Article
Toxicology
Xiaohui Liu, Yutaka Matsuyama, Miki Shimohigashi, Yasuyuki Shimohigashi
Summary: This study demonstrated the significant role of dispersion force in the bifunctional ER alpha-agonist and ER beta-antagonist activities of bisphenol compounds. The electronic effects are not only present in halogens but also in hydrocarbon groups, indicating dispersion force as a major driving force in their activities.
TOXICOLOGY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Sorina Andreea Anghel, Rodica Aura Badea, Gabriela Chiritoiu, David Sebastian Patriche, Petruta Ramona Alexandru, Florentina Pena
Summary: GLP-1 secretion plays a crucial role in controlling blood glucose levels. A newly developed cell line allowed for rapid assessment of GLP-1 secretion. The discovery of quercetin as a potent GLP-1 secretagogue opens up possibilities for developing alternative glucose-lowering therapies.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Preeti Pandey, Jitendra Subhash Rane, Aroni Chatterjee, Abhijeet Kumar, Rajni Khan, Amresh Prakash, Shashikant Ray
Summary: This study investigated the interaction of 10 potential naturally occurring compounds with the SARS-CoV-2 spike protein, indicating their potential to disrupt the binding of the hACE2-S complex. Molecular docking studies and molecular dynamics simulation suggested that flavonoids and non-flavonoids may serve as anti-SARS-CoV-2 agents with drug-likeness properties.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Chengfeng Bai, Shuangjie Wu, Shengnan Ren, Meiqi Zhu, Guoshun Luo, Hua Xiang
Summary: A novel series of covalent antagonists targeting estrogen receptor alpha were designed, synthesized, and evaluated for their antiproliferative efficacy in ER+ breast cancer cells, with compound 19d showing potent antagonistic activity and high selectivity, making it a potential therapeutic option for breast cancer treatment.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Xiaohui Liu, Keitaro Suyama, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi
Summary: The study reports the dual action of bisphenol compounds on ER alpha and ER beta receptors, with the bisphenol E analogs exhibiting enhanced agonist/antagonist activities due to an electrostatic halogen bond. Bisphenol C (BPC) is found to be a bifunctional ER alpha-agonist and ER beta-antagonist, with high ER alpha activity and inhibitory activity against ER beta. The intensified receptor interaction of BPC is attributed to the presence of an n-pi-pi-n conjugation system mediated through the >C = CCl2 double bond.
Article
Oncology
Lisa Marie Kaiser, Mirja Harms, Daniel Sauter, Vijay P. S. Rawat, Mirco Glitscher, Eberhard Hildt, Daniel Tews, Zachary Hunter, Jan Muench, Christian Buske
Summary: Waldenstrom's Macroglobulinemia is a B-cell lymphoma with aggressive disease in patients with CXCR4 mutations. A natural peptide called EPIX4 and its derivatives have shown to impair lymphoma cell growth, indicating potential novel therapies in Waldenstrom's Macroglobulinemia.
Article
Biochemistry & Molecular Biology
Chun-Yu Li, Hao-Nan Wang, Rong-Jing He, Jian Huang, Li-Lin Song, Yun-Qing Song, Peng-Chao Huo, Jie Hou, Guang Ji, Guang-Bo Ge
Summary: This study discovered a natural compound called AMF that can inhibit lsBSH produced by gut microbes, thus modulating bile acid metabolism. AMF reversibly inhibits the catalytic activity of lsBSH in a mixed-inhibition manner and binds to lsBSH through hydrophobic interactions and hydrogen bonding.
Article
Endocrinology & Metabolism
Liva S. L. Krogh, Kristine Henriksen, Signe Stensen, Kirsa Skov-Jeppesen, Natasha C. Bergmann, Joachim Storling, Mette M. Rosenkilde, Bolette Hartmann, Jens J. Holst, Laerke S. Gasbjerg, Filip K. Knop
Summary: The effects of GIP(1-30)NH2 on glucose and bone metabolism in humans and in isolated human pancreatic islets are similar to those of GIP(1-42).
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kang Zhou, Song Yang, Shu-Ming Li
Summary: This review covers the distribution of naturally occurring chalcones up to July 2020, with a focus on the biological and pharmacological activities of the widely investigated xanthohumol and isobavachalcone in plants. It also discusses the structural characteristics and biosynthesis of prenylated chalcones, as well as the metabolism of xanthohumol.
NATURAL PRODUCT REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kolade Olatubosun Faloye, Boris Davy Bekono, Emmanuel Gabriel Fakola, Marcus Durojaye Ayoola, Oyenike Idayat Bello, Oluwabukunmi Grace Olajubutu, Onikepe Deborah Owoseeni, Shafi Mahmud, Mohammed Alqarni, Ahmed Abdullah Al Awadh, Mohammed Merae Alshahrani, Ahmad J. Obaidullah
Summary: The study identified potential glucokinase activators from prenylated flavonoids using molecular docking, molecular dynamics simulation, density functional theory, and ADMET analysis. The top-ranked molecules, including arcommunol B, kuwanon S, manuifolin H, and kuwanon F, showed stability at the active site of glucokinase enzyme and were suggested as potential drug-like candidates with glucokinase activating potentials. Further evaluation of these compounds for their in vitro and in vivo effects is recommended.
Article
Infectious Diseases
Mark A. Deka, Antonio R. Vieira, William A. Bower
Summary: This study compiled occurrence data of confirmed human and animal cases of anthrax from 1954 to 2021 in 94 countries, and developed updated maps of the global predicted ecological suitability of anthrax. The study revealed the relative risk and transmission risk associated with anthrax globally.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Mahmoud Salehi
Summary: Thermodynamic and kinetic parameters are crucial in evaluating enzyme stability and activity. This study addresses and corrects mistakes in the measurement of key parameters and introduces a new parameter, 8, for predicting the potential industrial application of enzymes. Additionally, this study provides a comprehensive collection of all thermodynamic and kinetic parameters for proteases, serving as a valuable resource for understanding the relationships between these parameters and the industrial potential of enzymes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Multidisciplinary
Muhammad Imran, Sana Iqbal, Ajaz Hussain, Jalal Uddin, Mohsin Shahzad, Tanwir Khaliq, Abdul Razzaq Ahmed, Laiba Mushtaq, Muhammad Kashif, Khalid Mahmood
Summary: The study found that naturally occurring flavonoids can interact with the key binding sites of the novel coronavirus, making them potential drug candidates. Compounds with the most potential demonstrated good pharmacokinetic properties and stability in in vitro and in vivo studies.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Behavioral Sciences
Christiana K. Miller, John Meitzen
Summary: This study investigates the modulation of anxiety-related and locomotor behaviors in female rodents by the sex steroid hormone 17 beta-estradiol (estradiol) and its Estrogen Receptors (ERs). The results suggest that estradiol mitigates anxiety-related behaviors through activating Estrogen Receptor (ER) beta and increases locomotor behaviors through ER alpha. However, the influence of ERs on these behaviors cannot always be detected.
HORMONES AND BEHAVIOR
(2023)
Article
Physiology
Zhi-Lin Luan, Wen-Hua Ming, Xiao-Wan Sun, Cong Zhang, Yang Zhou, Feng Zheng, Yong-Liang Yang, You-Fei Guan, Xiao-Yan Zhang
Summary: This study identified alisol B 23-acetate (ABA) as a natural agonist of farnesoid X receptor (FXR) from Alismatis rhizoma, a traditional Chinese medicine, which exerts renoprotective effects against ischemic acute kidney injury (AKI) in an FXR-dependent manner. ABA showed potential as a novel therapeutic agent for AKI treatment in the future by improving renal function, reducing renal tubular apoptosis, ameliorating oxidative stress, and suppressing inflammatory factor expression.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Majji Rambabu, Sivaraman Jayanthi
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
(2020)
Article
Biochemistry & Molecular Biology
Githa Elizabeth Mathew, Jong Min Oh, Kumar Mohan, M. V. Kumudhavalli, Sivaraman Jayanthi, Hoon Kim, Bijo Mathew
PROCESS BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Uttariya Pal, Mohan C. Manjegowda, Anil Mukund Limaye
Summary: The G-protein coupled estrogen receptor (GPER) is involved in short-term non-genomic effects of estrogen. There are known variants of GPER, but a novel variant, called GPER-v5, has been identified and shown to be expressed in human cancer cell lines, potentially representing a new GPER mRNA variant that requires further exploration in primary cells and tissues.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Biochemistry & Molecular Biology
A. Singh, G. Bhatt, N. Gujre, S. Mitra, R. Swaminathan, A. M. Limaye, L. Rangan
Summary: Karanjin, a bioactive furanoflavonoid isolated from Pongamia pinnata, exhibits various health benefits such as anti-diabetic, anti-cancer, and anti-inflammatory properties. Toxicological studies have confirmed that karanjin is non-toxic under physiological conditions. Its potential as a novel drug lead in medicinal and industrial applications is highlighted, suggesting the need for further investigations into its metabolic fate and cellular effects.
Article
Genetics & Heredity
Ajay Kumar, Arun Dhillon, Mohan Chowdenahalli Manjegowda, Neha Singh, Dixcy Jaba Sheeba John Mary, Sachin Kumar, Deepak Modi, Anil Mukund Limaye
Summary: This study reveals that estrogen suppresses HOXB2 expression, with ERα playing a role in this suppression. Future investigations should explore the implications of estrogen-mediated suppression on the proposed tumor suppressor function of HOXB2.
Article
Biochemistry & Molecular Biology
Snigdha Saikia, Uttariya Pal, Deep Jyoti Kalita, Avdhesh Kumar Rai, Anupam Sarma, Amal Chandra Kataki, Anil Mukund Limaye
Summary: High expression of RUNX1T1 in breast tumors is associated with a favorable prognosis and is positively associated with overall survival, relapse-free survival, and distant metastasis-free survival in breast cancer patients. RUNX1T1 expression influences the overall survival of patients with ER alpha-positive and ER alpha-negative breast tumors. In ER alpha-positive breast tumors, estrogen downmodulates the expression of RUNX1T1 mRNA through ER alpha signaling, suggesting a potential role in breast cancer progression.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Chemistry, Organic
Drashti G. Daraji, Dhanji P. Rajani, Sivaraman Jayanthi, Hitesh D. Patel
Summary: In recent years, the development of new drugs as antibacterial agents has been a crucial resolution to combat drug-resistant pathogens. Imidazole derivatives were synthesized and characterized for their antimicrobial activity, with some showing potential against clinically relevant strains. Additionally, these compounds were also evaluated for their antituberculosis and antimalarial activities.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Genetics & Heredity
Gaurav Bhatt, Akshita Gupta, Latha Rangan, Anil Mukund Limaye
Summary: Karanjin, a furanoflavonoid compound, has diverse biological effects in vivo and in vitro. This study explored the transcriptomic footprint of Karanjin in MCF-7 breast cancer cells, revealing its potential estrogen-like activity and cautioning its anticancer potential. Further investigations are needed to understand the mechanism of action.
Article
Education, Scientific Disciplines
Akanksha Dubey, Jayanthi Sivaraman
Summary: In this study, fucoidan was extracted, purified and characterized from Dictyota bartayresiana. It was found to possess antioxidant and cytotoxic properties, making it helpful in managing hepatocellular carcinoma.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Vinod Devaraji, Jayanthi Sivaraman, S. Prabhu
Summary: Researchers are investigating the medicinal properties of herbal plants around the world and using computational methods to screen for potential anti-diabetic plants. They created an in-house Indian herbal plant database and used molecular docking to identify Cassia angustifolia as a plant with phytochemicals that can bind to alpha amylase for anti-diabetic prophylaxis. Experimental extraction and biological activity evaluation confirmed the computational predictions. This study aims to inspire the exploration of plant therapeutic repurposing using computational methods.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Juana Hatwik, Uttariya Pal, Anil Mukund Limaye
Summary: Enterolactone (EL) is a mammalian enterolignan produced in the intestine through microbial biotransformation of dietary lignans. EL has potential nutraceutical properties, including anticancer effects. However, it binds to estrogen receptor-alpha and induces proliferation of breast cancer cells. In this study, RNA-seq data of MCF-7 breast cancer cells treated with EL for 72 hours were obtained to analyze the transcriptomic alterations associated with cell proliferation.
Article
Genetics & Heredity
Uttariya Pal, Mohan C. Manjegowda, Neha Singh, Snigdha Saikia, Betty S. Philip, Deep Jyoti Kalita, Avdhesh Kumar Rai, Anupam Sarma, Vandana Raphael, Deepak Modi, Amal Chandra Kataki, Anil Mukund Limaye
Summary: This study demonstrated the positive association between GPER and ERα in breast tumors, and revealed that GPER expression is induced by estrogen-ERα signaling axis. These findings have implications in understanding the interplay between GPER and ERα in breast tumor development, progression, and treatment.
Article
Biotechnology & Applied Microbiology
Dubey Akanksha, Sivaraman Jayanthi
Summary: A powerful method for synthesizing metal nanoparticles is crucial in nanotechnology. Algae-mediated nanoparticle synthesis serves as an alternative to traditional methods. This study explores the inhibitory effect of phytochemicals on penicillin-binding proteins, leading to the synthesis of silver nanoparticles with antibacterial properties using Dictyota bartayresiana extract, and subsequent computational and experimental investigations further demonstrate the interaction between the nanoparticles and phytochemicals, resulting in antibacterial activity.
RESEARCH JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sagunthala Murugesan Udaya Prakash, Yasin Nazeer, Sivaraman Jayanthi, Mohammad Anaul Kabir
MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Aaftaab Sethi, Swetha Sanam, Sharon Munagalasetty, Sivaraman Jayanthi, Mallika Alvala