Review
Biochemistry & Molecular Biology
Margherita Correnti, Elena Gammella, Gaetano Cairo, Stefania Recalcati
Summary: Iron is essential for cellular processes, especially in erythropoiesis. The hormone hepcidin, produced by the liver, regulates iron homeostasis by interacting with ferroportin. During enhanced erythropoiesis, hepcidin expression is inhibited, allowing increased iron export and facilitating erythropoiesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anna Pato, Kata Bolcskei, Agnes Donko, Diana Kaszas, Melinda Boros, Lilla Bodrogi, Gyorgy Varady, Veronika F. S. Pape, Benoit T. Roux, Balaz Enyedi, Zsuzsanna Helyes, Fiona M. Watt, Gabor Sirokmany, Miklos Geszt
Summary: Keratinocytes of the mammalian skin produce hydrogen peroxide upon the activation of the NADPH oxidase dual oxidase 1 (DUOX1), which can be activated by increasing cytosolic calcium levels. DUOX1 knockout animals show increased sensitivity towards certain noxious stimuli, and this sensitivity is not due to structural changes in the skin. Hydrogen peroxide released by activated DUOX1 alters the activity of neuronal TRPA1 and redox-sensitive potassium channels in dorsal root ganglia primary sensory neurons, acting as a paracrine mediator of nociceptive signal transmission. These findings suggest a novel redox mechanism in modulating noxious sensory signals.
Article
Biochemistry & Molecular Biology
Gregory E. Conner
Summary: The redox status of cells is crucial for cellular activities; H2O2 metabolism regulates the redox status by modifying protein cysteine oxidation; Calcium-stimulated epithelial Duox H2O2 synthesis is transient and prevents harmful changes in redox tone following continuous stimulation.
Article
Biochemistry & Molecular Biology
Ramona Pap, Edina Pandur, Gergely Janosa, Katalin Sipos, Attila Agocs, Jozsef Deli
Summary: Lutein exerts protective effects by suppressing H2O2-induced ROS, influencing iron utilization, and altering the secretion of anti-inflammatory and pro-inflammatory cytokines in BV-2 cells.
Article
Biochemistry & Molecular Biology
Eloisa A. Vilas-Boas, Christopher Carlein, Lisa Nalbach, Davidson C. Almeida, Emmanuel Ampofo, Angelo R. Carpinelli, Leticia P. Roma, Fernanda Ortis
Summary: In the development of type 1 diabetes, proinflammatory cytokines released by immune cells lead to increased reactive oxygen species production in beta-cells. NOX2 may be a potential target for therapies against early beta-cell dysfunction.
Review
Biochemistry & Molecular Biology
Peter Benko, Katalin Gemes, Attila Feher
Summary: The metabolism and regulation of cellular polyamines play a crucial role in maintaining cell homeostasis and function. Polyamine oxidases (PAOs) generate hydrogen peroxide (H2O2) during catabolic and back-conversion processes, which has been found to be involved in various plant developmental processes and stress responses. The relationship between PAOs and NADPH oxidases (RBOHs) in controlling cellular reactive oxygen species is discussed, suggesting that these enzymes regulate each other's abundance/function indirectly through H2O2.
Article
Biochemistry & Molecular Biology
Matea Juric, Varun Rawat, Radhika Amaradhi, Jacek Zielonka, Thota Ganesh
Summary: In this study, a new Nox2 inhibitor, TG15-132, was discovered to prevent oxygen consumption and reactive oxygen species formation. It also showed inhibitory effects on the expression of inflammatory cytokines and iNOS. TG15-132 has a relatively long plasma half-life and excellent brain permeability, making it a potential neuroprotective agent. Furthermore, it does not exhibit toxicity on vital organs or blood biomarkers.
Article
Physiology
Daichi Sumi, Nanako Hayashi, Keiichi Yamaguchi, Claire E. Badenhorst, Kazushige Goto
Summary: The study found that 3 consecutive days of endurance training in hypoxia did not significantly affect hepcidin concentrations compared to training in normoxia. Serum iron, ferritin, and ketone body concentrations increased significantly during the training period in both hypoxia and normoxia trials, while haptoglobin concentrations remained stable.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Review
Ecology
Colleen M. Hansel, Julia M. Diaz
Summary: Reactive oxygen species (ROS) production plays essential roles in signaling, growth, biological interactions, and physiochemical defense systems in various organisms. Additionally, biological ROS production significantly influences natural fluxes of ROS in the ocean, affecting the fate of carbon, metals, oxygen, and climate-relevant gases.
ANNUAL REVIEW OF MARINE SCIENCE, VOL 13, 2021
(2021)
Article
Biology
Zhong-Da Li, Meng-Yu Geng, Song-Rui Dou, Xuan Wang, Zi-Han Zhang, Yan-Zhong Chang
Summary: Caffeine can decrease hepcidin expression by inhibiting inflammation and the activation of the IL-6/STAT3 pathway, suggesting it as a potential therapeutic for anemia of inflammation.
Article
Medicine, Research & Experimental
Amanda Spring de Almeida, Gabriele Cheiran Pereira, Evelyne da Silva Brum, Cassia Regina Silva, Caren Tatiane de David Antoniazzi, Daniel Ardisson-Araujo, Sara Marchesan Oliveira, Gabriela Trevisan
Summary: This study investigated the anti-nociceptive effect of a repeated-dose TRPA1 antagonist administration in a model of breast cancer pain, and found that it produced an antinociceptive effect without altering TRPA1 expression in bone tissue. Using SRA strategy, no residual transcription of TRPA1 was detected in bone cell lines and mouse tissues, suggesting the potential of TRPA1 as a target for new painkillers in bone cancer treatment.
Article
Biology
Edouard Charlebois, Carine Fillebeen, Angeliki Katsarou, Aleksandr Rabinovich, Kazimierz Wisniewski, Vivek Venkataramani, Bernhard Michalke, Anastasia Velentza, Kostas Pantopoulos
Summary: This study investigates how iron affects inflammatory hepcidin levels and the subsequent hypoferremic response, revealing the antagonistic effect of iron on hepcidin induction and the critical role of de novo ferroportin synthesis in serum iron levels.
Article
Biotechnology & Applied Microbiology
Fuju Tai, Shuai Wang, Benshuai Liang, Yue Li, Jiakai Wu, Chenjie Fan, Xiuli Hu, Hezhong Wang, Rui He, Wei Wang
Summary: This study discovered the positive effect of fullerene-based carbon nanomaterials on maize root-hair growth under induced oxidative stress. The application of IFQA can ameliorate oxidative stress by decreasing NADPH oxidase activity, improving ROS scavenging through the ASA-GSH cycle, and regulating the expressions of genes affecting maize-root-hair development. This research enriches the understanding of the mechanism by which fullerene-based nanoelicitors promote plant growth and protect against oxidative stress.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Plant Sciences
Yifei Zhang, Yishan Sun, Weiqing Li, Jiayu Li, Rongqiong Xu, Jiarui Du, Zesong Li, Guibin Li, Kejun Yang
Summary: The effects of iminodisuccinic acid on maize seed germination under lead stress were explored. It was found that iminodisuccinic acid delayed seed germination under normal conditions but alleviated the inhibitory effects of lead stress. The supplementation of iminodisuccinic acid improved the balance of reactive oxygen species and promoted seed germination and seedling growth.
Article
Cell Biology
Ruijie Zhang, Chunxiao Liu, Liu Yang, Tong Ji, Nana Zhang, Xiaoqing Dong, Xin Chen, Jing Ma, Wei Gao, Shile Huang, Long Chen
Summary: Research shows that PD toxins induce neuronal apoptosis by generating H2O2 through NOX2, hindering the AMPK/Akt-mTOR signaling pathway. Inhibiting NOX2 or using antioxidants may help alleviate neuronal loss caused by oxidative stress.
CELLULAR SIGNALLING
(2022)
Article
Substance Abuse
Bruno Christian Koehler, Tatjana Arslic-Schmitt, Theresa Peccerella, Anna-Lena Scherr, Henning Schulze-Bergkamen, Thomas Bruckner, Georg Gdynia, Dirk Jaeger, Sebastian Mueller, Helmut Bartsch, Helmut K. Seitz
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2016)
Article
Gastroenterology & Hepatology
Felix Piecha, Teresa Peccerella, Tom Bruckner, Helmut-Karl Seitz, Vanessa Rausch, Sebastian Mueller
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2016)
Article
Gastroenterology & Hepatology
Sebastian Mueller, Pierre Nahon, Vanessa Rausch, Tessa Peccerella, Ines Silva, Eray Yagmur, Beate K. Straub, Carolin Lackner, Helmut K. Seitz, Pierre Rufat, Angela Sutton, Heike Bantel, Thomas Longerich
Article
Gastroenterology & Hepatology
Johannes Mueller, Hanna Raisi, Vanessa Rausch, Teresa Peccerella, David Simons, Christian Herbert Ziener, Heinz-Peter Schlemmer, Helmut Karl Seitz, Nina Waldburger, Thomas Longerich, Beate Katharina Straub, Sebastian Mueller
JOURNAL OF HEPATOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Ines Silval, Vanessa Rausch, Teresa Peccerella, Gunda Millonig, Helmut-Karl Seitz, Sebastian Mueller
Article
Medical Laboratory Technology
Teresa Peccerella, Nadine Lukan, Ralf Hofheinz, Dirk Schadendorf, Markus Kostrezewa, Michael Neumaier, Peter Findeisen
CLINICAL CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Gunda Millonig, Ingo Ganzleben, Teresa Peccerella, Guillem Casanovas, Lidia Brodziak-Jarosz, Katja Breitkopf-Heinlein, Tobias P. Dick, Helmut-Karl Seitz, Martina U. Muckenthaler, Sebastian Mueller
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Microbiology
Alexander W. Beham, Kerstin Puellmann, Rebecca Laird, Tina Fuchs, Roswita Streich, Caroline Breysach, Dirk Raddatz, Septimia Oniga, Teresa Peccerella, Peter Findeisen, Julia Kzhyshkowska, Alexei Gratchev, Stefan Schweyer, Bernadette Saunders, Johannes T. Wessels, Wiebke Moebius, Joseph Keane, Heinz Becker, Arnold Ganser, Michael Neumaier, Wolfgang E. Kaminski
Article
Gastroenterology & Hepatology
Hamish Innes, Stephan Buch, Sharon Hutchinson, Indra Neil Guha, Joanne R. Morling, Eleanor Barnes, Will Irving, Ewan Forrest, Vincent Pedergnana, David Goldberg, Esther Aspinall, Stephan Barclay, Peter C. Hayes, John Dillon, Hans Dieter Nischalke, Philipp Lutz, Ulrich Spengler, Janett Fischer, Thomas Berg, Mario Brosch, Florian Eyer, Christian Datz, Sebastian Mueller, Teresa Peccerella, Pierre Deltenre, Astrid Marot, Michael Soyka, Andrew McQuillin, Marsha Y. Morgan, Jochen Hampe, Felix Stickel
Review
Cell Biology
Zhou Xu, Kai Hu, Peter Bailey, Christoph Springfeld, Susanne Roth, Roma Kurilov, Benedikt Brors, Thomas Gress, Malte Buchholz, Jingyu An, Kongyuan Wei, Teresa Peccerella, Markus W. Buechler, Thilo Hackert, John P. Neoptolemos
Summary: Pancreatic ductal adenocarcinoma is a highly lethal malignancy with a high mortality rate. Treatment of pancreatic cancer is challenging due to factors such as genetic mutations, activation of gene signaling pathways, and tumor microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Substance Abuse
Sebastian Mueller, Teresa Peccerella, Hua Qin, Katharina Glassen, Ruediger Waldherr, Christa Flechtenmacher, Beate K. Straub, Gunda Millonig, Felix Stickel, Thomas Bruckner, Helmut Bartsch, Helmut Karl Seitz
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Vanessa Rausch, Teresa Peccerella, Carolin Lackner, Eray Yagmur, Helmut-Karl Seitz, Thomas Longerich, Sebastian Mueller
WORLD JOURNAL OF HEPATOLOGY
(2016)
Article
Gastroenterology & Hepatology
Ulrike Teufel, Teresa Peccerella, Guido Engelmann, Thomas Bruckner, Christa Flechtenmacher, Gunda Millonig, Felix Stickel, Georg Hoffmann, Peter Schirmacher, Sebastian Mueller, Helmut Bartsch, Helmut Seitz
HEPATOBILIARY SURGERY AND NUTRITION
(2015)
Article
Gastroenterology & Hepatology
Kirsten-Berit Linhart, Katharina Glassen, Teresa Peccerella, Rudiger Waldherr, Heinz Linhart, Helmut Bartsch, Helmut Seitz
HEPATOBILIARY SURGERY AND NUTRITION
(2015)