Article
Pediatrics
Shetal Shah, Emily Miller, Allison Rose, Krystle Perez
Summary: Pasteurized donor human milk (PDHM) has been shown to reduce the incidence of necrotizing enterocolitis in very low birth weight infants. However, lack of Medicaid and private insurance coverage for PDHM use in neonatal intensive care units leads to disparities based on birth state and socioeconomic status. Through collaboration between local and national American Academy of Pediatrics (AAP) chapters, a PDHM Advocacy Toolkit was created to promote Medicaid coverage. Over 5 years, advocacy efforts led by neonatologists and incentivized by AAP funds resulted in 5 additional states providing Medicaid payment for PDHM, increasing the coverage to over 55% of nationally born very low birth weight infants. This case study provides a template for other pediatric specialists to advocate for niche-focused issues at the state level.
Review
Pediatrics
Erin Grace, Cathie Hilditch, Judith Gomersall, Carmel T. Collins, Alice Rumbold, Amy K. Keir
Summary: The study found that using human milk-based fortifiers reduced the risk of necrotising enterocolitis compared to cow's milk-based fortifiers. However, there was no clear evidence of an effect on late-onset sepsis or other outcomes. The overall quality of evidence was considered to be low due to imprecision and lack of blinding in one study.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Review
Nutrition & Dietetics
Jogender Kumar, Jitendra Meena, Ankit Ranjan, Praveen Kumar
Summary: This systematic review examined the effect of oropharyngeal application of colostrum or mother's own milk on preterm infants, and found that it can reduce the risk of infection and necrotizing enterocolitis, and has benefits in early feeding.
Article
Nutrition & Dietetics
Marwyn Sowden, Mirjam Maria van Weissenbruch, Andre Nyandwe Hamama Bulabula, Lizelle van Wyk, Jos Twisk, Evette van Niekerk
Summary: The study found that a multi-strain probiotic formulation is effective in preventing necrotizing enterocolitis and feeding intolerances in premature neonates. This research is of great importance in exploring treatment methods for preventing intestinal diseases in premature infants.
Article
Obstetrics & Gynecology
Gregory Valentine, Steven Ford, Joseph Hagan, Heeju Yang, Jeffery Chen, Nancy Hurst, Kjersti Aagaard, Amy Hair
Summary: The study suggests that promoting mother's own milk consumption in the first 2-4 weeks is crucial for achieving exclusive mother's own milk feeding at discharge, with minimal impact of increasing mother's own milk consumption after 28 days.
JOURNAL OF PERINATOLOGY
(2021)
Article
Medicine, Research & Experimental
D. Mallardi, C. Tabasso, P. Piemontese, S. Morandi, T. Silvetti, F. Biscarini, P. Cremonesi, B. Castiglioni, V Pica, M. Stuknyte, I De Noni, O. Amato, N. Liotto, F. Mosca, P. Roggero
Summary: The study showed that inoculating PDHM with mother's own milk could restore bacterial growth and personalize the human milk microbiome in PDHM. This personalized effect is beneficial due to the presence of maternal probiotic bacteria in the milk, making PDHM more similar to the mother's own milk.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Pediatrics
Natalie A. Strobel, Claire Adams, Daniel R. McAullay, Karen M. Edmond
Summary: In preterm and low birth weight infants, feeding with infant formula compared with mother's own milk has little effect on mortality, infection, growth, or neurodevelopment, but increases the risk of developing necrotizing enterocolitis.
Article
Pediatrics
Shan He, Gang Liu, Xueping Zhu
Summary: This study demonstrates the beneficial effects of human breast milk-derived exosomes in preventing necrotizing enterocolitis by reducing inflammation and injury, and restoring intestinal tight-junction proteins.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
K. C. Sudeep, Jogender Kumar, Somosri Ray, Sourabh Dutta, Ritu Aggarwal, Praveen Kumar
Summary: Oral application of mother's own milk (OMOM) can reduce the incidence of late-onset sepsis in preterm infants, especially those born at 29-30 weeks gestation, without adverse effects.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Xiaoyun Xiong, Yanqiong Wang, Xueyu Chen, Bingchun Lin, Yanzhu Zhuang, Li Luo, Huiyan Wang, Chuanzhong Yang
Summary: This study explores the influence of different proportions of human milk (HM) on the risk of necrotizing enterocolitis (NEC). The results show that a low ratio of HM significantly increases the risk of NEC in infants with very low birth weight (VLBW).
BREASTFEEDING MEDICINE
(2023)
Review
Pediatrics
Anitha Ananthan, Haribalakrishna Balasubramanian, Diwakar Mohan, Shripada Rao, Sanjay Patole
Summary: The study found that early prophylactic EPO can reduce the risk of NEC in preterm neonates, especially definite NEC. However, the results for definite NEC were no longer significant in some sensitivity analyses.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Roberta Vitali, Gianluca Terrin, Francesca Palone, Ilaria Laudadio, Salvatore Cucchiara, Giovanni Boscarino, Maria Di Chiara, Laura Stronati
Summary: This study demonstrated that fecal HMGB1 could be a reliable marker for early identification of necrotizing enterocolitis (NEC) risk in preterm neonates. Further investigation and studies are needed to evaluate the diagnostic accuracy of this marker in managing preterm newborns at risk of NEC, especially in more severe forms of the disease.
FRONTIERS IN PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Nadine Scholten, Alicia Fitzgerald, Katja Matthias, Mi-Ran Okumu, Tim Ohnhaeuser, Katharina Schmitz, Christine Schreiner, Isabella Schwab, Anna Stirner, Ricarda Wullenkord, Till Dresbach, Andreas Mueller, Till Dresbach, Martin Hellmich, Nicole Ernstmann, Antje Hammer, Friederike Eyssel, Angela Kribs, Juliane Koeberlein-Neu, Katharina Lugani, Eva Mildenberger, Jens Ulrich Rueffer, Katja Matthias, Anne Sunder-Plassmann, Daniel Wiesen, Dirk Horenkamp-Sonntag, Melanie Klein
Summary: Mother's own milk is the optimal nutrition for newborns, especially preterm infants with very low birth weight. If unavailable, human donor milk is the preferred alternative. Providing structured breastfeeding and lactation support, as well as promoting the establishment of human donor milk banks, is crucial for mothers of preterm infants who often struggle with insufficient milk production.
Review
Pediatrics
Jogender Kumar, Jitendra Meena, Piyush Mittal, Jeeva Shankar, Praveen Kumar, Arvind Shenoi
Summary: Avoiding routine prefeed gastric residue aspiration in preterm infants led to earlier achievement of full enteral feeds, shorter duration of hospitalization, and lower incidence of late-onset sepsis. However, there was no significant difference in other outcomes such as time to regain birth weight and all-cause mortality between the two groups.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Food Science & Technology
Wenjuan Chen, Xiaohui Chen, Yun Qian, Xingyun Wang, Yahui Zhou, Xiangyun Yan, Boshi Yu, Shuwen Yao, Zhangbin Yu, Jingai Zhu, Shuping Han
Summary: The study reveals the complexity of lipid expression profiles in exosomes derived from preterm and term human milk. The top 50 lipids identified in the exosomes regulate intestinal epithelial cell function via the ERK/MAPK pathway, providing novel mechanistic insight on how human milk prevents the development of necrotizing enterocolitis (NEC).
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Nursing
Jessica A. Davis, Kelley Baumgartel, Michael J. Morowitz, Vivianna Giangrasso, Jill R. Demirci
JOURNAL OF HUMAN LACTATION
(2020)
Article
Nursing
Jessica A. Davis, Melissa Glasser, Diane L. Spatz, Paul Scott, Jill R. Demirci
Summary: This study aimed to evaluate the relationship between early exclusive birth/lactating parent's own milk (B/LPOM) feeds and cumulative B/LPOM patterns during surgical infants' neonatal intensive care unit (NICU) hospitalization. The study found that infants who received B/LPOM feeds early had a higher percentage of B/LPOM feeds throughout their NICU stay and at NICU discharge.
ADVANCES IN NEONATAL CARE
(2022)
Article
Nursing
Jessica A. Davis, Melissa Glasser, Michele Clemens, Barbara Eichhorn, Kalyani Vats, Jill R. Demirci
Summary: This study explores the potential of antenatal milk expression as a lactation support intervention for parents of surgical infants and highlights the need for further research in this area.
JOURNAL OF PERINATAL & NEONATAL NURSING
(2022)