Article
Fisheries
Amro M. Soliman, Daniel R. Barreda
Summary: Acute inflammation plays a crucial role in the immune responses of fish, protecting the host from infection and promoting tissue repair. Inflammatory signals and mediators drive leukocyte recruitment, antimicrobial mechanisms, and resolution of inflammation. Understanding the kinetics and unique characteristics of fish inflammation is important for studying fish diseases and potential treatments.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Microbiology
Alberto Ruiz, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep a. Calduch-Giner, Marc Vinas, Jaume Perez-Sanchez, Enric Gisbert
Summary: Given the potential role of bile salts in lipid digestion, this study evaluated the effects of bile salts supplementation on gut immune response and microbial populations in gilthead seabream. The results showed differential modulation of the microbiota in the anterior and posterior intestine, as well as changes in gene expression related to intestinal health and immune response. Overall, bile salts supplementation could enhance fish farming without compromising intestinal health.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Vivian Naa Amua Wellington, Vijaya Lakshmi Sundaram, Soudamani Singh, Uma Sundaram
Summary: The gut microbiome plays a significant role in gastrointestinal health and can be affected by dietary choices. Dietary supplementation with anti-inflammatory supplements may help restore gut microbiota homeostasis and reduce intestinal inflammation in inflammatory bowel disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Ashraf M. Abd El-latif, Eman A. Abd El-Gawad, Eman Soror, Ramy M. Shourbela, Eman Zahran
Summary: The study demonstrated that dietary supplementation of Salvadora persica can improve the immune and biochemical parameters of Nile tilapia, reduce oxidative stress, and enhance disease resistance against A. hydrophila infection.
AQUACULTURE REPORTS
(2021)
Article
Fisheries
Milena Souza dos Santos Sanchez, Mariana Lins-Rodrigues, Jhonis Ernzen Pessini, Fabio Bittencourt, Wilson Rogerio Boscolo, Altevir Signor
Summary: This study evaluated the effects of dietary supplementation with L-carnitine on growth performance, gut and muscle histological parameters, blood hematology, plasma biochemical parameters, and antioxidant enzymes in Nile tilapia juveniles. Results showed that supplementation with L-carnitine improved growth performance and reduced lipid content in the filet, while also increasing the activity of the enzyme catalase in the liver. Different inclusion levels of L-carnitine had varying effects on weight gain, fat deposition, and triacylglycerol in the fish.
Review
Immunology
Yanrui Wu, Chuan Liu, Weiguo Dong
Summary: Growing evidence suggests that micronutrient status may affect the course of inflammatory bowel disease (IBD), but deficiencies are often overlooked during treatment. Studies have focused on vitamin D and iron supplementation, but research on other vitamins and minerals is still limited. This review provides an overview of the therapeutic effects of micronutrient supplementation in IBD, aiming to draw attention to monitoring and supplementation in IBD patients and provide perspectives for future research.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Food Science & Technology
Xiaolan Li, Zhi-Hong Zhang, Hossain M. Zabed, Junhua Yun, Guoyan Zhang, Xianghui Qi
Summary: Inflammatory bowel disease is a complex gastrointestinal disorder closely related to individual's immune regulation, gene-microbiota interactions, and dietary factors. Tryptophan and its metabolic pathways play vital roles in regulating intestinal inflammation by influencing cytokines, immune cells, and intestinal microbial composition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Agriculture, Multidisciplinary
Nan Gao, Yang Yang, Siqi Liu, Chunyang Fang, Xiujing Dou, Licong Zhang, Anshan Shan
Summary: Tryptophan modulates metabolic pathways to maintain gut immune defense, reduce inflammation, and protect intestinal mucosal barrier and gut microbiota composition. These effects are mainly mediated through the regulation of the AMPK-SIRT1-autophagy pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Parniyan Goodarzi, Mohammad Habibi, Kennedy Roberts, Julia Sutton, Cedrick Ndhumba Shili, Dingbo Lin, Adel Pezeshki
Summary: The study found that tryptophan supplementation can reduce hepatic lipogenesis and gluconeogenesis, but increase glycolysis in LBW piglets. Peripheral serotonin is likely involved in the regulation of feeding behavior, particularly in LBW piglets fed with diets supplemented with a higher dose of tryptophan.
Article
Fisheries
Phadet Hongmanee, Sutee Wongmaneeprateep, Suttisak Boonyoung, Bundit Yuangsoi
Summary: The study investigates the important roles of dietary taurine on the growth performance and feed utilization of juvenile snakehead fish. The results show that supplementation of 0.5% taurine in plant protein-based diet improves the growth performance of the fish.
Article
Veterinary Sciences
Qiufen Li, Jingxin Ouyang, Chenxi Deng, Hua Zhou, Jinming You, Guanhong Li
Summary: This study found that heat stress can increase rectal temperature, alter hormone levels, suppress humoral immunity, and change cecal microflora composition in broiler chickens. However, dietary supplementation of tryptophan (Trp) can decrease rectal temperature, improve microbiota community and Trp metabolism, and enhance humoral immunity in heat-stressed broilers.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Oncology
Yumiko Shirai, Shunsuke Morita, Takashi Iwata, Hiroko Nakai, Mayu Yoshikawa, Kazuma Yoshida, Hiroshi Iwamoto, Kazuhiro Miyaji, Yoshinaga Okugawa, Chikao Miki, Koji Tanaka
Summary: This study investigated the effects of dietary supplementation combined with fish oil containing relatively low levels of EPA and DHA on the inflammatory and nutritional status of patients with epithelial cancer. The results suggest that intake of relatively low EPA and DHA supplements may be effective for mild chronic inflammation in patients with epithelial cancer without infection, although it is difficult to suppress acute inflammation associated with infection.
Article
Immunology
Hui Su, Renjie Chang, Weiwei Zheng, Yuena Sun, Tianjun Xu
Summary: This study identified two miRNAs, miR-210 and miR-3570, which negatively regulate host antibacterial immunity in miiuy croaker. These miRNAs inhibit inflammatory cytokine production by targeting RIPK2, thereby modulating the NF-kappa B signaling pathway and playing a regulatory role in bacteria-induced inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
R. Oyarzun-Salazar, J. L. P. Munoz, O. Mardones, B. S. Labbe, A. Romero, D. Nualart, L. Vargas-Chacoff
Summary: This study investigated the effects of supplementing fish diets with MEL and L-Trp on the physiology and acute stress responses in post-smolt salmon. The results suggest that MEL and L-Trp have different effects on the physiology of the fish, and MEL supplementation attenuates the acute stress response.
Review
Chemistry, Multidisciplinary
Michelle M. Mitchener, Thomas J. Begley, Peter C. Dedon
Summary: tRNA is an integral part of protein translation, functioning as adaptor molecules that link the genetic code in mRNA to amino acids. The existence of multiple synonymous codons and wobble base pairing introduced complexity to tRNA function, but this was resolved with the discovery of tRNA modifications. These modifications stabilize codon-anticodon interactions and prevent translation errors. Recent findings also show that cancer cells exploit this mechanism to promote their own growth and chemotherapy resistance.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Marina Machado, Sergio Fernandez-Boo, Carla Teixeira, Michael Viegas, Renata Serradeiro, Jorge Dias, Benjamin Costas Refojos, Karthik Masagounder
Summary: This study evaluated the effects of feeding whiteleg shrimp with increasing levels of methionine dipeptide on their performance, immune and antioxidant pathways. It was found that gradually increasing the content of methionine dipeptide in the feed up to 0.24% significantly improved the growth performance, feed efficiency, nutrient and nitrogen utilization, and survival rate of the shrimp. Additionally, the methionine dipeptide feed improved the concentration of free amino acid pool and nitrogen metabolites, and reduced signs of oxidative stress.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Parasitology
Sergio Fernandez-Boo, Catarina Duarte, Eric Guevelou, Joana Sousa, Rosa Freitas, Sandra Joaquim, Benjamin Costas, Luisa Magalhaes, Domitilia Matias, Andreia Cruz
Summary: The effect of Perkinsus olseni infection on the reproduction ability of clams has been underestimated. In this study, clams were injected with two different doses of P. olseni parasites, and the effects on reproduction, biochemical parameters and mortality were evaluated. The results showed that the infection had significant effects on the clams' biochemical parameters, mortality, and delayed gonad maturation, leading to impaired reproductive capacity.
Article
Fisheries
Mariana Ferreira, Marina Machado, Catia S. C. Motac, Helena Abreu, Joana Silva, Margarida R. G. Maia, Viswanath Kiron, Benjamin Costas, Luisa M. P. Valente
Summary: Aquaculture intensification is often linked to disease outbreaks, but nutritional approaches, such as algae-derived compounds, can help alleviate the burden caused by diseases. This study evaluated the immunomodulatory activity of an algae blend on farmed seabass's resistance to a bacterial pathogen. The results showed that a 4% inclusion level of the algae blend was the most effective in preventing adhesion and colonization of the pathogen on mucosal tissues, leading to reduced disease progression and mortality.
Article
Fisheries
Joao Estevao, Hugo Osorio, Benjamin Costas, Andreia Cruz, Sergio Fernandez-Boo
Summary: This study characterized the haemolymph proteomic profiles of the grooved carpet shell in response to P. olseni infection. It identified biomarkers associated with tolerance and susceptibility, and found that tolerant clams have an efficient pathogen elimination mechanism and better metabolic regulation.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Sara Jorge, Luis Felix, Benjamin Costas, Ana M. M. Valentim
Summary: Proper housing conditions are important for fish welfare. This study found that environmentally enriched housing conditions had minor effects on zebrafish behavior, but no significant influence on body length and stress hormone levels. It suggests that housing conditions should be considered in future research.
Article
Agriculture, Dairy & Animal Science
Claudia Aragao, Rita Teodosio, Rita Colen, Nadege Richard, Ivar Ronnestad, Jorge Dias, Luis E. C. Conceicao, Laura Ribeiro
Summary: In contemporary aquaculture, the inclusion of plant-protein sources is common practice. However, this may lead to an unbalanced supply of nutrients, such as taurine. Taurine plays important roles in lipid metabolism, and this study aimed to evaluate the effects of taurine supplementation to plant-based diets on the metabolism of taurine and lipids in Senegalese sole.
Article
Microbiology
Antonio Louvado, Carolina Castro, Davide A. M. Silva, Vanessa Oliveira, Luis E. C. Conceicao, Daniel F. R. Cleary, Newton C. M. Gomes
Summary: Live feed enrichments are commonly used in fish larvicultures to enhance growth and survival. This study investigated the effects of two commercial rotifer enrichments on bacterial communities in turbot larvae and post-larval guts during larviculture. The results showed that the enrichments had significant effects on bacterial composition in turbot larvae at 10 days after hatching (DAH), but not in the larval gut communities or bacterioplankton communities. However, a more detailed analysis revealed differences in the abundance of Vibrionales, suggesting that rotifer diets can affect the colonization of Vibrio in post-larval turbot guts.
Article
Engineering, Marine
Filipe M. R. C. Soares, Ana M. D. Nobre, Andreia I. G. Raposo, Rodrigo C. P. Mendes, Sofia A. D. Engrola, Paulo J. A. P. Rema, Luis E. C. Conceicao, Tome S. Silva
Summary: This manuscript introduces the FEEDNETICS model, a detailed mechanistic nutrient-based model for fish farming. The model consists of a fish model, simulating fish growth and nutrient utilization at the individual level, and a farm model, upscaling the information to the population level. The model was calibrated and validated for five commercially relevant farmed fish species, and showed consistent results with a mean absolute percentage error between 11.7 and 13.8%. Several use cases were presented to demonstrate the tool's potential in experimental trial design, interpretation, and evaluating nutritional and environmental effects at the farm level. FEEDNETICS contributes to more efficient fish farming by transforming data into useful information.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Carlos Fajardo, Paulo Santos, Ricardo Passos, Mariana Vaz, Rita Azeredo, Marina Machado, Sergio Fernandez-Boo, Teresa Baptista, Benjamin Costas
Summary: Turbot early immune responses to infection with A. salmonicida subsp. salmonicida were evaluated in this study. The results showed no significant differences in blood and humoral parameters, as well as oxidative stress indicators. However, changes in the expression of genes related to inflammation and immunity were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Physiology
Alejandro S. Mechaly, Jorge M. O. Fernandes, Benjamin Costas, Elvira Fatsini
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Immunology
Ines A. Ferreira, Diogo Peixoto, Ana Paula Losada, Maria Isabel Quiroga, Ana do Vale, Benjamin Costas
Summary: This study aimed to understand the early innate immune response of European sea bass to T. maritimum infection. The results showed that T. maritimum induced a local immune response in the skin, gills, and posterior-intestine of the fish. This may be due to the bacteria's ability to adhere, colonize, and damage these organs. The infected fish also exhibited systemic responses, including increased neutrophils, signs of anemia, and decreased bactericidal and lysozyme activities in the plasma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Diana Martin, M. Camino Ordas, Ines Carvalho, Patricia Diaz-Rosales, Noelia Nunez-Ortiz, Samuel Vicente-Gil, Aitor Arrogante, Carlos Zarza, Marina Machado, Benjamin Costas, Carolina Tafalla
Summary: This study investigates the effects of methionine, tryptophan, and lysine on the functionality of rainbow trout IgM(+) B cells. The results show that methionine supplementation significantly increases cell proliferation and IgM secretion, while tryptophan and lysine have minor or even negative effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Francisco Javier Toledo-Solis, Ana M. Larran, Juan B. Ortiz-Delgado, Carmen Sarasquete, Jorge Dias, Sofia Morais, Ignacio Fernandez
Summary: To ensure food security and nutrition, sustainable aquafeeds with reduced fish meal content should be used in fish farming. Soybean meal is commonly used as an alternative raw material, but its high content can affect fish growth and physiology. This study found that the expression of six microRNAs in blood plasma was associated with high soybean meal content and related physiological consequences. These findings contribute to our understanding of the physiological impact of soybean meal content in farmed fish and suggest that circulating microRNAs may be suitable biomarkers for fish physiology monitoring.
Article
Fisheries
Fernando Pagels, Ines Garrido, Carla Teixeira, Tania G. Tavares, Benjamin Costas, F. Xavier Malcata, Luisa M. P. Valente, A. Catarina Guedes
Summary: Sea urchin's gut, obtained as a co-product in the canning industry, has been found to be a valuable source of bioactive compounds, showing high antioxidant capacity and bactericidal activity. It can also serve as a source of phenolic compounds, carotenoids, and PUFAs, making it a potentially valuable ingredient in aquafeeds.
AQUATIC LIVING RESOURCES
(2023)