Article
Clinical Neurology
Pin-Yuan Chen, I-Chang Su, Chun-Ying Shih, Yen-Chun Liu, Yu-Kai Su, Li Wei, Hui-Tzung Luh, Hui-Chuan Huang, Pei-Shan Tsai, Yen-Chun Fan, Hsiao-Yean Chiu
Summary: This study examined the effects of low-resolution tomography Z-score neurofeedback (LZNFB) and theta/beta neurofeedback on cognitive impairment, return to productive activity, and quality of life in patients with traumatic brain injury (TBI). The results showed that LZNFB significantly improved memory, attention, and productive activity, while theta/beta NFB only improved memory and attention.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Medicine, General & Internal
Nicole von Steinbuechel, Ugne Krenz, Fabian Bockhop, Inga K. Koerte, Dagmar Timmermann, Katrin Cunitz, Marina Zeldovich, Nada Andelic, Philine Rojczyk, Michaela Veronika Bonfert, Steffen Berweck, Matthias Kieslich, Knut Brockmann, Maike Roediger, Michael Lendt, Anna Buchheim, Holger Muehlan, Ivana Holloway, Laiene Olabarrieta-Landa
Summary: In this study, a structural equation model was used to test the relationships between pre-injury and injury-related characteristics and post-TBI outcomes, as well as their impact on disease-specific health-related quality of life. The final model showed a fair goodness-of-fit and explained a significant amount of the variance in the four latent variables and TBI-specific HRQoL. The relationships between pre-injury and post-injury outcomes, as well as between post-injury outcomes and TBI-specific HRQoL, were moderately strong.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Isabel Rosalie Arianne Retel Helmrich, David van Klaveren, Nada Andelic, Hester Lingsma, Andrew Maas, David Menon, Suzanne Polinder, Cecilie Roe, Ewout W. Steyerberg, Ernest Van Veen, Lindsay Wilson
Summary: This study aimed to examine the relationship between disability and health-related quality of life (HRQoL) following traumatic brain injury (TBI), while considering variation in personal, injury-related, and environmental factors.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Critical Care Medicine
Sara M. Lippa, Louis M. French, Tracey A. Brickell, Angela E. Driscoll, Megan E. Glazer, Corie E. Tippett, Jamie K. Sullivan, Rael T. Lange
Summary: This study found that PTSD symptoms were more strongly related to cognitive performance in individuals with a history of complicated mild/moderate TBI compared to those with severe/penetrating TBI. The impact of PTSD symptoms on cognition should be considered in individuals with complicated mild/moderate TBI.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Health Care Sciences & Services
Isabel R. A. Retel Helmrich, David van Klaveren, Simone A. Dijkland, Hester F. Lingsma, Suzanne Polinder, Lindsay Wilson, Nicole von Steinbuechel, Joukje van der Naalt, Andrew I. R. Maas, Ewout W. Steyerberg
Summary: Predictors of Health-Related Quality of Life (HRQoL) following traumatic brain injury (TBI) are related to physical and mental health, as well as pre-injury quality of life. Medical and injury-related characteristics play a significant role in predicting physical health, while patient-related characteristics are more important for predicting mental health and overall quality of life after TBI.
QUALITY OF LIFE RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Y. Liang, Lele Chen, Qilong Cao, Wei Lin, Qihao Guo, Yuhai Wang
Summary: This study found that depression significantly affects the cognition and activities of daily living of TBI patients, with patients with depression having a higher risk of cognitive impairment and low activities of daily living compared to those without depression.
CURRENT PSYCHOLOGY
(2021)
Article
Clinical Neurology
Niall J. Bourke, Celia Demarchi, Sara De Simoni, Ravjeet Samra, Maneesh C. Patel, Adam Kuczynski, Quen Mok, Neil Wimalasundera, Fareneh Vargha-Khadem, David J. Sharp
Summary: Long-term outcomes of paediatric traumatic brain injury are difficult to predict. Traumatic brain injury can lead to reductions in brain volume and is associated with cognitive, emotional, and behavioral impairments. This study investigates the impact of brain injury on healthy brain development and shows that volumetric abnormalities are common after moderate/severe traumatic brain injury in both grey and white matter regions.
Article
Medicine, General & Internal
Nicole von Steinbuechel, Stefanie Hahm, Holger Muehlan, Juan Carlos Arango-Lasprilla, Fabian Bockhop, Amra Covic, Silke W. Schmidt, Ewout Steyerberg, Andrew I. R. Maas, David Menon, Nada Andelic, Marina Zeldovich, CTR TBI Participants Investigators
Summary: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. This study aims to understand the impact of TBI on various outcome domains, evaluating factors contributing to worsening or improving outcomes. The study used patient-reported outcome measures and identified different trajectory classes for outcome after TBI, including stable good health, persistent impairments, improving health, and deteriorating health. Individuals with persistent impairments and deterioration need special attention and long-term clinical monitoring and therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Ashley N. Clausen, Heather C. Bouchard, Kathleen A. Welsh-Bohmer, Rajendra A. Morey
Summary: This study compared the chronic effects of combat-related blast mTBI and subconcussive blast exposure on neuropsychological performance in Veterans. Results showed that Veterans with combat-related blast mTBI exhibited significantly slower processing speed compared to controls, even after controlling for PTSD and depressive symptoms. However, there were no significant differences in cognition between subconcussive and control groups, or between subconcussive and combat-related blast mTBI groups, suggesting that neurocognitive assessment may not be sensitive enough to detect the long-term effects of subconcussive blast exposure.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Critical Care Medicine
Mary Jo Pugh, Eamonn Kennedy, James J. Gugger, Jamie Mayo, David Tate, Alicia Swan, Jacob Kean, Hamada Altalib, Shaila Gowda, Alan Towne, Sidney Hinds, Anne Van Cott, Maria R. Lopez, Carlos A. Jaramillo, Blessen C. Eapen, Randall R. McCafferty, Martin Salinsky, Joyce Cramer, Katherine K. McMillan, Andrea Kalvesmaki, Ramon Diaz-Arrastia
Summary: Understanding the risk of epilepsy among those who experience mild traumatic brain injury (mTBI) is crucial for intervention and prevention, yet these cases are often undocumented in health records and pose challenges in population-based assessments. The MINUTE study revealed high rates of undocumented lifetime TBIs among veterans with epilepsy, highlighting the impact of epilepsy combined with TBI on physical functioning and health-related quality of life.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Gastroenterology & Hepatology
Simon R. Knowles, David Skvarc, Alexander C. Ford, Olafur S. Palsson, Shrikant I. Bangdiwala, Ami D. Sperber, Antonina Mikocka-Walus
Summary: This study used the Rome Foundation Global Epidemiology Survey database to evaluate the impact of individual disorders of gut-brain interaction (DGBI), gastrointestinal anatomical regions, and the number of overlapping DGBI on overall quality of life, as well as by age and sex. The study found that quality of life significantly worsened with an increasing number of overlapping DGBI. Men with DGBI reported better quality of life than women, and those aged >65 years reported better quality of life than those <65 years. Age, sex, number of overlapping DGBI, somatization, anxiety, depression, and functional experiences relating to DGBI were significant predictors of poorer physical and mental quality of life.
Article
Immunology
Kajal Bagri, Rahul Deshmukh
Summary: Vinpocetine may have neuroprotective potential in alleviating cognitive and motor impairments caused by traumatic brain injury. It exerts its effects through antioxidant activity and restoration of brain neurochemical levels under stressed conditions.
INFLAMMOPHARMACOLOGY
(2022)
Article
Critical Care Medicine
Raj G. Kumar, Daniel Klyce, Risa Nakase-Richardson, Mary Jo Pugh, William C. Walker, Kristen Dams-O'Connor
Summary: Experts have long recognized the importance of studying traumatic brain injury (TBI) among active-duty service members and veterans. Most research has been conducted in Veterans Administration (VA) or Department of Defense settings, but little is known about military personnel who seek medical care outside of these settings. This study aimed to investigate the associations between military history and various health outcomes in the first 5 years after TBI.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Raj G. Kumar, Daniel Klyce, Risa Nakase-Richardson, Mary Jo Pugh, William C. Walker, Kristen Dams-O'Connor
Summary: For many years, experts have recognized the importance of studying traumatic brain injury (TBI) among active-duty service members and veterans. However, there is limited knowledge about military personnel who seek medical care outside of Veterans Administration (VA) or Department of Defense settings. The purpose of this study was to examine the associations between military history and various health outcomes in the first 5 years after TBI. The findings suggest that individuals with military history and TBI have diverse health outcomes, with some being favorable and others being detrimental, potentially influenced by characteristics of military service.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Health Care Sciences & Services
Tracey A. Brickell, Megan M. Wright, Hamid Ferdosi, Louis M. French, Rael T. Lange
Summary: The study examined the relationship between caregiver pain interference, caregiver age, and service member/veteran functional ability, as well as the longitudinal change in pain interference over 5 years. The results showed that caregivers with high pain interference had lower health-related quality of life scores compared to those with low or neutral pain interference. Caregiver age, fatigue, strain, perceived rejection, and economic quality of life were identified as the strongest predictors of pain interference. The findings emphasize the importance of studying pain in the context of caregiver quality of life, regardless of age.
QUALITY OF LIFE RESEARCH
(2022)
Article
Clinical Neurology
Harper Lee Kaye, Daniel San-Juan, Ricardo Salvador, Maria Chiara Biagi, Laura Dubreuil-Vall, Ugur Damar, Alvaro Pascual-Leone, Giulio Ruffini, Mouhsin M. Shafi, Alexander Rotenberg
Summary: This study demonstrates the safety and efficacy of multifocal, personalized, multichannel cathodal transcranial direct current stimulation in reducing seizure frequency in patients with drug-resistant focal epilepsy. However, there is a possibility of seizure exacerbation in some patients.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Lars Nyberg, Micael Andersson, Anders Lundquist, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Naiara Demnitz, Christian A. Drevon, Sandra Duezel, Klaus P. Ebmeier, Paolo Ghisletta, Richard Henson, Daria E. A. Jensen, Rogier A. Kievit, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Anna Plachti, Sara Pudas, James M. Roe, Kathrine Skak Madsen, Cristina Sole-Padulles, Yasmine Sommerer, Sana Suri, Eniko Zsoldos, Anders M. Fjell, Kristine B. Walhovd
Summary: We found heterogeneity in regional-atrophy patterns through latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. Our findings suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
Article
Geriatrics & Gerontology
Tammy T. Hshieh, Eva M. Schmitt, Tamara G. Fong, Steve Arnold, Michele Cavallari, Bradford C. Dickerson, Simon T. Dillon, Richard N. Jones, Towia A. Libermann, Edward R. Marcantonio, Alvaro Pascual-Leone, Mouhsin M. Shafi, Alexandra Touroutoglou, Thomas G. Travison, Ray Yun Gou, Douglas Tommet, Ayesha Abdeen, Brandon Earp, Lisa Kunze, Jeffrey Lange, Kamen Vlassakov, Sharon K. Inouye
Summary: The SAGES II study aims to enhance our understanding of the correlation between delirium and dementia by examining various biomarkers in older adults undergoing major surgery. The study utilizes a range of assessment methods and techniques, including cognitive testing, neuroimaging, and neurophysiology. This study provides valuable insights into the relationship between delirium and dementia.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Jessica M. Ross, Emiliano Santarnecchi, Shu Jing Lian, Tamara G. Fong, Alexandra Touroutoglou, Michele Cavallari, Thomas G. Travison, Edward R. Marcantonio, Towia A. Libermann, Eva M. Schmitt, Sharon K. Inouye, Mouhsin M. Shafi, Alvaro Pascual-Leone
Summary: Post-surgical delirium is a serious complication that can lead to cognitive decline and loss of function. This study found that neurophysiologic measures, such as resting-state EEG and transcranial magnetic stimulation, could predict the risk of delirium in older patients undergoing surgery.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Chun Liang Hsu, Brad Manor, Thomas Travison, Alvaro Pascual-Leone, Lewis A. Lipsitz
Summary: This study investigated differences in sensorimotor network (SMN) and frontoparietal network (FPN) in older adults with/without decline in gait speed and their association with cognitive function. The results showed that maintainers had lower baseline connectivity in SMN and higher connectivity in FPN compared to decliners. Lower connectivity in primary motor-premotor network was correlated with maintenance of delayed-recall performance on HVLT.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Neurosciences
Ali Jannati, Lindsay M. Oberman, Alexander Rotenberg, Alvaro Pascual-Leone
Summary: Transcranial magnetic stimulation (TMS) is a promising non-invasive technique for the diagnosis and treatment of neurological and psychiatric disorders. This review focuses on repetitive TMS (rTMS) protocols and their metrics of brain plasticity, such as theta-burst stimulation (TBS). It also discusses the use of TMS-EEG technique, neuronavigation, and the effects of age and genetic factors on TBS aftereffects. Furthermore, it summarizes alterations of TMS-TBS measures of plasticity in major neurological and psychiatric disorders.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Maria Cabello-Toscano, Lidia Vaque-Alcazar, Gabriele Cattaneo, Javier Solana-Sanchez, Ivet Bayes-Marin, Kilian Abellaneda-Perez, Didac Macia-Bros, Lidia Mulet-Pons, Cristina Portellano-Ortiz, Miquel Angel Fullana, Laura Oleaga, Sofia Gonzalez, Nuria Bargallo, Jose M. Tormos, Alvaro Pascual-Leone, David Bartres-Faz
Summary: This study investigates the resilience to the mental health impact of the COVID-19 pandemic and identifies the demographic, psychological, and neurobiological factors associated with interindividual differences. The findings suggest that age, sex, coping strategies, and brain network status are all related to mental health. Therefore, preventive strategies should consider these factors to promote mental health during similar adverse events.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Clinical Neurology
Alejandro Garcia-Rudolph, Mark Wright, Loreto Garcia, Joan Sauri, Blanca Cegarra, Josep Maria Tormos, Eloy Opisso
Summary: Being able to survive independently in the long-term is a concern for patients with spinal cord injury (SCI), their relatives, and healthcare providers. Previous studies have focused on predicting functional dependency within one year after injury.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Rehabilitation
Alejandro Garcia-Rudolph, Joan Sauri, Katryna Cisek, John D. D. Kelleher, Vince Istvan Madai, Dietmar Frey, Eloy Opisso, Josep Maria Tormos, Montserrat Bernabeu
Summary: This study investigated the relationship between inpatient rehabilitation variables and long-term community integration among stroke patients. Three different trajectories of rehabilitation were identified: lowest community integration, highest community integration, and intermediate community integration. Baseline factors such as age, functional independence measure, hypertension, length of stay, and education level were found to predict long-term community integration trajectories.
TOPICS IN STROKE REHABILITATION
(2023)
Article
Clinical Neurology
Kilian Abellaneda-Perez, Gabriele Cattaneo, Maria Cabello-Toscano, Javier Solana-Sanchez, Lidia Mulet-Pons, Lidia Vaque-Alcazar, Ruben Perellon-Alfonso, Cristina Sole-Padulles, Nuria Bargallo, Josep M. Tormos, Alvaro Pascual-Leone, David Bartres-Faz
Summary: A higher sense of purpose in life can enhance the brain's resilience against cognitive impairment in middle age and promote better cognitive function. This is achieved through better functional integration of specific brain networks.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Selma Delgado-Gallen, M. D. Soler, Maria Cabello-Toscano, Kilian Abellaneda-Perez, Javier Solana-Sanchez, Goretti Espana-Irla, Alba Roca-Ventura, David Bartres-Faz, Josep M. Tormos, Alvaro Pascual-Leone, Gabriele Cattaneo
Summary: Pain processing involves emotional and cognitive factors that can modify pain perception. Pain catastrophizing is implicated in maladaptive plastic changes related to chronic pain. Functional magnetic resonance imaging studies have shown an association between chronic pain and the default mode and dorsoattentional networks. The efficient functioning of these networks and catastrophizing can predict pain progression and minimize the impact on daily life activities.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Linguistics
Toms Voits, Jason Rothman, Marco Calabria, Holly Robson, Naiara Aguirre, Gabriele Cattaneo, Victor Costumero, Mireia Hernandez, Montserrat Juncadella Puig, Lidon Marin-Marin, Anna Suades, Albert Costa, Christos Pliatsikas
Summary: Bilingualism has been found to increase resilience against cognitive aging, but its effects on neurocognitive outcomes in individuals with Mild Cognitive Impairment (MCI) are still unclear. This study examines the impact of bilingual language experience on structural brain data in a cohort of bilinguals diagnosed with MCI. The results indicate a non-linear relationship between bilingual language entropy and hippocampal volume, although no significant effect on episodic memory performance or age of MCI diagnosis was found.
BILINGUALISM-LANGUAGE AND COGNITION
(2023)
Article
Psychiatry
I. Bayes-Marin, M. Cabello-Toscano, G. Cattaneo, J. Solana-Sanchez, D. Fernandez, C. Portellano-Ortiz, J. M. Tormos, A. Pascual-Leone, D. Bartres-Faz
Summary: The study aimed to identify trajectories of mental health during a two-year follow-up of the COVID-19 pandemic and investigate the associations between these trajectories and various factors. They found that most participants belonged to the "resilient" trajectory, while a smaller proportion belonged to the "chronic-worsening" trajectory. Protective factors and risk factors played different roles in different mental health outcomes.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2023)
