Review
Immunology
Taif Shah, Zahir Shah, Nafeesa Yasmeen, Zulqarnain Baloch, Xueshan Xia
Summary: This article examines the pathogenesis and impact of coinfection between COVID-19 and TB, highlighting the diagnostic challenges associated with this dual infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jianjun Wang, Yujie Li, Nan Wang, Jianhong Wu, Xiaojian Ye, Yibiao Jiang, Lijun Tang
Summary: Tuberculosis (TB) is a fatal bacterial contagious disease caused by Mycobacterium tuberculosis (M. tb), and recent studies suggest that exosomes could be a novel option for TB diagnosis and treatment. Exosomes are nanovesicles (30-150 nm) released from various cells, carrying lipids, proteins, and non-coding RNAs (ncRNAs), and they play a role in cell-to-cell communication. Exosomal ncRNAs have shown diagnostic potential in bacterial infections, including TB, and also regulate the functions of M. tb-infected cells, serving as diagnostic markers for TB. This review explores the biological roles and diagnostic application prospects of exosomal ncRNAs in TB, as well as their pathogenic and therapeutic functions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Nina Germic, Aref Hosseini, Darko Stojkov, Kevin Oberson, Meike Claus, Charaf Benarafa, Sara Calzavarini, Anne Angelillo-Scherrer, Isabelle C. Arnold, Anne Mueller, Carsten Riether, Shida Yousefi, Hans-Uwe Simon
Summary: The study demonstrates that knocking out Atg5 in eosinophils results in a decrease in mature eosinophils, an increase in immature cells, and affects cell proliferation and differentiation. Additionally, Atg5-deficient eosinophils show enhanced degranulation and bacterial killing abilities, leading to better clearance of bacterial infections in vivo models.
Article
Microbiology
Marianne Martin, Angelique deVisch, Yves-Marie Boudehen, Philippe Barthe, Claude Gutierrez, Obolbek Turapov, Talip Aydogan, Laurene Heriaud, Jerome Gracy, Olivier Neyrolles, Galina V. Mukamolova, Francois Letourneur, Martin Cohen-Gonsaud
Summary: Mtb infection reprograms host metabolism, promoting its survival and spread. The secreted protein Rv1813c from Mtb manipulates host metabolism by targeting mitochondria, boosting ATP production and delaying cytochrome c release. This study reveals a novel class of mitochondrial effectors that may participate in host cell metabolic reprogramming and apoptosis control during Mtb infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Cell Biology
Zhen Gong, Shuang Han, Tian Liang, Hongyang Zhang, Qingyu Sun, Huimin Pan, Haolin Wang, Jiao Yang, Liting Cheng, Xi Lv, Qijia Yue, Lin Fan, Jianping Xie
Summary: Mycobacterium tuberculosis effector PPE36 blocks macrophage M1 polarization, reducing the cytokine storm and alleviating inflammatory damage to mouse immune organs. PPE36 inhibits macrophage polarization into mature M1 macrophages by suppressing the ERK signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Microbiology
Lucas Boeck, Sophie Burbaud, Marcin Skwark, Will H. Pearson, Jasper Sangen, Andreas W. Wuest, Eleanor K. P. Marshall, Aaron Weimann, Isobel Everall, Josephine M. Bryant, Sony Malhotra, Bridget P. Bannerman, Katrin Kierdorf, Tom L. Blundell, Marc S. Dionne, Julian Parkhill, R. Andres Floto
Summary: This study demonstrates the use of phenogenomic analysis, combining high-dimensional phenotyping with whole-genome sequencing, to rapidly reveal insights into bacterial pathobiology. By phenotyping 331 clinical isolates of Mycobacterium abscessus, three distinct clusters of isolates were discovered, each associated with different virulence traits and clinical outcomes. Genome-wide association studies, proteome-wide structural modeling, and direct coupling analysis were employed to identify causal variants and gene networks, leading to the discovery of clinically relevant virulence factors. This highlights the potential of phenogenomics in uncovering critical pathways in emerging pathogenic bacteria.
NATURE MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohd Hatimi Tukiman, Mohd Nor Norazmi
Summary: Tuberculosis remains a major threat to global public health. This review seeks to explore the mucosal immunometabolism of resident effector cells in response to Mtb infection and how Mtb manipulates them for its survival and growth, with the aim of filling knowledge gaps and potentially contributing to future vaccination and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yujie Li, Yingfen Qian, Nan Wang, Dewen Qiu, Hui Cao, Yihua Wang, Hao Luo, Xiaodong Shen, Hanwei Cui, Jianjun Wang, Hong Zhu
Summary: Extracellular vesicles (EVs) produced by Mycobacterium tuberculosis play critical roles in understanding vesicle biogenesis, modulating cellular immune responses, and developing new strategies for prevention and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Yujie Li, Yingfen Qian, Nan Wang, Dewen Qiu, Hui Cao, Yihua Wang, Hao Luo, Xiaodong Shen, Hanwei Cui, Jianjun Wang, Hong Zhu
Summary: Extracellular vesicles originating from Mycobacterium tuberculosis play critical roles in bacterial physiology and host-pathogen interactions. They facilitate the transmission of biological molecules and interact with the host, revealing new aspects of tuberculosis pathogenesis. This review discusses the significant functions of M. tuberculosis EVs in vesicle biogenesis, modulating cellular immune responses, and the development of preventive, therapeutic, or diagnostic strategies against tuberculosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Microbiology
Nan Zheng, Joy Fleming, Peilei Hu, Jianjian Jiao, Guoqin Zhang, Ruifang Yang, Chuanyou Li, Yi Liu, Lijun Bi, Hongtai Zhang
Summary: By studying M. tuberculosis infection models and peripheral blood cells from pulmonary tuberculosis patients, this study identifies CD84 as a potential receptor involved in T and B cell immunosuppression during M. tuberculosis pathogenesis and inhibitory role in B cell activation. CD84-deficient mice exhibit improved M. tuberculosis clearance and survival rates compared to wild-type mice, suggesting CD84 may be a suitable target for TB-specific checkpoint immunotherapies.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Renuga Devi Kanabalan, Le Jie Lee, Tze Yan Lee, Pei Pei Chong, Latiffah Hassan, Rosnah Ismail, Voon Kin Chin
Summary: The Mycobacterium tuberculosis complex (MTBC) consists of nine closely related species that cause tuberculosis in animals and humans, with Mycobacterium tuberculosis being the primary causative agent for human tuberculosis globally. The pathogenesis of human tuberculosis involves complex interactions between host factors and bacterial determinants. Research indicates the potential of host biomarkers in early diagnosis, disease differentiation, and treatment monitoring for tuberculosis.
MICROBIOLOGICAL RESEARCH
(2021)
Review
Microbiology
Shweta Parmar, Elitza I. Tocheva
Summary: Mycobacterium abscessus, a nontuberculosis mycobacterium, is associated with various nosocomial infections and respiratory disorders. The pathogenesis of M. abscessus is closely related to compositional changes in its cell envelope, including the decrease in presence of glycopeptidolipids and the presence of drug efflux pumps. Additionally, type VII secretion systems ESX-3 and ESX-4 have been implicated in host-pathogen interactions and virulence.
Review
Microbiology
Pablo Soldevilla, Cristina Vilaplana, Pere-Joan Cardona
Summary: Science has benefited greatly from animal models since ancient Greece and has obtained important findings throughout history. The mouse, especially in research on infectious diseases like tuberculosis, has been one of the most popular models. Research on mice has provided useful information about host and bacterial traits related to susceptibility to tuberculosis, as well as the effects of aging, sexual dimorphisms, route of infection, genetic differences, and immunity imbalances on Mycobacterium tuberculosis infection and tuberculosis development. Despite some discrepancies and gaps in certain areas, these studies will continue to help biomedical researchers in designing new tools for the diagnosis, treatment, and prevention of tuberculosis.
Review
Immunology
G. Marcela Rodriguez, Nishant Sharma, Ashis Biswas, Nevadita Sharma
Summary: This article reviews the response of Mycobacterium tuberculosis to changes in iron availability, its relevance to TB pathogenesis, and the potential for new therapeutic interventions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Prabhakar Tiwari, Tannu Priya Gosain, Saurabh Chugh, Mamta Singh, Gaurav D. Sankhe, Garima Arora, Saqib Kidwai, Sakshi Agarwal, Deepak K. Saini, Ramandeep Singh
Summary: The study highlights the importance of enzymes involved in PolyP homeostasis in the physiology and virulence of M. tuberculosis. These enzymes contribute to biofilm formation, survival in nutrient limiting and low oxygen conditions, and establishment of infection in guinea pigs and mice. Targeting these enzymes could lead to the development of novel interventions against drug-sensitive and drug-resistant M. tuberculosis.
MICROBIAL PATHOGENESIS
(2022)
Article
Biology
Haaris S. Khan, Vidhya R. Nair, Cody R. Ruhl, Samuel Alvarez-Arguedas, Jorge L. Galvan Rendiz, Luis H. Franco, Linzhang Huang, Philip W. Shaul, Jiwoong Kim, Yang Xie, Ron B. Mitchell, Michael U. Shiloh
Article
Biochemistry & Molecular Biology
Cody R. Ruhl, Breanna L. Pasko, Haaris S. Khan, Lexy M. Kindt, Chelsea E. Stamm, Luis H. Franco, Connie C. Hsia, Min Zhou, Colton R. Davis, Tian Qin, Laurent Gautron, Michael D. Burton, Galo L. Mejia, Dhananjay K. Naik, Gregory Dussor, Theodore J. Price, Michael U. Shiloh
Review
Biochemistry & Molecular Biology
Priscila C. Campos, Danielle T. Cunha, Luiz P. Souza-Costa, Michael U. Shiloh, Luis H. Franco
Summary: This article summarizes the latest advances on the role of ubiquitination and ubiquitin ligases in host immunity against Mycobacterium tuberculosis infection. It focuses on innate immunity signaling, inflammation, and antimicrobial autophagy. Understanding the mechanisms of ubiquitin ligases in mediating immunity to Mtb could aid in the development of new host-directed antimicrobials.
TRENDS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Salwa Sebti, Zhongju Zou, Michael U. Shiloh
Summary: Macroautophagy/autophagy is essential for lifespan extension in various model organisms, and dysfunction in autophagy can affect age-related phenotypes and diseases. Aging wild-type mice maintain functional autophagic flux in heart, kidney, and skeletal muscle, but not in the liver, whereas old Becn1(F121A) mice exhibit increased autophagic flux in these organs compared with wild type, indicating an organ-specific role for autophagy in impacting organ aging phenotypes.
Review
Immunology
Kathryn C. Rahlwes, Beatriz R. S. Dias, Priscila C. Campos, Samuel Alvarez-Arguedas, Michael U. Shiloh
Summary: Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, posing one of the greatest threats to global health. By utilizing its arsenal of virulence factors, Mtb invades the airway, evades the host immune response, and establishes a niche for survival. Understanding the interplay between Mtb virulence factors and host defenses is crucial for developing effective vaccines and therapeutics.
Proceedings Paper
Computer Science, Theory & Methods
Luiz Ricardo Begosso, Luis Henrique Buzzo Franco, Douglas Sanches da Cunha, Luiz Carlos Begosso
PROCEEDINGS OF 9TH INTERNATIONAL CONFERENCE ON INFORMATION COMMUNICATION AND MANAGEMENT (ICICM 2019)
(2019)
Correction
Microbiology
Luis H. Franco, Vidhya R. Nair, Caitlyn R. Scharn, Ramnik J. Xavier, Jose R. Torrealba, Michael U. Shiloh, Beth Levine
CELL HOST & MICROBE
(2017)
Article
Microbiology
Luis H. Franco, Vidhya R. Nair, Caitlyn R. Scharn, Ramnik J. Xavier, Jose R. Torrealba, Michael U. Shiloh, Beth Levine
CELL HOST & MICROBE
(2017)