Article
Biochemistry & Molecular Biology
Fang-Yi Wu, Hsin-Chieh Lin
Summary: Synthetic bioactive aromatic peptide amphiphiles are recognized as key elements of emerging biomedical strategies due to their biocompatibility, design flexibility, and functionality. We investigated the self-assembly driving force of two supramolecular materials and found ordered π-π interactions and secondary structures in both compounds. In cell experiments, PFB-IKVAV showed promise as a potential supramolecular biomaterial for biomedical applications.
Article
Polymer Science
Thomas Babut, Mona Semsarilar, Marc Rolland, Damien Quemener
Summary: In this study, a waterborne approach was proposed to co-assemble peptide amphiphiles (PA) and polyelectrolytes into porous membranes with nanostructured networks. Various production methods were explored to shape the material and optimize the structure, leading to a membrane material in the ultrafiltration range with a pore radius of about 7.6 nm.
Article
Engineering, Biomedical
Ziv Azoulay, Polina Aibinder, Ayala Gancz, Jacob Moran-Gilad, Shiri Navon-Venezia, Hanna Rapaport
Summary: FKF, a tripeptide with potential antimicrobial activity, forms a pure peptide hydrogel phase made of natural amino acids. The hydrogel exhibits bactericidal activity against E. coli and P. aeruginosa, and reduces P. aeruginosa contamination in a rat skin lesion model.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Applied
Huimin Chen, Tianrui Zhang, Yongqi Tian, Lijun You, Yan Huang, Shaoyun Wang
Summary: This study provides insights into the mechanism of peptide gelation, offering a way to control self-assembly behaviors and achieve a variety of nanostructures. The peptide assembly process involves five stages and is highly influenced by the charging status of terminal groups. Additionally, the successful loading of curcumin into different self-assembly nanostructures demonstrates high encapsulation efficiency and effective protection.
FOOD HYDROCOLLOIDS
(2022)
Article
Biotechnology & Applied Microbiology
Yang Wang, Xiao Li, Juzheng Yuan, Xudan Wang, Kaishan Tao, Jin Yan
Summary: In this study, an injectable hydrogel with hemostatic and bactericidal function based on Bionic Self-Assembling Peptide (BSAP) was developed. The hydrogel showed rapid formation of a network structure in vivo and exhibited excellent physicochemical properties. It effectively reduced blood clotting time and bleeding volume, and also reduced inflammatory responses by blocking bacterial infection and promoting wound healing. The results provide a strategy for developing a high-biosecurity hydrogel with hemostatic and antibacterial properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rie Wakabayashi, Ayato Higuchi, Hiroki Obayashi, Masahiro Goto, Noriho Kamiya
Summary: This study investigated the self-assembly and enzymatic post-modification of short aromatic peptide amphiphiles, showing that these molecules can form fibrous structures and their assembly is influenced by solution pH. Moreover, enzymatic reactions showed different rates at varying pH, indicating pH dependency in the enzyme-catalyzed post-modification process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Liangchun Li, Li Xie, Renlin Zheng, Rongqin Sun
Summary: This review discusses the design and structures of self-assembly linear dipeptide hydrogels, as well as the strategies for preparing the new generation of hydrogels. With a deeper understanding of the relationship between the structures and properties of dipeptides, it is believed that dipeptide hydrogels have great potential in preparing minimal biocompatible materials.
FRONTIERS IN CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Naoki Tsutsumi, Akitaka Ito, Azumi Ishigamori, Masato Ikeda, Masayuki Izumi, Rika Ochi
Summary: In this study, a novel bola-amphiphilic glycosylated lipopeptide-type supramolecular hydrogelator is presented, exhibiting reversible thermochromism and gel-sol transition. The investigation focused on the effects of different numbers of F residues on gelation ability and morphology of self-assembled nanostructures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Gal Yosefi, Nitsan Eliraz, Sofiya Kolusheva, Hanna Rapaport, Ronit Bitton
Summary: This study reports on the formation and characterization of self-assembled membranes made with & lambda;-carrageenan and cationic & beta;-sheet peptides. The results show that the polysaccharide conformation, solution viscosity, and interactions between polysaccharides and peptides affect the properties of the membranes. The interplay between polymer-peptide interactions and polysaccharide chain stiffness could be used to control the structure-function relationship of the membranes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Xuejiao Yang, Honglei Lu, Yinghua Tao, Hongyue Zhang, Huaimin Wang
Summary: This study reports a method to control the fiber alignment, chirality, and stiffness of aromatic peptide hydrogels through heterodimerization of enantiomeric mixtures. The relative ratio of L and D enantiomers can also regulate the adhesion and morphology of mammalian cells. This work provides a new strategy for controlling supramolecular chirality in materials science.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhicheng Jin, Yi Li, Ke Li, Jiajing Zhou, Justin Yeung, Chuxuan Ling, Wonjun Yim, Tengyu He, Yong Cheng, Ming Xu, Matthew N. Creyer, Yu-Ci Chang, Pavla Fajtova, Maurice Retout, Baiyan Qi, Shuzhou Li, Anthony J. O'Donoghue, Jesse V. Jokerst
Summary: In this study, a colorimetric biosensor using plasmonic gold and surfactant-like peptides (SLPs) was developed, which exhibited a strong aggregation propensity of the FFPC tail without the polar DDD head. The SLPs had specificity towards the target protease M-pro, a biomarker for SARS-CoV-2. This simple and visual tool showed detection limits of 15.7, 20.8, and 26.1 nM for M-pro in phosphate buffer, exhaled breath condensate, and saliva, respectively, and may have potential in designing other protease testing methods.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yanxin Xiang, Can Liu, Shinan Ma, Xiaoting Wang, Linyong Zhu, Chunyan Bao
Summary: In this study, a pH-responsive peptide (MA-FIID) is designed and introduced into a poly(N-isopropyl acrylamide) backbone (PNIPAM) to construct bilayer and heterogeneous hydrogel actuators based on the assembly and disassembly of peptide molecules under different pH conditions. These peptide-containing hydrogel actuators can perform controllable bending, bucking, and complex deformation under pH stimulation. Meanwhile, the Hofmeister effect of PNIPAM hydrogels endows these peptide-containing hydrogels with enhanced mechanical strength, ionic stimulus response (CaCl2), and excellent shape-memory property.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Yudai Tominaga, Sayuki Kanemitsu, Shota Yamamoto, Toshihisa Kimura, Yuki Nishida, Kenta Morita, Tatsuo Maruyama
Summary: A thermo-irreversible hydrogel was constructed using dynamic covalent chemistry and a low-molecular-weight gelator, which consisted of a peptide, an alkyl chain, and an aromatic ring. The hydrogel exhibited a gel-to-sol transition upon heating but did not revert back to the gel state upon cooling, indicating its thermo-irreversibility. The hydrogel was also demonstrated to record thermal history without the need for electrical power in logistics applications.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Multidisciplinary
M. Hussain Sangji, Hiroaki Sai, Stacey M. Chin, Sieun Ruth Lee, Ivan R. Sasselli, Liam C. Palmer, Samuel Stupp
Summary: The morphology of supramolecular peptide nanostructures is influenced by factors such as the balance of molecule packing, the diversity of peptide sequences, and the twisting of beta-sheets. Altering the peptide sequence can change the morphology and supramolecular chirality of the nanostructures. Additionally, increasing charge repulsion between molecules leads to a change in morphology.
Article
Biochemistry & Molecular Biology
Xiaoli Zhao, Yifan Yang, Xuerong Su, Ying Xie, Yiyao Liang, Tong Zhou, Yangqian Wu, Liuqing Di
Summary: In this study, a transferrin-modified Triptolide (TP) liposome was developed for the treatment of hepatocellular carcinoma. The results showed that the liposome had good physicochemical properties and drug loading, and effectively inhibited tumor growth in vitro and in vivo. The modification with transferrin enhanced the drug targeting to the tumor tissues and reduced its toxic effects in normal tissues.
Article
Computer Science, Information Systems
Pengcheng Zhang, Huagui He, Yun Wang, Yang Liu, Hong Lin, Liang Guo, Weijun Yang
Summary: This article presents and tests the fusion process of LiDAR and photogrammetric point clouds using the U-Net deep learning model segmentation. The results show that the U-Net method is effective for high-resolution image extraction and the fused point clouds with high point density and RGB color information can improve building extraction.
Article
Chemistry, Analytical
Pengcheng Zhang, Bing Yan, Guoqiang Gu, Zitong Yu, Xi Chen, Zengbo Wang, Hui Yang
Summary: Near-field optics based sensing techniques are important for highly-sensitive detection of various targets. However, efficiently introducing analytes into the desired location of the near-field light focusing and quantitatively measuring the enhanced optical signal are still challenging. In this work, a localized photonic nanojet based sensing platform is presented for quantitative biosensing through a unique light-analyte interaction system.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Pharmacology & Pharmacy
Chao Zheng, Wen Zhang, Jinming Wang, Yihui Zhai, Fengqin Xiong, Ying Cai, Xiang Gong, Binyu Zhu, Helen He Zhu, Hao Wang, Yaping Li, Pengcheng Zhang
Summary: This study designed a synthetic high-density lipoprotein (LV-sHDL) loaded with lenvatinib and vadimezan for the combination immunochemotherapy of metastatic triple-negative breast cancer (TNBC). The use of LV-sHDL improved the intratumoral infiltration of cytotoxic T lymphocytes (CTLs), inhibited tumor growth and metastasis, and prolonged survival.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Zi-tong Zhao, Jue Wang, Lei Fang, Xin-di Qian, Ying Cai, Hai-qiang Cao, Guan-ru Wang, Mei-lin He, Yan-yan Jiang, Dang-ge Wang, Ya-ping Li
Summary: In this study, a novel nanocarrier system was developed to inhibit tumor angiogenesis and phosphorylation of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) through dual-responsive drug release, resulting in improved therapeutic effects.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Multidisciplinary
Zitong Zhao, Lei Fang, Ping Xiao, Xiangshi Sun, Lei Zhou, Xiaochen Liu, Jue Wang, Guanru Wang, Haiqiang Cao, Pengcheng Zhang, Yanyan Jiang, Dangge Wang, Yaping Li
Summary: In this study, walking dead TNBC cells were developed by conjugating anti-PD-1 and doxorubicin-loaded liposomes onto cell corpses for temporal chemo-immunotherapy against lung metastasis. The walking dead TNBC cells improved drug accumulation and local retention in the lungs, reprogrammed the lung microenvironment, and prolonged overall survival in mice with lung metastasis.
ADVANCED MATERIALS
(2022)
Article
Metallurgy & Metallurgical Engineering
Yang Gu, Hui-bin Wu, Zhi-Hui Zhang, Peng-Cheng Zhang, Rui Yuan, Xin-tian Wang, Hui Guo
Summary: This study investigated the corrosion behavior of rolled oxidized sheet of 5Cr steel in a high-temperature, high-pressure CO2 environment. The results showed that the oxide scale, composed of Fe3O4 and Fe2O3, delayed the occurrence of corrosion and eventually formed a double-layer product film similar to bare steel.
ISIJ INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Rui Yang, S. M. Enamul Hoque Yousuf, Jaesung Lee, Pengcheng Zhang, Zuheng Liu, Philip X. -L. Feng
Summary: This study experimentally demonstrates dynamical phonon softening in atomically thin molybdenum disulfide (MoS2) NEMS resonators by directly coupling Raman spectroscopy with optical interferometry resonance motion detection. High-amplitude nonlinear resonances can enhance the Raman signal amplitude and introduce Raman modes softening up to 0.8 cm(-1).
Article
Engineering, Biomedical
Xiang Gong, Jie Li, Xiaoxuan Xu, Yao Wu, Ying Lei, Huanzhen Liu, Xindi Qian, Yaping Li, Zhiwen Zhang
Summary: This study presents a microvesicle-inspired strategy for effective cancer treatment by using a poly-fluorocarbon nanosystem, loaded with DiIC18(5) and halofuginone (M-FDH), to improve tumor oxygenation, intratumor distribution, disrupt tumor stroma and boost anti-tumor immunity in combination with radiotherapy.
Article
Pharmacology & Pharmacy
Xiandi Qian, Guanru Wang, Jie Li, Xinyue Zhang, Minghui Zhang, Qingmin Yang, Zhiwen Zhang, Yaping Li
Summary: This study developed a bioadhesive liposome loaded with water-insoluble idebenone to enhance its intestinal absorption and oral bioavailability, resulting in significantly improved tissue concentrations in the duodenum, jejunum, and ileum as well as enhanced oral bioavailability compared to other formulations.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Zhihui Zhang, Gang Niu, Jing Li, Pengcheng Zhang, Huibin Wu
Summary: A low Mo-containing fire-resistant weathering construction steel with the synergistic effect of low Mo and Ti microalloying was developed, which exhibited excellent high-temperature strength, weather resistance, and corrosion resistance superior to traditional Q345 steel.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Chemistry, Multidisciplinary
Jiaoying Wang, Jie Li, Yao Wu, Xiaoxuan Xu, Xindi Qian, Ying Lei, Huanzhen Liu, Zhiwen Zhang, Yaping Li
Summary: This study developed a ROS-responsive albumin nanocomplex that enhanced T cell activation and reduced immunosuppressive cells, resulting in significant inhibition of tumor growth in breast and colon tumor models. The nanocomplex offers a promising platform for effective cancer immunotherapy with enhanced intratumor delivery capacity.
Article
Cell Biology
Yuman He, Zhongzhong Ji, Yiming Gong, Liancheng Fan, Penghui Xu, Xinyu Chen, Juju Miao, Kai Zhang, Wentian Zhang, Pengfei Ma, Huifang Zhao, Chaping Cheng, Deng Wang, Jinming Wang, Na Jing, Kaiyuan Liu, Pengcheng Zhang, Baijun Dong, Guanglei Zhuang, Yujie Fu, Wei Xue, Wei-Qiang Gao, Helen He Zhu
Summary: Cell plasticity and neuroendocrine differentiation in prostate and lung adenocarcinomas contribute to therapeutic resistance. This study reveals that neuroendocrine cancer cells rely on glycolysis and have fragmented mitochondria with low membrane potential. The Numb/Parkin pathway plays a crucial role in mitochondrial quality control and its deficiency causes metabolic reprogramming and upregulation of neuroendocrine-associated genes through lactate acid production and histone lactylation. These findings suggest that targeting Numb/Parkin-directed mitochondrial fitness could be a promising therapeutic strategy for cancer cell plasticity.
Article
Chemistry, Multidisciplinary
Pengcheng Zhang, Yujuan Zhang, Lin Wang, Kaikai Qiu, Xiaoyi Tang, John K. Gibson, Xue Liu, Lei Mei, Shuwen An, Zhiwei Huang, Peng Ren, Yi Wang, Zhifang Chai, Weiqun Shi
Summary: Inspired by the super adhesion of multi-point suction cups on octopus tentacles, researchers constructed a 2D lamellar membrane (2DLM) from Ti3C2Tx MXene supported by the macrocyclic multi-point molecule cucurbit[5]uril (CB5). The 2DLM exhibited excellent nanofiltration performance and swelling resistance at high salinity, and it could be recycled at least 30 times without significant degradation. This novel membrane provides a new strategy for constructing highly stable 2DLMs for various applications.
