First‐in‐Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers

TTR (Transthyretin) Stabilizers Are Associated With Improved Survival in Patients With TTR Cardiac Amyloidosis

(2018) Hannah Rosenblum et al.   Circulation-Heart Failure

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

(2018) Merrill D. Benson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis

(2018) Mark Miller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

(2018) Mathew S. Maurer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tenosynovial and Cardiac Amyloidosis in Patients Undergoing Carpal Tunnel Release

(2018) Brett W. Sperry et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association Between Ruptured Distal Biceps Tendon and Wild-Type Transthyretin Cardiac Amyloidosis

(2017) Hallie I. Geller et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sixty years of transthyretin familial amyloid polyneuropathy (TTR-FAP) in Europe

(2016) Yesim Parman et al.   CURRENT OPINION IN NEUROLOGY

Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Val30Met: A phase III, open-label study

(2016) Yukio Ando et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Amyloidogenic V122I Transthyretin Variant in Elderly Black Americans

(2015) C. Cristina Quarta et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasma Transthyretin as a Biomarker of Lean Body Mass and Catabolic States

(2015) Yves Ingenbleek et al.   Advances in Nutrition

Repurposing Diflunisal for Familial Amyloid Polyneuropathy

(2015) John L. Berk et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic Stabilization of Transthyretin, Cerebrovascular Disease, and Life Expectancy

(2013) Louise S. Hornstrup et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

(2013) S. C. Penchala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transthyretin (TTR) Cardiac Amyloidosis

(2012) Frederick L. Ruberg et al.   CIRCULATION

Cardiac Amyloidosis

(2012) C. Cristina Quarta et al.   CIRCULATION

Tafamidis for transthyretin familial amyloid polyneuropathy: A randomized, controlled trial

(2012) T. Coelho et al.   NEUROLOGY

A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin

(2010) Sungwook Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Serum transthyretin levels in senile systemic amyloidosis: effects of age, gender and ethnicity

(2008) Joel Buxbaum et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS