Article
Medicine, General & Internal
Mingyang Shao, Qing Tao, Yahong Xu, Qing Xu, Yuke Shu, Yuwei Chen, Junyi Shen, Yongjie Zhou, Zhenru Wu, Menglin Chen, Jiayin Yang, Yujun Shi, Tianfu Wen, Hong Bu
Summary: The expression of glutamine synthetase (GS) and arginase 1 (Arg1) is closely related to the prognosis and treatment response in hepatocellular carcinoma (HCC). GS- HCC patients have better prognosis and are more likely to benefit from sorafenib treatment. Immunostaining of GS may serve as a simple and applicable method for HCC molecular stratification to predict prognosis and guide targeted therapy.
CHINESE MEDICAL JOURNAL
(2023)
Article
Chemistry, Physical
Kabelo B. Dilebo, Njabulo J. Gumede, Winston Nxumalo, Thabe M. Matsebatlela, Dikgale Mangokoana, Ngaoko R. Moraone, Bernard Omondi, Richard M. Mampa
Summary: A series of quinazolines were successfully synthesized via Sonogashira cross-coupling and dechloroamination reactions, showing potential anti-Mycobacterium tuberculosis properties with promising minimum inhibitory concentrations. The possible mode of interaction with Mtb was theoretically explained through molecular protein 3ZXR, revealing the compounds' SAR to MtGS.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Jaydeepsinh Chavda, Anjali Rajwar, Dhiraj Bhatia, Iti Gupta
Summary: Novel zinc porphyrins containing pharmacophoric groups derived from Sorafenib were found to have excellent PDT based autophagy inhibition of cancer cells. Molecular docking studies showed strong binding with mTOR protein kinase. These findings suggest that these zinc porphyrins have potential as theranostic agents for anti-cancer applications.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Oncology
Jonathan Blachier, Aurore Cleret, Nathalie Guerin, Clara Gil, Jean-Marc Fanjat, Florian Tavernier, Laura Vidault, Fanny Gallix, Nicolas Rama, Rodrigue Rossignol, Diana Piedrahita, Aurely Andrivon, Marie Chalons-Cottavoz, Karine Aguera, Fabien Gay, Francoise Horand, Bastien Laperrousaz
Summary: L-Asparaginase is critical in ALL therapy, but its efficacy in solid tumors is unclear due to ASNS expression. However, it has a glutaminase activity in pancreatic cancer. By studying L-Asparaginase-resistant pancreatic cancer cells, we identified GS as a marker of resistance and its correlation with L-Asparaginase efficacy in various cancer cell lines. Furthermore, GS inhibition prevents cancer cell adaptation to L-Asparaginase-induced glutamine starvation, suggesting potential drug combinations to overcome resistance.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Plant Sciences
Kim-Teng Lee, Hong-Sheng Liao, Ming-Hsiun Hsieh
Summary: Glutamine (Gln) is the first synthesized amino acid in plant nitrogen assimilation. Glutamine synthetase (GS), an ancient enzyme, converts glutamate (Glu) and NH4+ into Gln at the expense of ATP. Plants have multiple GS isoenzymes that ensure sufficient Gln supply for growth and development. Gln serves as a building block for protein synthesis and as a nitrogen donor for the biosynthesis of various molecules.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Oncology
Andreas Schmidt, Angela Armento, Ovidio Bussolati, Martina Chiu, Verena Ellerkamp, Marcus O. Scharpf, Philip Sander, Evi Schmid, Steven W. Warmann, Joerg Fuchs
Summary: Glutamine depletion inhibits proliferation and cell viability in embryonal hepatoblastoma cell lines. High GLUL expression is associated with longer survival time, while ASNS expression has no correlation with overall survival in hepatoblastoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Go Woon Kim, Dong Hoon Lee, Yu Hyun Jeon, Jung Yoo, So Yeon Kim, Sang Wu Lee, Ha Young Cho, So Hee Kwon
Summary: Glutamine plays a crucial role in cancer metabolism, with cancer cells consuming excessive amounts for rapid proliferation, especially in poorly vascularized cancers. Glutamine synthetase (GS) is essential in cancer metabolism as the sole enzyme responsible for synthesizing glutamine, which supports nucleotide synthesis. GS exhibits pro-tumoral features by providing glutamine to cancer cells in the tumor microenvironment, enabling cancer cells to maintain sufficient glutamine levels for catabolism, ultimately supporting cancer cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Robert Schoeppe, Nathalie Babl, Sonja-Maria Decking, Gabriele Schoenhammer, Andreas Siegmund, Christina Bruss, Katja Dettmer, Peter J. Oefner, Linus Frick, Anna Weigert, Jonathan Jantsch, Wolfgang Herr, Michael Rehli, Kathrin Renner, Marina Kreutz
Summary: Glutamine synthetase (GS) is important for the survival of tumor cells in a glutamine deficient environment, but its impact on survival and function of myeloid cells is minimal except for the monocytic leukemia cell line THP-1. Inhibition of GS also targets immune cells such as dendritic cells (DCs) and macrophages, reducing their survival and reversing the proliferation rescue of THP-1 cells caused by glutamate supplementation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Laxmi Deswal, Vikas Verma, Devinder Kumar, Ashwani Kumar, Meenakshi Bhatia, Yogesh Deswal, Anil Kumar
Summary: This study focuses on the synthesis of novel antimicrobials by preparing a series of azole hybrids and evaluating their antibacterial and antifungal activities, with the potential to discover molecules that are superior to established drugs.
FUTURE MEDICINAL CHEMISTRY
(2021)
Editorial Material
Microbiology
Mark R. Sullivan, Eric J. Rubin, Charles L. Dulberger
Summary: Mycobacterium abscessus (Mab) is highly tolerant to current antibiotic therapies, leading to a high failure rate of standard care. Phages may offer a promising alternative treatment with few side effects. Two studies shed light on the natural phage complement of Mab and the factors that may drive susceptibility to these phages, paving the way for more effective phage therapy development.
Article
Fisheries
Xue Li, Shidong Wang, Muzi Zhang, Yangping Yu, Ming Li
Summary: In this study, the role of GS in ammonia detoxification was investigated in yellow catfish. The results showed that GS plays a crucial role in regulating glutamine synthesis and ammonia detoxification in yellow catfish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Yan Xu, Zhixiu Xia, Xiaoyu Sun, Baojun Wei, Yang Fu, Du Shi, Yuyan Zhu
Summary: A novel Glutamine Metabolism Immunity Index (GMII) was established to predict the prognosis and therapeutic response of bladder cancer patients based on the analysis of glutamine metabolism-related genes. The GMII showed promising accuracy in predicting survival and immunotherapeutic efficacy in bladder cancer patients and identified potential small-molecule drugs targeting the GMII core target proteins.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Applied
Hind Ashraf Hassan, Omnia Hesham Abdelhafez, Nourhan Hisham Shady, Ramadan Yahia, Nada M. Mohamed, Mostafa E. Rateb, Lina Akil, Ibrahim Khadra, Stefanie P. Glaeser, Peter Kampfer, Usama Ramadan Abdelmohsen, Mo'men Hamed El-Katatny
Summary: Endophytic fungi in Allium cepa were investigated for their potential as a source of anti-infective drugs. One isolate, Penicillium sp. LCEF10, showed significant anti-infective activity against several tested microbes and was identified as Penicillium oxalicum NRRL 787. Metabolomic analysis revealed the presence of various bioactive compounds in the ethyl acetate extract of Penicillium sp. LCEF10, including polyketides, macrolides, phenolics, and terpenoids. Molecular docking study predicted the compounds most likely responsible for the anti-infective activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Francesco Pacifico, Stefano Mellone, Maurizio D'Incalci, Mariano Stornaiuolo, Antonio Leonardi, Elvira Crescenzi
Summary: This study reveals that the antineoplastic drug trabectedin can suppress the escape of cancer cells from therapy-induced senescence and reduce the population of cancer stem cells. Trabectedin exerts its effect by interfering with glutamine metabolism.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Tarek El-Sewedy, Afrah Fatthi Salama, Amro E. Mohamed, Nashwa M. Elbaioumy, Ali H. El-Far, Aisha Nawaf Albalawi, Alaa Elmetwalli
Summary: This study found a synergistic effect between amygdalin and sorafenib in targeting AMPK/mTOR and BCL-2, which may potentially inhibit angiogenesis and induce apoptosis in HepG2 cells. The findings suggest that amygdalin could be a potential alternative therapeutic option for HCC.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)