Article
Cardiac & Cardiovascular Systems
Mark Dennis, Sashie Howpage, Margaret McGill, Shashwati Dutta, Yen Koay, Lisa Nguyen-Lal, Sean Lal, Ted Wu, Martin Ugander, Alexandra Wang, Phillip A. Munoz, Jencia Wong, Maria I. Constantino, John F. O'Sullivan, Stephen M. Twigg, Rajesh Puranik
Summary: This study aims to identify biomarkers of cardiomyopathy in T2DM patients and explore the associations between functional status, metabolomic profile, and myocardial fibrosis. The results show that patients with well-controlled T2DM exhibit myocardial fibrosis, which is associated with reduced exercise tolerance and specific metabolites.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Oncology
Huan-Tang Lin, Mei-Ling Cheng, Chi-Jen Lo, Wen-Chuin Hsu, Gigin Lin, Fu-Chao Liu
Summary: The study found that various metabolites in CSF samples are significantly associated with the aging process in cerebral circulation, with levels of citrate, lactate, leucine, tyrosine, and valine significantly increased in old patients compared to young patients. The combined changes in these CSF metabolites correlated better with the aging process across all age groups.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Assim A. Alfadda, Abdulrahman M. Almaghamsi, Suphia Murad Sherbeeni, Adel N. Alqutub, Abdullah S. Aldosary, Arthur C. Isnani, Nasser Al-Daghri, Simon D. Taylor-Robinson, Rukhsana Gul
Summary: This study aimed to understand the changes in circulating lipid and lipoprotein metabolism in patients with Type 2 diabetes mellitus (T2DM) with or without non-alcoholic fatty liver disease (NAFLD). The comprehensive metabolic lipid profiling of serum samples of 434 T2DM patients was analyzed using NMR metabolomics. The results revealed altered lipid metabolism in T2DM patients with NAFLD compared to those without NAFLD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Medicine, General & Internal
Huan-Tang Lin, Mei-Ling Cheng, Chi-Jen Lo, Gigin Lin, Fu-Chao Liu
Summary: The study identifies altered metabolic markers in the cerebrospinal fluid and plasma of diabetic patients with DKD, which could be valuable for monitoring the progression of DKD.
Article
Nutrition & Dietetics
Erwin Garcia, Irina Shalaurova, Steven P. Matyus, Joelle C. Schutten, Stephan J. L. Bakker, Robin P. F. Dullaart, Margery A. Connelly
Summary: The study found that ionized magnesium levels measured by an optimized nuclear magnetic resonance method were associated with type 2 diabetes. In IRAS participants, ionized magnesium levels were significantly lower in prediabetes and type 2 diabetes patients, possibly influenced by gender, and predicted the development of future type 2 diabetes.
Article
Medicine, General & Internal
Loukia Spanou, Aikaterini Dimou, Christina E. Kostara, Eleni Bairaktari, Eleni Anastasiou, Vasilis Tsimihodimos
Summary: This study accurately characterized the altered metabolic pathways of gestational diabetes mellitus (GDM) and assessed their similarities to type 2 diabetes mellitus (DM2) using nuclear magnetic resonance (NMR) spectroscopy. The results showed that GDM and DM2 share similarities in some metabolic pathways, but also have differences.
Review
Food Science & Technology
Dilek Eltemur, Peter Robatscher, Michael Oberhuber, Matteo Scampicchio, Alberto Ceccon
Summary: Nuclear magnetic resonance (NMR) spectroscopy is a promising technique for the analysis of bovine milk due to its non-destructive nature, minimal sample preparation requirements, and comprehensive approach. This review provides an overview of the applications of NMR techniques in assessing the quality and authenticity of bovine milk, highlighting key studies and emphasizing the versatility and significance of NMR spectroscopy in milk metabolomics research.
Article
Biochemistry & Molecular Biology
Livia Noemi Kolb, Alaa Othman, Lucia Rohrer, Jan Kruetzfeldt, Arnold von Eckardstein
Summary: Biomarkers are important for early detection and stratification of diabetes and its complications. In this study, we used NMR spectrometry to analyze metabolic parameters in plasma samples of healthy volunteers and diabetic patients. Our results showed independent associations between diabetes and branched-chain amino acids, lactate, linoleic acid, and HDL diameter. Additionally, we found imbalances in the concentrations of free cholesterol in different lipoprotein subclasses in diabetic subjects compared to non-diabetic controls, which may reflect disturbances in cholesterol transfer processes.
Article
Environmental Sciences
Sheng-Han Lee, Zhi-Yi Du, Wei-Chen Tseng, Wan-Yu Lin, Mei-Huei Chen, Ching-Chun Lin, Hao-Jan Liang, Hui-Ju Wen, Yue-Leon Guo, Pau-Chung Chen, Ching-Yu Lin
Summary: This study used a metabolomic approach to reveal associations between phthalate exposure and the serum metabolome in Taiwanese children. Unique phthalate exposures were associated with distinct serum metabolite profiles, potentially affecting energy mechanisms, oxidative stress, and lipid metabolism in children.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Nyuk Ling Ma, Su Datt Lam, Wan Afifudeen Che Lah, Aziz Ahmad, Joerg Rinklebe, Christian Sonne, Wanxi Peng
Summary: This study investigates the cellular mechanisms of salinity stress recovery in plants by comparing tolerance and susceptible genotypes, revealing upregulation of specific metabolites in the recovered-tolerant genotype. Rice can survive in high saline affected areas with the right selection of salt-tolerant species, showcasing potential for sustainable farming practices.
ENVIRONMENTAL POLLUTION
(2021)
Article
Endocrinology & Metabolism
Antonio J. Amor, Irene Vinagre, Maite Valverde, Xavier Urquizu, Eva Meler, Eva Lopez, Nuria Alonso, Adriana Pane, Marga Gimenez, Laura Codina, Ignacio Conget, Maria J. Barahona, Veronica Perea
Summary: This study evaluated the role of plasma metabolomics in atherosclerosis based on the presence of type 1 diabetes (T1D) or previous preeclampsia in 105 women. The results showed significant differences in lipidic-, energetic- and nitrogen-related metabolites according to the presence of T1D/preeclampsia, with lipidomic-related metabolites being associated with atherosclerosis in the whole sample. Stronger associations were observed in women with previous preeclampsia for certain metabolites.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Biochemical Research Methods
Cristina Licari, Leonardo Tenori, Francesca Di Cesare, Claudio Luchinat, Betti Giusti, Ada Kura, Rosina De Cario, Domenico Inzitari, Benedetta Piccardi, Mascia Nesi, Cristina Sarti, Francesco Arba, Vanessa Palumbo, Patrizia Nencini, Rossella Marcucci, Anna Maria Gori, Elena Sticchi
Summary: Metabolic perturbations and inflammatory mediators play a fundamental role in adverse post-acute ischemic stroke outcomes. This study found associations between specific metabolic features and outcomes such as hemorrhagic transformation, non-response to thrombolytic treatment, and functional outcome. These metabolic changes indicate a state of energy failure, oxidative stress, and systemic inflammation.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Multidisciplinary Sciences
Shaopeng Yang, Zhuoting Zhu, Shida Chen, Yixiong Yuan, Mingguang He, Wei Wang
Summary: The reduced thickness of retinal pigment epithelium (RPE) is identified as a significant risk factor for future type 2 diabetes mellitus (T2DM) and its microvascular phenotypes. Analyses of circulating plasma metabolites reveal a wide range of metabolic fingerprints associated with the reduced RPE, which can improve predictability and clinical utility for stratifying future T2DM and related microvascular phenotypes, highlighting the promising role of retinas as a window to systemic health.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Karolina Anna Mielko, Natalia Pudelko-Malik, Aneta Tarczewska, Piotr Mlynarz
Summary: Nuclear magnetic resonance (NMR) is a key method in metabolomics and structural analysis, with high demand for solvents that can be simplified for biological studies with D2O and H2O, but more complex metabolomics studies require MeOH or MeCN. The use of NMR as an eco-friendly method aligns with solvent sustainability guidelines.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Review
Agriculture, Dairy & Animal Science
M. Ashokan, Ekta Rana, Kadimetla Sneha, C. Namith, G. S. Naveen Kumar, N. Azharuddin, K. Elango, S. Jeyakumar, K. P. Ramesha
Summary: Advancements in NMR and MS technologies, along with developments in omics sciences, have led to a better understanding of molecular mechanisms and pathways related to the physiological and pathological state of animals. Metabolomics, a post-genomics tool, provides valuable information about an organism's status by analyzing small molecular metabolites within a given time frame. Recently, researchers have focused on metabolomics studies in various fields of livestock management and precision dairying. This review aims to provide insights into the current research and application of metabolomics in different areas of livestock, including nutri-metabolomics, disease diagnosis advancements, reproductive disorders, pharmaco-metabolomics, genomics studies, and dairy production studies.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yueh-Hsiang Huang, Yi-Hong Wu, Hsiang-Yu Tang, Szu-Tah Chen, Chih-Ching Wang, Wan-Jing Ho, Yi-Hsuan Lin, Geng-Hao Liu, Pei-Yeh Lin, Chi-Jen Lo, Yuan-Ming Yeh, Mei-Ling Cheng
Summary: This study found that the concentrated herbal extract formula YH1 improved blood glucose and lipid control in patients with type 2 diabetes and hyperlipidemia by modulating microbiota constituents and altering fecal and plasma bile acid compositions.
Article
Biochemistry & Molecular Biology
Li-Chung Chiu, Hsiang-Yu Tang, Chun-Ming Fan, Chi-Jen Lo, Han-Chung Hu, Kuo-Chin Kao, Mei-Ling Cheng
Summary: Acute respiratory distress syndrome (ARDS) is characterized by dysregulated immune-inflammatory responses and high mortality. This study found that the activation of the kynurenine pathway, a metabolic pathway, is associated with mortality in ARDS patients. Plasma kynurenine levels and the kynurenine/tryptophan ratio were higher in non-survivors compared to survivors. Urine metabolic profiling also revealed higher tryptophan degradation in non-survivors. These findings suggest that the kynurenine pathway could serve as a prognostic marker and a target for therapeutic interventions in ARDS.
Article
Medicine, General & Internal
Huan-Tang Lin, Mei-Ling Cheng, Chi-Jen Lo, Gigin Lin, Fu-Chao Liu
Summary: The study identifies altered metabolic markers in the cerebrospinal fluid and plasma of diabetic patients with DKD, which could be valuable for monitoring the progression of DKD.
Article
Biochemistry & Molecular Biology
Zi-Wei Chen, Gigin Lin, Hsuan-Jen Shih, Chiao-En Wu
Summary: This article reports a case of a patient with non-small cell lung cancer with EGFR gene mutations who responded well to brigatinib monotherapy after intolerable adverse events from afatinib and osimertinib treatments. The patient had EGFR del19/T790M/cis-C797S mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Tiing Yee Siow, Chih-Hua Yeh, Gigin Lin, Chien-Yu Lin, Hung-Ming Wang, Chun-Ta Liao, Cheng-Hong Toh, Sheng-Chieh Chan, Ching-Po Lin, Shu-Hang Ng
Summary: The study found that using MRI radiomic models combined with traditional clinical parameters can more accurately predict the survival rate of patients with hypopharyngeal cancer who undergo concurrent chemoradiotherapy. This research is important for informing tailored management strategies.
Article
Cell Biology
Kuo-Hsuan Chang, Mei-Ling Cheng, Chi-Jen Lo, Chun-Ming Fan, Yih-Ru Wu, Chiung-Mei Chen
Summary: 112 lipoprotein subfractions and components were measured in the plasma of 20 normal controls, 24 symptomatic (sympHD) and 9 presymptomatic (preHD) HD patients. Significant changes were found in 30 lipoprotein subfractions and components in all HD patients. Components of VLDL5, LDL3, LDL4, LDL5, and HDL4 show potential as biomarkers for HD diagnosis and disease progression.
Review
Medicine, General & Internal
I-Liang Liu, An-Hsun Chou, Chien-Hung Chiu, Yu-Ting Cheng, Huan-Tang Lin
Summary: We present a case of difficult upper airway management in a patient with a metastatic tracheal tumor, requiring emergency tracheostomy and venovenous extracorporeal membrane oxygenation (VV-ECMO) support for tumor resection. Our case highlights the importance of emergency tracheostomy and standby VV-ECMO in life-saving airway management.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Biochemistry & Molecular Biology
Yi-Hsiu Chung, Tsai-Hsien Hung, Ching-Fang Yu, Cheng-Kun Tsai, Chi-Chang Weng, Fujie Jhang, Fang-Hsin Chen, Gigin Lin
Summary: The study aims to develop a noninvasive diagnostic platform for early detection of metastasis in lung cancers using F-18-FDG PET and H-1-NMR-based serum metabolomics. The experiment involved implanting NCI-H460 cells in mice to simulate localized and metastatic lung tumors. Serum metabolites were analyzed using H-1-NMR during PET/CT scans and the glycolysis status and cell proliferation were validated through Western blotting and staining. The combination of SUVmean and serum pyruvate level showed high diagnostic accuracy for localized and metastatic tumors.
Article
Biochemistry & Molecular Biology
Mei-Ling Cheng, Cheng-Hung Yang, Pei-Ting Wu, Yi-Chin Li, Hao-Wei Sun, Gigin Lin, Hung-Yao Ho
Summary: 7-Ketocholesterol (7KCh), the major oxidized product of cholesterol, induces cellular oxidative damage. This study investigated the physiological responses of cardiomyocytes to 7KCh. Treatment with 7KCh inhibited the growth of cardiac cells and their mitochondrial oxygen consumption, while also resulting in compensatory increase in mitochondrial mass and adaptive metabolic remodeling. The accumulation of malonyl-CoA was found to play a role in the growth inhibitory effect of 7KCh.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Fu-Chao Liu, Mei-Ling Cheng, Chi-Jen Lo, Wen-Chuin Hsu, Gigin Lin, Huan-Tang Lin
Summary: In this study, CSF metabolomics using LC-MS was employed to investigate the metabolic changes during aging. Several metabolites were found to be significantly correlated with age, and sex differences were also observed. These findings may provide valuable insights into healthy brain aging and warrant further exploration.
Article
Medicine, General & Internal
Bo-Syuan Huang, Ching-Yi Hsieh, Wen-Yen Chai, Yenpo Lin, Yen-Ling Huang, Kuan-Ying Lu, Hsin-Ju Chiang, Rolf F. Schulte, Chien-Yuan Eddy Lin, Gigin Lin
Summary: The aim of this study was to explore the potential of magnetic resonance fingerprinting (MRF) in measuring relaxation values of female pelvic tissues compared to the conventional magnetic resonance image compilation (MAGiC) sequence. The study included 32 female patients who underwent routine pelvic MRI exams. The findings demonstrated significant correlations between MRF and MAGiC measured T1 and T2 values for various pelvic tissues.
Article
Medicine, General & Internal
Reza Kalantar, Sebastian Curcean, Jessica M. Winfield, Gigin Lin, Christina Messiou, Matthew D. Blackledge, Dow-Mu Koh
Summary: T-2 weighted magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) are essential for cervical cancer diagnosis. A novel multi-head framework using dilated convolutions and shared residual connections is proposed to improve tumor segmentation performance. The study highlights the critical importance of T2W and ADC channels for accurate tumor segmentation, while showing that b1000 DWI has a minor impact on overall segmentation performance.
Article
Biochemistry & Molecular Biology
Hsiang-Yu Tang, Jyh-En Huang, Ming-Tong Tsau, Chi-Jen Chang, Ying-Chang Tung, Gigin Lin, Mei-Ling Cheng
Summary: Volume overload and heart failure have an impact on metabolic changes in the kidney, including purine metabolism, taurine metabolism, glycine, serine, and threonine metabolism, glycerophospholipid metabolism, and histidine metabolism. Metabolic profiles are more sensitive than clinical parameters in responding to kidney damage in HF.
