Article
Psychiatry
Eef Lien Theunissen, Kim Paula Colette Kuypers, Natasha Leigh Mason, Johannes Gerardus Ramaekers
Summary: This study compares the psychoactive effects of natural cannabis and synthetic cannabinoids at psychotropic dose equivalence. The findings suggest that both drugs impair psychomotor, divided attention, and impulse control to a similar extent, but synthetic cannabinoids have a more pronounced dissociative effect compared to natural cannabis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Mario Barbieri, Micaela Tirri, Sabrine Bilel, Raffaella Arfe, Giorgia Corli, Beatrice Marchetti, Lorenzo Caruso, Marie Soukupova, Virginia Cristofori, Giovanni Serpelloni, Matteo Marti
Summary: This study investigated the in vivo pharmacological activity and brain electrical effects of JWH-073, a synthetic cannabinoid. The results showed that JWH-073 temporarily decreased motor activity and visual sensorimotor responses in mice, while also affecting memory function and brain electrical responsiveness. These findings suggest that JWH-073 poses a subtle threat to consumers who underestimate its potential harm.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Chrysostomos Charalambous, Tereza Havlickova, Marek Lapka, Nina Puskina, Romana Slamberova, Martin Kuchar, Magdalena Sustkova-Fiserova
Summary: The study indicates that GHS-R1A plays an important role in the rewarding/reinforcing effects of cannabinoids, while the GHS-R1A antagonist JMV2959 can reduce THC-induced CPP and behavioral stimulation, decrease self-administration, and relapse propensity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Nicole C. Reyna, John T. Madden, Kenneth J. Thiel, Nathan S. Pentkowski
Summary: This study used a conditioned place preference model to examine the influence of methamphetamine and social rewards in adolescent male rats. The results showed that rats receiving methamphetamine with a social partner demonstrated a significantly greater preference shift compared to other groups, highlighting the importance of social context in influencing drug reward during adolescence.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Xinjian Zhang, Kiyoyuki Kitaichi, Akihiro Mouri, Xinzhu Zhou, Toshitaka Nabeshima, Kiyofumi Yamada, Taku Nagai
Summary: Although opioids have clinical benefits as analgesics, their misuse and addiction are on the rise. This study investigated the optimal ratio of an opioid and the opioid receptor antagonist, naloxone, in abuse-deterrent formulations. The conditioned place preference test showed that naloxone effectively inhibited the rewarding effects induced by opioids. The study suggests that the ratio of naloxone with opioids can serve as an index for developing abuse-deterrent formulations.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Behavioral Sciences
Hynek Danda, Nikola Pinterova-Leca, Klara Sichova, Kristyna Stefkova-Mazochova, Katerina Syrova, Lucie Olejnikova, Marketa Koncicka, Vladimir Mazoch, Eva Lhotkova, Martin Kuchar, Tomas Palenicek
Summary: This study aimed to evaluate the addictive potential of Naphyrone in rats and found that it has addictive properties and poses a significant risk to users.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Sam Craft, Jason A. Ferris, Monica J. Barratt, Larissa J. Maier, Michael T. Lynskey, Adam R. Winstock, Tom P. Freeman
Summary: The study found that withdrawal symptoms of SCRAs are more likely to occur with higher frequency of use, and compared to high-potency herbal cannabis, SCRAs have more severe withdrawal symptoms.
PSYCHOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Skyler M. Sklenarik, Christopher N. Burrows, Robert S. Astur
Summary: This study examines the establishment of conditioned place preference (CPP) using virtual alcohol cues and finds that participants with alcohol use spend significantly more time in the conditioned room compared to participants without alcohol use during the test session. However, participants with alcohol use do not subjectively report a preference for the conditioned room.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Substance Abuse
Shane Darke, Samuel Banister, Michael Farrell, Johan Duflou, Julia Lappin
Summary: This paper examines the characteristics of synthetic cannabinoid receptor agonists and argues that the term 'synthetic cannabis' is inaccurate, advocating for the use of the term SCRAs instead. The differences between SCRAs and THC are outlined, highlighting the need for distinct policy responses to address the evolving nature of this drug class.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2021)
Article
Clinical Neurology
L. Rocco, A. Pisera-Fuster, M. P. Faillace, R. Bernabeu
Summary: This study used a modified conditioned place preference paradigm to assess zebrafish's preference for nicotine and its association with environmental cues. The results showed that zebrafish's seeking behavior was closely related to the shades of compartment colors, and they spent more time in the environment associated with nicotine.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Lucia Martinez, Nunzia La Maida, Esther Papaseit, Clara Perez-Mana, Lourdes Poyatos, Manuela Pellegrini, Simona Pichini, Mireia Ventura, Liliana Galindo, Francesco Paolo Busardo, Magi Farre
Summary: Synthetic cannabinoids are a group of new psychoactive drugs with potential health risks. Different synthetic cannabinoids have been found to have different physiological and subjective effects on the body.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Substance Abuse
Thaisa Barros-Santos, Matheus Libarino-Santos, Alexia Anjos-Santos, Juliana F. Lins, Joao P. C. Leite, Roseliz C. Pacheco, Victor Nascimento-Rocha, Natali D. Kisaki, Eduardo K. Tamura, Alexandre J. Oliveira-Lima, Lais F. Berro, Ana Paula T. Uetanabaro, Jacques R. Nicoli, Eduardo A. Marinho
Summary: The study identified sex differences in the development of conditioned place preference (CPP) induced by intragastric alcohol administration in mice for the first time. Male mice were more sensitive to lower doses of alcohol for CPP induction compared to females, and there were significant differences in the potency and efficacy of alcohol between male and female mice. The findings suggest that the protocol used for administering alcohol and the doses differ between male and female Swiss mice, providing a more translational approach to studying alcohol reward effects in mice.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Chemistry, Medicinal
Joana Barbosa, Sandra Leal, Frederico C. Pereira, Ricardo Jorge Dinis-Oliveira, Juliana Faria
Summary: Tramadol and tapentadol, two commonly prescribed synthetic opioids, have unique pharmacological properties that optimize their analgesic effects and safety. However, both drugs have addiction and dependence potential. While studies have shown that tramadol can reinforce addictive behavior, no similar studies have been conducted on tapentadol. In this study, both opioids were found to have short-term reinforcing effects, but only tramadol caused long-term place preference retention and increased craving. This suggests that tapentadol may be less addictive than tramadol, despite its higher central nervous system activity and stricter scheduling.
Article
Chemistry, Medicinal
Yusuf S. Althobaiti
Summary: Quetiapine, an atypical antipsychotic, is effective in treating schizophrenia, depression, and anxiety. This study showed for the first time that quetiapine has abuse potential in an animal model, likely mediated by activating D1 receptors.
Article
Biochemical Research Methods
Krishna Chaturvedi, Caroline S. Anthony, Pankaj Pandey, Robert J. Doerksen, Murrell Godfrey
Summary: This study evaluated the interactions between the CB1 receptor and ligands from the JWH synthetic cannabinoid family, as well as newly designed JWH-like virtual compounds. The results revealed important structural characteristics that influenced the predicted CB1 binding affinity, including the carbonyl group and the length of the alkyl chain.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2024)
Correction
Toxicology
Young-Jung Kim, Shi-Xun Ma, Kwang-Hyun Hur, Youyoung Lee, Yong-Hyun Ko, Bo-Ram Lee, Seon-Kyung Kim, Su-Jeong Sung, Kyeong-Man Kim, Hyoung-Chun Kim, Seok-Yong Lee, Choon-Gon Jang
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kwang-Hyun Hur, Shi-Xun Ma, Bo-Ram Lee, Yong-Hyun Ko, Jee-Yeon Seo, Hye Won Ryu, Hye Jin Kim, Seolmin Yoon, Yong-Sup Lee, Seok-Yong Lee, Choon-Gon Jang
Summary: The recreational use of synthetic cannabinoids is on the rise, posing a threat to public health. Despite being falsely advertised as legal and safe, they have been reported to cause acute intoxication and addictive disorders. Due to the lack of scientific evidence, synthetic cannabinoids are weakly regulated and continue to circulate in illegal drug markets.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Kwang-Hyun Hur, Seong-Eon Kim, Shi-Xun Ma, Bo-Ram Lee, Yong-Hyun Ko, Jee-Yeon Seo, Seon-Kyung Kim, Young-Jung Kim, Su-Jeong Sung, Youyoung Lee, Young Hoon Jung, Yong-Sup Lee, Seok-Yong Lee, Choon-Gon Jang
Summary: The study demonstrates that methoxphenidine exhibits addictive and schizophrenia-like behaviors, inducing neurochemical changes in brain regions associated with these behaviors. These findings suggest that methoxphenidine could be utilized in developing animal disease models and calls for legal restrictions on its recreational use.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Young-Hoon Kim, Pureum Kang, Chang-Keun Cho, Eui Hyun Jung, Hye-Jeong Park, Yun Jeong Lee, Jung-Woo Bae, Choon-Gon Jang, Seok-Yong Lee
Summary: Celecoxib, a drug commonly used for arthritis and pain, is metabolized by CYP2C9 genetic polymorphism. A PBPK model was developed to predict the pharmacokinetics of Celecoxib based on different genotypes of subjects. The study shows the potential for personalized dosing of Celecoxib using genetic information and contributes to precision medicine.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Chemistry, Medicinal
Eun-Joo Shin, Ji Hoon Jeong, Yeonggwang Hwang, Naveen Sharma, Duy-Khanh Dang, Bao-Trong Nguyen, Seung-Yeol Nah, Choon-Gon Jang, Guoying Bing, Toshitaka Nabeshima, Hyoung-Chun Kim
Summary: Methamphetamine (MA) intoxication can cause neurological deficits similar to Parkinson's disease (PD), and anti-Parkinsonian medications have been shown to mitigate the motor impairments induced by MA. Various mechanisms such as mitochondrial dysfunction, oxidative stress, and neuroinflammation play important roles in MA neurotoxicity, sharing commonalities with PD pathogenesis. Rodent models of neurotoxic binge administration of MA have been suggested as a valid tool for studying the neuropathogenesis of PD.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Food Science & Technology
Naveen Sharma, Eun-Joo Shin, Duc Toan Pham, Garima Sharma, Duy-Khanh Dang, Chu Xuan Duong, Sang Won Kang, Seung-Yeol Nah, Choon-Gon Jang, Xin Gen Lei, Toshitaka Nabeshima, Guoying Bing, Ji Hoon Jeong, Hyoung-Chun Kim
Summary: Selenium-dependent glutathione peroxidase GPx-1 may play a protective role against methamphetamine-induced dopaminergic toxicity, and overexpression of GPx-1 can significantly mitigate dopaminergic toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Neurosciences
June Bryan de la Pena, Paulino Barragan-Iglesias, Tzu-Fang Lou, Nikesh Kunder, Sarah Loerch, Tarjani Shukla, Lokesh Basavarajappa, Jane Song, Dominique N. James, Salim Megat, Jamie K. Moy, Andi Wanghzou, Pradipta R. Ray, Kenneth Hoyt, Oswald Steward, Theodore J. Price, Jason Shepherd, Zachary T. Campbell
Summary: Studies have shown that activity-dependent protein Arc plays an important role in translational regulation in sensory neurons, potentially regulating neurogenic inflammation in the skin through intercellular signaling.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Chrislean Jun Botanas, Raly James Perez Custodio, Hee Jin Kim, June Bryan de la Pena, Leandro Val Sayson, Darlene Mae Ortiz, Mikyung Kim, Hyun Jun Lee, Srijan Acharya, Kyeong-Man Kim, Cheol Jung Lee, Jong Hoon Ryu, Yong Sup Lee, Jae Hoon Cheong
Summary: The study reveals that both S-MXE and R-MXE exhibit antidepressant effects in mice, possibly mediated via glutamatergic and serotonergic mechanisms. R-MXE induces fewer behavioral side effects compared to S-MXE, making it a safer antidepressant option.
Article
Chemistry, Medicinal
Nam-Tae Kim, Chang-Keun Cho, Pureum Kang, Hye-Jung Park, Yun Jeong Lee, Jung-Woo Bae, Choon-Gon Jang, Seok-Yong Lee
Summary: The CYP2C9*3 and *13 alleles significantly affect the pharmacokinetics of glipizide, resulting in elevated plasma concentrations of the drug. Individuals with the CYP2C9*3 and *13 genotypes show a significant increase in mean AUC(0-infinity) of glipizide compared to those with the wild-type CYP2C9*1/*1 genotype, while the effects of glipizide on plasma glucose and insulin levels are not significantly different among CYP2C9 genotype groups.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Plant Sciences
Bo-Ram Lee, Su-Jeong Sung, Kwang-Hyun Hur, Seong-Eon Kim, Shi-Xun Ma, Seon-Kyung Kim, Yong-Hyun Ko, Young-Jung Kim, Youyoung Lee, Seok-Yong Lee, Choon-Gon Jang
Summary: The study demonstrates that Korean Red Ginseng extract (RGE) has therapeutic potential to suppress METH-induced addictive behaviors by regulating dopaminergic and NMDAergic system.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Chemistry, Medicinal
Kwang-Hyun Hur, YouYoung Lee, Audrey Lynn Donio, Shi-Xun Ma, Bo-Ram Lee, Seon-Kyung Kim, Jae-Gyeong Lee, Young-Jung Kim, MinJeong Kim, SeolMin Yoon, SooYeun Lee, Yong-Sup Lee, Seok-Yong Lee, Choon-Gon Jang
Summary: In this study, we found that Mepirapim has addictive potential and induces addiction-related behaviors through neurochemical maladaptation in the brain. Furthermore, the pharmacological effects of Mepirapim are mainly mediated by cannabinoid receptor one.
Article
Neurosciences
Nikesh Kunder, June Bryan de la Pena, Tzu-Fang Lou, Rebecca Chase, Prarthana Suresh, Jennifer Lawson, Tarjani Shukla, Bryan Black, Zachary T. Campbell
Summary: In this study, the researchers found that HuR protein plays an important role in translation and local control of mRNA stability. It also reveals a new biological function for a broadly conserved post-transcriptional regulatory factor.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Seong Shoon Yoon, Bong Hyo Lee, Seong Ho Lee, Seong Hun Choi, Seon-Ju Jeong, Sang Chan Kim, Chae Ha Yang
Summary: The study found that isoflurane reduced cocaine- and nicotine-reinforced responses, but its effect was not selective for cocaine and nicotine.
PSYCHOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Chang-Keun Cho, Pureum Kang, Hye-Jung Park, Yun Jeong Lee, Jung-Woo Bae, Choon-Gon Jang, Seok-Yong Lee
Summary: The study aimed to develop and validate physiologically based pharmacokinetic (PBPK) model of tamsulosin in different CYP2D6 genotypes using Simcyp (R) simulator. Results showed that genetic polymorphism can affect the pharmacokinetics of tamsulosin.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Meeting Abstract
Clinical Neurology
June Bryan de la Pena, Paulino Barragan-Iglesias, Tzu-Fang Lou, Sarah Loerch, Nikesh Kunder, Tarjani Shukla, Lokesh Basavarajappa, Jane Song, Salim Megat, Jamie Moy, Andi Wanghzou, Pradipta Ray, Jason Shepherd, Kenneth Hoyt, Oswald Steward, Theodore Price