The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events

Title
The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events
Authors
Keywords
gene-editing outcomes, euchromatin, heterochromatin, CRISPR-Cas9 nucleases, double-stranded DNA breaks, DNA repair pathways, homologous recombination, non-homologous end joining, donor DNA
Journal
Molecular Therapy-Nucleic Acids
Volume 16, Issue -, Pages 141-154
Publisher
Elsevier BV
Online
2019-02-20
DOI
10.1016/j.omtn.2019.02.009

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