Article
Polymer Science
Ting He, Die Hu, Qian Ren, Zhongcheng Li, Sili Han, Longjiang Ding, Ziqian Lu, Linglin Zhang
Summary: Biomimetic mineralization is a promising strategy for dentin repair. However, the degradation of collagen fibrils and the lack of sustained supply of calcium and phosphorus ions are two main limitations. In this study, a novel nanoscale platform called PA-ACP/NPs was proposed to address these limitations. PA-ACP/NPs effectively protected collagen and induced complete intrafibrillar mineralization, facilitating remineralization of demineralized dentin. The nanoscale delivery of PA-ACP/NPs exhibited excellent effects in stabilizing collagen and providing long-term mineral ions supply.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Xing Fu, Qian-cheng Zhao, Dong Uk Ahn, Mei-hu Ma, Xi Huang
Summary: This study developed biomineralization scaffolds using eggshell membranes as the bio-template, which showed better mineralization potential and cell adhesion ability after enzyme treatment.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Qingli Zhou, Mengxi Guo, Qunlin Zhang, Quan-Li Li, Chris Ying Cao
Summary: A novel calcium phosphate prenucleation clusters (CaP-PNCs)/starch complex is proposed in this study, which can be converted between liquid and spongy solid through freeze-drying and redissolution, with long-term stability. When mixed with alpha-amylase during application, starch templates are removed by enzymolysis and CaP-PNCs are released to trigger on-site biomimetic mineralization for repairing tooth tissue defects.
MATERIALS & DESIGN
(2021)
Article
Chemistry, Physical
Song Chen, Yuanli He, Linna Zhong, Wenjia Xie, Yiyuan Xue, Jian Wang
Summary: The study modified porous titanium discs with calcium phosphate (CaP) and lactoferrin (LF) to enhance their antibacterial effects and osteogenic bioactivity. The LF-M group showed controlled release of LF, effectively inhibiting bacterial adhesion and proliferation while promoting osteogenic differentiation, making it a promising option for dental implant applications.
Article
Chemistry, Multidisciplinary
Meng Cai, Haoyue Song, Qihang Wang, Zhaoyong Zou, Zhengyi Fu
Summary: Researchers have successfully synthesized biomimetic fluorapatite nanorods using track-etched membranes and found that additives play an important role in controlling the crystallization process of the crystals. These findings provide valuable inspiration for the rapid synthesis of biomimetic materials with outstanding properties.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Yangwu Chen, Yuxiang Zhang, Xiaoyi Chen, Jiayun Huang, Bo Zhou, Tao Zhang, Wei Yin, Cailian Fang, Zi Yin, Haihua Pan, Xiongfeng Li, Weiliang Shen, Xiao Chen
Summary: Soft and hard tissues have distinct biological properties. To overcome the challenge of integrating soft and hard tissue interfaces, a biomimetic mineralization strategy was employed to engineer mineralized tendons, which exhibited characteristics similar to bone tissue and facilitated the integration between soft and hard tissues.
Article
Nanoscience & Nanotechnology
Stephanie Colon, Alexander Paige, Rylie Bolarinho, Hailey Young, Aren E. Gerdon
Summary: This study demonstrates the influence of DNA aptamers with known G-quadruplex structures on calcium carbonate mineralization for the first time. Aptamers show kinetic inhibition of mineral formation, sequence and pH-dependent uptake into the mineral, and morphological control of calcite material in controlled solution conditions. In reactions initiated from ocean water, DNA aptamers enhance mineralization kinetics and result in amorphous material. This work provides new biomimetic tools for controlled mineralization and highlights the importance of template secondary structure in material formation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Yuchen Zhang, Shaoyang Ma, Jiaming Nie, Zhongbo Liu, Faming Chen, Ang Li, Dandan Pei
Summary: Bone mineralization is a complex process involving the interplay between organic and inorganic components of bone tissues. This review focuses on the evolution of mineral precursors in the bone mineralization process and highlights the tight control organisms have over each step. The connection between biomineralization and biomaterial design strategies is discussed, along with the detailed implementation of mineral precursor-based biomaterials in various bone graft materials.
Article
Chemistry, Multidisciplinary
Susrut Akkineni, Gregory S. Doerk, Chenyang Shi, Biao Jin, Shuai Zhang, Stefan Habelitz, James J. De Yoreo
Summary: The study demonstrates how the supramolecular structures of matrix proteins can be synthetically directed into predetermined patterns while retaining their functionality. They used block copolymer lamellar patterns to direct the assembly of peptide nanoribbons, which template calcium phosphate nucleation by creating a low-energy interface. The results show that the patterned nanoribbons maintain their structure and function, and successfully direct the formation of calcium phosphate with high fidelity.
Article
Biochemistry & Molecular Biology
Aya K. Cloyd, Kyle Boone, Qiang Ye, Malcolm L. Snead, Paulette Spencer, Candan Tamerler
Summary: Overcoming the short lifespan of current dental adhesives is a significant clinical need. Adhesives rely on the hybrid layer formation to adhere to dentin, but complete enclosure of demineralized collagen fibrils is currently unattainable. The use of peptide-based approach enables collagen intrafibrillar mineralization, providing a promising route for improving the long-term prospects of composite resins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Lumiao Yan, Chen Zheng, Ding Yuan, Zhengxi Guo, Yihao Cui, Zhijian Xie, Zhi Chen, Ruikang Tang, Zhaoming Liu
Summary: This study demonstrates a fast in situ crosslinking method of calcium phosphate oligomers (CPOs) with collagen matrices for efficient reconstruction of the organic-inorganic interface. By using damaged dentin as an example, it was found that the method could rebuild a structurally integrated organic-inorganic interface identical to natural dentin within only 5 minutes, fully recovering the damaged dentin to a healthy state.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Physical
Jooseong Kim, Sukyoung Kim, Inhwan Song
Summary: This study compared the bone regeneration capacity of OCP products with two commonly used materials and found that OCP showed significantly higher resorption and new bone formation. OCP bone substitutes can enhance bone regeneration significantly by activating osteoblasts and a rapid phase transition of OCP crystals to biological apatite crystals (mineralization), as well as providing additional space for new bone formation by rapid resorption.
Article
Chemistry, Multidisciplinary
Kohei Okuda, Ryosuke Shigemasa, Ken Hirota, Tadashi Mizutani
Summary: Nanohydroxyapatite (HAP) was crystallized in an aqueous solution of carboxymethyl cellulose (CMC) to prepare composites with a stable interface between them. The mechanical properties of the composites were optimized by adjusting the temperature and CMC concentration. The optimized composite exhibited high flexural strength and elastic modulus, making it a potential replacement for petroleum-derived engineering plastics.
Article
Chemistry, Physical
Jihye Lee, Adama Konate, Clement Guibert, Jessem Landoulsi
Summary: In this study, a biomimetic method for growing a hybrid calcium phosphate (CaP) - collagen coating is described. The versatility of layer-by-layer (LbL) method is explored to incorporate collagen and alkaline phosphatase (ALP), and control their organization and bioactivity. The presence of collagen fibrils in the LbL film plays a crucial role in the growth mechanism of the biomimetic mineral layer. The approach provides a straightforward way for designing biomimetic hybrid coatings in biomedical applications.
SURFACES AND INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Yu Li, Wei Jiang, Nanfang Nie, Jiaqi Xu, Xiaozhao Wang, Junwen Zhang, Jiahuan Guan, Chengcheng Zhu, Cheng Zhang, Ying Gu, Xiaoyi Chen, Shasha Yao, Zi Yin, Bingbing Wu, Hongwei Ouyang, Xiaohui Zou
Summary: In this study, the size- and dose-dependent body-wide organ transcriptomic responses to calcium phosphate nanomaterials were investigated. The results showed that the gene expression trajectories correlated with the dose of the nanomaterials and tissue-specific risk effects. Lung tissue exhibited the most significant risk signatures related to apoptosis, cell proliferation, and cell stress, while the spleen showed risk signatures associated with immune response and DNA damage. The study also found that smaller calcium phosphate nanomaterials had greater tissue-specific risk effects in multiple organs compared to larger nanoparticles. A risk prediction model was built based on the findings to evaluate the risk of local nanomaterials delivery. This study provides valuable insights into the size- and dose-dependent risk assessment of nanoparticles at the transcriptomic level.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
Christopher Connelly, Thomas Cicuto, Jason Leavitt, Alexander Petty, Amy Litman, Henry C. Margolis, Aren E. Gerdon
COLLOIDS AND SURFACES B-BIOINTERFACES
(2016)
Article
Chemistry, Multidisciplinary
Melissa D. Carter, Sarah S. Pierce, Albert D. Dukes, Rebecca H. Brown, Brian S. Crow, Rebecca L. Shaner, Leila Heidari, Samantha L. Isenberg, Jonas W. Perez, Leigh Ann Graham, Jerry D. Thomas, Rudolph C. Johnson, Aren E. Gerdon
JOURNAL OF CHEMICAL EDUCATION
(2017)
Article
Chemistry, Analytical
Emma Duffy, John Florek, Stephanie Colon, Aren E. Gerdon
ANALYTICA CHIMICA ACTA
(2020)
Article
Chemistry, Multidisciplinary
Aren E. Gerdon
JOURNAL OF CHEMICAL EDUCATION
(2020)
Article
Chemistry, Analytical
Robert G. Tzepos, Easwer Raman, Lauren E. Toote, David W. Wright, Aren E. Gerdon
Summary: The study demonstrates that sensitive, inexpensive, and portable detection of protein biomarkers can be achieved with the use of CoP nanoparticles and electrochemical signal amplification technology. The limit of detection for CoP was 4 nM, and the target protein could be detected at 100 pM.
Article
Chemistry, Multidisciplinary
Michelle L. Kovarik, Betty Cristina Galarreta, Peter J. Mahon, Daniel A. McCurry, Aren E. Gerdon, Steven M. Collier, Marjorie E. Squires
Summary: The survey of 322 analytical chemistry instructors in Spring 2021 revealed that most courses require students to take two analytical chemistry courses, with over 80% also requiring an analytical lab course. Calibration methods were rated as the most important topic, with many other key topics being taught in required courses and hands-on laboratories.
JOURNAL OF CHEMICAL EDUCATION
(2022)
Article
Nanoscience & Nanotechnology
Stephanie Colon, Alexander Paige, Rylie Bolarinho, Hailey Young, Aren E. Gerdon
Summary: This study demonstrates the influence of DNA aptamers with known G-quadruplex structures on calcium carbonate mineralization for the first time. Aptamers show kinetic inhibition of mineral formation, sequence and pH-dependent uptake into the mineral, and morphological control of calcite material in controlled solution conditions. In reactions initiated from ocean water, DNA aptamers enhance mineralization kinetics and result in amorphous material. This work provides new biomimetic tools for controlled mineralization and highlights the importance of template secondary structure in material formation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Obstetrics & Gynecology
Gretchen E. Stepanovich, Cole A. Chapman, Krista L. Meserve, Julie M. Sturza, Lindsay A. Ellsworth, Ryan C. Bailey, Jennifer R. Bermick
Summary: This study aimed to determine if age and chorioamnionitis exposure affect serum cytokine and chemokine levels in preterm neonates. The results showed differences in the trends of inflammatory markers between chorioamnionitis-exposed and unexposed neonates during the first month of life. Chorioamnionitis-exposed neonates demonstrated altered IL-10 and TNF-alpha trajectories over the first twelve weeks of life.
JOURNAL OF PERINATOLOGY
(2023)
Article
Biochemical Research Methods
Krista Meserve, Abraham J. Qavi, M. Javad Aman, Hong Vu, Larry Zeitlin, John M. Dye, Jeffrey W. Froude, Daisy W. Leung, Lan Yang, Frederick W. Holtsberg, Gaya K. Amarasinghe, Ryan C. Bailey
Summary: This article describes the use of silicon photonic microring resonator sensors for detecting Ebola virus and Sudan virus soluble glycoprotein. The protocol includes chip functionalization, protein detection in sera, calibration standard preparation, and quantification of results. This method can be adapted for other analytes.
Article
Biochemical Research Methods
Abraham J. Qavi, Krista Meserve, M. Javad Aman, Hong Vu, Larry Zeitlin, John M. Dye, Jeffrey W. Froude, Daisy W. Leung, Lan Yang, Frederick W. Holtsberg, Ryan C. Bailey, Gaya K. Amarasinghe
Summary: This study describes a rapid and sensitive diagnostic method for Ebola virus disease (EVD), using microring resonator sensors and the specific biomarker soluble glycoprotein (sGP) of Ebola infection. The method can detect sGP in a short time period with a low detection limit in serum.
CELL REPORTS METHODS
(2022)
Review
Multidisciplinary Sciences
Deshui Yu, Matjaz Humar, Krista Meserve, Ryan C. Bailey, Sile Nic Chormaic, Frank Vollmer
Summary: The concept of Whispering Gallery Mode (WGM) has evolved from describing the curvilinear propagation of sound waves to include continuous reflection of light waves for interferometric sensing. WGM resonators, based on glass microspheres, microtoroids, microcapillaries and silicon microrings, use multiple-cavity passes for sensitive measurements. The applications cover in vivo and single-molecule sensing, gyroscopes and microcavity quantum electrodynamics, with various sensing mechanisms employed.
NATURE REVIEWS METHODS PRIMERS
(2021)
Article
Chemistry, Multidisciplinary
K. R. Baillargeon, K. Meserve, S. Faulkner, S. Watson, H. Butts, P. Deighan, A. E. Gerdon
CHEMICAL COMMUNICATIONS
(2017)
