Article
Biochemistry & Molecular Biology
Vojtech Pavlik, Lubos Sobotka, Jaroslav Pejchal, Martin Cepa, Kristina Nesporova, Monika Arenbergerova, Adela Mrozkova, Vladimir Velebny
Summary: The study compared the healing of chronic wounds treated with a standard silver dressing and a dressing containing octenidine antiseptic, finding that the octenidine dressing promoted wound healing, reduced wound slough, and observed direct effects of silver on wound cells during treatment.
Article
Endocrinology & Metabolism
Nicole Lafontaine, Jane Jolley, Mervyn Kyi, Sophie King, Laura Iacobaccio, Eva Staunton, Brent Wilson, Catherine Seymour, Sonja Rogasch, Paul Wraight
Summary: This study aimed to assess whether silver dressings in acute diabetes-related foot ulcers increased the proportion of ulcers healed. The results showed that silver dressings did not improve wound healing or reduce the need for antibiotics compared with non-silver dressings.
Article
Medicine, General & Internal
Yen-Hsi Lin, Yen-Chin Chen, Kuo-Sheng Cheng, Po-Jui Yu, Jiun-Ling Wang, Nai-Ying Ko
Summary: This study found a positive correlation between higher periwound temperatures and better wound healing, as well as a link between higher malnutrition scores and poor wound healing. Multivariate analysis showed that changes in periwound temperature can be a useful indicator for predicting pressure ulcer healing outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Huda S. AlSalem, Abeer Abdulaziz H. Bukhari
Summary: Three biodegradable wound dressings were successfully prepared using freeze drying technique. The dressings were based on binary Collagen (COL), Hyaluronic acid (HA) crosslinked and loaded with silver nanoparticles (AgNPs), Gentamicin (GENT), or AgNPs/GENT. The dressings showed physically interaction between polymer network and the loaded antibiotic, superior swelling properties, and rapid degradation. They exhibited antibacterial activity against G+, G-, yeast, and fungi. Cytotoxicity and wound healing evaluations showed superior results for all dressings except the one mixed with AgNPs and Gentamicin. The results recommended individually loaded COL/HA with either AgNPs or Gentamicin as antibacterial and wound healing dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Salim Ullah, Zahid Hussain, Ismat Ullah, Li Wang, Shah Mehmood, Yuanshan Liu, Mojtaba Mansoorianfar, Xingzhu Liu, Fanshu Ma, Renjun Pei
Summary: Diabetes wounds are difficult to heal due to various factors such as inflammation, decreased blood vessel growth, infection, and oxidative stress. In this study, insulin-loaded and silver-coated mesoporous polydopamine nanoparticles were synthesized and used to create a fibrous hydrogel for wound healing. The nanoparticle-reinforced hydrogel showed excellent properties such as antibacterial and antioxidant effects, good swelling capacity, and mechanical stability. It also promoted angiogenesis, reduced inflammation, increased collagen deposition, and accelerated wound repair in diabetic mice. This research suggests that the designed fibrous hydrogel could be a promising candidate for diabetic wound treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Kummara Madhusudana Rao, Eunbi Kim, Hyeon Jin Kim, Uluvangada Thammaiah Uthappa, Sung Soo Han
Summary: A water-soluble hyaluronic acid-quercetin (HA-Q) pendant drug conjugate was synthesized and evaluated for its potential wound-healing properties. The conjugation was confirmed using FTIR, UV-Vis, and NMR spectroscopy techniques. HA-Q showed good biocompatibility, supported cell growth and migration, and exhibited improved radical scavenging capacity compared to quercetin alone. These results confirm the potential role of HA-Q in wound healing applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Min Wang, Juanjuan Hu, Yangcen Ou, Xueling He, Yanjun Wang, Chenyu Zou, Yanlin Jiang, Feng Luo, Dan Lu, Zhen Li, Jiehua Li, Hong Tan
Summary: There is an urgent need for wound dressings that can promote quick hemostasis and efficient wound healing in response to increasing clinical demands. This study presents a versatile method for constructing biodegradable hybrid cryogels that can rapidly stop bleeding. The cryogel's specific macroporous structure allows for stable fixation and quick swelling, making it ideal for minimally invasive surgery. Furthermore, the cryogel exhibits excellent biocompatibility and activates the endogenous coagulation system, leading to fast blood coagulation. In in vivo evaluations, the cryogel demonstrated great potential in promoting wound healing, reducing immune inflammation, and inducing angiogenesis and hair follicle regeneration. These findings highlight the high-performance capabilities of the cryogel as a wound dressing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Multidisciplinary
Qiusheng Wang, Shuiqing Zhou, Lu Wang, Renchuan You, Shuqin Yan, Qiang Zhang, Mingzhong Li
Summary: This study presents a novel bioactive scaffold designed with biomimetic technology by mimicking the chemical components and biophysical nanostructures of extracellular matrix. The scaffold showed better cytocompatibility to support cell spread, proliferation and differentiation. In vivo experiments demonstrated that the scaffold with nanofibers as a template not only accelerated wound healing but also regulated collagen arrangement to inhibit scar formation.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Carolini Mendes, Anand Thirupathi, Rubya Pereira Zaccaron, Maria Eduarda Anastacio Borges Correa, Joao V. S. Bittencourt, Laura de Roch Casagrande, Anadhelly C. S. de Lima, Lara L. de Oliveira, Thiago A. M. de Andrade, Yaodong Gu, Paulo Emilio Feuser, Ricardo A. Machado-de-Avila, Paulo Cesar Lock Silveira
Summary: This study aimed to investigate the effects of iontophoresis and hyaluronic acid (HA) combined with a gold nanoparticle (GNP) solution in an excisional wound model. The results demonstrate that the combination therapy group showed better results in anti-inflammation and tissue repair process compared to the single therapy group.
Article
Engineering, Biomedical
Yihao Liu, Haoyi Niu, Chengwei Wang, Xiaoxiao Yang, Wentao Li, Yuxin Zhang, Xiaojun Ma, Yuanjing Xu, Pengfei Zheng, Jinwu Wang, Kerong Dai
Summary: This study developed a new hydrogel material with biocompatibility, easy degradation, and wound healing properties using physical electrostatic cross-linking and freeze-drying. The material showed excellent antibacterial and pro-coagulation abilities, promoting hemostasis and reducing blood loss in both in vitro and in vivo experiments. Additionally, it exhibited superior cytocompatibility and biodegradability. Therefore, this material has great potential for clinical application as a hemostatic and wound healing material.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Zijian Wang, Wenjie You, Wang Wang, Weiqun Tian, Fangjin Chen, Yu Xiao, Yun Chen, Xinghuan Wang
Summary: This study successfully improved wound healing effects through a novel nanofiber material, which exhibited multifunctional properties and showed promising results in experimental animal models.
ADVANCED FIBER MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Ebrahim Astaneh, Narges Fereydouni
Summary: Diabetic wounds pose a significant clinical challenge due to impaired healing and increased risk of complications. Nanofiber-based wound dressings, particularly those containing hyaluronic acid, show promise in promoting wound healing by enhancing skin hydration, controlling inflammation, and facilitating revascularization. However, challenges and limitations, such as reproducibility and proper characterization, exist in the field of nanofiber technology. Future directions involve addressing these issues and optimizing nanofiber formulations for improved efficacy in diabetic wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Marcel Nani Leite, Marco Andrey Cipriani Frade
Summary: This study evaluated the efficacy of 0.2% hyaluronic acid in enhancing the healing of skin abrasions in rats, showing that the hyaluronic acid group had better re-epithelialization and thinner crust compared to other groups. There were also differences in myeloperoxidase enzyme levels among the groups.
Article
Pharmacology & Pharmacy
Lisa Marinelli, Ivana Cacciatore, Erica Costantini, Marilisa Pia Dimmito, Federica Serra, Antonio Di Stefano, Marcella Reale
Summary: In this study, the application of water-soluble carvacrol prodrugs (WSCPs) and hyaluronic acid (HA) was investigated to improve wound healing and regulate the inflammatory response. The results showed that WSCPs/HA formulations significantly increased the wound closure rate and modulated the expression of reparative and inflammatory mediators.
Article
Dentistry, Oral Surgery & Medicine
Jeong Hyun Lee, Ko Eun Lee, Sang Wook Kang, Seung Hwan Park, Yong Kwon Chae, Myoung-Han Lee, Dong-Keun Kweon, Sung Chul Choi, Ok Hyung Nam
Summary: The objective of this study was to evaluate the healing effect of hyaluronic acid films on palatal wounds. The results showed that hyaluronic acid films outperformed gels in terms of palatal wound healing in both rat and human models. Therefore, hyaluronic acid films have potential for the treatment of palatal wounds.