Article
Microbiology
Guoyun Wang, Cheng Lv, Cheng Liu, Wenjun Shen
Summary: This study identified the ratio of neutrophils to lymphocytes (NLR) as a potential biomarker for predicting susceptibility to symptomatic influenza. An elevated NLR was detected in susceptible hosts, who may have defects in B cell-mediated immunity or impaired function in cellular metabolism, cell cycle, or signal transduction.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Pauline Jacob, Julie Bonnefoy, Stephanie Ghislin, Jean-Pol Frippiat
Summary: This study evaluated the relevance of two easily-implemented biomarkers for monitoring immune system in astronauts and suggested using neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) to assess long-lasting immune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ebru Yuce
Summary: The role of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting spontaneous preterm birth was investigated. Retrospective data collected from hospital records between February 2018 and November 2022 showed that NLR and PLR values can predict preterm birth with high sensitivity and specificity. Predicting preterm birth allows for sensitive and smooth management of the pregnancy process.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Alice Nicoleta Dragoescu, Vlad Padureanu, Andreea Doriana Stanculescu, Cristiana Geormaneanu, Paul Tomescu, Rodica Padureanu, Vlad Florin Iovanescu, Bogdan Silviu Ungureanu, Andrei Panus, Octavian Petru Dragoescu
Summary: Neutrophil to lymphocyte ratio (NLR) is a good marker to predict the severity of sepsis, showing significant correlation with SOFA score and presepsin. NLR is less expensive and easier to perform, potentially becoming a good alternate option for evaluating sepsis severity.
Review
Oncology
Mate Naszai, Alina Kurjan, Timothy S. Maughan
Summary: Inflammation is closely related to cancer, and NLR from routine blood testing serves as an easily accessible prognostic biomarker, aiding in assessing clinical outcomes in colorectal cancer patients. Combining results from numerous studies, high NLR was found to be associated with poor clinical outcomes, despite limitations in some studies, it should be routinely collected in clinical trials.
Article
Environmental Sciences
Yu Meng, Kan Wang, Tuanwei Wang, Yuting Tu, Shiyang Gong, Yunxia Zhang, Guanghui Zhang, William Au, David C. Christiani, Zhao-lin Xia
Summary: The study systematically assessed the effects of occupational lead exposure on leukocyte ratios and genotoxicity, finding that lead exposure increased NLR and induced genotoxicity. Elevated NLR was positively associated with DNA damage, and % tail DNA mediated part of the effect of lead on increasing NLR, suggesting potential mechanistic involvement of inflammation in the elevation of NLR caused by lead exposure.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Oncology
Siheng Zhang, Chao Qiu, Hanzhi Yu, Yan Xu, Xiaoming Xu
Summary: The neutrophil to lymphocyte ratio (NLR) is an inflammatory biomarker that has been shown to be closely associated with tumor prognosis and treatment response in gastric cancer (GC) patients receiving immune checkpoint inhibitors (ICIs). This meta-analysis confirms that elevated NLR is significantly linked to worse overall survival (OS) in GC patients receiving ICIs, and lowering NLR can improve objective response rate (ORR).
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Kian Heshmat-Ghahdarijani, Vida Sarmadi, Afshin Heidari, Alireza Falahati Marvasti, Sina Neshat, Sina Raeisi
Summary: This article evaluates the prognostic potential of the neutrophil-to-lymphocyte ratio (NLR) in cancer. By reviewing recent studies, the association between NLR and various malignancies is identified. These findings contribute to a better understanding of the role of NLR in cancer prognosis and provide guidance for future research directions.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Sho Yasui, Tomoaki Takata, Yu Kamitani, Yukari Mae, Hiroki Kurumi, Yuichiro Ikebuchi, Akira Yoshida, Koichiro Kawaguchi, Kazuo Yashima, Hajime Isomoto
Summary: The study demonstrates an association between NLR and PLR with the histological diagnosis of gastric cancer, suggesting that NLR could be a useful marker for assessing early gastric cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Yasuyoshi Sato, Kenji Nakano, Xiaofei Wang, Naoki Fukuda, Tetsuya Urasaki, Akihiro Ohmoto, Naomi Hayashi, Mayu Yunokawa, Makiko Ono, Junichi Tomomatsu, Masanori Saito, Yusuke Minami, Keiko Hayakawa, Yuki Funauchi, Taisuke Tanizawa, Keisuke Ae, Seiichi Matsumoto, Shunji Takahashi
Summary: The second-line systematic therapy options for soft-tissue sarcoma (STS) have remained unchanged for decades, but challenges with molecular-targeted treatments led to the approval of pazopanib. This study investigated the use of the neutrophil-to-lymphocyte ratio (NLR) as a predictor for the efficacy and prognosis of pazopanib in STS patients. The findings suggest that baseline NLR may predict the efficacy and patient prognosis of pazopanib for STS.
Review
Endocrinology & Metabolism
Parisa Hashemi Moghanjoughi, Sina Neshat, Abbas Rezaei, Kiyan Heshmat-Ghahdarijani
Summary: This study demonstrates a relationship between neutrophil-to-lymphocyte ratio (NLR) and metabolic syndrome. NLR, as an inflammatory marker, is associated with obesity, diabetes, hypertension, and hyperlipidemia.
ENDOCRINE PRACTICE
(2022)
Review
Green & Sustainable Science & Technology
Tissa Wijeratne, Carmela Sales, Rohit Menon, Leila Karimi, Mihajlo Jakovljevic
Summary: Stroke is a major cause of adult disability and death worldwide, with the immune system playing a significant role in the pathobiological process. The neutrophil to lymphocyte ratio (NLR) has been identified as a potential biomarker with implications for diagnosis, prognosis, and therapy in acute ischemic stroke (AIS). Studies have shown that an inflammatory response involving excessive neutrophils and reduced lymphocytes is associated with worse outcomes during acute interventions and recovery trajectory in stroke, highlighting the importance of a systems biology-based approach in stroke care.
Article
Immunology
Ruilin Pan, Yaning Ren, Qingqing Li, Xuming Zhu, Jian Zhang, Yubao Cui, Hao Yin
Summary: This study evaluated the associations between neutrophil-lymphocyte ratio (NLR), NLR-alanine aminotransferase ratio (NAR), and NLR-albumin ratio (NBR) with the diagnosis of childhood asthma. The combination of NLR + NAR + NBR was found to distinguish asthmatic children with exacerbation from healthy children. Therefore, our results suggest that NLR + NAR + NBR could be used as a clinical biomarker for asthma in children.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Chao-Wei Lee, Sey-En Lin, Ming-Chin Yu, Hao-Wei Kou, Cheng-Han Lee, Tony Kuo, Kuan-Chieh Lee, Hsin- Tsai
Summary: This study demonstrated the predictive capability of combining NLR with AFP, CEA and uric acid in identifying CK19 expression in HCC patients preoperatively, suggesting a potential for improving diagnosis and treatment strategies for these patients. Further prospective, large-scale studies are needed to validate the findings.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Pinar Simsek-Onat, Hayriye Hizarcioglu-Gulsen, Yasin Maruf Ergen, Ersin Gumus, Hasan Ozen, Hulya Demir, Seza Ozen, Inci Nur Saltik-Temizel
Summary: This study found that neutrophil-to-lymphocyte ratio (NLR) values in pediatric inflammatory bowel disease (IBD) were significantly higher during diagnosis and active disease compared to the remission period. NLR can be used as a non-invasive inflammatory biomarker for initial evaluation and follow-up of disease activity in children with IBD.
DIGESTIVE DISEASES AND SCIENCES
(2023)
