Review
Genetics & Heredity
A. Losada-Garcia, S. A. Cortes-Ramirez, M. Cruz-Burgos, M. Morales-Pacheco, Carlos D. Cruz-Hernandez, Vanessa Gonzalez-Covarrubias, Carlos Perez-Plascencia, M. A. Cerbon, M. Rodriguez-Dorantes
Summary: Neoplasic transformation is a continuous process that the immune system can recognize and suppress, but transformed cells can evade immune defenses and progress into tumors. Hormones can modulate the immune system and are involved in the pathogenesis of autoimmune diseases and cancer.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Federica Murgia, Florianna Giagnoni, Lorena Lorefice, Paola Caria, Tinuccia Dettori, Maurizio N. N. D'Alterio, Stefano Angioni, Aran J. J. Hendren, Pierluigi Caboni, Monica Pibiri, Giovanni Monni, Eleonora Cocco, Luigi Atzori
Summary: Sex hormones are correlated with the clinical activity of multiple sclerosis. Estrogens and progesterone may have a neuroprotective effect in MS, supporting further research on their therapeutic uses.
Review
Immunology
Jim Q. Ho, Mohammad Reza Sepand, Banafsheh Bigdelou, Tala Shekarian, Rahim Esfandyarpour, Prashant Chauhan, Vahid Serpooshan, Lalit K. Beura, Gregor Hutter, Steven Zanganeh
Summary: This review examines the immune response to SARS-CoV-2 infection in the context of sex, with emphasis on potential biological mechanisms explaining differences in clinical outcomes. Understanding sex differences in the pathophysiology of SARS-CoV-2 infection will help promote the development of specific strategies to manage the disease.
Article
Multidisciplinary Sciences
Lucie Pepino, Pascale Malapert, Andrew J. Saurin, Aziz Moqrich, Ana Reynders
Summary: Mounting evidence suggests that women experience more chronic pain than men, but the biological basis for these differences is still not fully understood. In this study, researchers used a mouse model to show that female mice exhibit two distinct types of pain responses to formalin, depending on their estrus cycle phase. They also found that formalin-induced pain is associated with immune modulation, particularly involving neutrophils, and this immune response is more pronounced in males than females. These findings contribute to our understanding of pain perception and immune regulation in a sex-specific manner.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Maria Popescu, Talia B. Feldman, Tanuja Chitnis
Summary: This study examines the impact of endocrine disruptors on gender bias in autoimmune diseases, highlighting how environmental factors may interfere with immune-related endocrine signaling and potentially lead to autoimmunity. It also emphasizes that the heterogeneity in research on endocrine disruptors may pose challenges in interpreting and translating results.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Michelle F. Huffaker, Srinath Sanda, Sindhu Chandran, Sharon A. Chung, E. William St Clair, Gerald T. Nepom, Dawn E. Smilek
Summary: The article reviews concepts evolved from the clinical trial experience of the Immune Tolerance Network, focusing on lessons learned from innovative mechanistic studies and new strategies for tolerance induction.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Virology
Sabitha Vadakedath, Venkataramana Kandi, Ranjan K. Mohapatra, Venkata B. K. Pinnelli, Richa R. Yegurla, Praveen R. Shahapur, Vikram Godishala, Senthilkumar Natesan, Kranti S. Vora, Khan Sharun, Ruchi Tiwari, Muhammad Bilal, Kuldeep Dhama
Summary: The human immune system is not well-equipped to eliminate new microbes, leading to serious damage upon first exposure. Male patients are more likely to experience high-intensity inflammation and disease severity compared to females, potentially due to hormonal differences.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Immunology
Nicole M. Wilkinson, Ho-Chung Chen, Melissa G. Lechner, Maureen A. Su
Summary: Strong epidemiological evidence supports the important role of sex as a biologic variable in immunity, particularly in relation to COVID-19. However, the underlying mechanisms of sex differences in immune-mediated conditions still require further investigation. Recent experimental data have provided insights into how sex-defining factors impact immune responses and have potential implications for personalized patient care. This review focuses on recent findings regarding sex differences in autoimmunity, SARS-CoV-2 infection, and cancer immunotherapy, and emphasizes the importance of understanding these mechanisms for the development of sex-based approaches to disease screening and treatment.
ANNUAL REVIEW OF IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesca Sciarra, Federica Campolo, Edoardo Franceschini, Francesco Carlomagno, Mary Anna Venneri
Summary: Sex hormones play a crucial role in gender-related differences and influence growth and development during puberty. They also have a significant impact on immune cell functions, with a distinct immune response between males and females. Clinical and animal studies have shown that androgens, estrogens, and progestogens are involved in gender-specific immune responses, affecting susceptibility to infectious diseases and autoimmune disorders. Androgens and progestogens mainly promote immunosuppressive or immunomodulatory effects, while estrogens enhance humoral immunity in both genders. This study reviews the available evidence on the physiological effects of sex hormones on human immune cell function and the underlying biological mechanisms, particularly focusing on gender differences triggered by different levels of androgens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Carola Horn, Rosanne Sprute, Alina Chloe Kretschmer, Carolin Do, Oliver A. Cornely, Norma Jung, Clara Lehmann, Julia Fischer
Summary: The immune responses to antigen stimulation, vaccinations and infections differ between women and men due to genetic, epigenetic and hormonal factors. Females exhibit stronger immune responses but more adverse reactions to infections and vaccinations, while males are more prone to severe diseases caused by bacterial, viral and fungal infections. Understanding the sex-specific differences in immune response will have a long-term impact on the prevention, diagnostics and treatment of infectious diseases, ultimately improving healthcare for both women and men.
Review
Immunology
Muhammad Bilal Tariq, Juneyoung Lee, Louise D. McCullough
Summary: Ischemic stroke has a greater impact on women, especially older women, leading to poorer outcomes and sex-specific inflammatory responses. Factors such as gonadal hormone exposure, sex chromosome compliment, and environmental/social factors contribute to differences in immune responses. Understanding these differences is crucial for identifying therapeutic options for both men and women.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Review
Immunology
Lauren M. F. Merlo, Weidan Peng, Laura Mandik-Nayak
Summary: Indoleamine-2,3-dioxygenase (IDO)1 and IDO2 are closely related enzymes that modulate T cell and B cell function. IDO1 inhibits inflammatory B cell responses while IDO2 drives them. Targeting IDO1 and/or IDO2 shows promise as a therapeutic approach for inflammatory autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Layana Pacheco de Araujo Albuquerque, Amanda Miranda da Silva, Francisca Miriane de Araujo Batista, Ingridi de Souza Sene, Dorcas Lamounier Costa, Carlos Henrique Nery Costa
Summary: Hormonal variations influence the immune response to leishmaniases differently in males and females, with androgens potentially presenting immunosuppressive effects in males. This leads to higher susceptibility, mortality, and complications in men compared to women.
PARASITE IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Lachlan M. Moldenhauer, Min Jin, Jasmine J. Wilson, Ella S. Green, David J. Sharkey, Mark D. Salkeld, Thomas C. Bristow, M. Louise Hull, Gustaaf A. Dekker, Sarah A. Robertson
Summary: Research has shown that oral contraception use can impact the number and phenotype of Treg cells, leading to physiological changes and altered disease susceptibility.
Review
Cell Biology
Christina E. Zielinski
Summary: Sodium chloride has been proposed to have potent effects on T cell responses in the context of autoimmune, allergic, and infectious tissue inflammation in both mouse models and humans. It is stringently regulated in the blood by the kidneys but displays differential deposition patterns in peripheral tissues, which may be influenced by dietary intake and intentional behavior. Its downstream cellular activities represent a potential therapeutic target given its effects on T cell cytokine production.
Article
Biochemistry & Molecular Biology
Angela Maselli, Marina Pierdominici, Cristiana Vitale, Elena Ortona
Article
Immunology
Cristiana Barbati, Cristiano Alessandri, Marta Vomero, Rosa Vona, Tania Colasanti, Davide Vacirca, Serena Camerini, Marco Crescenzi, Monica Pendolino, Simona Truglia, Fabrizio Conti, Tina Garofalo, Maurizio Sorice, Marina Pierdominici, Guido Valesini, Walter Malorni, Elena Ortona
JOURNAL OF AUTOIMMUNITY
(2015)
Article
Oncology
Marina Pierdominici, Angela Maselli, Barbara Varano, Cristiana Barbati, Paola Cesaro, Cristiano Spada, Angelo Zullo, Roberto Lorenzetti, Marco Rosati, Gabriella Rainaldi, Maria Rosaria Limiti, Luisa Guidi, Lucia Conti, Sandra Gessani
Article
Oncology
Angela Maselli, Sara Capoccia, Patrizia Pugliese, Carla Raggi, Francesca Cirulli, Alessandra Fabi, Walter Malorni, Marina Pierdominici, Elena Ortona
Article
Endocrinology & Metabolism
Angela Maselli, Fabrizio Conti, Cristiano Alessandri, Tania Colasanti, Cristiana Barbati, Marta Vomero, Laura Ciarlo, Mario Patrizio, Francesca Romana Spinelli, Elena Ortona, Guido Valesini, Marina Pierdominici
BIOLOGY OF SEX DIFFERENCES
(2016)
Article
Immunology
Gloria Donninelli, Manuela Del Corno, Marina Pierdominici, Beatrice Scazzocchio, Rosaria Vari, Barbara Varano, Ilenia Pacella, Silvia Piconese, Vincenzo Barnaba, Massimo D'Archivio, Roberta Masella, Lucia Conti, Sandra Gessani
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Rheumatology
C. Ciccacci, C. Perricone, C. Alessandri, A. Latini, C. Politi, F. Delunardo, M. Pierdominici, F. Conti, G. Novelli, E. Ortona, P. Borgiani
Review
Biochemistry & Molecular Biology
Marina Pierdominici, Cristiana Barbati, Marta Vomero, Silvia L. Locatelli, Carmelo Carlo-Stella, Elena Ortona, Walter Malorni
Review
Biochemistry & Molecular Biology
Elena Ortona, Marina Pierdominici, Lev Berstein
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2014)
Article
Oncology
S. L. Locatelli, L. Cleris, G. G. Stirparo, S. Tartari, E. Saba, M. Pierdominici, W. Malorni, A. Carbone, A. Anichini, C. Carlo-Stella
Article
Toxicology
Marina Pierdominici, Angela Maselli, Serena Cecchetti, Antonella Tinari, Arianna Mastrofrancesco, Michela Alfe, Valentina Gargiulo, Carlo Beatrice, Gabriele Di Blasio, Giulia Carpinelli, Elena Ortona, Antonello Giovannetti, Silvana Fiorito
PARTICLE AND FIBRE TOXICOLOGY
(2014)
Article
Immunology
Maria Luisa Dupuis, Fabrizio Conti, Angela Maselli, Maria Teresa Pagano, Anna Ruggieri, Simona Anticoli, Alessandra Fragale, Lucia Gabriele, Maria Cristina Gagliardi, Massimo Sanchez, Fulvia Ceccarelli, Cristiano Alessandri, Guido Valesini, Elena Ortona, Marina Pierdominici
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Bruno Lagana, Angelo Zullo, Maria Lia Scribano, Maria Sole Chimenti, Alberto Migliore, Andrea Picchianti Diamanti, Roberto Lorenzetti, Palma Scolieri, Lorenzo Ridola, Elena Ortona, Marina Pierdominici, Vincenzo Bruzzese
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Rheumatology
Cristiano Alessandri, Francesco Ciccia, Roberta Priori, Elisa Astorri, Giuliana Guggino, Riccardo Alessandro, Aroldo Rizzo, Fabrizio Conti, Antonina Minniti, Cristiana Barbati, Marta Vomero, Monica Pendolino, Annacarla Finucci, Elena Ortona, Tania Colasanti, Marina Pierdominici, Walter Malorni, Giovanni Triolo, Guido Valesini
ARTHRITIS RESEARCH & THERAPY
(2017)
