Article
Chemistry, Analytical
Ali Akmes, Aslihan Dalmaz, Sezen Sivrikaya Ozak
Summary: In this study, a hydrophilic deep eutectic solvent-liquid phase microextraction method using deep eutectic solvent (DES) was developed for the determination and microextraction of paraben preservatives in vitamin D for babies. The optimized DES consisted of a 1:4 M ratio of choline chloride and acetic acid, with extraction recovery values ranging from 87.40% to 102.98%. The method was successfully applied to real samples obtained from pharmacies, making it the first study of its kind in terms of paraben determination in vitamin D for babies.
MICROCHEMICAL JOURNAL
(2023)
Review
Chemistry, Analytical
Alvaro Santana-Mayor, Ruth Rodriguez-Ramos, Antonio Herrera-Herrera, Barbara Socas-Rodriguez, Miguel Angel Rodriguez-Delgado
Summary: The development of sustainable chemistry has led to the emergence of new materials, with deep eutectic solvents (DESs) as a promising non-toxic alternative to toxic organic solvents, seeing a significant increase in their applications in analytical chemistry in recent years. The vast amount of information generated from studies associated with DESs needs continuous revision.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Materials Science, Paper & Wood
Jinquan Tong, Wenchao Hu, Yizheng Qin, Yang Liu
Summary: This paper introduces the advantages of nanocellulose derived from lignocellulose materials, such as high strength, lightweight, biodegradability, and renewability. Due to the complex and dense cell wall structure and poor solubility in water and most solvents, lignocellulose materials are difficult to dissolve directly and utilize effectively in practical production. The pretreatment technology is discussed, which exposes the amorphous areas, eliminates unnecessary non-cellulose components, and facilitates the subsequent applications. Traditional and green solvents used in the pretreatment of lignocellulose materials, as well as their mechanisms, advantages, and disadvantages, are introduced. Furthermore, the mechanism, process, advantages, and potential applications of deep eutectic solvent as a pretreatment solvent are discussed, along with suggestions for the future use of green solvents in treating lignocellulose materials.
Article
Chemistry, Multidisciplinary
Binglin Chen, Zheng Li, Yunchao Feng, Weiwei Hao, Yong Sun, Xing Tang, Xianhai Zeng, Lu Lin
Summary: The study successfully synthesized the versatile bio-platform molecule CMF using a three-constituent deep eutectic solvent and obtained high yields of CMF from various waste materials, opening new avenues for the preparation of CMF.
Article
Chemistry, Physical
Km. Ankita Singh, Debashis Kundu
Summary: This study estimates the physico-chemical properties of pure deep eutectic solvent (DES), heavy crude oil (saturate, aromatic, resin and asphaltene i.e. SARA), and DES-SARA mixtures. The variations in SARA from different geographic locations and DESs with hydrophilic and hydrophobic nature, as well as the effects of temperature and concentration, are considered. Various models and equations are used to calculate the properties and understand the characteristics of this system.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Multidisciplinary
Nguyen Nhat Nam, Hoang Dang Khoa Do, Kieu The Loan Trinh, Nae Yoon Lee
Summary: The first report of deep eutectic solvents (DESs) in 2003 introduced them as a new type of ionic liquid (IL) with innovative chemical and physical characteristics. DESs, using green solvent technology, provide a sustainable approach for nanomaterial fabrication, allowing for the design of nanostructures with specific morphology and properties by adjusting reaction conditions. Their use in synthesis reactions reduces energy consumption and environmental contamination risks. This review paper discusses and highlights the recent applications and advancements in the use of DESs for green synthesis of nanomaterials, including wet-chemical processes, nanosize reticular material fabrication, electrodeposition/electrochemical synthesis of nanostructures, electroless deposition, DESs-based nano-catalytic systems, and nanofluidic systems.
Article
Food Science & Technology
Yinjuan Cao, Zhaoyang Song, Chunjuan Dong, Wenjing Ni, Keqi Xin, Qunli Yu, Ling Han
Summary: In this study, an efficient natural deep eutectic solvent (NADES) coupled with ultrasonication was used to extract phenolic compounds from broccoli leaves. The optimal phenolic extraction parameters were determined, and neochlorogenic acid was found to be the most abundant phenolic compound. The ultrasonication-assisted extraction coupled with NADES yielded higher total phenolic content and stronger antioxidant and antibacterial activities compared to other extraction methods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yang Zhou, Ya-Jiao Wu, Lei Wang, Juan Han, Jia-Cong Wu, Chun-Mei Li, Yun Wang
Summary: The study focused on using natural deep eutectic solvent (NADES) to improve enzyme stability, finding that the enhanced stability of carbonic anhydrase (CA) was due to the presence of a three-dimensional hydrogen bonding network, rather than the individual or synergistic effect of betaine and glyceride.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Willyan Araujo da Costa, Vanessa Freire de Franca, Layanny Samara da Silva Souza, Adrielly Silva Albuquerque de Andrade, Demetrius Antonio Machado de Araujo, Edilene Dantas Teles Moreira, Liliana Fatima Bezerra Lira Pontes
Summary: The search for new analytical methods in green analytical chemistry aims to address environmental issues. Green solvents, particularly deep eutectic solvents (DESs), have been identified as promising substitutes for dangerous organic solvents. This study investigated the physical-chemical and ecotoxicological properties of seven different DESs and found that their properties are influenced by the chemical structure of their precursors. These findings provide new insights into the conscious usage of DESs in green analytical chemistry.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Ding-Tao Wu, Kang-Lin Feng, Ling Huang, Ren-You Gan, Yi-Chen Hu, Liang Zou
Summary: The study found that the use of deep eutectic solvent (DES) assisted extraction of polysaccharides can specifically extract acidic polysaccharides with good bioactivities from lotus leaves, showing potential for improving the application of lotus leaves in the functional food industry.
Article
Chemistry, Multidisciplinary
Maninder Meenu, Vasudha Bansal, Sudha Rana, Nitya Sharma, Vinod Kumar, Vaishali Arora, Monika Garg
Summary: Anthocyanins are extracted using alternative solvents such as ionic liquids, deep eutectic solvents, and natural deep eutectic solvents, which are more environmentally friendly and efficient compared to conventional solvents. Acid-based deep eutectic solvents with 20-30% water content showed the highest anthocyanin extraction yield. Ultrasonic-assisted extraction was the most common and efficient method, and DES-based extracts exhibited the highest stability and antioxidant activity. Fruits and their by-products are the most commonly used samples, while cereal and legumes are less explored.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Engineering, Environmental
Chun-Chi Chen, Yen -Hui Huang, Jia-Yu Fang
Summary: The study demonstrates that hydrophobic deep eutectic solvents (DESs) are efficient in eliminating hydrophilic VOCs due to their high absorption capacity and favorable gas-to-liquid mass transfer. Among the DESs explored, the one containing thymol and decanoic acid in a 1:1 molar ratio exhibits the highest acetone absorption capacity, showing the key role of hydrogen bonding interaction in achieving superior solubility of acetone in DESs. The absorbed acetone can be easily removed from the DESs, making the process economically and ecologically beneficial for hydrophilic VOC elimination.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Yanbin Wang, Feijia Xu, Junwen Cheng, Xueqian Wu, Juan Xu, Chunru Li, Weiqi Li, Na Xie, Yuqin Wang, Liang He
Summary: This study optimized the extraction of Paecilomyces hepiali polysaccharides (PHPS) using a carboxylic acid-based deep eutectic solvent (DES) and compared it with hot-water extraction. The results showed that the DES method resulted in higher yield and improved structural and immunomodulatory properties of the extracted polysaccharides. The study highlights the potential of carboxylic acid-based DES in the preparation of acidic polysaccharides and the development of functional foods using P. hepiali.
Article
Chemistry, Analytical
Nguyen Thu Hang, Trieu Thi Tu Uyen, Nguyen Van Phuong
Summary: This study prepared and investigated 34 choline and betaine-based deep eutectic solvents for extracting apigenin and luteolin from celery seeds. The optimal extraction conditions were determined, and antisolvent combined with distillation was proposed for efficient recovery of the compounds. Molecular dynamics revealed interactions between the components of DES and the role of water molecules in the ability to dissolve apigenin and luteolin.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Kuan-Ting Lin, Chenxi Wang, Mond F. Guo, Edoardo Apra, Ruoshui Ma, Arthur J. Ragauskas, Xiao Zhang
Summary: This study developed a new deep eutectic solvent that can efficiently extract lignin and control its structural properties. By carefully selecting treatment conditions and ratios of reactants, lignin with different chemical bond content and molecular weight can be generated.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Sandra Fusco, Mario Barra, Lorenzo Gontrani, Matteo Bonomo, Federico Chianese, Simone Galliano, Roberto Centore, Antonio Cassinese, Marilena Carbone, Antonio Carella
Summary: Three novel diketopyrrolopyrrole (DPP) based small molecules were synthesized and characterized in terms of their chemical-physical, electrochemical and electrical properties. The molecules have a central DPP electron acceptor core symmetrically functionalized with donor bi-thienyl moieties and flanked by three different auxiliary electron-acceptor groups. The molecular structure allows for significant absorption at longer wavelengths and has a narrow optical bandgap. Organic field-effect transistors (OFETs) were fabricated using the DPP dyes as active layers and showed different charge-transport properties depending on the end-functionalization. Additionally, well-balanced ambipolar transistors were achieved by blending the most performant n-type and p-type dyes.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Giovanni Ghigo, Matteo Bonomo, Achille Antenucci, Chiara Reviglio, Stefano Dughera
Summary: Deep eutectic solvent (DES)-like mixtures based on glycerol and different halide organic and inorganic salts have been successfully used as new media for copper-free halodediazoniation of arenediazonium salts. The reactions are conducted without the need for metal-based catalysts, at room temperature, and in a short period of time. Pure target products are obtained without the requirement of chromatographic separation. The solvents have been fully characterized and a computational study has been presented in order to understand the reaction mechanism.
Review
Biochemistry & Molecular Biology
Lorenzo Gontrani, Pietro Tagliatesta, Domenica Tommasa Donia, Elvira Maria Bauer, Matteo Bonomo, Marilena Carbone
Summary: Deep Eutectic Solvents (DES) have gained significant attention in recent years due to their wide applicability, simple preparation, high biocompatibility, and harmlessness. One valuable application of DES is in the synthesis and modification of inorganic materials, particularly nanoparticles. The inherent structural inhomogeneity of DES leads to a notable templating effect, which has attracted increasing studies to explore the use of these new reaction media for nanomaterial preparation. This review aims to summarize the numerous and recent achievements in this field, presenting examples of the newest mixtures obtained from natural feedstocks and linking them to well-established methods that use classical DES like choline chloride.
Article
Chemistry, Physical
F. De Rossi, B. Taheri, M. Bonomo, V Gupta, G. Renno, N. Yaghoobi Nia, P. Rech, C. Frost, C. Cazzaniga, P. Quagliotto, A. Di Carlo, C. Barolo, M. Ottavi, F. Brunetti
Summary: This paper evaluates the stability of unencapsulated flexible perovskite solar cells against fast neutron irradiation at two different fluence levels. Both commercially available spiro-OMeTAD and an inhouse modified P3HT as the hole transport materials degrade under neutron irradiation. However, the modified P3HT cells show smaller voltage and current losses compared to spiro-OMeTAD cells, indicating their potential resilience. Further investigations are needed to improve the perovskite/polymer interface and promote the development of flexible perovskite solar cells for space and avionic applications.
Article
Chemistry, Physical
Elena Palmieri, Luca Montaina, Giuseppina Polino, Matteo Bonomo, Gioele Giordanengo, Claudia Barolo, Gaio Paradossi, Francesca Brunetti, Emanuela Tamburri, Silvia Orlanducci
Summary: Given the environmental crisis, it is crucial to use sustainable materials and less time and energy-consuming methods in the fabrication of flexible electronics. This study proposes a method for producing large-area PEDOT:PSS electrodes with low environmental impact. By modifying the surface of standard copy paper, the electrodes achieved improved conductivity stability and electromechanical performance, making them suitable for wearable electronic devices.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Applied
Antonio Carella, Marcello Franzini, Sandra Fusco, Roberto Centore, Mario Barra, Fabio Chiarella, Antonio Cassinese, Matteo Bonomo, Stefano Nejrotti, Marilena Carbone, Lorenzo Gontrani
Summary: Eight novel isoindigo-based small molecules with different terminal electron withdrawing groups have been synthesized and their structure and properties have been systematically studied. The optical properties of the dyes in chloroform solution are modulated by the terminal EWGs, while the solid films exhibit a general broadening and red shift of the absorption. The dyes show narrow bandgaps, good thermo-oxidative stability, and unipolar n-type charge transport in organic field-effect transistors.
Article
Chemistry, Inorganic & Nuclear
Lorenzo Gontrani, Domenica Tommasa Donia, Elvira Maria Bauer, Pietro Tagliatesta, Marilena Carbone
Summary: DES demonstrates remarkable added value in the synthesis of inorganic materials, especially nanoparticles, due to its inherent and highly-tunable nano-homogeneities. This study describes the synthesis of zinc-containing nanoparticles using metal type-IV Deep Eutectic Solvents, a pathway that has not been explored before. The prepared materials have layered shapes, with pure layered ZnO obtained when zinc nitrate is used as a DES component, forming nanometric platelets that assemble into flower-like aggregates. The prepared nanoparticles exhibit intrinsic fluorescence and are being further investigated for sensor applications in contaminant detection.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Francesco Cappelluti, Alessandro Mariani, Matteo Bonomo, Alessandro Damin, Luigi Bencivenni, Stefano Passerini, Marilena Carbone, Lorenzo Gontrani
Summary: This paper presents a procedure based on computational tools for a priori predictions of Deep Eutectic Solvents (DESs) formation, which is validated by experimental data. The computational findings demonstrate remarkable and unprecedented predictive power, and a linear correlation between the calculated results and experimental data is identified.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Chemistry, Multidisciplinary
Stefano Nejrotti, Achille Antenucci, Carlotta Pontremoli, Lorenzo Gontrani, Nadia Barbero, Marilena Carbone, Matteo Bonomo
Summary: This article provides an outline of the sustainable advantages of Deep Eutectic Solvents (DESs) by analyzing popular DESs and their green features. The evaluation aims to reinforce or question the sustainability of these solvents through a tangible and evidence-based approach.
Article
Energy & Fuels
Vincenzo Scarano, Lorenzo Gontrani, Ana Yancy Segura Zarate, Simone Galliano, Raffaele Borrelli, Marilena Carbone, Danilo Dini, Daniele Mirante, Marta Feroci, Matteo Bonomo, Leonardo Mattiello
Summary: We synthesized two new dyes as sensitizers for p-type dye-sensitized solar cells (DSCs). Inspired by the state-of-art dye PMI-6 T-TPA, we designed the molecules to optimize the absorption and energy level stability. Among them, A6D sensitizer showed superior performance in NiOx-based p-type DSCs.
Article
Chemistry, Physical
Lorenzo Gontrani, Elvira Maria Bauer, Alessandro Talone, Mauro Missori, Patrizia Imperatori, Pietro Tagliatesta, Marilena Carbone
Summary: The report investigates the relationship between synthesis methods and the size and morphology of copper oxide nanoparticles. It is found that hydrothermal synthesis without surfactants leads to spheroidal dandelion-like aggregates, while the addition of surfactants promotes directional growth of nanostructures. The structure and properties of the nanoparticles are studied using powder X-ray diffraction, scanning electron microscopy, and diffuse reflectance spectroscopy. The effect of morphology on electronic properties is evaluated using DRS, and the results are compared with computational models.
Article
Chemistry, Multidisciplinary
Giovanni Ghigo, Matteo Bonomo, Achille Antenucci, Alessandro Damin, Stefano Dughera
Summary: A deep eutectic solvent (DES) based on glycerol and KF has been developed for the Ullmann homocoupling of arenediazonium salts. The reaction can be carried out under mild conditions and the desired products are obtained in good yields. Computational studies and Raman spectroscopy were used to investigate the reaction mechanism.
Article
Chemistry, Inorganic & Nuclear
Barbara Centrella, Gabriele Deplano, Alessandro Damin, Matteo Signorile, Mariagrazia Tortora, Claudia Barolo, Matteo Bonomo, Silvia Bordiga
Summary: The effect of different substituted 2,2'-bipyridine ligands on the reversible oxidation of Cu-I homoleptic complexes was investigated using various techniques. One of the tested complexes displayed peculiar behavior during oxidation, and further analysis revealed changes in the oxidation state of the copper ion and modifications in the local structure of the metal. These findings confirm the potential of these simple Cu-I complexes as model catalysts for partial oxygenation reactions.
DALTON TRANSACTIONS
(2022)