Journal
GENES
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/genes10070492
Keywords
gene expression; gene regulation; evolution; allele specific expression; expression quantitative trait loci (eQTL); RNAseq; ChIPseq; chromatin; Assay for Transposase-Accessible Chromatin using sequencing (ATACseq); genotype-phenotype map
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Funding
- Emmy Noether Programme of the Deutsche Forschungsgemeinschaft [PO 1648/3-1]
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Research in various fields of evolutionary biology has shown that divergence in gene expression is a key driver for phenotypic evolution. An exceptional contribution of cis-regulatory divergence has been found to contribute to morphological diversification. In the light of these findings, the analysis of genome-wide expression data has become one of the central tools to link genotype and phenotype information on a more mechanistic level. However, in many studies, especially if general conclusions are drawn from such data, a key feature of gene regulation is often neglected. With our article, we want to raise awareness that gene regulation and thus gene expression is highly context dependent. Genes show tissue- and stage-specific expression. We argue that the regulatory context must be considered in comparative expression studies.
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