Article
Biochemistry & Molecular Biology
Jae-Eun Lee, Jijeong Oh, Daeun Song, Mijeong Lee, Dongyup Hahn, Yong Chool Boo, Nam Joo Kang
Summary: Research has shown that RES, OXYRES, and their acetylated derivatives have enhanced stability and anti-aging effects in cosmetics, inhibiting oxidative discoloration and unpleasant odor. They work by suppressing H2O2-induced ROS levels and inhibiting skin aging through various cellular signaling pathways.
Article
Multidisciplinary Sciences
Amani Musa, Emanuel Wiman, Robert Selegard, Daniel Aili, Torbjoern Bengtsson, Hazem Khalaf
Summary: The study characterized the antimicrobial effects of PLNC8αβ on human keratinocytes infected with S. aureus, showing significant antimicrobial activity and modulation of inflammatory responses without affecting cell viability. PLNC8αβ may be developed as a therapeutic agent against Staphylococcus spp. infections.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Lara Camillo, Laura C. Gironi, Elisa Zavattaro, Elia Esposto, Paola Savoia
Summary: Nicotinamide (NAM) has protective effects against UV-induced oxidative stress and inflammation in skin cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Plant Sciences
Hui Sin Lim, Samson Eugin Simon, Yoon-Yen Yow, R. Saidur, Kuan Onn Tan
Summary: The methanolic extract of Lignosus rhinocerus (TM02-ME) has photoprotective effects on UVB-irradiated human keratinocytes, reducing DNA damage and cell death and up-regulating the expression of genes involved in DNA repair and skin barrier function. TM02-ME also increases the expression of pro-survival proteins, providing protection against UVB-induced cell death.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Mansheng Li, Xiao Li, Binghui Liu, Luye Lv, Wenjuan Wang, Dunqin Gao, Qiyu Zhang, Junyi Jiang, Mi Chai, Zhimin Yun, Yingxia Tan, Feng Gong, Zhihong Wu, Yunping Zhu, Jie Ma, Ling Leng
Summary: Skin aging is a complex physiological issue with ECM playing a crucial role, yet the understanding of it remains limited. Variations in ECM composition, expression, and function across different age groups impact skin development and aging processes. The insights gained from studying ECM characteristics provide valuable information for understanding skin aging mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Sheila Rocha, Sara Garcia Rates, Tumisang Moswete, Kristopher Kalleberg, Anna Villa, Jason P. Harcup, Susan A. Greenfield
Summary: T14 is a bioactive peptide derived from acetylcholinesterase (AChE) that enhances calcium influx in various cell types. It selectively binds to the alpha-7 receptor and can have both beneficial and toxic effects, depending on its activation. In this study, we found that T14 is present in human keratinocytes and its levels decrease with age, especially with chronic exposure to sunlight. This suggests that T14, known to promote cell growth and renewal in other parts of the body, also plays a role in skin and could be linked to degenerative diseases and epidermal cell profile.
Article
Medicine, Research & Experimental
Hye-Sun Lim, Kyeongno Yoon, Dong Hun Lee, Yong-Seok Lee, Jin Ho Chung, Gunhyuk Park
Summary: We have discovered that 20-hydroxyecdysone (20E), a steroid prohormone secreted by insects, can inhibit skin aging induced by UVB radiation. By inhibiting aldosterone synthase and reducing corticosterone levels, 20E reduces stress and protects against the decrease in collagen levels caused by UV radiation, making it a potential candidate for preventing skin aging.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Hwa Lee, Soo-Yong Kim, Sang Woo Lee, Sehan Kwak, Hulin Li, Renzhe Piao, Ho-Yong Park, Sangho Choi, Tae-Sook Jeong
Summary: This study is the first to demonstrate the anti-aging effects of Selaginella rossii (SR) on skin cells induced by UVB and oxidative stress. The 95% ethanol extract of SR contains a higher amount of amentoflavone (AMF) compared to other Selaginellaceae plants and is effective in inhibiting the expression of matrix metalloproteinase (MMP)-1. SR95E significantly decreases MMP expression and enhances collagen synthesis in fibroblasts and keratinocytes. Additionally, SR95E inhibits signaling pathways related to skin aging and regulates cellular senescence-related markers.
Article
Multidisciplinary Sciences
Jurandir Tomaz de Miranda, Fabiana de Andrade Bringel, Ana Paula Pereira Velosa, Veronica Protocevich, Sandra de Morais Fernezlian, Pedro Leme Silva, Vera Luiza Capelozzi, Monica Beatriz Mathor, Walcy Rosolia Teodoro
Summary: This study aimed to report the effects of different doses of ionizing radiation on the adherence of human skin grafts in Nude mice wounds. The results showed that ionizing radiation at 25 kGy improved the adherence of human skin grafts and promoted the inflammation and repair stage of wound healing.
Article
Plant Sciences
Sariya Mapoung, Sonthaya Umsumarng, Warathit Semmarath, Punnida Arjsri, Kamonwan Srisawad, Pilaiporn Thippraphan, Supachai Yodkeeree, Pornngarm Dejkriengkraikul
Summary: The study found that the hyperoside-enriched fraction from Houttuynia cordata has significant photoprotective effects against UVB-induced skin aging by inhibiting intracellular ROS production, inflammatory cytokine secretions, and promoting collagen synthesis. The active compounds identified in the H. cordata extract play a key role in regulating the MAPK signaling pathway to prevent UVB-induced skin aging. These findings suggest that H. cordata extract could be a potential ingredient in pharmaceutical or cosmetic formulations to combat skin aging.
Article
Environmental Sciences
Silvina Acosta, Lucia Canclini, Juan Jose Marizcurrena, Susana Castro-Sowinski, Paola Hernandez
Summary: The recombinant CPD-photolyase PhrAHym from the Antarctic bacterium shows a highly efficient repair effect on DNA lesions induced by UVC light in human keratinocytes. This non-cytotoxic enzyme repairs CPD-photoproducts and reduces the formation of gamma H2AX, suggesting its potential as a biotherapeutic agent against UV-induced skin cancer, photoaging, and related diseases.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian-Xiang Liu, Dao-Lei Cui, Dan-Lei Yang, Jing-Ya Li, Zi-Yue Yang, Jin-Zhou Su, Cai-Xia Ren, You-Ya Niu, Ping Xiang
Summary: Tris (1-chloro-2-propyl) phosphate (TCPP) is a commonly detected organophosphorus flame retardant in the environment. This study investigated the detrimental effects of TCPP on human skin keratinocytes and found that it decreased cell viability, induced reactive oxygen species generation and DNA damage, arrested the cell cycle at the G1 phase, and caused cellular senescence through the p53-dependent DNA damage signal pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Jeong-Yong Park, Ji Yeon Lee, YongGyeong Kim, Chang-Ho Kang
Summary: In this study, the photoprotective effects of different strains of lactic acid bacteria on UVB-exposed skin fibroblasts were evaluated. Four specific strains were found to have potential photoprotective properties by inhibiting MMPs, MAPK, and AP-1 protein expression, and enhancing collagen production while reducing inflammation.
Article
Microbiology
Ji Yeon Lee, Jeong-Yong Park, YongGyeong Kim, Chang-Ho Kang
Summary: Bifidobacterium animalis subsp. lactis MG741 has the potential to reduce wrinkles and skin thickness, and inhibit skin inflammation by modulating skin photoaging markers.
Article
Biochemistry & Molecular Biology
Yuri Lee, Mi Hee Shin, Min-Kyoung Kim, Yeon Kyung Kim, Hye Sun Shin, Dong Hun Lee, Jin Ho Chung
Summary: The study found that the expression of HDAC4 and HDAC11 is universally decreased in UV-irradiated and intrinsically aged skin, suggesting a universal role in increased histone acetylation associated with skin aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)