Thermoresponsive and Protease‐Cleavable Interferon‐Polypeptide Conjugates with Spatiotemporally Programmed Two‐Step Release Kinetics for Tumor Therapy

Site-selective protein modification with polymers for advanced biomedical applications

(2018) Xinyu Liu et al.   BIOMATERIALS

Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action

(2018) Caslin A. Gilroy et al.   JOURNAL OF CONTROLLED RELEASE

Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer

(2018) Mengmeng Sun et al.   Theranostics

Polymerization Induced Self-Assembly of a Site-Specific Interferon α-Block Copolymer Conjugate into Micelles with Remarkably Enhanced Pharmacology

(2018) Xinyu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren's syndrome

(2018) Hao Guo et al.   JOURNAL OF CONTROLLED RELEASE

Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy

(2017) Zhuoran Wang et al.   JOURNAL OF CONTROLLED RELEASE

One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer

(2017) Kelli M. Luginbuhl et al.   Nature Biomedical Engineering

Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy

(2016) Jin Hu et al.   BIOMATERIALS

In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy

(2016) Jin Hu et al.   JOURNAL OF CONTROLLED RELEASE

Enhancing Pharmacokinetics, Tumor Accumulation, and Antitumor Efficacy by Elastin-Like Polypeptide Fusion of Interferon Alpha

(2015) Jin Hu et al.   ADVANCED MATERIALS

Design of tumor-homing and pH-responsive polypeptide–doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects

(2015) Jin Hu et al.   CHEMICAL COMMUNICATIONS

PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo

(2015) Kadi-Liis Veiman et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis of well-defined protein–polymer conjugates for biomedicine

(2015) Wenguo Zhao et al.   POLYMER

A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models

(2015) Jayanta Bhattacharyya et al.   Nature Communications

A Hybrid Protein–Polymer Nanoworm Potentiates Apoptosis Better than a Monoclonal Antibody

(2014) Suhaas Rayudu Aluri et al.   ACS Nano

Curb challenges of the “Trojan Horse” approach: Smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery

(2013) Yongzhuo Huang et al.   ADVANCED DRUG DELIVERY REVIEWS

Elastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo

(2013) Pu Shi et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety

(2013) L. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Injectable protease-operated depots of glucagon-like peptide-1 provide extended and tunable glucose control

(2013) M. Amiram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation

(2012) Peng Zou et al.   AAPS Journal

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation

(2010) W. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection

(2009) J. Andrew MacKay et al.   NATURE MATERIALS

In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics

(2009) W. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY