRs. DNAM-1 specifically recognizes PVR and Nectin-2 ligands expressed on a wide range of tumor cells and virus-infected cells. Although NK cells engineered with different antigen chimeric receptors or chimeric NKG2D receptors have been extensively studied, the use of DNAM-1 chimeric receptor-engineered NK cells has only been proposed in a recent proof-of-concept study. This perspective study aims to explain the rationale behind using this novel tool as a new anti-cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jang Hyuck Lee, Seung Soo Yoo, Mi Jeong Hong, Jin Eun Choi, Soyoun Kim, Hyo-Gyoung Kang, Sook Kyung Do, Ji Hyun Kim, Sun Ah Baek, Won Kee Lee, Jae Do Yoo, Sun Ha Choi, Yong Hoon Lee, Hyewon Seo, Jaehee Lee, Shin Yup Lee, Seung Ick Cha, Chang Ho Kim, Jae Yong Park
Summary: The genetic variants of CD155 rs1058402G>A and CD226 rs763361C>T are significantly associated with treatment outcomes in small cell lung cancer patients, and may serve as predictors for the clinical prognosis after chemotherapy.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Tomohei Matsuo, Akiko Iguchi-Manaka, Akira Shibuya, Kazuko Shibuya
Summary: CD155 is a ligand that can activate or inhibit immune receptors, namely DNAM-1 and TIGIT, which play roles in regulating tumor immune responses in natural killer cells and T cells. Recent research suggests that a mutation in CD155, resulting in decreased affinity for DNAM-1, is associated with worse overall survival in small cell lung cancer patients. However, our findings show that this mutation actually increases the binding affinity for TIGIT and leads to a stronger signal, suppressing immune responses in the tumor microenvironment.
Article
Immunology
Jie Zhang, Long Zhou, Jiang-Dong Xiang, Chun-Sheng Jin, Ming-Qing Li, Yin-Yan He
Summary: The study found that artemisinin has inhibitory effects on proliferation and migration, promotes apoptosis, and induces autophagy in uterine corpus endometrial carcinoma cells. Artemisinin-induced autophagy elevated CD155 levels in cancer cells, enhancing NK92 cell cytotoxicity by modulating the interaction between CD155 and its receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Kazuki Sato, Yumi Yamashita-Kanemaru, Fumie Abe, Rikito Murata, Yuho Nakamura-Shinya, Kazumasa Kanemaru, Masafumi Muratani, Andre Veillette, Motohito Goto, Mamoru Ito, Akira Shibuya, Kazuko Shibuya
Summary: DNAM-1 regulates Treg cell function via TIGIT signaling, and can potentially serve as a molecular target for enhancing Treg function in inflammatory diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Kyoko Oh-oka, Fumie Abe, Akira Shibuya, Kazuko Shibuya
Summary: CD96 deficiency in mice leads to lower production of IL-17A and milder psoriasis-like dermatitis. Transfer of CD96-deficient dermal gamma delta T cells into the skin of Rag1-deficient mice results in milder IMQ-induced dermatitis. CD96 provides a costimulatory signal for the production of IL-23-induced IL-17A.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Hematology
Jessica Li, Sarah Whelan, Maya F. Kotturi, Deborah Meyran, Criselle D'Souza, Kyle Hansen, Spencer Liang, John Hunter, Joseph A. Trapani, Paul J. Neeson
Summary: The study showed that PVRIG blockade enhanced NK-cell killing of AML cell lines and increased NK-cell activation and degranulation in patient primary AML blasts. However, NK-cell PVRIG expression levels were not increased in AML patient bone marrow. The findings suggest that anti-PVRIG blocking antibody can target the PVRIG-PVRL2 immune checkpoint axis for NK-mediated immunotherapy of PVRL2(+) AML.
Article
Oncology
Kyle Hansen, Sandeep Kumar, Kathryn Logronio, Sarah Whelan, Samir Qurashi, Hsin-Yuan Cheng, Andrew Drake, Margaret Tang, Patrick Wall, David Bernados, Ling Leung, Eran Ophir, Zoya Alteber, Gady Cojocaru, Moran Galperin, Masha Frenkel, Mark White, John Hunter, Spencer C. Liang, Maya F. Kotturi
Summary: TIGIT and its cognate ligand PVR are widely expressed in human cancers, and the antibody COM902 targeting TIGIT shows potential in enhancing anti-tumor immune responses both in-vitro and in-vivo, making it a promising candidate for the treatment of advanced malignancies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Immunology
Pooya Farhangnia, Mahzad Akbarpour, Mahboubeh Yazdanifar, Amir Reza Aref, Ali-Akbar Delbandi, Nima Rezaei
Summary: This review article highlights the importance and limitations of immune checkpoint molecules in cancer immunotherapy, focusing on the role of CD96 and TIGIT in tumor immunotherapy. It discusses ongoing clinical trials and combination therapies, as well as the potential of anti-CD96/TIGIT-related combination therapies.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Duygu Ozmadenci, Jayanth S. Shankara Narayanan, Jacob Andrew, Marjaana Ojalill, Allison M. Barrie, Shulin Jiang, Samhita Iyer, Xiao Lei Chen, Michael Rose, Valeria Estrada, Alfredo Molinolo, Thomas Bertotto, Zbigniew Mikulski, Michael C. McHale, Rebekah R. White, Denise C. Connolly, Jonathan A. Pachter, Vijay K. Kuchroo, Dwayne G. Stupack, David D. Schlaepfer
Summary: High-grade serous ovarian cancer (HGSOC) is a lethal malignancy with immunosuppressive tumor microenvironment. This study reveals the association between elevated active focal adhesion kinase (FAK) and TIGIT checkpoint ligands in HGSOC tumors. Inhibition of FAK activity reduces tumor burden and increases tumor infiltrating lymphocytes (TILs), while combination treatment with FAK inhibitor and TIGIT antibody prolongs host survival and promotes lymphoid structure formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Yangyang Li, Yu Zhang, Guoshuai Cao, Xiaodong Zheng, Cheng Sun, Haiming Wei, Zhigang Tian, Weihua Xiao, Rui Sun, Haoyu Sun
Summary: The study found that PVRIG blockade could slow tumor growth and prolong survival in mice by inhibiting exhaustion of NK cells and CD8(+) T cells. Combined blockade of PVRIG and PD-L1 showed better efficacy in controlling tumor growth. These results highlight the importance of NK cells and provide insights for clinical application of PVRIG-targeted drugs.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Editorial Material
Immunology
Stefano Caserta, Alejandra Pera
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Martina Formentini, Ana Navas, Fakhri Hassouneh, Nelson Lopez-Sejas, Corona Alonso, Raquel Tarazona, Rafael Solana, Alejandra Pera
Summary: Immunosenescence affects innate and adaptive immunity, with chronic CMV infection contributing to early immunosenescence. The markers CD57, CD300a, and CD161 define distinct T-cell subsets, showing varied functionality and molecular signatures. Different T-cell populations based on these markers have implications for disease risk in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Immunology
Alexander Batista-Duharte, Alejandra Pera, Salvador F. Alino, Rafael Solana
Summary: Regulatory T cells play a crucial role in maintaining immune tolerance, but their excessive activity may reduce the effectiveness of vaccines. Increased activity of regulatory T cells in older adults may contribute to the observed lower vaccine effectiveness in this age group.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fakhri Hassouneh, David Goldeck, Alejandra Pera, Diana van Heemst, P. Eline Slagboom, Graham Pawelec, Rafael Solana
Summary: The study revealed that CMV infection and aging impact the function and phenotype of T-cells, with CD57+ T-cells being more polyfunctional than CD57- T-cells. The expansion of cytotoxic T-cells is mainly associated with CMV infection, highlighting the significant role of CMV in driving the expansion of highly polyfunctional CD57+ T-cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Alexander Batista-Duharte, Fakhri Hassouneh, Pablo Alvarez-Heredia, Alejandra Pera, Rafael Solana
Summary: The combination of immune checkpoint inhibitors (ICIs) with vaccines has shown promise in improving vaccine immunogenicity and efficacy. Most studies have focused on anti-tumor vaccines combined with monoclonal antibodies targeting specific checkpoints. However, new strategies using ICIs as molecular adjuvants hold great potential for future advances in vaccine research.
Review
Biochemistry & Molecular Biology
Jani-Sofia Almeida, Jose Manuel Casanova, Manuel Santos-Rosa, Raquel Tarazona, Rafael Solana, Paulo Rodrigues-Santos
Summary: CD56+ T cells, categorized as NKT-like cells, have been impacted by aging and various diseases. This review explores the current knowledge on human NKT-like cells. NKT-like cells are highly differentiated T cells with CD1d-independent antigen recognition and MHC-unrestricted cell killing. Understanding their origin and role in pathological conditions is crucial for their potential use as prognostic markers and indicators of immune health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pablo Alvarez-Heredia, Jose Joaquin Dominguez-del-Castillo, Irene Reina-Alfonso, Carmen Gutierrez-Gonzalez, Fakhri Hassouneh, Alexander Batista-Duharte, Antonio Trujillo-Aguilera, Rosalia Lopez-Romero, Ignacio Munoz, Rafael Solana, Alejandra Pera
Summary: Aortic stenosis is a common cardiac disease characterized by valvular calcification, fibrosis, and inflammation. Recent studies suggest that it is an active inflammatory atherosclerotic-like process involving immune cells and persistent antigens. However, the study of calcified aortic valves has been limited by histological and immunohistochemical methods. This study presents a cytometry-based protocol that allows for the identification and quantification of inflammatory leukocytes in aortic valve explants, providing a more in-depth analysis of cell markers. This protocol can be applied to other cardiac diseases with an inflammatory component.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Pablo Alvarez-Heredia, Irene Reina-Alfonso, Jose Joaquin Dominguez-del-Castillo, Carmen Gutierrez-Gonzalez, Fakhri Hassouneh, Alexander Batista-Duharte, Ana-Belen Perez, Raquel Tarazona, Rafael Solana, Alejandra Pera
Summary: Coinfection with SARS-CoV-2 and CMV leads to accelerated T cell senescence and increased risk of cardiovascular disease. SARS-CoV-2 vaccination appears to provide some protection against this phenomenon.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Sofia Carreira-Santos, Nelson Lopez-Sejas, Marina Gonzalez-Sanchez, Eva Sanchez-Hernandez, Alejandra Pera, Fakhri Hassouneh, Esther Duran, Rafael Solana, Javier G. Casado, Raquel Tarazona
Summary: This study provides a deep phenotypic characterization of in vitro-expanded CIML NK cells. Moreover, the correlations found between NK cell receptors and degranulation capacity of CIML NK cells allowed the identification of several biomarkers that could be useful in clinical settings.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Nieves Pastor, Lorena Espadas, Massimo Santella, Luis Javier Ezquerra, Raquel Tarazona, Maria Esther Duran
Summary: Strain elastography is an accurate method for discriminating between different histological types of malignant mammary neoplasms in dogs. It provides real-time complementary information for diagnosis and can be helpful in choosing surgical techniques.
VETERINARY SCIENCES
(2022)