Article
Endocrinology & Metabolism
Afnan Mansour, Mira Mousa, Dima Abdelmannan, Guan Tay, Ahmed Hassoun, Habiba Alsafar
Summary: This study conducted an Exome-Wide Association Study (EWAS) on Emirati individuals with type 2 diabetes mellitus (T2DM) to identify susceptibility loci associated with T2DM-related complications. The results showed associations between various genes and each complication category. The study also highlighted the limitations of the current genotyping arrays in representing diverse populations, emphasizing the need for better representation in future studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jens Christian Laursen, Hatice Isik Mizrak, Huda Kufaishi, Sofie Korsgaard Hecquet, Elisabeth Buur Stougaard, Ninna Hahn Tougaard, Marie Frimodt-Moller, Tine Willum Hansen, Christian Stevns Hansen, Peter Rossing
Summary: The study found that hypoxemia is associated with increased prevalence of albuminuria, retinopathy, and neuropathy in type 1 diabetes, but not with cardiovascular disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Nutrition & Dietetics
Rosario Suarez, Sebastian P. Chapela, Ludwig Alvarez-Cordova, Estefania Bautista-Valarezo, Yoredy Sarmiento-Andrade, Ludovica Verde, Evelyn Frias-Toral, Gerardo Sarno
Summary: A long-term complication of obesity is the development of type 2 diabetes (T2D), which involves epigenetic modifications. Epigenetics refers to post-transcriptional modifications of DNA or associated factors that influence gene expression. The epigenetic modifications involved in T2D include DNA methylation, acetylation, ubiquitylation, SUMOylation, and phosphorylation. These modifications have been observed in various tissues and are also found in chronic complications of T2D. A new drug, apabetalone, which targets epigenetic readers, is being studied as a potential treatment for T2D and its cardiovascular complications.
Article
Medicine, General & Internal
Mamunur Rashid, Mohanad Alkhodari, Abdul Mukit, Khawza Iftekhar Uddin Ahmed, Raqibul Mostafa, Sharmin Parveen, Ahsan H. Khandoker
Summary: This study used a machine learning approach to predict microvascular complications in type 2 diabetic patients, achieving high prediction accuracy. This has significant implications in preventing patients from developing further complications leading to premature death.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Xinyang Guo, Yiqiao Xing, Wei Jin
Summary: Diabetic microangiopathy is a common and severe problem in diabetics, and it includes diabetic retinopathy, nephropathy, neuropathy, and cardiomyopathy. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is significantly elevated in patients with type 2 diabetes and microvascular complications. ADMA promotes the occurrence and progression of microvascular complications in type 2 diabetes through influencing endothelial cell function, oxidative stress damage, inflammation, and fibrosis. This review paper explores the association between ADMA and microvascular complications of diabetes, and provides new insights and potential treatment options.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Khalid Siddiqui, Teena P. P. George, Muhammad Mujammami, Arthur Isnani, Assim A. A. Alfadda
Summary: Chronic hyperglycemia in patients with type 2 diabetes mellitus induces pathogenic changes in the vascular endothelium, leading to the development of microvascular complications. The levels of cell adhesion molecules and selectins are significantly different in diabetic patients with and without microvascular complications, and the baseline level of VCAM-1 is significantly associated with the development of microvascular complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Valeriya Lyssenko, Allan Vaag
Summary: Diabetes is associated with excess morbidity and mortality due to both micro- and macrovascular complications. Genetic factors play a role in the development of microvascular complications. More extensive phenotyping and adjustments for confounding factors are needed to understand the genetics of microvascular complications.
Article
Medicine, General & Internal
Mohammad Dweib, Nuha El Sharif
Summary: This study investigated the factors associated with diabetes-related microvascular complications among individuals with diabetes in the West Bank of Palestine. The results showed that age, education level, residency location, and adherence to diabetes management guidelines were all associated with the occurrence of microvascular complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Instruments & Instrumentation
Kopal Agarawal, Yogesh Anant Kulkarni, Sarika Wairkar
Summary: This review article focuses on the application of flavonoid nanoformulations in the treatment of diabetes, overcoming limitations by enhancing solubility, absorption, and therapeutic efficacy. These nanoformulations have the potential to be effective interventions for diabetes and its complications.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Environmental Sciences
Paul Minh Huy Tran, Eileen Kim, Lynn Kim Hoang Tran, Bin Satter Khaled, Diane Hopkins, Melissa Gardiner, Jennifer Bryant, Risa Bernard, John Morgan, Bruce Bode, John Chip Reed, Jin-Xiong She, Sharad Purohit
Summary: Modifying risk factors can reduce the development of complications in patients with type 1 diabetes. A clinical risk score was developed using a cross-sectional cohort to assess the risk of diabetic peripheral neuropathy, autonomic neuropathy, retinopathy, and nephropathy in these patients. The tool aims to inform patients of their current risk and motivate them to control their HbA1c and systolic blood pressure to reduce the risk of complications.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Cardiac & Cardiovascular Systems
Rianneke de Ritter, Simone J. S. Sep, Carla J. H. van der Kallen, Marleen M. J. van Greevenbroek, Marit de Jong, Rimke C. Vos, Michiel L. Bots, Jos P. H. Reulen, Alfons J. H. M. Houben, Carroll A. B. Webers, Tos T. J. M. Berendschot, Pieter C. Dagnelie, Simone J. P. M. Eussen, Miranda T. Schram, Annemarie Koster, Sanne A. E. Peters, Coen D. A. Stehouwer
Summary: The study investigated the associations between diabetes and microvascular complications in a population-based cohort, finding that men with type 2 diabetes had higher risks of certain microvascular complications compared to men with normal glucose metabolism, while women did not show significant sex differences.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Medicine, General & Internal
Naba Al-Sari, Svetlana Kutuzova, Tommi Suvitaival, Peter Henriksen, Flemming Pociot, Peter Rossing, Douglas McCloskey, Cristina Legido-Quigley
Summary: Using blood small molecule profiling and machine learning, the risk of developing complications, such as kidney disease and retinopathy, in diabetes patients can be predicted. This precision diagnostic approach has the potential to be implemented in clinical settings to screen patients early and prevent complications.
Article
Multidisciplinary Sciences
Kun Lin, Yixi Wu, Shuo Liu, Jiaqi Huang, Guishan Chen, Qiong Zeng
Summary: The study found that evaluating skin conductance can effectively screen for microvascular complications in diabetic patients. SUDOCAN can be used as a tool for early screening of microvascular complications.
Article
Endocrinology & Metabolism
Sung Keun Park, Min-Ho Kim, Ju Young Jung, Chang-Mo Oh, Eunhee Ha, Do Jin Nam, Eun Hye Yang, Woo Yeon Hwang, Sangho Lee, Jae-Hong Ryoo
Summary: Long-term and heavy smoking increases the risk of microvascular complications, including nephropathy and neuropathy, in patients with diabetes mellitus. Quitting smoking and reducing smoking amount are crucial in preventing microvascular complications in diabetic patients.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Cell Biology
Xiaoyu Deng, Shiqi Wang, Yan Yang, Aizhen Chen, Jinger Lu, Jinkui Hao, Yufei Wu, Qinkang Lu
Summary: This study used OCTA to assess macular microvascular alterations in type 2 diabetic patients with and without peripheral neuropathy (DPN and NDPN). The results showed significantly lower vascular length density (VLD) values in DPN patients compared to healthy controls and NDPN patients. DPN patients also exhibited lower VLD values in specific regions of the superficial vascular complex (SVC). Additionally, VLD values in the deep vascular complex (DVC) had a higher ability to discriminate microvascular damage in DPN patients compared to NDPN patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Yeelen Ballesteros Atala, Mozania Reis De Matos, Denise Engelbrecht Zantut-Wittmann, Alejandro Rosell Castillo, Daniele P. Santos-Bezerra, Maria Lucia Correa-Giannella, Maria Candida Ribeiro Parisi
Summary: This study compared the prevalence of early involvement (El) of cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes using two different methodologies. The results showed that the use of CARTs method diagnosed a higher proportion of individuals with early involvement of CAN.
CURRENT DIABETES REVIEWS
(2022)
Article
Nutrition & Dietetics
Priscila Sala, Natasha Mendonca Machado, Raquel Susana Matos de Miranda Torrinhas, Danielle C. Fonseca, Beatriz A. M. Ferreira, Robson Kiyoshi Ishida, Ismael Francisco Mota Siqueira Guarda, Eduardo Guimaraes Hourneaux de Moura, Paulo Sakai, Marco Aurelio Santo, Steven B. Heymsfield, Maria Lucia Correa-Giannella, Dan Linetzky Waitzberg
Summary: This study evaluated the intestinal transcriptome response to Roux-en-Y gastric bypass (RYGB) in obese women with type 2 diabetes (T2D) and found that changes in the intestinal transcriptome may be associated with T2D remission and glycemic control. The analysis of differentially expressed genes (DEGs) revealed significant correlations between specific genes and glycemic markers, particularly in the duodenum. These findings suggest a potential role of intracellular cholesterol and lipid homeostasis in glucose control after RYGB.
Article
Biochemistry & Molecular Biology
Mauy Frujuello Mana, Maria Candida R. Parisi, Maria Lucia Correa-Giannella, Arnaldo Moura Neto, Ademar Yamanaka, Marlone Cunha-Silva, Ana Mercedes Cavaleiro, Cristina Rodrigues dos Santos, Celia Regina Pavan, Tiago Seva-Pereira, Sergio S. J. Dertkigil, Daniel F. Mazo
Summary: The study evaluated the associations between PNPLA3 and FGF21 gene polymorphisms with NAFLD, liver fibrosis, and serum biomarkers in T2D patients from Brazil. The findings suggest an association between PNPLA3 polymorphisms and NAFLD, with a high proportion of liver fibrosis in NAFLD patients.
Article
Geriatrics & Gerontology
Felipe Seiti Sekiya, Clarisse Pereira Nunes da Silva, Sueli Mieko Oba-Shinjo, Daniele Pereira Santos-Bezerra, Felipe Gustavo Ravagnani, Carlos Augusto Pasqualucci, Saulo Gil, Bruno Gualano, Mauricio da Silva Baptista, Maria Lucia Correa-Giannella, Suely Kazue Nagahashi Marie
Summary: This study evaluated the relationship between mitochondrial DNA replication, oxidative stress, and gene expression related to diabetes. The results showed a positive correlation between mtDNA copy number and tissue autofluorescence, as well as a negative correlation between PINK and PRKN gene expressions with age. The expression of mitochondriogenesis genes and TXNIP was higher in individuals with type 2 diabetes mellitus.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Nutrition & Dietetics
Priscilla Sampaio, Dan Linetzky Waitzberg, Natasha Mendonca Machado, Raquel Susana Matos de Miranda Torrinhas, Danielle C. Fonseca, Beatriz A. M. Ferreira, Mariane Marques, Samira Barcelos, Robson Kiyoshi Ishida, Ismael Francisco Mota Siqueira Guarda, Eduardo Guimaraes Hourneaux de Moura, Paulo Sakai, Marco Aurelio Santo, Steven B. Heymsfield, Maria Lucia Correa-Giannella, Mariana Doce Passadore, Priscila Sala
Summary: This study aimed to examine changes in the expression of vitamin A pathway encoding genes in the gastrointestinal tract after RYGB surgery and evaluate the potential mechanisms associated with hypovitaminosis A. The results showed significant downregulation of several genes in the intestinal mucosa after RYGB, which may result in lower availability of vitamin A.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Carolina C. Betonico, Aline Vial Cobello, Daniele P. Santos-Bezerra, Andre Z. de A. Leite, Maria Lucia Correa-Giannella, Marcia Nery, Marcia S. Queiroz
Summary: This study demonstrates that modifying diet can improve postprandial glycemic excursion and the perception and severity of gastroparesis symptoms.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2022)
Article
Multidisciplinary Sciences
Omar Asdrubal Vilca Mejia, Renato Cesar de Souza, Aritania S. Santos, Bianca Meneghini, Ana Carolina Carvalho Silva, Guilherme Visconde Brasil, Vagner Oliveira Carvalho Rigaud, Luis Roberto Palma Dallan, Luiz Felipe Pinho Moreira, Luiz Augusto Ferreira Lisboa, Luis Alberto Oliveira Dallan, Jorge Kalil, Edecio Cunha-Neto, Ludmila Rodrigues Pinto Ferreira, Fabio Biscegli Jatene
Summary: This study performed miRNA profiling of patients before coronary artery bypass grafting (CABG) surgery to identify miRNAs that could predict Vasoplegic syndrome (VS). Six miRNAs were increased and two were decreased in patients who developed VS compared to those who did not. The combination of hsa-miR-30d-5p and hsa-miR-770-5p showed high accuracy in predicting VS.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Marcos Tadashi K. Toyoshima, Monique F. M. Santana, Amanda R. M. Silva, Gabriela B. B. Mello, Daniele P. P. Santos-Bezerra, Marisa F. S. Goes, Adriana A. A. Bosco, Bruno Caramelli, Graziella E. E. Ronsein, Maria Lucia Correa-Giannella, Marisa Passarelli
Summary: This study explores the proteomics of HDL subfractions in type 1 diabetes (T1D) and its association with clinical variables and subclinical atherosclerosis. Different protein expressions were observed in HDL2 and HDL3 of T1D patients compared to controls, and these proteins were related to lipid metabolism, inflammation, and antioxidant response. HDL proteomics was found to be predictive of subclinical atherosclerosis in T1D.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Multidisciplinary Sciences
Maria Isabela Bloise Alves Caldas Sawada, Monique de Fatima Mello Santana, Mozania Reis, Sayonara Ivana Santos de Assis, Lucas Alves Pereira, Danielle Ribeiro Santos, Valeria Sutti Nunes, Maria Lucia Cardillo Correa-Giannella, Luiz Henrique Gebrim, Marisa Passarelli
Summary: The association between plasma lipids and breast cancer, especially high-density lipoprotein cholesterol (HDLc) levels, is still conflicting. HDLc may not reflect the role of HDL in limiting tumor growth, inflammation, and metastasis.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Caio Yogi Yonamine, Marisa Passarelli, Claudia Kimie Suemoto, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Venancio Avancini Ferreira Alves, Suely Kazue Nagahashi Marie, Maria Lucia Correa-Giannella, Luiz Roberto Britto, Ubiratan Fabres Machado
Summary: Diabetes mellitus is a risk factor for dementia and can induce neuronal dysfunctions through inflammation and other processes. This study found that obese individuals with diabetes had reduced GLUT4 expression and neuronal soma area in the hippocampus. Inflammatory activation decreased GLUT4 expression and negatively affected genes related to neuronal function. Inhibiting HDAC3 could potentially improve GLUT4 expression and counteract the negative effects of inflammation.
Article
Endocrinology & Metabolism
Marluce da Cunha Mantovani, Ilana Gabanyi, Carlos Andres Pantanali, Vinicius Rocha Santos, Maria Lucia Cardillo Correa-Giannella, Mari Cleide Sogayar
Summary: Background: Type 1 diabetes mellitus (T1D) is a condition caused by autoimmune destruction of pancreatic beta cells. Transplantation of isolated pancreatic islets from donors is a potential treatment for T1D, but the limited availability of suitable pancreas donors is a major challenge. Methods: A retrospective study was conducted to analyze the profile of brain-dead human pancreas donors and the reasons for organ refusal. Results: The main reasons for refusal were hyperglycemia, technical issues, age, positive serology, and hyperamylasemia. Conclusions: This study provides insights to improve the availability of suitable pancreas donors and enhance the outcome of islet isolation and transplantation.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Biochemistry & Molecular Biology
Monique de Fatima Mello Santana, Maria Isabela Bloise Alves Caldas Sawada, Aritania Sousa Santos, Mozania Reis, Jacira Xavier, Maria Lucia Correa-Giannella, Andrea Harumy de Lima Hirata, Luiz Henrique Gebrim, Francisco Garcia Soriano, Cleber Pinto Camacho, Marisa Passarelli
Summary: The study examined the expression of inflammation-related miRs bound to HDLs in breast cancer patients and controls. It was found that HDL from breast cancer patients had higher anti-inflammatory activity compared to controls, especially in advanced stages of the disease. The miRs 223-3p and 375-3p in HDLs were significantly higher in breast cancer patients and showed high discriminatory power between breast cancer and controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Juliana Regina Chamlian Zucare Penno, Daniele Pereira Santos-Bezerra, Ana Mercedes Cavaleiro, Ana Maria da Silva Sousa, Tatiana Assuncao Zaccara, Rafaela Alkmin da Costa, Rossana Pulcineli Vieira Francisco, Maria Lucia Correa-Giannella
Summary: This study found that SNP rs17619600 in the HTR2B gene is associated with an increased risk of gestational diabetes mellitus (GDM). The minor allele C of this SNP is associated with a higher risk of GDM, possibly affecting glucose homeostasis through insulin release.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Letter
Gastroenterology & Hepatology
Renata D'Alpino Peixoto, Carlos Del Cistia Donnarumma, Luiz Henrique Gomes Matheus, Aritania Sousa Santos, Daniele Pereira Santos-Bezerra, Mozania Reis de Matos, Jose Antonio Januario Neves, Cleber Pinto Camacho, Maria Lucia Correa-Giannella
