Journal
TOXINS
Volume 11, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/toxins11060366
Keywords
aplysiatoxin; cyanobacteria; Moorea producens; cytotoxicity; biosynthesis
Categories
Funding
- Japan Society for the Promotion of Science (JSPS) [16K01911, 19K06220, 15K01798]
- Grants-in-Aid for Scientific Research [15K01798, 19K06220] Funding Source: KAKEN
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Cyanobacteria have been shown to produce a number of bioactive compounds, including toxins. Some bioactive compounds obtained from a marine cyanobacterium Moorea producens (formerly Lyngbya majuscula) have been recognized as drug leads; one of these compounds is aplysiatoxin. We have isolated various aplysiatoxin derivatives from a M. producens sample obtained from the Okinawan coastal area. The frozen sample was extracted with organic solvents. The ethyl acetate layer was obtained from the crude extracts via liquid-liquid partitioning, then separated by HPLC using a reversed-phase column. Finally, 1.1 mg of the compound was isolated. The chemical structure of the isolated compound was elucidated with spectroscopic methods, using HR-MS and 1D and 2D NMR techniques, and was revealed to be oscillatoxin I, a new member of the aplysiatoxin family. Oscillatoxin I showed cytotoxicity against the L1210 mouse lymphoma cell line and diatom growth-inhibition activity against the marine diatom Nitzschia amabilis.
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