Core-shell hydrogel beads with extracellular matrix for tumor spheroid formation

Alginate core-shell beads for simplified three-dimensional tumor spheroid culture and drug screening

(2015) Linfen Yu et al.   BIOMEDICAL MICRODEVICES

Mixed hydrogel bead-based tumor spheroid formation and anticancer drug testing

(2014) Yaolei Wang et al.   ANALYST

Deconstructing Signaling in Three Dimensions

(2014) Matthew G. Rubashkin et al.   BIOCHEMISTRY

Rapid disorganization of mechanically interacting systems of mammary acini

(2013) Q. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

(2013) K. Alessandri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The XTT Cell Proliferation Assay Applied to Cell Layers Embedded in Three-Dimensional Matrix

(2012) Lynn Huyck et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Microtissue size and hypoxia in HTS with 3D cultures

(2012) Amish Asthana et al.   DRUG DISCOVERY TODAY

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

The multicellular tumor spheroid model for high-throughput cancer drug discovery

(2012) Daniel V LaBarbera et al.   Expert Opinion on Drug Discovery

Reversal of diabetes by βTC3 cells encapsulated in alginate beads generated by emulsion and internal gelation

(2012) Corinne A. Hoesli et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Collagen I fiber density increases in lymph node positive breast cancers: pilot study

(2012) Samata M. Kakkad et al.   JOURNAL OF BIOMEDICAL OPTICS

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Collagen microsphere production on a chip

(2012) Sungmin Hong et al.   LAB ON A CHIP

Increased initiation and growth of tumor cell lines, cancer stem cells and biopsy material in mice using basement membrane matrix protein (Cultrex or Matrigel) co-injection

(2012) Rafael Fridman et al.   Nature Protocols

Development of Multicellular Tumor Spheroid (MCTS) Culture from Breast Cancer Cell and a High Throughput Screening Method Using the MTT Assay

(2012) Wan Yong Ho et al.   PLoS One

Microdrop Printing of Hydrogel Bioinks into 3D Tissue-Like Geometries

(2011) Kris Pataky et al.   ADVANCED MATERIALS

3D in vitro bioengineered tumors based on collagen I hydrogels

(2011) Christopher S. Szot et al.   BIOMATERIALS

Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates

(2011) Amy Y. Hsiao et al.   BIOMEDICAL MICRODEVICES

384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids

(2011) Amy Y. Hsiao et al.   BIOTECHNOLOGY AND BIOENGINEERING

IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition

(2011) Logan A Walsh et al.   Cell Communication and Signaling

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Evolving standards in the treatment of docetaxel-refractory castration-resistant prostate cancer

(2011) E S Antonarakis et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Scalable robotic biofabrication of tissue spheroids

(2011) A Nagy Mehesz et al.   Biofabrication

The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D cultures

(2010) Silva Krause et al.   BMC CANCER

Role of extracellular signal-regulated kinase (ERK)1/2 in multicellular resistance to docetaxel in MCF-7 cells

(2010) Kang   INTERNATIONAL JOURNAL OF ONCOLOGY

Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing

(2010) Linfen Yu et al.   LAB ON A CHIP

Tailoring Mechanical Properties of Collagen-Based Scaffolds for Vascular Tissue Engineering: The Effects of pH, Temperature and Ionic Strength on Gelation

(2010) Matteo Achilli et al.   Polymers

pH effects on collagen fibrillogenesis in vitro: Electrostatic interactions and phosphate binding

(2009) Yuping Li et al.   Materials Science & Engineering C-Materials for Biological Applications

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

(2008) Paolo P. Provenzano et al.   BIOPHYSICAL JOURNAL

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization

(2008) M. A. Qadir et al.   BREAST CANCER RESEARCH AND TREATMENT

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

3-D Tumor Model forIn VitroEvaluation of Anticancer Drugs

(2008) Jayme L. Horning et al.   MOLECULAR PHARMACEUTICS

Prognostic Breast Cancer Signature Identified from 3D Culture Model Accurately Predicts Clinical Outcome across Independent Datasets

(2008) Katherine J. Martin et al.   PLoS One

On-Chip Alginate Microencapsulation of Functional Cells

(2007) Victoria L. Workman et al.   MACROMOLECULAR RAPID COMMUNICATIONS