Article
Biochemistry & Molecular Biology
Yusuke Motoji, Ryuji Fukazawa, Ryosuke Matsui, Noriko Nagi-Miura, Yasuo Miyagi, Yasuhiko Itoh, Yosuke Ishii
Summary: This study found that Kawasaki disease may promote the development of atherosclerosis in adulthood. Long-term treatment with HMG-CoA inhibitors (statins) effectively suppressed the occurrence of atherosclerosis and inflammatory cell infiltration. Therefore, statin treatment may be used for secondary prevention of cardiovascular events during the chronic phase of Kawasaki disease.
Article
Gastroenterology & Hepatology
Rui Sun, Matija Hedl, Clara Abraham
Summary: This study demonstrates that TNFSF15 plays a critical role in promoting antimicrobial pathways in macrophages by regulating bacterial clearance through various signaling mechanisms. Individuals carrying the IBD risk genotype with higher TNFSF15 expression levels show increased levels of antimicrobial pathways in macrophages.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Hironobu Kobayashi, Motoko Y. Kimura, Ichita Hasegawa, Eisuke Suganuma, Yuzuru Ikehara, Kazuhiko Azuma, Toshihiro Ito, Ryota Ebata, Yosuke Kurashima, Yohei Kawasaki, Yuki Shiko, Naoki Saito, Hirotaro Iwase, Youngho Lee, Magali Noval Rivas, Moshe Arditi, Masahiko Zuka, Hiromichi Hamada, Toshinori Nakayama
Summary: Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects children. The expression of Myl9, a protein involved in cellular contractility, is significantly increased during KD vasculitis, and Myl9 levels may serve as a useful biomarker for estimating inflammation and IVIG responsiveness in KD patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Myron Odingo, Megan Rutter, Jonathan Bowley, Emily J. Peach, Peter C. Lanyon, Matthew J. Grainge, Peter Stillwell, Sean McPhail, Mary Bythell, Jeanette Aston, Sarah Stevens, Rachael McCormack, Paul Brogan, Fiona A. Pearce
Summary: The objective of this study was to describe the incidence of Kawasaki Disease (kDa) in England from 2006 to 2021. The study identified cases using hospital episode statistics with an ICD-10 diagnostic code for kDa and validated the diagnoses using medical records. The results showed higher incidence rates of kDa in children under 16, especially among non-White ethnicities and more deprived socioeconomic groups.
Review
Pediatrics
Maryam Piram
Summary: The annual incidence of KD in Europe is about 10-15 per 100,000 children under 5 years old and seems to be relatively stable over time and space. Demographic characteristics are in line with those in other countries of the world, with a higher incidence in children from Asia and possibly North African origin. The occurrence of peaks during pandemics, microbiological findings and a possible link with southerly winds support the hypothesis of an airborne infectious agent.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
I-Hsin Tai, Kai-Sheng Hsieh, Ho-Chang Kuo
Summary: Kawasaki disease (KD) is a febrile systemic vasculitis that mainly affects children aged under five years old. The formation of coronary aneurysm is the most common complication after KD.
Article
Critical Care Medicine
Mia DelVechio, Juliano Alves, Alina Z. Saiyid, Shubhnita Singh, Joseph Galley, Wanessa M. C. Awata, Rafael M. Costa, Ariane Bruder-Nascimento, Thiago Bruder-Nascimento
Summary: This study investigates the relationship between Kawasaki disease and vascular function and blood pressure using a murine model. The findings suggest that Kawasaki disease may be associated with vascular dysfunction, which may be dependent on COX-derived products, oxidant properties, and NO bioavailability. Vascular smooth muscle cells may play an important role in the development of vascular dysfunction and vasculitis via the Toll-like receptor 4 pathway. However, the CAWS model seems inappropriate for studying Kawasaki disease-associated shock. Further studies are needed to understand whether vascular dysfunction and COXs are triggers for vasculitis.
Review
Immunology
Estefany Y. Reyes, Mari L. Shinohara
Summary: Fungal infections in the central nervous system (CNS) have high morbidity and mortality rates, which have been increasing in recent years. Although clinical interventions for CNS mycoses are limited, understanding the mechanisms of host-pathogen interaction in CNS mycoses is crucial for developing new treatments.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Pediatrics
Lilin Huang, Shumei Peng, Jing Li, Danyu Xie
Summary: This is a rare case report on the association between Kawasaki disease and myositis. The author reported a case of an 18-month-old child with Kawasaki disease who presented with lower limb muscle weakness. The lower limb muscle weakness fully recovered after prednisolone treatment. This case adds value to the literature exploring the association of Kawasaki disease with myositis.
FRONTIERS IN PEDIATRICS
(2022)
Review
Cell Biology
Conor Hennessy, Declan P. McKernan
Summary: PRRs play a central role in inflammation following microbial infection by recognizing molecular patterns, and targeting them may offer a potential therapeutic approach for chronic inflammatory diseases and infections.
Article
Cardiac & Cardiovascular Systems
Xiaoliang Liu, Lin Wang, Shuran Shao, Nanjun Zhang, Mei Wu, Lei Liu, Yimin Hua, Kaiyu Zhou, Li Yu, Hua Wang, Chuan Wang
Summary: The incidence of sterile pyuria is relatively low in KD patients. Patients with sterile pyuria in KD exhibited a more severe inflammatory burden and were more likely to develop the initial IVIG resistance and moderate/giant CAAs. The overall prognosis of KD patients with sterile pyuria was satisfactory.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Virology
Mohammad Farahmand, Abbas Ahmadi-Vasmehjani, Abdoulreza Esteghamati, Shirin Sayyahfar, Sara Minaeian, Khadijeh Khanaliha, Mehri Naghdalipour, Ahmad Tavakoli
Summary: The study reveals strong associations between KD and human parvovirus B19 viremia, EBV IgM seropositivity, and human herpesvirus-6 IgG seropositivity.
Article
Rheumatology
Mark E. McClure, Yajing Zhu, Rona M. Smith, Seerapani Gopaluni, Joanna Tieu, Tasneem Pope, Karl Emil Kristensen, David R. W. Jayne, Jessica Barrett, Rachel B. Jones
Summary: This study aimed to develop relapse and infection risk prediction models for patients with ANCA-associated vasculitis receiving rituximab maintenance therapy. While the models lacked the power to discriminate risk between individual patients, they were able to assign patients into risk groups, which may help guide decisions regarding the potential benefit of ongoing rituximab treatment. Prospective multi-centre validation studies are recommended before using these prediction models in practice.
Review
Gastroenterology & Hepatology
Natsuki Okai, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Hajime Honjo, Masatoshi Kudo
Summary: Crohn's disease (CD) is caused by the loss of tolerance to intestinal microbiota and excessive production of pro-inflammatory cytokines. Impaired activation of pattern recognition receptor (PRR)-mediated signaling pathways and dysfunction of the autophagic machinery may be involved in the development of CD.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Andrea Frustaci, Maria Alfarano, Romina Verardo, Chiara Agrati, Rita Casetti, Fabio Miraldi, Nicola Galea, Claudio Letizia, Cristina Chimenti
Summary: Necrotizing coronary vasculitis (NCV) is a rare entity associated with myocarditis, with both viral and immune-mediated causes identified. Patients with NCV showed improvement in cardiac function with immunosuppression therapy, suggesting an immunologic pathway linked to therapeutic response.
EUROPEAN HEART JOURNAL
(2021)
