Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes

Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity

(2016) Prashant Tarale et al.   Biomed Research International

Genome-wide analysis of DNA methylation during antagonism of DMOG to MnCl2-induced cytotoxicity in the mouse substantia nigra

(2016) Nannan Yang et al.   Scientific Reports

The PARK2/Parkin receptor on damaged mitochondria revisited—uncovering the role of phosphorylated ubiquitin chains

(2015) Noriyuki Matsuda et al.   Autophagy

Impact of ferromanganese alloy plants on household dust manganese levels: Implications for childhood exposure

(2015) E.L. Lucas et al.   ENVIRONMENTAL RESEARCH

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders

(2015) Susan Searles Nielsen et al.   PARKINSONISM & RELATED DISORDERS

DNA methylation changes in the placenta are associated with fetal manganese exposure

(2015) Jennifer Z.J. Maccani et al.   REPRODUCTIVE TOXICOLOGY

Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features

(2015) Gunnar Kwakye et al.   International Journal of Environmental Research and Public Health

A zebrafish model of manganism reveals reversible and treatable symptoms that are independent of neurotoxicity

(2014) Subha Bakthavatsalam et al.   Disease Models & Mechanisms

Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response

(2013) Julia Bornhorst et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

(2013) Matthew J Lyst et al.   NATURE NEUROSCIENCE

Epigenetic Landscape of Parkinson’s Disease: Emerging Role in Disease Mechanisms and Therapeutic Modalities

(2013) Navneet Ammal Kaidery et al.   Neurotherapeutics

The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism

(2013) Raja Settivari et al.   NEUROTOXICOLOGY

PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1

(2013) Arnaud Berthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: Attenuation of thymine base lesions by glutathione and N-acetylcysteine

(2013) Adrienne P. Stephenson et al.   TOXICOLOGY LETTERS

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

PARK2 gene mutations in early onset Parkinson's disease patients of South India

(2012) M. Vishwanathan Padmaja et al.   NEUROSCIENCE LETTERS

Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration

(2012) Anumantha Kanthasamy et al.   NEUROTOXICOLOGY

Increased risk of parkinsonism associated with welding exposure

(2012) Brad A. Racette et al.   NEUROTOXICOLOGY

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

Environmental epigenetics in metal exposure

(2011) Ricardo Martinez-Zamudio et al.   Epigenetics

MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function

(2011) Elena Miñones-Moyano et al.   HUMAN MOLECULAR GENETICS

Maneb and Paraquat-Mediated Neurotoxicity: Involvement of Peroxiredoxin/Thioredoxin System

(2011) James R. Roede et al.   TOXICOLOGICAL SCIENCES

Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line

(2011) Danhui Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

α-Synuclein overexpression during manganese-induced apoptosis in SH-SY5Y neuroblastoma cells

(2009) Yan Li et al.   BRAIN RESEARCH BULLETIN

Epigenetics and environmental chemicals

(2009) Andrea Baccarelli et al.   CURRENT OPINION IN PEDIATRICS

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Environmental-induced oxidative stress in neurodegenerative disorders and aging

(2008) Lucia Migliore et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

(2008) C. A. Gautier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE