Article
Obstetrics & Gynecology
Caterina Tiozzo, Mark Bustoros, Xinhua Lin, Claudia Manzano De Mejia, Ellen Gurzenda, Martin Chavez, Iman Hanna, Paola Aguiari, Laura Perin, Nazeeh Hanna
Summary: This study investigated the role of endotoxin tolerance failure in inflammation-mediated preterm birth, focusing on the placenta-specific microRNA-519c as a key regulator at the maternal-fetal interface. The findings demonstrated that repeated exposure of the human placenta to endotoxin challenges induced a tolerant phenotype mediated by microRNA-519c within placental extracellular vesicles. This suggests that microRNA-519c may serve as a potential biomarker for infection-induced preterm birth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Immunology
Yuanyao Chen, Lin Xiao, Jia Xu, Jingming Wang, Zhiquan Yu, Kai Zhao, Huiping Zhang, Shibin Cheng, Surendra Sharma, Aihua Liao, Chunyan Liu
Summary: Autophagy is a crucial pathway for cellular homeostasis and development, and recent studies have revealed its impact on immune responses. In turn, immune cells strongly influence autophagy. In this review, we focus on the induction of autophagy at the maternal-fetal interface and its role in decidu- alization and placental development, as well as its involvement in the immune micro-environment, including innate immunity, adaptive immunity, and immune tolerance molecules. This review highlights new research directions and prospects.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Fisheries
Lihan Wang, Dianli Zhao, Renmin Han, Yan Wang, Jingjie Hu, Zhenmin Bao, Mengqiang Wang
Summary: This study investigates the potential function of exosomes in scallop innate immunity and identifies numerous innate immune-related proteins in the exosomal shuttle protein of Chlamys farreri. The research provides insights into the role of exosomes in intercellular communication and immune responses and expands the understanding of immune defense systems in marine invertebrates.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Immunology
Hiroyuki Oshiumi
Summary: Vaccination is the best way to prevent infectious diseases, but vaccine efficacy and adverse reactions vary among individuals. miRNAs in serum EVs can regulate immune responses and vaccine efficacy, such as miR-192 and miR-21. EV miRNAs can be used as tools to improve vaccine efficacy and predict immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Francisco Leiva, Scarlet Bravo, Killen Ko Garcia, Javier Moya, Osiel Guzman, Rodrigo Vidal
Summary: Piscirickettsiosis, the most important bacterial disease in the Chilean salmon industry, may potentially benefit from unbalanced modulation of Coho salmon EV-miRNAs to promote hyper-inflammatory response during infection.
MARINE BIOTECHNOLOGY
(2021)
Review
Immunology
Yin-Fu Sun, Jiang Pi, Jun-Fa Xu
Summary: Exosomes are important signal transport vectors for cell-cell communication and immune modulation, playing a critical role in anti-MTB immune response. Infected-cell-derived exosomes trigger different immune responses during tuberculosis infection, highlighting their potential in developing new vaccination and treatment strategies for TB. Exosomes, as a novel kind of delivery system, show promise in the field of novel anti-MTB vaccines and therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Reproductive Biology
Kelly J. Baines, Rachel C. West
Summary: Fetal sex influences the immune response of the fetal, placental, and maternal during pregnancy. Male and female have different immune responses, with males prioritizing growth and being more susceptible to adverse outcomes. Male placentas and fetuses also respond to infection and inflammation differently than females. These gender-specific differences in the immune response contribute to increased male perinatal morbidity and mortality. This review explores the genetic and hormonal contributions to the sexual dimorphism of fetal and placental immunity, as well as the impact on fetal and maternal health.
BIOLOGY OF REPRODUCTION
(2023)
Review
Developmental Biology
Avery C. Kramer, Thomas Jansson, Tracy L. Bale, Theresa L. Powell
Summary: Altered placental function may mediate the link between the maternal environment and fetal growth and development, through nutrient sensing, modulation of transporters, and changes in extracellular vesicles. Maternal diet and stress can also influence fetal development and metabolism, and fetal growth restriction may increase the risk of chronic disease later in life.
Review
Cell Biology
Mohammad Hossein Razizadeh, Alireza Zafarani, Mahsa Taghavi-Farahabadi, Hossein Khorramdelazad, Sara Minaeian, Mohammad Mahmoudi
Summary: This article initially examines the role of natural killer cells in various viral infections and the mechanisms used by viruses to evade these important immune system cells. Subsequently, it discusses the role of NK cell-derived exosomes in controlling various viral infections. Finally, it reviews the current position of these cells in the treatment of viral infections and the therapeutic potential of their exosomes.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Reproductive Biology
Yanshe Xie, Changhua Wu, Weidong Chen, Zhenfang Wu, Gengyuan Cai, Linjun Hong
Summary: Extracellular vesicles (EVs) are nanoscale lipid vesicles derived from cells that participate in cell-cell communication by delivering cargo such as mRNAs, proteins, and non-coding RNAs to recipient cells. MicroRNAs (miRNAs), typically 22 nucleotides long, play a crucial role in developmental and pathophysiological processes by regulating gene expression in recipient cells. Infertility is a global health issue, and the use of EVs-encapsulated miRNAs in assisted reproductive technology (ART) could potentially optimize ART, improve reproductive rate, and treat infertility. This review discusses the current understanding of EVs-encapsulated miRNAs in reproductive regulation.
Review
Immunology
Jinli Ding, Yan Zhang, Xiaopeng Cai, Lianghui Diao, Chaogang Yang, Jing Yang
Summary: The immune tolerance microenvironment at the maternal-fetal interface is crucial for pregnancy establishment and maintenance. Macrophages and trophoblasts play essential roles in this process and their interaction influences trophoblast behaviors and the state of the maternal-fetal immune microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Maria M. Guzewska, Kamil Myszczynski, Yael Heifetz, Monika M. Kaczmarek
Summary: In this study, EVs were observed at the embryo-maternal interface through transmission electron microscopy, and different secretion pathways were identified. It was found that embryonic signals can regulate the biogenesis and secretion of EVs, as well as the gene expression in endometrial cells. These findings highlight the important role of embryonic signals in modulating endometrial secretory activity during early pregnancy.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Francesca Pontis, Luca Roz, Mavis Mensah, Miriam Segale, Massimo Moro, Giulia Bertolini, Ilaria Petraroia, Giovanni Centonze, Anna Maria Ferretti, Paola Suatoni, Ugo Pastorino, Orazio Fortunato, Gabriella Sozzi
Summary: This study investigated the role of extracellular vesicles (EVs) in lung cancer, finding that high-risk MSCpos-EVs had different membrane composition, biological cargo, and pro-tumorigenic activity compared to low-risk MSCneg-EVs. The study also showed that specific miRNAs inside EVs, such as miR-126 and miR-320, could promote angiogenesis and M2 polarization in endothelial cells and macrophages, respectively. Additionally, EVs containing miR-320 were identified as a new prognostic biomarker in lung cancer patients, with higher levels correlating with shorter overall survival.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Sutonuka Bhar, Guanqi Zhao, Julia D. Bartel, Heather Sterchele, Alexa Del Mazo, Lisa E. Emerson, Mariola J. Edelmann, Melissa K. Jones
Summary: Human norovirus is a major cause of non-bacterial gastroenteritis worldwide and is the second leading cause of diarrheal deaths in children in developing countries. This study shows that bacterial extracellular vesicles may play a role in controlling murine norovirus infection through modulation of the antiviral immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Phileno Pinge-Filho
Summary: Blood pathogenic trypanosomatids like Trypanosoma cruzi have specialized systems to export virulence factors into host cells. Extracellular vesicles shed by T. cruzi can enhance infection susceptibility of host cells. The relationship between damage-associated molecular patterns and extracellular vesicles sheds by T. cruzi in the context of Chagas Disease is still unclear.
MEDICAL HYPOTHESES
(2021)
Article
Health Care Sciences & Services
Ranjith Kamity, Melissa Grella, Maureen L. Kim, Meredith Akerman, Maria Lyn Quintos-Alagheband
Summary: By implementing K-card audits and family key card education, the compliance of central line maintenance bundles was increased leading to a significant reduction in CLABSI rates. This approach shows potential in improving healthcare initiatives.
BMJ QUALITY & SAFETY
(2021)
Article
Pediatrics
Ranjith Kamity, Louisa Ferrara, Vikramaditya Dumpa, Jenny Reynolds, Shahidul Islam, Nazeeh Hanna
FRONTIERS IN PEDIATRICS
(2020)
Article
Pharmacology & Pharmacy
Harshith Neeli, Nazeeh Hanna, Khaled Abduljalil, Jaclyn Cusumano, David R. Taft
Summary: Clinical studies in preterm neonates are rare due to ethical concerns and recruitment difficulties. Empirical dose selection for this population may not accurately predict drug kinetics, especially for gentamicin. Physiologically based pharmacokinetic-pharmacodynamic (PBPK-PD) modeling can support dosing decisions and predict antibacterial effects in preterm neonates. Results suggest that a higher dose administered every 36 hours may provide effective antibacterial therapy.
JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Noel Joseph, Tal Dror, Eva Takhalova, Ranjith Kamity, Ulka Kothari, Alena Connelly, Nazeeh Hanna, Amrita Nayak
Summary: Implementing a hypothermia algorithm and using K-cards and Key cards effectively reduced the incidence of hypothermia in the mother-baby-unit and decreased NICU admissions for isolated hypothermia.
JOURNAL OF PERINATOLOGY
(2021)
Article
Obstetrics & Gynecology
Caterina Tiozzo, Mark Bustoros, Xinhua Lin, Claudia Manzano De Mejia, Ellen Gurzenda, Martin Chavez, Iman Hanna, Paola Aguiari, Laura Perin, Nazeeh Hanna
Summary: This study investigated the role of endotoxin tolerance failure in inflammation-mediated preterm birth, focusing on the placenta-specific microRNA-519c as a key regulator at the maternal-fetal interface. The findings demonstrated that repeated exposure of the human placenta to endotoxin challenges induced a tolerant phenotype mediated by microRNA-519c within placental extracellular vesicles. This suggests that microRNA-519c may serve as a potential biomarker for infection-induced preterm birth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
Nazeeh Hanna, Xinhua Lin, Kristen Thomas, Anthony Vintzileos, Martin Chavez, Thomas Palaia, Louis Ragolia, Sourabh Verma, Poonam Khullar, Iman Hanna
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Amrita Nayak, Caterina Tiozzo, Xinhua Lin, Claudia Mejia, Ellen Gurzenda, Maureen Kim, Nazeeh Hanna
Summary: This study investigates the effects of HM maturation, fortification, and storage conditions on the levels of lactoferrin (LF) and its antibacterial properties. The results show that the highest LF levels are observed in preterm HM during the first week of lactation, but storage at 4 degrees C significantly decreases LF levels. LF levels and antibacterial activity in preterm HM are lower compared to term HM but higher than donor HM even after HM-based fortification.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Ranjith Kamity, Prasanna K. Kapavarapu, Amit Chandel
Summary: Preterm infants often require long-term healthcare due to potential oral feeding issues. Achieving oral feeding competency is essential for hospital discharge, but feeding problems may persist into adulthood. Early diagnosis and management are crucial for mitigating long-term challenges in preterm-born adults.
Review
Obstetrics & Gynecology
Arpit Gupta, Ranjith Kamity, Rishika Sharma, Martha Caprio, Pradeep Mally, Sourabh Verma
Summary: The COVID-19 pandemic has had a significant impact on mortality and morbidity globally. Guidelines for caring for pregnant women and newborns have evolved rapidly due to uncertainties surrounding transmission and the effects of COVID-19. Evidence suggests that pregnant women with symptomatic COVID-19 are at increased risk of severe illness and premature deliveries, while babies born to infected mothers may require intensive care. Vaccination during pregnancy is strongly recommended to reduce maternal morbidities and provide antibodies to newborns. Racial, ethnic, and socioeconomic disparities in outcomes and vaccination coverage exist for pregnant women.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Letter
Pediatrics
Nazeeh Hanna, Ari Heffes-Doon, Xinhua Lin, Claudia Manzano De Mejia, Bishoy Botros, Ellen Gurzenda, Amrita Nayak
Review
Biochemistry & Molecular Biology
Emily A. Schiller, Koral Cohen, Xinhua Lin, Rania El-Khawam, Nazeeh Hanna
Summary: Premature neonates are at an increased risk of developing inflammatory conditions with high mortality rates. Research has focused on identifying diagnostic biomarkers, such as microRNAs, in extracellular vesicles. This article discusses the latest findings in biomarker discovery for common conditions affecting premature neonates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Alexander Maad El-Ali, Selin Ocal, C. Austen Hartwell, Judith D. D. Goldberg, Xiaochun Li, Jaimelee Prestano, Ranjith Kamity, Laura Martin, Naomi Strubel, Shailee Lala
Summary: This retrospective study evaluated predictive factors for diagnostic ultrasound (US) for midgut volvulus and found that US was most frequently diagnostic in patients with bilious emesis or age less than 28 days. A non-diagnostic US for midgut volvulus requires a predetermined follow-up strategy to investigate potential midgut volvulus.
PEDIATRIC RADIOLOGY
(2023)
Meeting Abstract
Medicine, General & Internal
S. Abuso, J. J. Choi, M. Akerman, R. El-Khawam, R. Kamity, C. Clauss, N. Hanna, V. Dumpa
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Article
Pediatrics
Ranjith Kamity, Amrita Nayak, Vikramaditya Dumpa
Summary: Neonates born to mothers with COVID-19 have mostly been asymptomatic based on initial reports, but recent cases suggest an increase in complications such as pneumothorax.