Review
Biochemistry & Molecular Biology
Cheng Zhu, Qian Huai, Xu Zhang, Hanren Dai, Xiaolei Li, Hua Wang
Summary: This review summarizes the multiple roles of ceramides in the onset of fatty liver disease and the pathogenic mechanisms underlying their effects, and also discusses recent advances and challenges in pharmacological interventions targeting ceramide metabolism for the treatment of NAFLD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medical Laboratory Technology
Benjamin Lidgard, Andrew N. Hoofnagle, Leila R. Zelnick, Ian H. de Boer, Amanda M. Fretts, Bryan R. Kestenbaum, Rozenn N. Lemaitre, Cassianne Robinson-Cohen, Nisha Bansal
Summary: Patients with chronic kidney disease (CKD) have dysfunctional high-density lipoprotein (HDL) particles. This study investigated the association of estimated glomerular filtration rate (eGFR) and albuminuria with the lipid composition of HDL in CKD patients. The results showed that albuminuria was significantly associated with specific alterations in the lipid composition of HDL.
CLINICAL CHEMISTRY
(2023)
Article
Microbiology
Xiao-Lei Zhang, Lei Chen, Jiang Yang, Shan-Shan Zhao, Shi Jin, Na Ao, Jing Yang, Hui-Xin Liu, Jian Du
Summary: This study demonstrates that Vitamin D supplementation alleviates high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) by improving gut dysbiosis and enhancing specific metabolic pathways. The results suggest that Vitamin D could be a potential intervention for NAFLD treatment by targeting the specific microbiota.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Endocrinology & Metabolism
Meng Mei, Maochang Liu, Yan Mei, Jing Zhao, Yang Li
Summary: This article reviews the role and mechanism of sphingolipids in brain insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Sherif Mostafa, Nancy Nader, Khaled Machaca
Summary: Cell lipids play important roles in signaling, especially during the maturation of reproductive cells. This review summarizes the current understanding of lipid signaling and proposes future research directions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Melanie Le Barz, Cecile Vors, Emmanuel Combe, Laurie Joumard-Cubizolles, Manon Lecomte, Florent Joffre, Michele Trauchessec, Sandra Pesenti, Emmanuelle Loizon, Anne-Esther Breyton, Emmanuelle Meugnier, Karene Bertrand, Jocelyne Dral, Chloe Robert, Annie Durand, Charlotte Cuerq, Patrice Gaborit, Nadine Leconte, Annick Bernalier-Donadille, Eddy Cotte, Martine Laville, Stephanie Lambert-Porcheron, Lemlih Ouchchane, Hubert Vidal, Corinne Malpuech-Brugere, David Cheillan, Marie-Caroline Michalski
Summary: The study showed that milk polar lipid (PL) supplementation can reduce atherogenic sphingomyelins (SM) and ceramides (Cer) in the serum, associated with improvements in cardiovascular risk markers. Milk PL modulated specific SM and Cer species in the gut, suggesting their potential involvement in the beneficial effects of milk PL.
Article
Multidisciplinary Sciences
Dorin Sade Yazdi, Dana Laor Bar-Yosef, Hanaa Adsi, Topaz Kreiser, Shahaf Sigal, Santu Bera, Dor Zaguri, Shira Shaham-Niv, Damilola S. Oluwatoba, Davide Levy, Myra Gartner, Thanh D. Do, Dan Frenkel, Ehud Gazit
Summary: High levels of homocysteine have been linked to Alzheimer's disease. Metabolites may play a significant role in the pathogenesis of neurodegenerative diseases. Experimental evidence from yeast and mouse models suggests a molecular basis for the association between homocysteine and Alzheimer's disease pathology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Simone D'Angiolini, Luigi Chiricosta, Emanuela Mazzon
Summary: This study found that sphingolipid metabolism is related to both aging and Alzheimer's disease. The particular trend of genes suggests that sphingolipids could be early markers for the disease.
MEDICINA-LITHUANIA
(2022)
Article
Biochemistry & Molecular Biology
Bohdan Babiy, Bruno Ramos-Molina, Luis Ocana, Silvia Sacristan, Diego Burgos-Santamaria, Javier Martinez-Botas, Rebeca Busto, Cristian Perna, M. Dolores Frutos, Agustin Albillos, Oscar Pastor
Summary: A recent study found that dihydrosphingolipids are closely associated with the progression of non-alcoholic fatty liver disease (NAFLD). Through experiments with a high-fat diet-induced mouse model and analysis of human liver samples, it was discovered that the accumulation of dihydrosphingolipids is correlated with the histological severity of NAFLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Medicine, Research & Experimental
Yuqing Liu, Hongli Li, Xiaowei Wang, Jianhua Huang, Di Zhao, Yejun Tan, Zheyu Zhang, Zhen Zhang, Lemei Zhu, Beibei Wu, Zhibao Chen, Weijun Peng
Summary: In this study, the therapeutic effects and underlying mechanisms of icariin (ICA) on Alzheimer's disease (AD) were investigated using an integrated analysis of gut microbiota, metabolomics, and network pharmacology. The results showed that ICA significantly improved cognitive dysfunction and typical AD pathologies in mice, and reversed AD-induced gut microbiota dysbiosis and metabolic disorder. Network pharmacology analysis indicated that ICA might regulate the sphingolipid signaling pathway for AD treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Stephen A. Harrison, Guy Neff, Cynthia D. Guy, Mustafa R. Bashir, Angelo H. Paredes, Juan P. Frias, Ziad Younes, James F. Trotter, Nadege T. Gunn, Sam E. Moussa, Anita Kohli, Kristin Nelson, Mildred Gottwald, William C. G. Chang, Andrew Z. Yan, Alex M. DePaoli, Lei Ling, Hsiao D. Lieu
Summary: In a phase 2 trial of patients with NASH, aldafermin reduced liver fat content significantly and showed potential improvement in fibrosis.
Article
Chemistry, Medicinal
Yi-Yu Qi, Xia Heng, Zeng-Ying Yao, Shu-Yue Qu, Ping-Yuan Ge, Xin Zhao, Sai-Jia Ni, Rui Guo, Nian-Yun Yang, Qi-Chun Zhang, Hua-Xu Zhu
Summary: The study investigates the therapeutic effect of Huanglian Jiedu decoction (HLJDD) on Alzheimer's disease (AD) in relation to sphingolipid metabolism. The results show that HLJDD can potentially treat AD by correcting the abnormal sphingolipid metabolism in AD mice and BV2 cells.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Daphne E. Boer, Mina Mirzaian, Maria J. Ferraz, Kimberley C. Zwiers, Merel Baks, Marc D. Hazeu, Roelof Ottenhoff, Andre R. A. Marques, Rianne Meijer, Jonathan C. P. Roos, Timothy M. Cox, Rolf G. Boot, Navraj Pannu, Herman S. Overkleeft, Marta Artola, Johannes M. Aerts
Summary: Deficiency of glucocerebrosidase (GBA) causes Gaucher disease due to its complex catalytic functions, not only playing a key role in transglycosylation reactions, but also cleaving beta-xylosides. Patients with Gaucher disease have reduced GBA activity, leading to impaired related reactions.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Multidisciplinary Sciences
Loni Berkowitz, Marcela P. Henriquez, Cristian Salazar, Eric Rojas, Guadalupe Echeverria, Gayle D. Love, Attilio Rigotti, Christopher L. Coe, Carol D. Ryff
Summary: The study found a connection between psychological well-being and serum sphingolipids levels, with environmental mastery being inversely correlated with specific ceramides. Health behaviors were identified as potential mediators in these relationships. The findings suggest that sphingolipid metabolism may represent a novel pathway for health benefits associated with psychological well-being.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Amany Tawfik, Nehal M. Elsherbiny, Yusra Zaidi, Pragya Rajpurohit
Summary: Hyperhomocysteinemia (HHcy) is common among the aging population, and is linked to neurodegenerative diseases and eye diseases. The disruption of the blood barrier function in the brain and retina due to HHcy leads to inflammatory events that worsen disease pathology, particularly in Alzheimer's disease (AD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Cell Biology
Christophe Magnan, Philippe Valet
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Neurosciences
Benjamin Deckmyn, Dorothee Domenger, Chloe Blondel, Sarah Ducastel, Emilie Nicolas, Emilie Dorchies, Emilie Caron, Julie Charton, Emmanuelle Vallez, Benoit Deprez, Jean-Sebastien Annicotte, Sophie Lestavel, Anne Tailleux, Christophe Magnan, Bart Staels, Kadiombo Bantubungi
Summary: A study found that activation of the nuclear bile acid receptor in the brain can modify energy homeostasis by affecting the function of brown adipose tissue. Activation of brain FXR decreases the rate-limiting enzyme in catecholamine synthesis, which in turn reduces sympathetic tone. This research sheds new light on the complex control of energy homeostasis by bile acids through FXR.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Eleni Georgiadou, Charanya Muralidharan, Michelle Martinez, Pauline Chabosseau, Elina Akalestou, Alejandra Tomas, Fiona Yong Su Wern, Theodoros Stylianides, Asger Wretlind, Cristina Legido-Quigley, Ben Jones, Livia Lopez-Noriega, Yanwen Xu, Guoqiang Gu, Nour Alsabeeh, Celine Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Isabelle Leclerc, Yusuf Ali, Scott A. Soleimanpour, Amelia K. Linnemann, Tristan A. Rodriguez, Guy A. Rutter
Summary: Mitofusin gene expression is essential for maintaining normal glucose metabolism in pancreatic beta-cells, but does not affect incretin signaling. These findings are important for understanding the roles of mitofusins in beta-cells, the potential contributions of altered mitochondrial dynamics to diabetes development, and the impact of incretins on this process.
Article
Nutrition & Dietetics
Aurelie Joly-Amado, Maud Soty, Erwannha Philippe, Amelie Lacombe, Julien Castel, Bruno Pillot, Justine Vily-Petit, Carine Zitoun, Gilles Mithieux, Christophe Magnan
Summary: Stimulation of hepatoportal glucose sensors increases insulin tolerance in rat models of insulin resistance and requires the presence of capsaicin-sensitive nerves.
JOURNAL OF NUTRITION
(2022)
Article
Endocrinology & Metabolism
Ghislaine Garrel, Claude Rouch, David L'Hote, Salma Tazi, Nadim Kassis, Frank Giton, Julien Dairou, Pascal Dournaud, Pierre Gressens, Christophe Magnan, Celine Cruciani-Guglielmacci, Joelle Cohen-Tannoudji
Summary: Our study found that high-fat diet-induced defects in gonadotrope activity in male rats occurred despite a lack of pituitary inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Celine Cruciani-Guglielmacci, Kelly Meneyrol, Jessica Denom, Nadim Kassis, Latif Rachdi, Fatna Makaci, Stephanie Migrenne-Li, Fabrice Daubigney, Eleni Georgiadou, Raphael G. Denis, Ana Rodriguez Sanchez-Archidona, Jean-Louis Paul, Bernard Thorens, Guy A. Rutter, Christophe Magnan, Herve Le Stunff, Nathalie Janel
Summary: This study investigated the effects of an inborn defect in CBS on glucose homeostasis and found that CBS+/- mice exhibited impaired insulin secretion under HHcy, while mice with intermediate HHcy showed improved insulin sensitivity to maintain glucose tolerance. Islet isolation experiments suggested that lower parasympathetic tone might be partially responsible for the insulin secretion defect.
Article
Multidisciplinary Sciences
Aurelie Le Lay, Erwann Philippe, Fanny Roth, Ana Rodriguez Sanchez-Archidona, Florence Mehl, Jessica Denom, Rashmi Prasad, Olof Asplund, Ola Hansson, Mark Ibberson, Fabrizio Andreelli, Lyse Santoro, Paul Amouyal, Gilles Amouyal, Christian Brechot, Laure Jamot, Celine Cruciani-Guglielmacci, Christophe Magnan
Summary: The aim of this study was to investigate the role of Regenerating islet-derived protein 3 alpha (Reg3 alpha) in the control of glucose homeostasis and its potential as a target for treating type 2 diabetes. In an insulin-resistant mouse model fed a high fat diet, recombinant human Reg3 alpha protein was administered for one month. The results showed increased insulin sensitivity, decreased levels of a pro-inflammatory cytokine, and increased glucose uptake in skeletal muscle. Correlation studies using human and mouse muscle biopsies also revealed a negative correlation between intramuscular Reg3 alpha mRNA expression (or its murine isoform, Reg3 gamma) and insulin resistance. This study provides a proof of concept that Reg3 alpha could be a novel molecule of interest in the treatment of type 2 diabetes by improving insulin sensitivity through its effect on skeletal muscle.
Article
Multidisciplinary Sciences
Sophia Ladraa, Lola Zerbib, Charles Bayard, Antoine Fraissenon, Quitterie Venot, Gabriel Morin, Alexandre P. Garneau, Pierre Isnard, Celia Chapelle, Clement Hoguin, Sylvie Fraitag, Jean-Paul Duong, Laurent Guibaud, Alix Besancon, Sophie Kaltenbach, Patrick Villarese, Vahid Asnafi, Christine Broissand, Nicolas Goudin, Michael Dussiot, Ivan Nemazanyy, Thomas Viel, Gwennhael Autret, Celine Cruciani-Guglielmacci, Jessica Denom, Julie Bruneau, Bertrand Tavitian, Christophe Legendre, Julien Dairou, Jean-Marc Lacorte, Pacifique Levy, Mario Pende, Michel Polak, Guillaume Canaud
Summary: This study establishes a mouse model that mimics PIK3CA-related adipose tissue overgrowth and demonstrates the metabolic anomalies and endocrine disruption caused by PIK3CA mutations. The results also suggest the potential efficacy of alpelisib in preventing and improving PIK3CA-related adipose tissue overgrowth.
Article
Biology
Patrick Gonzalez, Alexandre Dos Santos, Marion Darnaud, Nicolas Moniaux, Delphine Rapoud, Claire Lacoste, Tung-Son Nguyen, Valentine S. Moulle, Alice Deshayes, Gilles Amouyal, Paul Amouyal, Christian Brechot, Celine Cruciani-Guglielmacci, Fabrizio Andreelli, Christophe Magnan, Jamila Faivre
Summary: Antimicrobial protein REG3A improves glucose and lipid homeostasis in mouse models of obesity and type 2 diabetes by combating oxidative stress, increasing AMPK phosphorylation, and enhancing insulin-stimulated glucose uptake in skeletal muscle tissue. This study sheds light on the dual function of REG3A in host-immune defense and metabolic regulation and highlights its importance in controlling oxidative protein damage during obesity and diabetes.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Justine Lallement, Ilyes Raho, Gregory Merlen, Dominique Rainteau, Mikael Croyal, Melody Schiffano, Nadim Kassis, Isabelle Doignon, Maud Soty, Floriane Lachkar, Michel Krempf, Matthias Van Hul, Patrice D. Cani, Fabienne Foufelle, Chloe Amouyal, Herve Le Stunff, Christophe Magnan, Thierry Tordjmann, Celine Cruciani-Guglielmacci
Summary: This study aimed to determine the role of de novo hepatic ceramide synthesis in energy and liver homeostasis. The results showed that mice lacking the Sptlc2 gene were protected against obesity induced by high fat diet and displayed a defect in lipid absorption. In addition, the deficiency enhanced glucose tolerance and attenuated hepatic glucose production, while the latter effect was dampened in presence of nSMase2 inhibitor. Furthermore, Sptlc2 disruption promoted apoptosis, inflammation, and progressive development of hepatic fibrosis. These findings highlight the importance of ceramides in liver homeostasis and metabolic functions.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Nutrition & Dietetics
Charlotte Corporeau, Christelle Le Foll, Celine Cruciani-Guglielmacci, Herve Le Stunff, Gilles Mithieux, Christophe Magnan, Jacques Delarue
Summary: LC n-3 PUFA can reduce weight gain and improve liver insulin resistance in obese rats, possibly by alleviating hypothalamic lipotoxicity.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Hugo Martin, Adeline Coursan, Justine Lallement, Mathieu Di Miceli, Janany Kandiah, Ilyes Raho, Jasmine Buttler, Jean-Philippe Guilloux, Philippe De Deurwaerdere, Sophie Laye, Vanessa H. Routh, Bruno P. Guiard, Christophe Magnan, Celine Cruciani-Guglielmacci, Xavier Fioramonti
Summary: This study aimed to determine the contribution of serotonin (5-HT) neurons in the regulation of the counter-regulatory response (CRR). The results showed that 5-HT neurons can detect iatrogenic hypoglycemia in response to increased insulin levels and may play an important role in the regulation of CRR.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Mireia Montaner, Jessica Denom, Wanqing Jiang, Christophe Magnan, Stefan Trapp, Hirac Gurden
Summary: The study investigates the role of the GLP-1/glucagon-like peptide-1 receptor (GLP-1R) system in the olfactory bulb (OB) in foraging behavior and odor-evoked Cephalic Phase Insulin Release (CPIR). The results demonstrate that GLP-1OB controls olfactory foraging and is required for odor-evoked CPIR.
MOLECULAR METABOLISM
(2023)