Article
Endocrinology & Metabolism
Limin Wang, Chenghong Liang, Xiaojian Song, Xiaoyan Jia, Xiudan Wang, Yun Zhang, Qinyuan Xie, Nan Zheng, Huijuan Yuan
Summary: This study aimed to assess alterations in the gut, oral, and ocular surface microbiota pre- and post-Cana treatment in patients with type 2 diabetes mellitus (T2DM). The results showed that there were significant changes in the gut, oral, and ocular surface microbiota after Cana treatment, which were related to changes in clinical parameters.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ophthalmology
Zhang Zhang, Xinrong Zou, Wenwen Xue, Pei Zhang, Shanshan Wang, Haidong Zou
Summary: The study investigated the ocular surface commensal bacteria profiles of patients with diabetes mellitus and dry eye disease, revealing differences in microbial composition between the groups. Patients with diabetes mellitus and dry eye disease had a more complex microbial composition compared to other groups, with unique core genera identified in each group. The findings provide insights into the microbial profile of dry eye disease in patients with diabetes mellitus.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Judy Weng, Steven Trinh, Rachel Lee, Rana Metwale, Ajay Sharma
Summary: The study found that high glucose exposure can lead to a decrease in gene expression of proteins involved in cellular proliferation of corneal and conjunctival epithelial cells, but does not affect the level or spatial distribution of glycocalyx components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Awgichew Shewasinad Yehualashet, Berhan Begashaw Yikna
Summary: There is a close relationship between intestinal microbiota and diabetes, with evidence suggesting that changes in the microbial ecosystem may be associated with the onset and progression of diabetes. Short chain fatty acids and bile acid stimulated receptors are likely to play essential roles in modulating the pathogenesis of diabetes.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Orathai Suwajanakorn, Vilavun Puangsricharern, Thanachaporn Kittipibul, Tanittha Chatsuwan
Summary: This study analyzed the ocular surface microbiome of non-diabetic and type 2 diabetic patients and found a higher prevalence of pathogenic microorganisms and antibiotic-resistant strains in diabetic patients, especially those with diabetic retinopathy. The study also identified differences in the ocular surface microbiome between diabetic and non-diabetic groups, as well as between diabetic patients with different levels of glycemic control.
SCIENTIFIC REPORTS
(2022)
Review
Microbiology
Qingyu An, Haidong Zou
Summary: People with diabetes mellitus are at a higher risk of developing dry eye disease (DED). The ocular surface microbiota (OSM) differs significantly between patients with DED and healthy people, indicating that OSM dysbiosis may contribute to the pathogenesis of DED. The high-glucose environment and subsequent pathological changes can cause OSM dysbiosis, leading to ocular surface inflammation and tear composition alterations.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Olimpia Mora-Janiszewska, Anna Faryniak-Zuzak, Dorota Darmochwal-Kolarz
Summary: Gestational diabetes mellitus (GDM) is a significant global problem that induces diabetogenic and obesogenic changes in an offspring's DNA through epigenetic mechanisms. Alterations in microbiota play a crucial role in this process. Identification of specific epigenetic marks may provide key solutions for personalized medicine. This manuscript summarizes available data on epigenetic changes among women with GDM and their offspring, in relation to microbiome alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Xiangjia Zhu, Ling Wei, Xianfang Rong, Yinglei Zhang, Qian Zhang, Xiaofeng Wen, Wenwen He, Keke Zhang, Feng Chen, Lai Wei, Yi Lu
Summary: The study found that the conjunctival microbiome of T2DM patients was more diverse compared to non-diabetic controls, with significant differences in composition and function, including enrichment of phylum Bacteroidetes and Fusobacteria, genus Pseudomonas, Haemophilus, and Empedobacter, and reduction of genus Streptococcus. The bacterial chemotaxis function was elevated in T2DM patients' conjunctival microbiome. Additionally, the conjunctival microbiome of T2DM patients responded differently to topical antibiotics, with certain genera becoming more abundant after 3 days of preoperative levofloxacin use.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Ting Chen, Yufeng Qin, Minjian Chen, Yuqing Zhang, Xu Wang, Tianyu Dong, Guanglin Chen, Xian Sun, Ting Lu, Richard Allen White, Peng Ye, Hein M. Tun, Yankai Xia
Summary: This study revealed significant changes in the meconium microbiota of neonates born to mothers with gestational diabetes mellitus (GDM), with a reduction in alpha diversity and alterations in the abundance of Firmicutes and Proteobacteria. Metabolomic analysis showed changes in metabolic pathways such as taurine and hypotaurine metabolism, pyrimidine metabolism, beta-alanine metabolism, and bile acid biosynthesis in GDM subjects. The findings highlight the impact of maternal factors on early-life metabolism.
Article
Biochemistry & Molecular Biology
Cristian-Ioan Craciun, Maria-Adriana Neag, Adrian Catinean, Andrei-Otto Mitre, Adriana Rusu, Cornelia Bala, Gabriela Roman, Anca-Dana Buzoianu, Dana-Maria Muntean, Anca-Elena Craciun
Summary: This review evaluates the pathogenetic association between microbiota and diabetes and explores new therapeutic agents that may modulate the microbiota. It provides new insights into the treatment of diabetes.
Article
Respiratory System
Hung-Ling Huang, Yong-Chun Luo, Po-Liang Lu, Cheng-Hsieh Huang, Kun-Der Lin, Meng-Rui Lee, Meng-Hsuan Cheng, Yao-Tsung Yeh, Cheng-Yuan Kao, Jann-Yuan Wang, Jinn-Moon Yang, Inn-Wen Chong
Summary: This study found that gut microbiota composition is associated with the development of tuberculosis, and a predictive algorithm can be used to diagnose latent tuberculosis infection (LTBI). In patients with diabetes, there are differences in microbiota composition and immune factor levels between those with and without LTBI.
RESPIRATORY RESEARCH
(2023)
Review
Pathology
Michael J. Zilliox, Charles S. Bouchard
Summary: The ocular surface microbiome is a new and emerging field of study that focuses on the microorganisms found on the surface of the eye and their role in maintaining homeostasis and causing diseases. It is not yet clear whether these microorganisms inhabit the ocular surface and if there is a core microbiome present in healthy eyes. The presence of novel organisms and their redistribution may play a role in disease pathogenesis, response to therapies, and the healing process. However, there are technical challenges in studying the ocular surface microbiome, and standardization is needed to advance the field.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Julita Tokarek, Emilian Budny, Maciej Saar, Kamila Stanczak, Ewa Wojtanowska, Ewelina Mlynarska, Jacek Rysz, Beata Franczyk
Summary: Cardiovascular diseases and diabetes mellitus have high morbidity and mortality rates, and they are closely linked with inflammation playing a significant role. SGLT-2 inhibitors and GLP-1 receptor agonists have a positive impact on both diseases. Furthermore, the composition of the gut microbiota can affect the progression of these conditions.
Article
Medicine, General & Internal
Dalan Jing, Xiaodan Jiang, Xiaotong Ren, Jie Su, Chen Huang, Jiarui Yang, Ran Hao, Xuemin Li
Summary: Using metagenomic nanopore sequencing, we investigated the composition of the ocular microbiome in patients with Meibomian gland dysfunction (MGD). The bacterial composition differed between different severity levels of MGD, with the severe cases having the simplest composition. Metagenomic nanopore sequencing detected more bacterial species compared to traditional culture methods.
FRONTIERS IN MEDICINE
(2022)
Review
Agriculture, Multidisciplinary
Zinan Guo, Jingjin Pan, Hanyue Zhu, Zhen-Yu Chen
Summary: This review summarizes the differences in gut microbiota between diabetic patients and healthy people, discusses the underlying mechanisms by which lipopolysaccharide, diet, and metabolites of the gut microbiota affect diabetes, and provides a new insight in the prevention and treatment of diabetes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Microbiology
ZhenHao Li, Yufang Gong, ShuZe Chen, SiQi Li, Yu Zhang, HuiMin Zhong, ZhouCheng Wang, YiFan Chen, QiXin Deng, YuTing Jiang, LiYing Li, Min Fu, GuoGuo Yi
JOURNAL OF MICROBIOLOGY
(2019)
Article
Endocrinology & Metabolism
ShuZe Chen, HuiMin Zhong, Yan Wang, ZiHong Wang, XiaoQian Liang, SiQi Li, ZhenHao Li, ZhengTong Yu, LiYing Li, GuoGuo Yi, Min Fu
ACTA DIABETOLOGICA
(2020)
Review
Biochemistry & Molecular Biology
Peixi Ying, Chang Huang, Yan Wang, Xi Guo, Yuchen Cao, Yuxi Zhang, Sheng Fu, Lin Chen, Guoguo Yi, Min Fu
Summary: The retina is composed of 11 types of cells, including neurons, glial cells, and vascular bed cells. Single-cell RNA sequencing (sRNA-seq) technology has revealed new cell subtypes and specific gene markers, which are significant for the diagnosis and treatment of retinal diseases. The high-throughput and high-resolution advantages of sRNA-seq contribute to the continuous discovery of retina-related gene targets.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Ophthalmology
Xiaotian Liang, Yingli Li, Ke Xiong, Shuze Chen, Zhenhao Li, Zhihan Zhang, Zhaoxia Xia, Guoguo Yi, Min Fu
Summary: Demodex infestation did not significantly affect the diversity of ocular surface microbial communities, but primarily changed the dominant flora and relative abundance of ocular surface microbial communities. Meibomian gland dysfunction may play an important role in this process.
OPHTHALMOLOGY AND THERAPY
(2021)
Review
Ophthalmology
Libing Hong, Yongqi Lin, Xiongyi Yang, Tong Wu, Yuxi Zhang, Zhuohang Xie, Jieli Yu, Hejia Zhao, Guoguo Yi, Min Fu
Summary: STAT proteins play crucial roles in diabetic retinopathy, participating in early stages through various mechanisms and exerting proangiogenic effects in late stages. Inhibiting STAT protein activity can effectively reverse pathological changes in DR, offering a new direction for treatment.
OPHTHALMOLOGY AND THERAPY
(2022)
