Article
Chemistry, Multidisciplinary
Bailei Li, Jiren Xu, Ruixue Ai, Haixing Zhang, Mingjun Wei, Rongqing Zhang, Chunling Bao, Wenhui Wu
Summary: This study presents a novel therapy for dentin hypersensitivity (DH) based on beta-chitooligosaccharide graft derivative (CAD) that demonstrates remarkable biosafety and durable therapeutic value. CAD restores the protective membrane in dentine tubules, promotes mineral deposition and bone anabolism, and regulates immunoglobulin levels and inflammatory factors. In vitro tests show that CAD occludes exposed dentine tubules with a depth of over 70 μm. In a study on Sprague-Dawley rats, the CAD group exhibits a 10.96% increase in molar dentin bone mineral density and an improvement in trabecular thickness of about 0.03 μm within 2 weeks. Overall, this research demonstrates the potential of modified marine biomaterials as safe and long-lasting therapy for DH.
Article
Chemistry, Multidisciplinary
Manuel Toledano-Osorio, Raquel Osorio, Estrella Osorio, Antonio L. Medina-Castillo, Manuel Toledano
Summary: In this study, dentifrices containing zinc-doped polymeric nanoparticles were found to effectively occlude dentinal tubules and enhance the mechanical properties of dentin. After a citric acid challenge, only the pastes with zinc-doped NPs maintained tubule occlusion, while mechanical properties were reduced in specimens treated with Sensodyne(R). Zinc-doped NPs at the lowest concentration demonstrated acid-resistant tubular occlusion and improved dentin's mechanical properties.
Article
Engineering, Biomedical
S. V. Aruna Rani, K. Rajkumar, B. Saravana Karthikeyan, S. Mahalaxmi, G. Rajkumar, V. Dhivya
Summary: The study aimed to evaluate the remineralization effectiveness of chicken eggshell-derived nanohydroxyapatite (CEnHAp) combined with phytosphingosine (PHS) on artificially induced dentinal lesions. The results showed that dentin treated with CEnHAp-PHS exhibited the highest microhardness values and complete tubular occlusion at all test time intervals.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Physical
Demet Sahin, Ceren Deger, Burcu Oglakci, Metehan Demirkol, Bedri Onur Kucukyildirim, Mehtikar Gursel, Evrim Eliguzeloglu Dalkilic
Summary: This study evaluates the effects of a novel nanohydroxyapatite gel and Er: YAG laser on the surface roughness, surface morphology, and elemental content after dentin hypersensitivity treatments. The results show that laser treatment can result in smoother surfaces, which can help prevent dental plaque accumulation.
Article
Nanoscience & Nanotechnology
Yuxue Cao, Chun Xu, Patricia P. Wright, Jingyu Liu, Yueqi Kong, Yue Wang, Xiaodan Huang, Hao Song, Jianye Fu, Fang Gao, Yang Liu, Laurence J. Walsh, Chang Lei
Summary: This study developed a combination nanomaterial system that achieved rapid and stable occlusion of dentin tubules, showing potential for the treatment of dentin hypersensitivity.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Medicinal
Jung-Chang Kung, Wei-Hsun Wang, Yu-Ching Chiang, Yuan-Ting Yang-Wang, Yueh-Ching Wang, Wen-Cheng Chen, Chi-Jen Shih
Summary: The study aimed to evaluate the remineralization and antibacterial effect of silver-containing mesoporous bioactive glass (MBG-Ag) sealing combined with Er:YAG laser irradiation on human demineralized dentin. Results showed that both MBG-Ag and Er:YAG laser have the ability to enhance remineralization and hydroxyapatite crystal precipitation, with superior treatment outcomes when combined.
Article
Dentistry, Oral Surgery & Medicine
Xiaoyi Zhao, Lin Wang, Jie Pan, Hans Malmstrom, Yan-Fang Ren
Summary: Desensitizing toothpastes containing CPP or PVM/MA effectively occlude dentin tubules after two brushing cycles. PVM/MA combined with submicron silica demonstrated stronger resistance to dynamic erosive challenges by acidic beverages. Inorganic fillers that can enter dentin tubules and resist erosive challenges may be crucial for desensitizing toothpastes.
Article
Biochemistry & Molecular Biology
Yuedan Xu, Xinni Pan, Dongni Shen, Yi Sun, Wei Liu, Ye Lin, Baiping Fu, Ling Zhang
Summary: This study developed a strategy for deep occlusion of dentinal tubules using occlusion media. By applying poly-L-aspartic acid-strontium and phosphate/fluoride, the dentinal tubules were effectively occluded to a depth of 150 mu m. The occlusion media showed resistance to abrasive and acidic challenges, outperforming commercial desensitizers. This strategy demonstrated sufficient biocompatibility and excellent performance in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Dentistry, Oral Surgery & Medicine
Anita Aminoshariae, James C. Kulild
Summary: The study identified five different mechanisms of dentinal sensitivity and suggested that these mechanisms may interact. Pulpal responses to tissue injury may alter the relative contribution of these mechanisms, for example, pulpal inflammation may lead to neuronal sprouting and peripheral sensitization.
JOURNAL OF ENDODONTICS
(2021)
Article
Engineering, Biomedical
Natalia Papazisi, Dimitrios Dionysopoulos, Olga Naka, Dimitris Strakas, Sotiria Davidopoulou, Kosmas Tolidis
Summary: The aim of this laboratory study was to investigate and compare the impact of five desensitizing techniques on tooth sensitivity after a tooth bleaching procedure. Intact human molars were collected and treated with different techniques, such as gels and air-abrasion. Scanning electron microscopy observations showed that BioMinF paste, SnF2-containing gel, and air-abrasion with ProSylc powder were the most effective treatments for occluding dentin tubules.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Multidisciplinary Sciences
Kathleen MacDonald, Effie Boudreau, Gavin Vaughan Thomas, Thomas Charles Badrock, Luke John Davies, Michael James Lloyd, Paul Steven Spradbery, Stephanie Turner-Cahill, Daniel Boyd
Summary: This study evaluated the therapeutic potential of two soluble bioactive glasses in treating dentin hypersensitivity and promoting enamel strength. The results showed that these additives had superior occlusion and mineralization effects compared to commercially available toothpastes.
Article
Polymer Science
Xiu Peng, Sili Han, Kun Wang, Longjiang Ding, Zhenqi Liu, Linglin Zhang
Summary: The study demonstrates that TVH-19 is effective in promoting dentin sealing by binding to periodontal dentin, promoting mineral deposition, and reducing the space between dentin tubules.
Article
Dentistry, Oral Surgery & Medicine
Chang-ha Lee, Seol-Ah Jo, Kyongok Kang, Jan Dhont, Jack Ferracane, In-bog Lee
Summary: The study developed a new device that utilizes shockwaves to improve the effect of desensitizer on dentin permeability, showing a significant reduction in dentin permeability compared to desensitizer alone. The application of shockwave in addition to desensitizer resulted in a higher reduction in dentin fluid flow rate, indicating the potential of shockwaves in enhancing the effectiveness of desensitizing agents.
Article
Dentistry, Oral Surgery & Medicine
Toshiyuki Suge, Kunio Ishikawa, Takashi Matsuo, Shigeyuki Ebisu
Summary: The study found that the CPP method is effective in occluding dentin tubules with proper plaque control, reducing the opening of dentin tubules significantly.
DENTAL MATERIALS JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Laryssa de Castro Oliveira, Vitoria Marega Marchetti, Fernanda de Souza e Silva Ramos, Alberto Carlos Botazzo Delbem, Marina Trevelin Souza, Bernhard Ganss, Leticia Helena Theodoro, Ticiane Cestari Fagundes
Summary: This study investigates the effect of in-office desensitizing materials on dentin permeability and tubule occlusion. The results show that SBU and AMTN solution are more effective in reducing dentin permeability by occluding dentin tubules.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Chemistry, Multidisciplinary
Ndivhuwo P. Shumbula, Siyabonga S. Nkabinde, Zakhele B. Ndala, Siyasanga Mpelane, Morgan P. Shumbula, Phumlani S. Mdluli, Zikhona Njengele-Tetyana, Phumlani Tetyana, Thulani Hlatshwayo, Mbuso Mlambo, Nosipho Moloto
Summary: Fabrication of bioactive nanomaterials with improved stability and low toxicity is of interest. Ag-PDA and Ag@PDA nanocomposites were successfully prepared to address the issue of agglomeration, and showed excellent biocompatibility and antimicrobial activity.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Review
Medicine, General & Internal
Busiswa Dyan, Palesa Pamela Seele, Amanda Skepu, Phumlane Selby Mdluli, Salerwe Mosebi, Nicole Remaliah Samantha Sibuyi
Summary: The high mortality rates among African women due to breast cancer can be attributed to a lack of access and high costs of diagnostic tools for late-stage diagnosis. Early detection of breast cancer is crucial for improving survival rates, especially in low-income countries. Nucleic-acid-based lateral flow assays (NABLFAs) have emerged as a promising method for point-of-care testing in resource-limited regions, as they combine molecular detection with immunochemical visualization principles.
Article
Multidisciplinary Sciences
Sisonke Sigonya, Stanley Chibuzor Onwubu, Phumlani Selby Mdluli, Thabang Hendrica Mokhothu
Summary: This study presents an optimized method for monitoring the occurrence of pharmaceuticals in aquatic environments. The method was applied in the coastal area of Durban city, South Africa, covering four seasons. Qualitative and quantitative detection of the extracted compounds was done using a high-performance liquid phase chromatographic instrument. The results showed that the concentration of the studied pharmaceuticals varied with the type of aquatic environment and season.
SN APPLIED SCIENCES
(2022)
Article
Chemistry, Physical
Sindisiwe F. Muthwa, Nontuthuko S. Zulu, Marcel Kistan, Stanley C. Onwubu, Ndivhuwo P. Shumbula, Nosipho Moloto, Siyasanga Mpelane, Thulani Hlatshwayo, Mbuso Mlambo, Phumlani S. Mdluli
Summary: This paper explores the use of smartphones and spectrophotometers to understand the color variation mechanism of DPC-AuNPs due to chromium addition. The Color Grab app captures and decodes colors from samples with varying concentrations of hexavalent chromium. The presence of Cr(VI) causes the DPC-AuNPs to aggregate, resulting in a color change from pink to blue and a decrease in peak intensity. The study also uses molecular dynamics calculations to simulate the aggregation process and suggests potential applications in metal ion detection.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Editorial Material
Nursing
Maureen Nokuthula Sibiya, Stanley Chibuzor Onwubu
Summary: The health and wellbeing of nurses and midwives are crucial for providing quality care. Ensuring support in various work environments is essential for the best outcomes. The Covid-19 pandemic has had a significant impact on nursing and midwifery practices in South Africa.
AFRICAN JOURNAL OF NURSING AND MIDWIFERY
(2022)
Article
Chemistry, Physical
Zakhele B. Ndala, Siyabonga S. Nkabinde, Ndivhuwo P. Shumbula, Ofentse A. Makgae, Tshwarela Kolokoto, Martin Ek, Siziwe S. Gqoba, Cebisa E. Linganiso, Phumlane S. Mdluli, Nosipho Moloto
Summary: The surface functionalization of ReSe2 nanostructures by different surfactants significantly affects their catalytic activity towards the hydrogen evolution reaction (HER). Binding of surfactants to the surface of ReSe2 nanostructures was confirmed through various spectroscopic techniques. Among the surfactants used, ReSe2 synthesized with trioctylphosphine oxide (TOPO) exhibited the best catalytic performance with the lowest onset potential, Tafel slope, and overpotential. The interaction between the surfactants and nanostructures played a crucial role in determining the catalytic activity.
APPLIED SURFACE SCIENCE
(2023)
Article
Polymer Science
Deneshree Naidoo, Stanley Chibuzor Onwubu, Thabang Hendrica Mokhothu, Phumlane Selby Mdluli, Ajay Kumar Mishra
Summary: This study explored the impact of adding milled fish scale powder (MFSP) to ether-based flexible polyurethane foam (PUF) composites under different temperature conditions. The composites exhibited enhanced physical properties such as tensile strength and tear resistance when 0.5wt% and 1wt% MFSP were incorporated into the PUF matrix. The cell structure of the composites also showed closed cells. These findings suggest that MFSP can serve as a reinforcing agent for PUF-based composites, leading to improved physical properties and potentially reduced costs and environmental impact.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Plant Sciences
Mokgadi Ursula Makgobole, Stanley Chibuzor Onwubu, Celenkosini Thembelenkosini Nxumal, Nomakhosi Mpofana, Abdulwakeel Ayokun-nun Ajao
Summary: The physiological condition of the oral cavity makes it prone to microbial growth and diseases. This study reviews the use of medicinal plants for oral health in West Africa and identifies the most commonly used plant species and their antimicrobial activities. It also emphasizes the need for further research on the ethnobotanical and ethnopharmacological studies of these plants.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Materials Science, Multidisciplinary
T. F. Mokgadi, Z. A. Y. Abdalla, M. Madhuku, E. G. Njoroge, M. Mlambo, P. Mdluli, A. Sohatsky, V. A. Skuratov, J. B. Malherbe, T. T. Hlatshwayo
Summary: The influence of He-induced defects on the migration of Sr implanted into SiC was investigated in this study. The results showed that co-implantation of He resulted in the formation of He-bubbles, blisters, and craters, and also caused the migration of Sr towards the bulk of SiC.
FRONTIERS IN MATERIALS
(2023)
Article
Environmental Sciences
R. Thakur, S. C. Onwubu
Summary: Household waste management is a significant challenge in informal settlements in South Africa due to the lack of infrastructure and limited government services. This study investigated waste management behavior among residents of Shannon Drive informal settlement in Durban, South Africa using the Theory of Planned Behaviour. The findings suggest that while individuals have a positive attitude towards managing their household waste, they believe it is solely the responsibility of the municipality, potentially impacting waste management policies and programs. Continued education and outreach efforts are needed to promote positive behavior in household waste management.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2024)
Article
Biophysics
Sandile Cromwell Mkhize, Stanley Chibuzor Onwubu, Thabang Hendrica Mokhothu, Phumlane Selby Mdluli, Ajay Kumar Mishra
Summary: This study compares the remineralization characteristics of nano-hydroxyapatite extracted from waste eggshells and fish scales. The results show that nano-hydroxyapatite extracted from eggshells has superior properties for remineralization of teeth. These findings are important for the development of sustainable and effective oral health care products using bio-waste materials.
JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ndivhuwo P. Shumbula, Zakhele B. Ndala, Siyabonga S. Nkabinde, Obakeng Nchoe, Khanani Macumele, Siyasanga Mpelane, Morgan P. Shumbula, Phumlane S. Mdluli, Nicole R. S. Sibuyi, Zikhona Njengele-Tetyana, Phumlani Tetyana, Mbuso Mlambo, Nosipho Moloto
Summary: This work presents the fabrication, characterization, antibacterial activity, and cytotoxicity of copper/polydopamine nanocomposites. The dispersion of copper nanoparticles was improved by incorporating them on the surface or within the matrix of polydopamine. The nanocomposites exhibited significant antibacterial activity, but higher concentrations showed cytotoxicity.
RESULTS IN CHEMISTRY
(2022)
