Article
Materials Science, Multidisciplinary
Luiz Otavio Guimaraes-Ervilha, Leoncio Lopes Soares, Isabela da Silva Pereira Bento, Renner Philipe Rodrigues Carvalho, Thaina Iasbik Lima, Fernanda Carolina Ribeiro Dias, Daniel Silva Sena Bastos, Jamile Fernanda Silva Cossolin, Ana Claudia Ferreira Souza, Emily Correna Carlo Reis, Jose Eduardo Serrao, Antonio Jose Natali, Mariana Machado-Neves
Summary: Pulmonary arterial hypertension (PAH) is characterized by elevated arterial pressure and vascular resistance. PAH may cause alterations in the microcirculation of several organs, including the kidney, liver, brain, and testes. This study investigated the impact of PAH on testicular morphology and function and found that PAH has deleterious effects on these parameters. However, resistance exercise training (RT) was shown to attenuate the negative effects of PAH on testicular parameters and improve testosterone levels.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Peripheral Vascular Disease
Anna Rogowska, Lukasz Obrycki, Zbigniew Kulaga, Claudia Kowalewska, Mieczyslaw Litwin
Summary: The study found that hypertensive children show signs of microcirculation remodeling and decreased neural layer of the retina, associated with hypertensive macrocirculation remodeling characterized by increased carotid intima-media thickness and elevated central systolic blood pressure.
Review
Medicine, General & Internal
Tijana Tuhy, Paul M. Hassoun
Summary: Systemic sclerosis is an autoimmune disorder that affects the connective tissue and causes skin thickening and complications in the internal organs. Pulmonary involvement, including pulmonary arterial hypertension and interstitial lung disease, is the main cause of morbidity and mortality in scleroderma patients. Current treatment options are not specific to pulmonary involvement in scleroderma, and patients with pulmonary arterial hypertension in this population tend to have worse outcomes and lower response to therapy compared to other forms of Group I pulmonary hypertension.
FRONTIERS IN MEDICINE
(2023)
Article
Genetics & Heredity
Aurelie Dewaele, Emilie Dujardin, Marjolaine Andre, Audrey Albina, Helene Jammes, Frank Giton, Eli Sellem, Genevieve Jolivet, Eric Pailhoux, Maelle Pannetier
Summary: This study investigates the role of estrogens in male reproductive system using a rabbit model. The findings suggest that testicular estrogens may be involved in sperm development and acquisition of motility.
Article
Cardiac & Cardiovascular Systems
R. Mark Grady, Matthew W. Canter, Fei Wan, Anton A. Shmalts, Ryan D. Coleman, Maurice Beghetti, Rolf M. F. Berger, Maria J. del Cerro Marin, Scott E. Fletcher, Russel Hirsch, Tilman H. Umpl, D. Dunbar Ivy, Edward C. Kirkpatrick, Thomas J. Kulik, Marilyne Levy, Shahin Moledina, Delphine Yung, Pirooz Eghtesady, Damien Bonnet
Summary: Pulmonary-to-systemic arterial shunt surgery provides significant clinical improvement for children with severe PH, with high survival rates after discharge, while children at high risk in-hospital are not suitable candidates for the procedure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Tomislav Susnjar, Ivana Kuzmic Prusac, Ivan Svagelj, Andela Jurisic, Tomislav Susnjar, Antonija Jurisic, Miro Jukic, Zenon Pogorelic
Summary: The study compared the consequences of single and triple testicular biopsies in pubertal rats using histological and immunohistochemical analysis. The results showed that a single biopsy had minimal effects on overall fertility, while triple biopsies caused more significant histological and immunohistochemical consequences without significantly impacting overall fertility. Sperm analysis demonstrated that both single and triple biopsies had no significant effect on sperm count, motility, and morphology.
Article
Biochemistry & Molecular Biology
Yanan Hao, Yanni Feng, Xiaowei Yan, Liang Chen, Ruqing Zhong, Xiangfang Tang, Wei Shen, Qingyuan Sun, Zhongyi Sun, Yonglin Ren, Hongfu Zhang, Yong Zhao
Summary: This study found that improving gut microbiota can significantly improve semen quality and male fertility in T1D patients. This is achieved through the production of specific fatty acids and the improvement of spleen and liver functions, which further promote a conducive environment for spermatogenesis.
MOLECULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Maria Antonietta Coschignano, Carolina De Ciuceis, Claudia Agabiti-Rosei, Valeria Brami, Claudia Rossini, Giulia Chiarini, Paolo Malerba, Francesca Fama, Deborah Cosentini, Maria Lorenza Muiesan, Massimo Salvetti, Alina Petelca, Sara Capellini, Chiara Arnoldi, Matteo Nardin, Salvatore Grisanti, Damiano Rizzoni, Alfredo Berruti, Anna Paini
Summary: Antiangiogenic therapies such as TKI and direct anti-VEGF monoclonal antibodies are increasingly used in the treatment of solid tumors, but they can lead to hypertension. This study evaluated the effects of these drugs on retinal arterioles and capillary density, finding that while they may require increased antihypertensive treatment, microvascular structure can be partially preserved under adequate blood pressure control.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Critical Care Medicine
Hussein J. Hassan, Mario Naranjo, Nour Ayoub, Traci Housten, Steven Hsu, Aparna Balasubramanian, Catherine E. Simpson, Rachel L. Damico, Stephen C. Mathai, Todd M. Kolb, Paul M. Hassoun
Summary: This study compared the characteristics and survival rates of patients with systemic sclerosis-associated pulmonary hypertension (SSc-PH) between the last two decades. The results showed that the transplant-free survival rate has significantly improved for patients with group 1 disease over the past decade, possibly due to earlier detection and better therapeutic management. In contrast, patients with group 2 or 3 disease continue to have a poor prognosis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Andrology
Misturah Y. Adana, Aminu Imam, Ahmed A. Bello, Olawale E. Sunmonu, Ezekiel P. Alege, Oluwafemi G. Onigbolabi, Moyosore Salihu Ajao
Summary: This study investigated the effects of thymoquinone on the testes after exposure to cyclophosphamide. The results showed that cyclophosphamide exposure caused functional and structural changes in the testes, but thymoquinone intervention was able to reverse these effects, suggesting a potential protective role.
Review
Biochemistry & Molecular Biology
Alessandro Mengozzi, Sarah Costantino, Alessia Mongelli, Shafeeq A. Mohammed, Era Gorica, Valentina Delfine, Stefano Masi, Agostino Virdis, Frank Ruschitzka, Francesco Paneni
Summary: Systemic arterial hypertension is a complex disease characterized by accelerated vascular aging and high cardiovascular morbidity and mortality. Recent evidence has shown the involvement of epigenetic signals in maladaptive vascular remodeling, sympathetic activation, and cardiometabolic alterations, all of which contribute to the development of hypertension. These epigenetic changes have long-lasting effects on gene regulation and are not easily reversible.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Dirk M. Wuttge, Anting L. Carlsen, Gabriel Teku, Marie Wildt, Goran Radegran, Mauno Vihinen, Niels H. H. Heegaard, Roger Hesselstrand
Summary: The study found a link between the expression levels of circulating plasma miRNAs and the occurrence of SSc-APAH in female patients with ACA-positive lcSSc.
Article
Pharmacology & Pharmacy
Carlos Jose Dias, Herikson Araujo Costa, Carlos Alberto Alves Dias-Filho, Andressa Coelho Ferreira, Bruno Rodrigues, Maria Claudia Irigoyen, Antonio Carlos Romao Borges, Vicenilma de Andadre Martins, Flavia Castello Branco Vidal, Rachel Melo Ribeiro, Natalino Salgado Filho, Cristiano T. Mostarda
Summary: The use of carvacrol in spontaneously hypertensive rats (SHR) showed antihypertensive effects and increased expression of MAS receptors in kidney tissue.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Atsunori Yamamoto, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki
Summary: The study revealed that the increased protein expression of CMKLR1 in the PVN of rats with hypertension is at least partly responsible for the systemic hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Chao Tang, Yunmei Luo, Sha Li, Bo Huang, Shangfu Xu, Lisheng Li
Summary: Inflammation plays a significant role in the pathogenesis of PAH. The study found that PAH induced by MCT progresses from an acute inflammatory phase to a chronic inflammatory phase, with changes in pro-inflammatory cytokines and macrophage ratios in the lung. The PI3K/Akt signaling pathway is also related to the progression of PAH and inflammation characteristics induced by MCT.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Obstetrics & Gynecology
Mariana Camargo, Emad Ibrahim, Paula Intasqui, Larissa B. Belardin, Mariana P. Antoniassi, Charles M. Lynne, Nancy L. Brackett, Ricardo P. Bertolla
Summary: Varicocele is associated with decreased semen quality and increased levels of inflammatory cytokines in seminal plasma. Varicocelectomy can lead to improvements in sperm morphology and decreased inflammatory activity in seminal plasma.
Article
Biotechnology & Applied Microbiology
Davide Di Bella, Joao P. S. Ferreira, Renee de Nazare O. Silva, Cinthya Echem, Aline Milan, Eliana H. Akamine, Maria H. Carvalho, Stephen F. Rodrigues
Summary: The study found that 20 nm cit-AuNP has important anti-inflammatory properties in the brain of mice with sepsis and could be a potential candidate as an adjuvant drug along with antibiotics in the treatment of sepsis to prevent SAE.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Renee de Nazare Oliveira da Silva, Rosangela Aparecida Santos-Eichler, Carolina Dias, Stephen Fernandes Rodrigues, Dominik S. Skiba, Richardt Gama Landgraf, Maria Helena Catelli de Carvalho, Tomasz Guzik, Ricardo Ambrosio Fock, Eliana Hiromi Akamine
Summary: The study revealed that the spleen has a protective role in the inflammatory profile of mesenteric PVAT during obesity, and splenectomy resulted in adipocyte hypertrophy, immune cell infiltration, and increased proinflammatory cytokines in mPVAT.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Gustavo Augusto Keusch Albano Nogueira, Valter Luiz Maciel, Aram Minas, Mariana Pereira Antoniassi
Summary: Research on varicocele mechanisms using animal models, particularly rats, is crucial due to ethical restrictions on human tissue study designs. Inducing varicocele in rats through surgical techniques provides insights into the pathophysiology, allowing for the development of new therapeutic approaches. Animal models also aid in exploring antioxidant and anti-inflammatory agents to address varicocele conditions, with a focus on the newly uncovered inflammasome complex's potential role in the disease's pathophysiology.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Editorial Material
Cell Biology
Stephen F. Rodrigues, Karen Y. Stokes, William T. Festuccia, Joilson O. Martins
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Bruna Moretto Rodrigues, Lucas Solla Mathias, Igor de Carvalho Depra, Sarah Santiloni Cury, Miriane de Oliveira, Regiane Marques Castro Olimpio, Maria Teresa De Sibio, Bianca Mariani Goncalves, Celia Regina Nogueira
Summary: This study provides new directions for elucidating the mechanisms of T3 action on osteoblast metabolism, with potential future implications for the treatment of endocrine-related bone pathologies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Reproductive Biology
Bianca M. Goncalves, Jones B. Graceli, Paula B. da Rocha, Helena P. Tilli, Ester M. Vieira, Maria T. de Sibio, Vinicius V. Peghinelli, Igor C. Depra, Lucas S. Mathias, Regiane M. C. Olimpio, Virginia C. Belik, Celia R. Nogueira
Summary: The placenta is a temporary organ that plays critical roles at the maternal-fetal interface. Its normal development and function depend on hormonal signaling pathways, which also make it vulnerable to endocrine disrupting chemicals. New placental models have been developed to assess and prevent developmental toxic harm caused by these chemicals. This review focuses on discussing the newest in vitro models for understanding the maternal-fetal interface and predicting placental development, physiology, and dysfunction.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tiago J. Costa, Paula R. Barros, Diego A. Duarte, Julio A. Silva-Neto, Sara Cristina Hott, Thamyris Santos-Silva, Claudio M. Costa-Neto, Felipe V. Gomes, Eliana H. Akamine, Cameron G. McCarthy, Francesc Jimenez-Altayo, Ana Paula Dantas, Rita C. Tostes
Summary: This study found that aging intensifies α1A-adrenergic signaling-mediated vasoconstriction in the carotid artery of female mice, by increasing intracellular calcium and the release of cyclooxygenase-derived prostanoids.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Obstetrics & Gynecology
L. B. Belardin, M. P. Antoniassi, M. Camargo, P. Intasqui, R. P. Bertolla
Summary: This study found that it is possible to remove sperm with damaged DNA from a semen sample by using immunomagnetic cell sorting that targets the sperm head-bound epididymal sperm-binding protein 1 (ELSPBP1).
HUMAN REPRODUCTION
(2023)
Review
Immunology
Aram Minas, Lucas Vasconcelos Soares Costa, Mika Alexia Miyazaki, Mariana Pereira Antoniassi
Summary: During the past decades, numerous factors influencing male infertility disease have been extensively studied. The role of inflammation in some major infertility-related conditions, such as varicocele, spinal cord injury, and obesity, has been investigated. Inflammation is the immune system's primary response to infection or cell damage, characterized by the release of inflammatory cytokines when homeostasis is disrupted. The activation of inflammasome, an important multiprotein complex, by pathogen-associated or damage-associated molecular patterns plays a crucial role in pro-inflammatory cytokine release. Although the involvement of inflammasome in male infertility has received recent attention, its potential as a target for drug therapy is promising. This review aims to provide insights into the activation of inflammasome complex, its implications in various male infertility conditions, and its localization in the male reproductive tract.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lucas Solla Mathias, Carina Herman-de-Sousa, Sarah Santiloni Cury, Celia Regina Nogueira, Paulo Correia-de-Sa, Miriane de Oliveira
Summary: The anti-obesity hormones T3 and irisin have been found to stimulate thermogenesis and energy consumption, while reducing lipid accumulation. This study investigated their effects on the purinergic signaling pathway in adipocytes, and found that T3 and irisin differentially regulate the transcription of purinergic signaling markers. These findings may offer new insights into the treatment of obesity and related metabolic disorders.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Review
Andrology
Aram Minas, Sina Mahmoudabadi, Naeimeh Shamsi Gamchi, Mariana Pereira Antoniassi, Arash Alizadeh, Ricardo Pimenta Bertolla
Summary: Testicular torsion is a condition where the testis rotates around its longitudinal axis and twists the spermatic cord, causing a decrease in blood flow and perfusion of testicular tissue. Surgical intervention (testicular detorsion) is the recommended treatment option to prevent recurrence. Possible side effects include reperfusion injury, endothelial cell injury, microcirculation disturbances, and germ cell loss.
Article
Nanoscience & Nanotechnology
Joao P. Ferreira, Davide Di Bella, Diana Z. Andreotti, Bryan F. Cortes, Maria H. Carvalho, Elisa M. Kawamoto, Stephen F. Rodrigues
Summary: Sepsis is a serious systemic disease that affects multiple organs, including the brain. The brain's condition, known as sepsis-associated encephalopathy (SAE), can cause acute and chronic symptoms. Acute symptoms include delirium, while chronic symptoms include cognitive impairment, locomotor dysfunction, and mood disorders such as depression. The pathophysiology of SAE involves systemic and local actions.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Review
Respiratory System
Nicolle R. Machado, Karina T. Dias, Bryan F. S. Cortes, Stephen F. Rodrigues
Summary: Coronavirus-induced diseases, including COVID-19, have been a global health issue for several decades, causing millions of deaths. This review focuses on the enhanced vascular permeability in the lungs of COVID-19 patients, which plays a crucial role in the morbidity and mortality caused by coronaviruses. The dysregulated vascular permeability is a potential target for both new and existing drugs.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Article
Multidisciplinary Sciences
Eduardo H. Moretti, Abner C. Rodrigues, Bruno V. Marques, Leonardo T. Totola, Caroline B. Ferreira, Camila F. Brito, Caroline M. Matos, Filipe A. da Silva, Robson A. S. Santos, Luciana B. Lopes, Thiago S. Moreira, Eliana H. Akamine, Luiz A. Baccala, Andre Fujita, Alexandre A. Steiner
Summary: Uncontrolled vasodilation is responsible for hypotension in advanced stages of sepsis, but the mechanisms of hypotension in earlier stages are unclear. This study found that early hypotension following bacterial lipopolysaccharide injection is caused by a decrease in vascular resistance while arterioles are still responsive. The prioritization of local blood flow regulation over brain-driven pressure regulation may underlie the development of early hypotension.
