Journal
BIOLOGY OF SEX DIFFERENCES
Volume 10, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13293-019-0246-6
Keywords
Sex differences; Sex hormones; Obesity; Diabetes; Hypertension; Endothelial function; Aging
Categories
Funding
- NIH [1R01HL130301-01, 5F32HL136191-02]
Ask authors/readers for more resources
It is well documented that the metabolic syndrome predisposes patients to increased cardiovascular risk. Emerging data indicates that cardiovascular risk conferred by metabolic syndrome is highly dependent on sex and sex hormone status throughout the lifetime. Both male and female sex hormones, as well as sex chromosomes themselves, contribute to the development of obesity and intervene in the control of insulin homeostasis and blood pressure. Furthermore, men and women develop age-associated cardiometabolic risk in a sex-specific fashion in association with changes in these sex hormonal levels. Therefore, the current notion of the metabolic syndrome as a sex-independent diagnosis is antiquated, and novel studies and clinical trials utilizing these known sex differences in the development of metabolic dysregulation and cardiometabolic risk are warranted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available