Interaction Between Staphylococcal Biofilm and Bone: How Does the Presence of Biofilm Promote Prosthesis Loosening?

Virulence factors produced by Staphylococcus aureus biofilms have a moonlighting function contributing to biofilm integrity

(2019) Alexander C Graf et al.   MOLECULAR & CELLULAR PROTEOMICS

Staphylococcus aureus Biofilm-Conditioned Medium Impairs Macrophage-Mediated Antibiofilm Immune Response by Upregulating KLF2 Expression

(2019) Talib Alboslemy et al.   INFECTION AND IMMUNITY

Role of Phenol-Soluble Modulins in Staphylococcus epidermidis Biofilm Formation and Infection of Indwelling Medical Devices

(2019) Katherine Y. Le et al.   JOURNAL OF MOLECULAR BIOLOGY

Resistance to leukocytes ties benefits of quorum sensing dysfunctionality to biofilm infection

(2019) Lei He et al.   Nature Microbiology

Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection: a prospective cohort study

(2018) C. Triffault-Fillit et al.   CLINICAL MICROBIOLOGY AND INFECTION

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Staphylococcus aureusbiofilms release leukocidins to elicit extracellular trap formation and evade neutrophil-mediated killing

(2018) Mohini Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad impact of extracellular DNA on biofilm formation by clinically isolated Methicillin-resistant and -sensitive strains of Staphylococcus aureus

(2018) Shinya Sugimoto et al.   Scientific Reports

Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?

(2018) G. Bori et al.   Biomed Research International

Survival of Staphylococcus epidermidis in Fibroblasts and Osteoblasts

(2018) Kimberly Perez et al.   INFECTION AND IMMUNITY

Heterogeneity of Ly6G+Ly6C+ myeloid-derived suppressor cell (MDSC) infiltrates during S. aureus biofilm infection

(2018) Cortney E. Heim et al.   INFECTION AND IMMUNITY

Phagocytosis of Staphylococci Biofilms by Polymorphonuclear Neutrophils: S. aureus and S. epidermidis Differ with Regard to Their Susceptibility Towards the Host Defense

(2018) Frank Guenther et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Destruction of Bacterial Biofilms by Polymorphonuclear Neutrophils: Relative contribution of Phagocytosis, DNA Release, and Degranulation

(2018) Eva Meyle et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Projected Volume of Primary Total Joint Arthroplasty in the U.S., 2014 to 2030

(2018) Matthew Sloan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Bone Environment Influences Irreversible Adhesion of a Methicillin-Susceptible Staphylococcus aureus Strain

(2018) Fany Reffuveille et al.   Frontiers in Microbiology

Do amyloid structures formed by Staphylococcus aureus phenol-soluble modulins have a biological function?

(2017) Yue Zheng et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis

(2017) Karen L de Mesy Bentley et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Staphylococcal protein A promotes osteoclastogenesis through MAPK signaling during bone infection

(2017) Yuan Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

IL-10 Plays Opposing Roles duringStaphylococcus aureusSystemic and Localized Infections

(2017) John M. Leech et al.   JOURNAL OF IMMUNOLOGY

Human prosthetic joint infections are associated with myeloid-derived suppressor cells (MDSCs): Implications for infection persistence

(2017) Cortney E. Heim et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Staphylococcus aureus Protein A induces osteoclastogenesis via the NF-κB signaling pathway

(2017) Li-Rong Ren et al.   Molecular Medicine Reports

Staphylococcus aureus biofilm elicits the expansion, activation and polarization of myeloid-derived suppressor cells in vivo and in vitro

(2017) Kuo-Ti Peng et al.   PLoS One

Osteoblast Differentiation and Bone Matrix Formation In Vivo and In Vitro

(2017) Harry C. Blair et al.   TISSUE ENGINEERING PART B-REVIEWS

Osteomacs and Bone Regeneration

(2017) Lena Batoon et al.   Current Osteoporosis Reports

Polymorphonuclear Neutrophils in Osteomyelitis: Link to Osteoclast Generation and Bone Resorption

(2017) M.M. Gaida et al.   European Journal of Inflammation

Bad to the Bone: On In Vitro and Ex Vivo Microbial Biofilm Ability to Directly Destroy Colonized Bone Surfaces without Participation of Host Immunity or Osteoclastogenesis

(2017) Adam Junka et al.   PLoS One

Staphylococcus lugdunensis : a virulent pathogen causing bone and joint infections

(2016) N. Douiri et al.   CLINICAL MICROBIOLOGY AND INFECTION

Poly-N-Acetylglucosamine Production by Staphylococcus epidermidis Cells Increases TheirIn VivoProinflammatory Effect

(2016) Pedro Ferreirinha et al.   INFECTION AND IMMUNITY

Cyclic di-AMP Released from Staphylococcus aureus Biofilm Induces a Macrophage Type I Interferon Response

(2016) Casey M. Gries et al.   INFECTION AND IMMUNITY

Staphylococcus lugdunensis, a serious pathogen in periprosthetic joint infections: comparison to Staphylococcus aureus and Staphylococcus epidermidis

(2016) J. Lourtet-Hascoët et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Innate Immune Response in Implant-Associated Infections: Neutrophils against Biofilms

(2016) Ulrike Dapunt et al.   Materials

Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?

(2016) Elaine M. Waters et al.   PLoS Pathogens

Pathophysiological Mechanisms of Staphylococcus Non-aureus Bone and Joint Infection: Interspecies Homogeneity and Specific Behavior of S. pseudintermedius

(2016) Yousef Maali et al.   Frontiers in Microbiology

Activation of phagocytic cells byStaphylococcus epidermidisbiofilms: effects of extracellular matrix proteins and the bacterial stress protein GroEL on netosis and MRP-14 release

(2016) Ulrike Dapunt et al.   Pathogens and Disease

Human Monocyte-Derived Osteoclasts Are Targeted by Staphylococcal Pore-Forming Toxins and Superantigens

(2016) Sacha Flammier et al.   PLoS One

Staphylococcal Persistence Due to Biofilm Formation in Synovial Fluid Containing Prophylactic Cefazolin

(2015) Sana S. Dastgheyb et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Important Contribution of the Novel LocuscomEBto Extracellular DNA-Dependent Staphylococcus lugdunensis Biofilm Formation

(2015) Nithya Babu Rajendran et al.   INFECTION AND IMMUNITY

The adhesive properties of the Staphylococcus lugdunensis multifunctional autolysin AtlL and its role in biofilm formation and internalization

(2015) Muzaffar Hussain et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

An Electrostatic Net Model for the Role of Extracellular DNA in Biofilm Formation by Staphylococcus aureus

(2015) Vanina Dengler et al.   JOURNAL OF BACTERIOLOGY

Orthopedic implant infections: Incompetence of Staphylococcus epidermidis , Staphylococcus lugdunensis , and Enterococcus faecalis to invade osteoblasts

(2015) Davide Campoccia et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

IL-12 Promotes Myeloid-Derived Suppressor Cell Recruitment and Bacterial Persistence duringStaphylococcus aureusOrthopedic Implant Infection

(2015) Cortney E. Heim et al.   JOURNAL OF IMMUNOLOGY

An Essential Role for Coagulase inStaphylococcus aureusBiofilm Development Reveals New Therapeutic Possibilities for Device-Related Infections

(2015) Marta Zapotoczna et al.   JOURNAL OF INFECTIOUS DISEASES

Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation

(2015) U. Dapunt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-10 production by myeloid-derived suppressor cells contributes to bacterial persistence during Staphylococcus aureus orthopedic biofilm infection

(2015) Cortney E. Heim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Staphylococcal manipulation of host immune responses

(2015) Vilasack Thammavongsa et al.   NATURE REVIEWS MICROBIOLOGY

Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin

(2015) Tyler D. Scherr et al.   mBio

Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis

(2015) Jérôme Josse et al.   Frontiers in Cellular and Infection Microbiology

The Foreign Body Giant Cell Cannot Resorb Bone, But Dissolves Hydroxyapatite Like Osteoclasts

(2015) Bas ten Harkel et al.   PLoS One

Foreign Body Reaction to Biomaterials: On Mechanisms for Buildup and Breakdown of Osseointegration

(2014) Ricardo Trindade et al.   Clinical Implant Dentistry and Related Research

Coagulase-Negative Staphylococci

(2014) Karsten Becker et al.   CLINICAL MICROBIOLOGY REVIEWS

Myeloid-Derived Suppressor Cells Contribute to Staphylococcus aureus Orthopedic Biofilm Infection

(2014) C. E. Heim et al.   JOURNAL OF IMMUNOLOGY

A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression duringStaphylococcus aureusInfection

(2014) Christina Tebartz et al.   JOURNAL OF IMMUNOLOGY

Dual Impact of Live Staphylococcus aureus on the Osteoclast Lineage, Leading to Increased Bone Resorption

(2014) Sophie Trouillet-Assant et al.   JOURNAL OF INFECTIOUS DISEASES

The Macrophage Inflammatory Proteins MIP1α(CCL3) and MIP2α(CXCL2) in Implant-Associated Osteomyelitis: Linking Inflammation to Bone Degradation

(2014) Ulrike Dapunt et al.   MEDIATORS OF INFLAMMATION

Alternative pathways of osteoclastogenesis in inflammatory arthritis

(2014) Iannis E. Adamopoulos et al.   Nature Reviews Rheumatology

The Extracellular Matrix of Staphylococcus aureus Biofilms Comprises Cytoplasmic Proteins That Associate with the Cell Surface in Response to Decreasing pH

(2014) L. Foulston et al.   mBio

Staphylococcus aureus Small Colony Variants (SCVs): a road map for the metabolic pathways involved in persistent infections

(2014) Richard A. Proctor et al.   Frontiers in Cellular and Infection Microbiology

Neutrophil-Derived Cytokines: Facts Beyond Expression

(2014) Cristina Tecchio et al.   Frontiers in Immunology

Staphylococcus aureus biofilms decrease osteoblast viability, inhibits osteogenic differentiation, and increases bone resorption in vitro

(2013) Carlos J Sanchez et al.   BMC MUSCULOSKELETAL DISORDERS

Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation

(2013) Jiseon Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Staphylococcus epidermidis in Orthopedic Device Infections: The Role of Bacterial Internalization in Human Osteoblasts and Biofilm Formation

(2013) Florent Valour et al.   PLoS One

Combination of Tumor Necrosis Factor α and Interleukin-6 Induces Mouse Osteoclast-like Cells With Bone Resorption Activity Both In Vitro and In Vivo

(2013) Kazuhiro Yokota et al.   Arthritis & Rheumatology

An extracellular Staphylococcus epidermidis polysaccharide: relation to Polysaccharide Intercellular Adhesin and its implication in phagocytosis

(2012) Anastasia I Spiliopoulou et al.   BMC MICROBIOLOGY

Human polymorphonuclear neutrophils express RANK and are activated by its ligand, RANKL

(2012) Alexander Riegel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Bacterial adhesion, intracellular survival and cytokine induction upon stimulation of mononuclear cells with planktonic or biofilm phase Staphylococcus epidermidis

(2012) Anastasia I. Spiliopoulou et al.   FEMS MICROBIOLOGY LETTERS

Immune Defense against S. Epidermidis Biofilms: Components of the Extracellular Polymeric Substance Activate Distinct Bactericidal Mechanisms of Phagocytic Cells

(2012) Eva Meyle et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection

(2012) T. Claro et al.   MICROBIOLOGY-SGM

sarAnegatively regulatesStaphylococcus epidermidisbiofilm formation by modulating expression of 1 MDa extracellular matrix binding protein and autolysis-dependent release of eDNA

(2012) Martin Christner et al.   MOLECULAR MICROBIOLOGY

MyD88-Dependent Signaling Influences Fibrosis and Alternative Macrophage Activation during Staphylococcus aureus Biofilm Infection

(2012) Mark L. Hanke et al.   PLoS One

How Staphylococcus aureus biofilms develop their characteristic structure

(2012) S. Periasamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Amyloids Composed of Phenol Soluble Modulins Stabilize Staphylococcus aureus Biofilms

(2012) Kelly Schwartz et al.   PLoS Pathogens

New Definition for Periprosthetic Joint Infection: From the Workgroup of the Musculoskeletal Infection Society

(2011) Javad Parvizi et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Murine Immune Response to a ChronicStaphylococcus aureusBiofilm Infection

(2011) Ranjani Prabhakara et al.   INFECTION AND IMMUNITY

Suppression of the Inflammatory Immune Response Prevents the Development of Chronic Biofilm Infection Due to Methicillin-Resistant Staphylococcus aureus

(2011) Ranjani Prabhakara et al.   INFECTION AND IMMUNITY

Staphylococcus epidermidis Uses Distinct Mechanisms of Biofilm Formation To Interfere with Phagocytosis and Activation of Mouse Macrophage-Like Cells 774A.1

(2011) Nina N. Schommer et al.   INFECTION AND IMMUNITY

Staphylococcus aureus Biofilms Prevent Macrophage Phagocytosis and Attenuate Inflammation In Vivo

(2011) L. R. Thurlow et al.   JOURNAL OF IMMUNOLOGY

Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of murine macrophages

(2011) F. Cerca et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Host defence against Staphylococcus aureus biofilms by polymorphonuclear neutrophils: Oxygen radical production but not phagocytosis depends on opsonisation with immunoglobulin G

(2010) Petra Stroh et al.   IMMUNOBIOLOGY

Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice

(2010) Rong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Interface membrane is the best sample for histological study to diagnose prosthetic joint infection

(2010) Guillem Bori et al.   MODERN PATHOLOGY

Biofilms

(2010) D. Lopez et al.   Cold Spring Harbor Perspectives in Biology

Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption

(2009) A. Chakravarti et al.   BLOOD

Host defence against Staphylococcus aureus biofilms infection: Phagocytosis of biofilms by polymorphonuclear neutrophils (PMN)

(2009) Frank Günther et al.   MOLECULAR IMMUNOLOGY

The giant extracellular matrix-binding protein ofStaphylococcus epidermidismediates biofilm accumulation and attachment to fibronectin

(2009) Martin Christner et al.   MOLECULAR MICROBIOLOGY

Modulation of eDNA Release and Degradation Affects Staphylococcus aureus Biofilm Maturation

(2009) Ethan E. Mann et al.   PLoS One

Functions of RANKL/RANK/OPG in bone modeling and remodeling

(2008) Brendan F. Boyce et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A Novel Staphylococcus aureus Biofilm Phenotype Mediated by the Fibronectin-Binding Proteins, FnBPA and FnBPB

(2008) E. O'Neill et al.   JOURNAL OF BACTERIOLOGY

Direct Demonstration of Viable Staphylococcus aureus Biofilms in an Infected Total Joint Arthroplasty

(2008) Paul Stoodley et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Biofilm Formation Induces C3a Release and ProtectsStaphylococcus epidermidisfrom IgG and Complement Deposition and from Neutrophil‐Dependent Killing

(2008) Sascha A. Kristian et al.   JOURNAL OF INFECTIOUS DISEASES

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY

The local inflammatory environment and microorganisms in “aseptic” loosening of hip prostheses

(2007) Caroline S. M. Hoenders et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS