Article
Nanoscience & Nanotechnology
Cheng Liu, Huimin Gao, Gaoqi Sun, Xuefeng Jiang, Saijie Song, Jun Zhang, Jian Shen
Summary: In this study, a multifunctional decellularized scaffolds (DCS)-based vascular patch was designed for porcine vascular repair. By coating ammonium phosphate zwitter-ion (APZI) and poly(vinyl alcohol) (PVA) hydrogel on the surface of DCS, the mechanical properties and biocompatibility of the artificial vascular patch were improved. The artificial vascular patch was further decorated with a heparin (Hep)-loaded metal-organic framework (MOF) to inhibit blood coagulation and promote vascular endothelialization. The results showed that the obtained artificial vascular patch had suitable mechanical properties, good biocompatibility, and blood compatibility, making it an excellent vascular replacement material.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Cheng Liu, Huimin Gao, Gaoqi Sun, Xuefeng Jiang, Saijie Song, Jun Zhang, Jian Shen
Summary: In this study, a multifunctional decellularized scaffolds (DCS)-based vascular patch with improved mechanical properties and biocompatibility was designed. The surface of the patch was coated with ammonium phosphate zwitter-ion (APZI) and poly(vinyl alcohol) (PVA) hydrogel, followed by the decoration of a heparin (Hep)-loaded metal-organic framework (MOF) to inhibit blood coagulation and promote vascular endothelialization. The obtained artificial vascular patch showed suitable mechanical properties, good biocompatibility, and blood compatibility. It also demonstrated enhanced proliferation and adhesion of endothelial progenitor cells (EPCs). The results from imaging techniques confirmed the patency of the implanted artificial vascular patch.
ACS APPLIED BIO MATERIALS
(2023)
Article
Materials Science, Biomaterials
Shijie Qiu, Lijin Liang, Peng Zou, Qi Chen
Summary: The study developed a bi-layer composite scaffold using decellularized small intestine submucosa and polylactic-co-glycolic acid, with minimal residual DNA in the former and satisfactory mechanical properties in the scaffold. Cellular interactions within the scaffold showed desirable cell proliferation and phenotypic behaviors, laying a solid foundation for future in vivo studies and clinical applications.
REGENERATIVE BIOMATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Zhanhong Fang, Bingyang Lv, Jiamian Zhan, Xianglong Xing, Chengbin Ding, Jianing Liu, Leyu Wang, Xiaoming Zou, Xiaozhong Qiu
Summary: Using a decellularized fish skin matrix, a flexible conductive cardiac patch is prepared through the polymerization of polydopamine and polypyrrole. This patch improves cardiomyocyte maturation and functionalization, reduces inflammation, enhances local microcirculation, and reconstructs the conductive microenvironment in infarcted myocardia. The excellent flexibility of the scaffold allows for implantation through a folding-delivering-re-stretching pathway, enabling microsurgery under endoscopy and avoiding secondary damage to the myocardium by traditional thoracotomy.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Xingyu Gui, Zhiyu Peng, Ping Song, Li Chen, Xiujuan Xu, Hairui Li, Pei Tang, Yixi Wang, Zixuan Su, Qingquan Kong, Zhenyu Zhang, Zhengyong Li, Ying Cen, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Summary: Currently, autologous costal cartilage is commonly used in clinical auricle reconstruction, but it has drawbacks such as high patient trauma, poor plasticity, and inaccurate shaping. This study investigated the combination of 3D printing and tissue engineering for precise auricle reconstruction, using a polylactic acid (PLA) scaffold customized to the patient's appearance and loaded with auricle cartilage fragments. The results showed promising potential for auricle reconstruction using autologous cartilage fragments and 3D printing technology.
BIO-DESIGN AND MANUFACTURING
(2023)
Article
Polymer Science
Eisner Salamanca, Cheuk Sing Choy, Lwin Moe Aung, Ting-Chia Tsao, Pin-Han Wang, Wei-An Lin, Yi-Fan Wu, Wei-Jen Chang
Summary: This study evaluated the properties and efficacy of PLA/FN in 3D-printed alloplastic bone grafts. The results showed that the PLA/FN grafts promoted osteogenesis in vitro and had great potential for customized bone regeneration.
Article
Nanoscience & Nanotechnology
Nur Setiawan Suroto, Asra Al Fauzi, Prihartini Widiyanti, Fitria Renata Bella
Summary: Stroke is the second leading cause of death, disability, morbidity, and mortality worldwide. Carotid stenosis is one of the main causes of ischemic stroke. This study used the electrospinning process to create a biomaterial using PLLA as a base material and adding chitosan and heparin to improve biocompatibility. The results showed that the biomaterial had strong physical properties and could modify the inflammatory response.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2023)
Article
Biophysics
Chayanan Khotchana, Pongsathon Phapugrangkul, Pakorn Opaprakasit, Dolnapa Kaewpa, Preeyaporn Chaiyasat, Amorn Chaiyasat
Summary: A novel method for preparing PLLA particles and capsules without the use of surfactant was proposed in this study. The nearly monodisperse products showed excellent inhibitory effects on microbial growth and were non-toxic to human cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Neerja Yadav, Lata Nain, Sunil Kumar Khare
Summary: Polylactic acid (PLA) is a key polymer due to its ecofriendly, biocompatible, and biodegradable properties, with potential to replace conventional polymers in various applications. Efforts to accelerate PLA degradation aim to enhance its commercial appeal, while the development of a bioprocess for high molecular weight PLA using enzymatic polymerization technique shows promise for future applications.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Nanoscience & Nanotechnology
Gaoqi Sun, Yajuan Li, Cheng Liu, Xuefeng Jiang, Lutao Yang, Lei He, Saijie Song, Jun Zhang, Jian Shen, Tong Qiao
Summary: This study developed a poly(vinyl alcohol)-coated decellularized scaffold as a vascular patch for vascular regeneration, and improved its biocompatibility through layer-by-layer assembly. In vitro experiments showed rapid endothelialization and good hemocompatibility of the vascular patch. In vivo experiments on a porcine model confirmed the vascular regeneration, with the porcine artery remaining unblocked for 5 months after implantation.
ACS APPLIED BIO MATERIALS
(2022)
Article
Biophysics
Xue Zhao, Qiangwei Xin, Dongqiong Yang, Xingxing Zhai, Jing Li, Xingyu Chen, Jianshu Li
Summary: This study investigated the biocompatibility of PLA-PMCP films in terms of protein adsorption, cell adhesion and proliferation, bacterial adhesion, blood compatibility, and inflammation in vivo. The results showed that the PLA-PMCP surface can resist protein adsorption and bacterial adhesion, promote cell adhesion and proliferation, and have good hemocompatibility and histocompatibility.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Applied
Jian He, Xulin Hu, Jianfei Cao, Yu Zhang, Jianping Xiao, LiJun Peng, Dongliang Chen, Chengdong Xiong, Lifang Zhang
Summary: A chitosan-coated microsphere scaffold was fabricated for bone regeneration, showing excellent biocompatibility and controlled drug release. The incorporation of PLLA, OA-HA, and VH into the scaffold slowed biodegradability while enhancing mechanical and surface properties. CS coating promoted osteoblast adhesion, and the release of OA-HA stimulated osteogenic proliferation.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Composites
Ilknur Kokcu, Meltem Eryildiz, Mirigul Altan, Melek Ipek Ertugrul, Sedat Odabas
Summary: Multifunctional polymer nanocomposite scaffolds were fabricated using the FDM method for biomedical applications. The scaffolds showed improved mechanical properties with the addition of 3%wt halloysite nanotube (HNT), including increased tensile, compression, and three-point flexural strength. The scaffolds also exhibited good in-vitro drug release and cell viability, without any cytotoxicity effects. Overall, the developed scaffolds hold promise for bone regeneration and replacement.
POLYMER COMPOSITES
(2023)
Article
Materials Science, Multidisciplinary
Karl W. Wieck, Matthew J. Panzer
Summary: A series of ionogel electrolytes were created to study the effects of varying the ZI fraction and lithium ion concentration on gel mechanical properties and ion transport. The results showed that increasing the MPC content from 6.3 mol% to 17 mol% in the precursor solution significantly increased the gel elastic modulus, while the room temperature ionic conductivity remained nearly constant in the 1M LiTFSI ILE.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Qingqing Dai, Wei Jiang, Fan Huang, Fei Song, Jiqian Zhang, Hongchuan Zhao
Summary: Liver transplantation is currently the only effective treatment for end-stage liver disease, but the scarcity of donor livers is a major concern. The use of a decellularized scaffold in liver engineering has gained attention as it can preserve the original liver structure and bioactive chemicals, allowing for the creation of a new liver for transplantation. This review discusses the liver structure, decellularization, recellularization, recent developments, and the criteria and obstacles for using a decellularized scaffold.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Gaoqi Sun, Xuefeng Jiang, Cheng Liu, Saijie Song, Jun Zhang, Jian Shen
Summary: This study reports the development of FeS@LAB-35@Ti3C2 nanozyme as a high-efficiency antibacterial agent for photothermal-enhanced chemodynamic antibacterial activity and wound healing. The nanozyme possesses peroxidase-like catalysis activity and exhibits enhanced catalytic activity under NIR light irradiation. It shows excellent antibacterial activity against Gram-negative EschenChia coli and Gram-positive Staphylococcus aureus. Animal experiments demonstrate its effectiveness in inhibiting wound ulceration and promoting wound healing.
Article
Chemistry, Organic
Bo Dong, Yifeng Chen, Shubing Xie, Jieying Zhang, Jian Shen, Lan-Gui Xie
Summary: Oxidative cross-coupling of two thiols is a direct and desirable method for synthesizing unsymmetrical disulfides. However, the formation of symmetrical by-products is a major issue. This study presents a method where the homo-coupling of thiols is effectively inhibited by sequential addition of the thiols, utilizing the rapid oxidation of thiols by bromodimethylsulfonium bromide.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Chemistry, Organic
Bo Dong, Jian Shen, Lan-Gui Xie
Summary: Alkenes and alkynes are important compounds in various industries. The functionalization of these compounds to form carbon-sulfur bonds provides a versatile route to synthesize sulfur-containing compounds. This review summarizes recent progress in this area, divided into different catalytic processes.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Analytical
Jialin Yu, Xinhui Wang, Fangkun Ren, Jingyi Zhang, Jian Shen, Hailong Liu, Jiahong Zhou
Summary: The simple CaP synthesized with cheap raw materials (CaCl2 center dot 2H(2)O and Na2HPO4 center dot 12H(2)O) can effectively enrich multi-phosphopeptides and identify phosphorylation sites, showing good specificity, high sensitivity, and stability. This facilitates the popularization and application of phosphoproteomics research.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biophysics
Shuqing Xiang, Mingqian Wang, Li Li, Jian Shen
Summary: A photothermal/photodynamic/NO synergistic antibacterial nanoplatform was proposed by loading L-arginine (LA) on mesoporous TiO2 and encapsulating it with polydopamine. The obtained TiO2_x-LA@PDA nanocomposite exhibited excellent antibacterial effects against various bacteria, along with the ability to generate nitric oxide (NO) under near-infrared (NIR) light irradiation. The developed nanoplatform can be further explored in the biomedical field of photothermal activation of multimodal combined antibacterial therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Wan Peng, Cheng Liu, Youjin Lai, Yanting Wang, Pingsheng Liu, Jian Shen
Summary: Most bioadhesives are ineffective on bleeding tissues and postoperative adhesion is a common issue. A three-layer biodegradable Janus tissue patch (J-TP) is developed to efficiently close bleeding wounds, promote clotting, and prevent tissue adhesion. The J-TP's adhesive hydrogel bottom layer forms strong adhesion to bleeding tissues through chemical bonding, while the middle layer improves tensile strength and the top layer prevents postoperative adhesion and inflammation. This J-TP shows promise in the clinical treatment of injured bleeding tissues with inhibited adhesion.
Article
Engineering, Biomedical
Peiming Liu, Jin Sun, Wan Peng, Yahui Gu, Xiaoxue Ji, Zhi Su, Pingsheng Liu, Jian Shen
Summary: Good's buffers have been widely used in cell/organ culture as biocompatible pH stabilizers. However, the emergence of adverse effects such as cellular uptake, autophagic activation, and cytotoxicity under light exposure raises concerns over its biocompatibility. Riboflavin in the cell culture medium produces reactive oxygen species (ROS) under light exposure, causing severe toxicity and disruption of normal cell functions. Zwitterionic betaines have been identified as a new generation of biocompatible pH buffers that do not exhibit these adverse effects.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Cheng Liu, Huimin Gao, Gaoqi Sun, Xuefeng Jiang, Saijie Song, Jun Zhang, Jian Shen
Summary: In this study, a multifunctional decellularized scaffolds (DCS)-based vascular patch was designed for porcine vascular repair. By coating ammonium phosphate zwitter-ion (APZI) and poly(vinyl alcohol) (PVA) hydrogel on the surface of DCS, the mechanical properties and biocompatibility of the artificial vascular patch were improved. The artificial vascular patch was further decorated with a heparin (Hep)-loaded metal-organic framework (MOF) to inhibit blood coagulation and promote vascular endothelialization. The results showed that the obtained artificial vascular patch had suitable mechanical properties, good biocompatibility, and blood compatibility, making it an excellent vascular replacement material.
ACS APPLIED BIO MATERIALS
(2023)
Article
Engineering, Biomedical
Juyang Zhang, Baohong Sun, Ming Zhang, Yutian Su, Wang Xu, Yuhan Sun, Huijun Jiang, Ninglin Zhou, Jian Shen, Fan Wu
Summary: Single-atomic nanozymes characterized by atomically dispersed single metal atoms have shown satisfactory catalytic activity and superior selectivity compared to their nanoscale counterparts, contributing to breakthroughs in biomedicine. Adjusting the coordination number of the metal atoms can improve their catalytic performance. In this study, atomically dispersed Co nanozymes with different nitrogen coordination numbers were synthesized, and it was found that Co nanozymes with a coordination number of 2 had the highest catalytic activity and antibacterial effect. This research provides proof of concept for enhancing single-atomic catalytic therapy by regulating the coordination number for various biomedical applications.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Yushuang Shang, Penghui Wang, Xiuzhen Wan, Lijuan Wang, Xu Liu, Jiang Yuan, Bo Chi, Jian Shen
Summary: Multifunctional hydrogel dressings with chlorhexidine(CHX) loaded double network hydrogels showed cytocompatibility, antioxidant capability, and enhanced antibacterial activity. The hydrogels exhibited acid, glutathione(GSH), and trypsin triple-responsive release behaviors, accelerating CHX release under wound microenvironments. The freeze-drying hydrogels could be ground into powders and sprinkled on irregular wounds to reform hydrogel in situ, which were more convenient for sterilization, formulation, and storage. The xerogel powder dressing significantly promoted collagen deposition and reduced inflammation in vivo, accelerating wound closure and regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Energy & Fuels
Qihui He, Xin Wang, Dongqing Dai, Yahui Feng, Renfu Xu, Jiandang Yan, Pengfei Wang, Jian Shen, Baixing Hu
Summary: In this study, the structures and properties of degradation products of polystyrene (PS) waste were characterized, and the optimal degradation conditions were investigated using various analytical techniques. It was found that using 1.0 wt% K2S2O8 as an assistant at 300°C for 24 hours was suitable for degrading PS waste. The degraded PS was then prepared into sodium polystyrene sulfonate (PSS), which showed excellent performance as a dispersant for coal-water slurry (CWS) when it had a sulfonation degree of more than 75% and a number average molecular weight (Mn) of about 9000.
INTERNATIONAL JOURNAL OF COAL PREPARATION AND UTILIZATION
(2023)
Review
Materials Science, Biomaterials
Nian Liu, Xiangyu Xiao, Ziqiang Zhang, Chun Mao, Mimi Wan, Jian Shen
Summary: Cancer vaccines are a promising therapeutic strategy in clinical oncology, stimulating antitumor immunity to fight against cancer. However, there are several challenges that hinder their broad clinical translation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Changrui Ying, Xiaolong Zhu, Shuqing Xiang, Mingqian Wang, Xuefeng Jiang, Jian Shen
Summary: This article investigates carbon-based single-atom catalysts and their potential application in photothermal catalytic antimicrobial therapy. Iron single-atom catalysts demonstrate significant catalytic activity, producing a large amount of hydroxyl radicals that can kill bacteria. The excellent photothermal properties of carbon materials enable the catalyst to rapidly generate high temperatures, enhancing its catalytic activity. Results show that the synergistic antimicrobial strategy of chemodynamic therapy and photothermal therapy is highly effective against bacteria.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Cheng Liu, Huimin Gao, Gaoqi Sun, Xuefeng Jiang, Saijie Song, Jun Zhang, Jian Shen
Summary: In this study, a multifunctional decellularized scaffolds (DCS)-based vascular patch with improved mechanical properties and biocompatibility was designed. The surface of the patch was coated with ammonium phosphate zwitter-ion (APZI) and poly(vinyl alcohol) (PVA) hydrogel, followed by the decoration of a heparin (Hep)-loaded metal-organic framework (MOF) to inhibit blood coagulation and promote vascular endothelialization. The obtained artificial vascular patch showed suitable mechanical properties, good biocompatibility, and blood compatibility. It also demonstrated enhanced proliferation and adhesion of endothelial progenitor cells (EPCs). The results from imaging techniques confirmed the patency of the implanted artificial vascular patch.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Physical
Gaoqi Sun, Xuefeng Jiang, Cheng Liu, Saijie Song, Jun Zhang, Jian Shen
Summary: The abuse of antibiotics leads to bacterial resistance, and it is important to develop new strategies for efficient antibacterial and wound healing. This study introduces a FeS@LAB-35@Ti3C2 nanozyme that integrates photothermal and chemodynamic therapy for bacterial inhibition and wound healing.
