Lysosomal P-gp-MDR1 Confers Drug Resistance of Brentuximab Vedotin and Its Cytotoxic Payload Monomethyl Auristatin E in Tumor Cells

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance

(2016) Nicole Seebacher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury

(2016) Xi Qiu et al.   MOLECULAR PHARMACEUTICS

Antibody-drug conjugates as novel anti-cancer chemotherapeutics

(2015) C. Peters et al.   BIOSCIENCE REPORTS

SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm

(2015) K. J. Hamblett et al.   CANCER RESEARCH

Antibody-targeted drugs and drug resistance—Challenges and solutions

(2015) LeeRon Shefet-Carasso et al.   DRUG RESISTANCE UPDATES

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter

(2015) Nicole A. Seebacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of Improved Lysomotropic Autophagy Inhibitors

(2015) Tong Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tumor Cells Chronically Treated with a Trastuzumab-Maytansinoid Antibody-Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments

(2015) F. Loganzo et al.   MOLECULAR CANCER THERAPEUTICS

Expression of MDR1 and MDR3 gene products in paclitaxel-, doxorubicin- and vincristine-resistant cell lines

(2013) Radosław Januchowski et al.   BIOMEDICINE & PHARMACOTHERAPY

A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies

(2013) J. Deckert et al.   BLOOD

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration

(2013) Tetsuo Yamagishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gemtuzumab Ozogamicin

(2013) Donna Przepiorka et al.   JOURNAL OF CLINICAL ONCOLOGY

Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes

(2013) Xi Qiu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Target-mediated drug disposition model and its approximations for antibody–drug conjugates

(2013) Leonid Gibiansky et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino Acid Homeostasis

(2012) B. Liu et al.   SCIENCE

Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance

(2010) Y. V. Kovtun et al.   CANCER RESEARCH

Evaluation of the therapeutic efficacy of a VEGFR2-blocking antibody using sodium-iodide symporter molecular imaging in a tumor xenograft model

(2010) Su-Jin Cheong et al.   NUCLEAR MEDICINE AND BIOLOGY

Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development

(2008) Shu-Feng Zhou et al.   CURRENT MEDICINAL CHEMISTRY