Article
Pharmacology & Pharmacy
SiChan Li, SanLan Wu, WeiJing Gong, Peng Cao, Xin Chen, Wanyu Liu, Liping Xiang, Yang Wang, JianGeng Huang
Summary: The joint population pharmacokinetic model of voriconazole and its metabolite was established in immunocompromised patients. The study found that pharmacokinetics of voriconazole was influenced by CYP2C19 genetic variations and recommended dosage regimens might need adjustment for different CYP2C19 genotypes. The proposed maintenance dose regimens could improve clinical outcomes and minimize drug-related toxicities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pediatrics
Juan Chen, Ying Wu, Yuelin He, Xiaoqin Feng, Yuqiong Ren, Shiting Liu
Summary: This study aimed to identify factors associated with voriconazole concentrations and dose requirements in pediatric patients. The results showed that CYP2C19 phenotypes, CRP concentrations, age, and the presence of immunosuppressants had significant effects on the pharmacokinetic changes in voriconazole. Combining relevant factors with dose adaptation strategies in therapeutic drug monitoring may help to reduce the incidence of subtherapeutic and supratherapeutic concentrations in clinical practice.
FRONTIERS IN PEDIATRICS
(2022)
Review
Health Care Sciences & Services
Marie Josette Deborah Pierre-Francois, Vincent Gagne, Ivan Brukner, Maja Krajinovic
Summary: Genetic variability in CYP2C19 can affect drug metabolism and therefore impact the efficacy and toxicity of drugs. This literature review highlights the importance of CYP2C19 genotyping in optimizing the treatment of pediatric patients receiving voriconazole, proton pump inhibitors, and antidepressants. Additionally, a method for detecting CYP2C19 gene variants is presented.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Microbiology
Xueke Tian, Congmin Zhang, Zifei Qin, Dao Wang, Jing Yang, Xiaojian Zhang
Summary: The study retrospectively analyzed the key factors influencing the plasma trough concentration of VRC, highlighting the impact of age, CYP2C19 phenotype, and combination medication on dosing. It was found that dose-normalized C-min values varied significantly between different metabolizer types, with additional considerations needed for optimal therapy in pediatric patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Lin Cheng, Zaiming Liang, Fang Liu, Ling Lin, Jiao Zhang, Linli Xie, Mingjie Yu, Fengjun Sun
Summary: This study aimed to investigate the independent factors influencing the concentration of voriconazole (VCZ) in order to optimize dosing regimens and maintain therapeutic concentrations. It was found that in younger adult patients, the levels of total bile acid (TBA), glutamic-pyruvic transaminase (ALT), and the use of proton-pump inhibitors were independent factors influencing VCZ concentration. In elderly patients, direct bilirubin (DBIL), albumin, and estimated glomerular filtration rate (eGFR) were found to be influential factors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Lin Hu, Shiqiong Huang, Qi Huang, Juanjuan Huang, Zeying Feng, Gefei He, Felix Bongomin
Summary: This study evaluated factors affecting voriconazole (VRC) pharmacokinetic parameters in Chinese pediatric patients and proposed optimal dosing regimens for different CYP2C19 genotypes. PPK analysis showed that CYP2C19 phenotype was a significant covariate for VRC clearance. Dose simulations suggested appropriate maintenance doses for different genotypes to achieve target concentrations.
Article
Biochemistry & Molecular Biology
Natalia Landeros, Alejandro H. Corvalan, Maher Musleh, Luis A. Quinones, Nelson M. Varela, Patricio Gonzalez-Hormazabal
Summary: This study identified seven novel associations and replicated one previously described in Caucasian population, providing insights into the understanding of miRNA genetic polymorphisms in gastric cancer pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sebastian Morales-Pison, Julio C. Tapia, Sarai Morales-Gonzalez, Edio Maldonado, Monica Acuna, Gloria M. Calaf, Lilian Jara
Summary: This study found that specific germline variants in driver genes MAP3K1, SF3B1, and SMAD4 contribute to the risk of breast cancer in the Chilean population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Takeo Yasu, Yuka Nomura, Yoshito Gando, Yasuhiko Matsumoto, Takashi Sugita, Nobuharu Kosugi, Masayuki Kobayashi
Summary: The study aimed to develop an ultra-simple method to measure plasma voriconazole concentration, which will help improve the implementation rate of voriconazole therapeutic drug monitoring and contribute to effective and safe use of the drug.
Article
Pharmacology & Pharmacy
Lin Cheng, Yue Zhao, Zaiming Liang, Xi You, Changsheng Jia, Xiuying Liu, Qian Wang, Fengjun Sun
Summary: This study aimed to develop a machine learning-based method for predicting toxic plasma trough concentration of voriconazole (VCZ). Three machine learning algorithms were used to model data from adult patients, and an external validation set was used to verify the reliability of the models. The results showed that these machine learning models can accurately predict the toxic concentration exposure of VCZ.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Rattanaporn Sukprasong, Sumonrat Chuwongwattana, Napatrupron Koomdee, Thawinee Jantararoungtong, Santirhat Prommas, Pimonpan Jinda, Jiratha Rachanakul, Nutthan Nuntharadthanaphong, Nutcha Jongjitsook, Apichaya Puangpetch, Chonlaphat Sukasem
Summary: This study examined the allele frequencies of cytochrome P450 polymorphisms in a Thai population and found significant differences in allele frequencies among different regions within Thailand. The results may contribute to understanding ethnic differences in drug responses and support the use of pharmacogenomics testing in clinical practice.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Christelle Boglione-Kerrien, Jeff Morcet, Lucie-Marie Scailteux, Francois Benezit, Christophe Camus, Jean-Baptiste Mear, Jean-Pierre Gangneux, Eric Bellissant, Camille Tron, Marie-Clemence Verdier, Florian Lemaitre
Summary: This study aimed to implement routine measurement of voriconazole N-oxide (NOX) concentrations, describe the metabolic ratio (MR), and propose a suggested dosage-adjustment algorithm for therapeutic drug monitoring (TDM) of patients treated with voriconazole (VRC). The MR based on NOX proved to be useful for interpretation and clinical decision-making, especially for complex patients. A dosing algorithm was suggested based on the results.
Article
Biotechnology & Applied Microbiology
Xinghua Fan, Hong Zhang, Zhipeng Wen, Xiaoli Zheng, Yi Yang, Jihong Yang
Summary: Voriconazole plasma concentrations in pediatric patients are mainly affected by CYP2C19 gene polymorphisms. CYP2C19*2 and CYP2C19*3 alleles were predictors of voriconazole plasma concentration, while CYP2C9 and CYP3A4 gene polymorphisms did not show significant associations with voriconazole levels.
PHARMACOGENETICS AND GENOMICS
(2022)
Article
Pharmacology & Pharmacy
Zebin Jiang, Zemin Wu, Ruixue Liu, Qin Du, Xian Fu, Min Li, Yongjun Kuang, Shen Lin, Jiaxuan Wu, Weiji Xie, Ganggang Shi, Yanqiang Peng, Fuchun Zheng
Summary: Dyslipidemia is a common complication in patients with kidney diseases and a major risk factor for cardiovascular events. Atorvastatin is commonly used to treat dyslipidemia, however, individual response to the drug varies. This study examined the association between genetic polymorphisms in drug metabolism and transport genes and plasma concentrations of atorvastatin and its metabolites in kidney disease patients. The results suggest that certain functional polymorphisms in the ABCC4 gene may affect the transcriptional activity, thereby affecting the release of atorvastatin and its metabolites from hepatocytes into circulation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nan Cai, Cunren Li, Xianfang Gu, Wenfeng Zeng, Jiawei Zhong, Jingfeng Liu, Guopeng Zeng, Junxing Zhu, Haifeng Hong
Summary: The study found that there is a relationship between CYP2C19 gene polymorphisms and hypertension in the Hakka population. Loss-of-function genotypes of CYP2C19 increase the risk of hypertension.
BMC CARDIOVASCULAR DISORDERS
(2023)