Article
Immunology
Ebru Yuce
Summary: The role of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting spontaneous preterm birth was investigated. Retrospective data collected from hospital records between February 2018 and November 2022 showed that NLR and PLR values can predict preterm birth with high sensitivity and specificity. Predicting preterm birth allows for sensitive and smooth management of the pregnancy process.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Immunology
E. Weijian, Zhixin Wang, Mingquan Pang, Yongliang Lu, Haining Fan
Summary: The NLR and PLR of AE patients were higher than those of CE patients, and the high inflammation of CE patients may be correlated to the reproductive mode of Echinococcus multilocularis. PLR and NLR have certain diagnostic values for disease classification, but PLR has higher specificity when compared with NLR.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Health Care Sciences & Services
Georgios Tzikos, Ioannis Alexiou, Sokratis Tsagkaropoulos, Alexandra-Eleftheria Menni, Georgios Chatziantoniou, Soultana Doutsini, Theodosios Papavramidis, Vasilios Grosomanidis, George Stavrou, Katerina Kotzampassi
Summary: In this study, the researchers investigated whether NLR and PLR could predict mortality and length of hospital stay after cardiac surgery. The results showed that NLR and PLR are efficient predictive factors for 90-day mortality and length of stay in cardiac surgery patients. Monitoring NLR and PLR postoperatively could provide a reliable predictor of patients' outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pediatrics
Spyridoula Gysi, Michael Doulberis, Corinne Legeret, Henrik Kohler
Summary: This retrospective analysis explored the utilization of PYMS as a screening tool for malnutrition in pediatric inpatients and investigated the correlation between PYMS and NLR and PLR. The study found a potential value of PLR as a predictive marker for moderate to severe malnutrition in hospitalized children.
Article
Medicine, General & Internal
Milena-Adina Man, Lavinia Davidescu, Nicoleta-Stefania Motoc, Ruxandra-Mioara Rajnoveanu, Cosmina-Ioana Bondor, Carmen-Monica Pop, Claudia Toma
Summary: The study showed that NLR and PLR had limited ability to differentiate between various respiratory diseases and were not suitable for making the differential diagnosis.
Article
Immunology
Pauline Jacob, Julie Bonnefoy, Stephanie Ghislin, Jean-Pol Frippiat
Summary: This study evaluated the relevance of two easily-implemented biomarkers for monitoring immune system in astronauts and suggested using neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) to assess long-lasting immune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cieszymierz Gawinski, Andrzej Mroz, Katarzyna Roszkowska-Purska, Iwona Sosnowska, Edyta Derezinska-Wolek, Wojciech Michalski, Lucjan Wyrwicz
Summary: This study investigated the role of systemic inflammatory response (SIR) markers in locally advanced rectal cancer (LARC). The results showed a significant positive correlation between lymphocyte-to-monocyte ratio (LMR) and cancer-related inflammatory infiltrate, as well as PD-L1 expression. Platelet-to-lymphocyte ratio (PLR) was correlated with nodal involvement. However, these markers demonstrated only moderate reproducibility and had no significant prognostic value. Further research is needed to establish their effectiveness as biomarkers in LARC.
Article
Emergency Medicine
Murat Seyit, Esin Avci, Rukiye Nar, Hande Senol, Atakan Yilmaz, Mert Ozen, Alten Oskay, Hulya Aybek
Summary: The study revealed that levels of CRP, LDH, PLR, and NLR were significantly higher in COVID-19 positive patients, while levels of eosinophil, lymphocyte, and platelets were significantly elevated in COVID-19 negative patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Endocrinology & Metabolism
Wenwen Chen, Kun Chen, Zhixiao Xu, Yepeng Hu, Yiying Liu, Wenyue Liu, Xiang Hu, Tingting Ye, Jing Hong, Hong Zhu, Feixia Shen
Summary: The study found that elevated platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) were associated with higher all-cause mortality in patients with diabetic foot ulcers (DFU) following amputations. Multivariate analysis identified age, Wagner classification, PLR, NLR, creatinine, and direct bilirubin as independent predictors of mortality after amputation.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Medicine, General & Internal
Yingjie Duan, Zhong Peng, Shuzhu Zhong, Hong Huang, Zhangxiu He
Summary: This study investigated the relationship between monocyte-to-lymphocyte ratio (MLR) and left ventricular ejection fraction (LVEF) in patients with peritoneal dialysis (PD), and found that platelet-to-lymphocyte ratio (PLR) was more reliable than neutrophil-to-lymphocyte ratio (NLR), MLR, and albumin in predicting left ventricular systolic dysfunction (LVSD) in PD patients.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Cieszymierz Gawinski, Wojciech Michalski, Andrzej Mroz, Lucjan Wyrwicz
Summary: Colorectal cancer is a leading cause of cancer-related mortality worldwide, requiring novel markers for patient risk assessment and treatment adjustments. Peripheral and local markers of cancer-related inflammation have been extensively studied and found to be highly prognostic. Despite the initial hypothesis, peripheral blood-based markers showed no correlation with tissue-based markers of tumor-infiltrating lymphocytes.
Article
Neurosciences
Katerina Dadouli, Michel B. Janho, Apostolia Hatziefthimiou, Ioanna Voulgaridi, Konstantina Piaha, Lemonia Anagnostopoulos, Panagiotis Ntellas, Varvara A. Mouchtouri, Konstantinos Bonotis, Nikolaos Christodoulou, Matthaios Speletas, Christos Hadjichristodoulou
Summary: The study found that patients with BD had higher NLR, MLR, and SII index compared to healthy controls during manic and depressive episodes, indicating a higher level of inflammation in BD patients.
Article
Psychiatry
Qi Zheng, Jin Liu, YaJuan Ji, Yan Zhang, XinChao Chen, BangShan Liu
Summary: This study compared the levels of inflammatory indicators derived from blood routine tests between adolescents with and without non-suicidal self-injury (NSSI). The results showed that adolescents with NSSI had significantly higher MLR and PLR compared to those without NSSI. MLR and PLR were independently associated with NSSI. ROC curve analysis demonstrated that MLR and PLR can be used to differentiate NSSI from non-NSSI.
Article
Medicine, General & Internal
Karim Mohamed-Noriega, Alan B. Trevino-Herrera, Jibran Mohamed-Noriega, Braulio H. Velasco-Sepulveda, Victor A. Martinez-Pacheco, Dante A. Guevara-Villarreal, Delia L. Rodriguez-Medellin, Anna G. Sepulveda-Salinas, Gerardo Villarreal-Mendez, Jesus H. Gonzalez-Cortes, Rodrigo E. Elizondo-Omana, Santos Guzman-Lopez, Jesus Mohamed-Hamsho
Summary: The study found that patients with severe visual impairment after repaired open globe injuries have increased pre-operative NLR and PLR levels. In univariate analysis, high NLR and PLR were identified as risk factors for severe visual impairment. Low OTS was also confirmed as a risk factor for severe visual impairment.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Sho Yasui, Tomoaki Takata, Yu Kamitani, Yukari Mae, Hiroki Kurumi, Yuichiro Ikebuchi, Akira Yoshida, Koichiro Kawaguchi, Kazuo Yashima, Hajime Isomoto
Summary: The study demonstrates an association between NLR and PLR with the histological diagnosis of gastric cancer, suggesting that NLR could be a useful marker for assessing early gastric cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Lorena Elena Melit, Cristina Oana Marginean, Maria Oana Sasaran, Simona Mocanu, Dana Valentina Ghiga, Adriana Crisan, Claudia Banescu
Summary: The aim of this study was to investigate the relationship between environmental, laboratory, and genetic factors and Helicobacter pylori (H. pylori) infection in children. The study found that poor living conditions and rural areas are risk factors for H. pylori infection. The rapid urease test is a reliable diagnostic tool for this infection. Certain genetic polymorphisms are associated with a more severe degree of systemic inflammation.
Article
Biochemistry & Molecular Biology
Lorena Elena Melit, Cristina Oana Marginean, Maria Oana Sasaran
Summary: Pediatric obesity is a global issue and its relationship with gut microbiota is not fully understood. Multiple factors, such as maternal diet and health, delivery method, and feeding patterns, shape the infant gut microbiome. Firmicutes and Bacteroidetes have been identified as important players in obesity risk, but there are inconsistencies in studies, especially in pediatric populations.
Review
Pediatrics
Cristina Oana Marginean, Lorena Elena Melit, Maria Teodora Cucuiet, Monica Cucuiet, Mihaela Ratiu, Maria Oana Sasaran
Summary: This case report describes a pediatric patient with MOGAD-transverse myelitis who developed motor deficits and bladder/bowel dysfunction after receiving the COVID-19 vaccine. Early diagnosis and treatment played a crucial role in the patient's recovery.
Review
Pediatrics
Lorena Elena Melit, Cristina Oana Marginean, Maria Oana Sasaran
Summary: Helicobacter pylori (H. pylori) infection is a common childhood infection that can lead to life-threatening complications if left untreated. The dysbiosis caused by H. pylori affects not only the gastric microenvironment but also the entire gastrointestinal tract. The eradication of H. pylori has become challenging due to antibiotic resistance and the side effects associated with eradication regimens. Probiotics have been shown to improve the eradication rate of H. pylori infection by producing antimicrobial compounds, altering gastric pH, and reducing H. pylori colonization. However, probiotics alone do not significantly increase the eradication rate.
Article
Medicine, General & Internal
Sasaran Maria Oana, Banescu Claudia, Riza Anca Lelia, Mocan Simona, Carstea Claudia, Dobru Ecaterina Daniela
Summary: This study aimed to assess the differential expression of miR-155 in relation to pediatric gastritis. The results showed that miR-155 expression was increased in patients with gastritis but did not significantly differ from controls. The authors concluded that pediatric gastritis increases miR-155 expression, but this does not greatly impact its prognostic role.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Maria Oana Sasaran, Cristina Oana Marginean, Heidrun Adumitrachioaiei, Lorena Elena Melit
Summary: Probiotics have strain-specific benefits in managing gastrointestinal disorders, especially acute gastroenteritis, in children. The most researched strains, such as Lactobacillus rhamnosus, L. reuteri, and S. boulardii, have proven to decrease diarrhea and hospitalization duration, particularly in rotavirus infection. Research on bacterial diarrhea and clinical trials within ambulatory care units are lacking and further investigation, including larger cohort studies, is needed.
Article
Pediatrics
Lorena Elena Melit, Andreea Ligia Dinca, Reka Borka Balas, Simona Mocanu, Cristina Oana Marginean
Summary: This article reports a case study emphasizing the importance of esophageal inlet patches. The case involves a 16-year-old female who experienced dyspeptic symptoms for approximately 1 month despite treatment with proton pump inhibitors. Clinical and endoscopic examinations revealed the presence of an esophageal inlet patch along with Helicobacter pylori infection and biliary reflux. Histopathological examination confirmed the diagnosis and showed regenerative changes in the gastric mucosa. This case serves as a reminder for gastroenterologists to consider the presence of esophageal inlet patches in patients with dyspeptic symptoms.
Review
Biochemistry & Molecular Biology
Amalia Fagarasan, Maria Sasaran, Liliana Gozar, Andrei Crauciuc, Claudia Banescu
Summary: Galectin-3 is a novel biomarker that can predict cardiac dysfunction and adverse outcomes caused by cardiovascular conditions. It has shown potential as a therapeutic target in congenital heart disease and has been associated with mortality and complications in both children and adults. However, the current studies lack validation and further research is needed to establish its long-term relationship with outcomes in pediatric CHD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Andreea Ligia Dinca, Lorena Elena Melit, Simona Gurzu, Simona Mocan, Dana Valentina Ghiga, Cristina Oana Marginean
Summary: This study compared the inflammatory status in children with H. pylori gastritis and non-H. pylori gastritis, as well as a control group. It was found that children with H. pylori-induced gastritis had higher levels of neutrophils compared to those with non-H. pylori gastritis, while children with non-H. pylori gastritis had higher levels of eosinophils. The study also found that gastritis, regardless of etiology, was significantly associated with increased gastric expression of tumor necrosis factor alpha.
APPLIED SCIENCES-BASEL
(2023)
Review
Pediatrics
Reka Borka Balas, Lorena Elena Melit, Cristina Oana Marginean
Summary: The aim of this review was to analyze the differences in pediatric Helicobacter pylori (Hp) antimicrobial-resistance trends between continents and countries. Asian pediatric patients showed the highest resistance to metronidazole (>50%), possibly due to its wide use for parasitic infections. In addition to increased resistance to metronidazole, different Asian countries also had high rates of resistance to clarithromycin, indicating that ciprofloxacin-based eradication therapy and bismuth-based quadruple therapy might be optimal choices for Hp eradication in Asian pediatric population. The evidence for America was limited, but there was an increasing resistance to clarithromycin (up to 79.6%), although not all studies agreed on this. Pediatric patients from Africa presented the highest resistance rate to metronidazole (91%), with contradictory results for amoxicillin. However, quinolones showed the lowest resistance rates in most African studies. Among European children, metronidazole and clarithromycin exhibited the most frequent resistance (up to 59% and 45%), with a predominance for clarithromycin compared to other continents. The differences in antibiotic use among continents and countries worldwide contribute to the discrepancies in Hp antimicrobial-resistance patterns, emphasizing the importance of global judicious antibiotic use to control increasing resistance rates.
Review
Nutrition & Dietetics
Ancuta Lupu, Elena Jechel, Cristina Maria Mihai, Elena Cristina Mitrofan, Silvia Fotea, Iuliana Magdalena Starcea, Ileana Ioniuc, Adriana Mocanu, Dragos Catalin Ghica, Alina Popp, Dragos Munteanu, Maria Oana Sasaran, Delia Lidia Salaru, Vasile Valeriu Lupu
Summary: Considered more complex than the human genome, the body's microbiome plays a crucial role in various pathological processes. This review updates the correlation between microbiome and asthma by classifying asthmatic patterns, exploring the development of microbiome from the perinatal period, and investigating the impact of pulmonary dysbiosis on asthmatic symptoms in children. It also addresses the effects of intestinal dysbiosis on internal environment homeostasis and the methods used for diagnostic purposes and research.
Review
Medicine, General & Internal
Maria Oana Sasaran, Cristina Oana Marginean, Ana Maria Koller
Summary: This review aimed to determine the influence of H. pylori infection and its eradication on platelet count and recovery in pediatric ITP. Some studies found lower platelet values among children with ITP and documented H. pylori infection, but improvement in platelet numbers after H. pylori treatment. However, the results are controversial.
Review
Critical Care Medicine
Lorena Elena Melit, Oana Marginean, Tudor Fleseriu, Alina Negrea, Maria Oana Sasaran, Simina Ghiraghosian-Rusu, Andrei Calin Dragomir, Mirela Oiaga, Carmen Suteu
Summary: This case report highlights the importance of echocardiographic monitoring in the management of pediatric inflammatory multisystem syndrome temporally associated with COVID-19. The case describes the clinical presentation, laboratory tests, and treatment of a patient with PIMS-TS.
JOURNAL OF CRITICAL CARE MEDICINE
(2022)