Up-regulation of Siah1 by ethanol triggers apoptosis in neural crest cells through p38 MAPK-mediated activation of p53 signaling pathway

Activation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluorouracil

(2014) Jing Gao et al.   CANCER BIOLOGY & THERAPY

miR-135a leads to cervical cancer cell transformation through regulation of β-catenin via a SIAH1-dependent ubiquitin proteosomal pathway

(2014) Carmen O.N. Leung et al.   CARCINOGENESIS

Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1

(2014) Toshiaki Tanaka et al.   CELLULAR SIGNALLING

Long term intake of 0.1% ethanol decreases serum adiponectin by suppressing PPARγ expression via p38 MAPK pathway

(2014) Chong Tian et al.   FOOD AND CHEMICAL TOXICOLOGY

Downregulation of dopamine D1 receptors and increased neuronal apoptosis upon ethanol and PTZ exposure in prenatal rat cortical and hippocampal neurons

(2014) Muhammad Imran Naseer et al.   NEUROLOGICAL SCIENCES

Involvement of seven in absentia homolog-1 in ethanol-induced apoptosis in neural crest cells

(2014) Haijing Sun et al.   NEUROTOXICOLOGY AND TERATOLOGY

Sulforaphane protects against ethanol-induced oxidative stress and apoptosis in neural crest cells by the induction of Nrf2-mediated antioxidant response

(2013) X Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evaluation of the BH3-only Protein Puma as a Direct Bak Activator

(2013) Haiming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Over-expression of Nrf2 diminishes ethanol-induced oxidative stress and apoptosis in neural crest cells by inducing an antioxidant response

(2013) Xiaopan Chen et al.   REPRODUCTIVE TOXICOLOGY

Ethanol-induced apoptosis in human liver adenocarcinoma cells (SK-Hep1): Fas- and mitochondria-mediated pathways and interaction with MAPK signaling system

(2013) Yuri Morio et al.   TOXICOLOGY IN VITRO

miR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis

(2013) Y K Adlakha et al.   Cell Death & Disease

Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells

(2011) Francis Raul   ONCOLOGY REPORTS

Induction of the Nrf2-driven antioxidant response by tert-butylhydroquinone prevents ethanol-induced apoptosis in cranial neural crest cells

(2010) Dong Yan et al.   BIOCHEMICAL PHARMACOLOGY

Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease

(2010) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

The expression of SIAH1 is downregulated and associated with Bim and apoptosis in human breast cancer tissues and cells

(2010) Yuan-Yuan Wen et al.   MOLECULAR CARCINOGENESIS

Ethanol induces mouse spermatogenic cell apoptosis in vivo through over-expression of Fas/Fas-L, p53, and caspase-3 along with cytochrome c translocation and glutathione depletion

(2010) Kuladip Jana et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1

(2009) Se-Yong Kim et al.   CANCER LETTERS

SIAH1 induced apoptosis by activation of the JNK pathway and inhibited invasion by inactivation of the ERK pathway in breast cancer cells

(2009) Yuan-Yuan Wen et al.   CANCER SCIENCE

siah-1 Protein Is Necessary for High Glucose-induced Glyceraldehyde-3-phosphate Dehydrogenase Nuclear Accumulation and Cell Death in Müller Cells

(2009) E. Chepchumba K. Yego et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neural crest and neural crest cells: discovery and significance for theories of embryonic organization

(2009) Brian K. Hall   JOURNAL OF BIOSCIENCES

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

PUMA, a potent killer with or without p53

(2009) J Yu et al.   ONCOGENE

Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Mouse Embryos Exposed to Ethanol in vivo: Implications for the Prevention of Fetal Alcohol Spectrum Disorders

(2008) Jian Dong et al.   ANTIOXIDANTS & REDOX SIGNALING

E2F1 represses β-catenin/TCF activity by direct up-regulation of Siah1

(2008) Wei Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Selective Activation of p38 Mitogen-Activated Protein Kinase in Dopaminergic Neurons of Substantia Nigra Leads to Nuclear Translocation of p53 in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice

(2008) S. Karunakaran et al.   JOURNAL OF NEUROSCIENCE